期刊
CANCER CAUSES & CONTROL
卷 22, 期 10, 页码 1471-1482出版社
SPRINGER
DOI: 10.1007/s10552-011-9827-3
关键词
Vitamin D; Sun exposure; Vitamin D-binding protein; NADSYN1; DHCR7; GC; Sun sensitivity; Supplementation; Insufficiency; CYP2R1
资金
- Cancer Research UK [C8216/A6129, C588/A4994, C588/A10589, C37059/A11941]
- NIH [R01 CA83115]
- Cancer Research UK [10589] Funding Source: researchfish
Background We report the determinants of serum levels of vitamin D in a UK melanoma case-control study benefitting from detailed exposure and genotyping data. Methods Sun exposure, supplemental vitamin D, and SNPs reported to be associated with serum levels were assessed as predictors of a single serum 25-hydroxyvitamin D-3 measurement adjusted for season, age, sex, and body mass index. Results Adjusted analyses showed that vitamin D levels were sub-optimal especially in the sun-sensitive individuals (-2.61 nmol/L, p = 0.03) and for inheritance of a genetic variant in the GC gene coding for the vitamin D-binding protein (-5.79 for heterozygotes versus wild type, p = <0.0001). Higher levels were associated with sun exposure at the weekend in summer (+4.71 nmol/L per tertile, p = <0.0001), and on hot holidays (+4.17 nmol/L per tertile, p = <0.0001). In smoothed scatter plots, vitamin D levels of 60 nmol/L in the non-sun-sensitive individuals were achieved after an average 6 h/day summer weekend sun exposure but not in the sun-sensitive individuals. Users of supplements had levels on average 11.0 nmol/L higher, p = <0.0001, and achieved optimal levels irrespective of sun exposure. Conclusions Sun exposure was associated with increased vitamin D levels, but levels more than 60 nmol/L were reached on average only in individuals reporting lengthy exposure (>= 12 h/weekend). The sun-sensitive individuals did not achieve optimal levels without supplementation, which therefore should be considered for the majority of populations living in a temperate climate and melanoma patients in particular. Inherited variation in genes such as GC is a strong factor, and carriers of variant alleles may therefore require higher levels of supplementation.
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