Article
Biochemistry & Molecular Biology
Yan Pu, Xu Wen, Zhangjun Jia, Yu Xie, Changxing Luan, Youjia Yu, Feng Chen, Peng Chen, Ding Li, Yan Sun, Jian Zhao, Haiqin Lv
Summary: Gastric cancer ranks second in incidence among all malignancies in China, posing a significant threat to human health. This study identified a significant association between the EFNA1 rs4971066 polymorphism and reduced susceptibility to gastric cancer development through the analysis of tagSNPs in GC related genes.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Multidisciplinary Sciences
Abdullah M. Alhadheq, Narasimha Reddy Parine, Jilani Purusottapatnam Shaik, Rana Alhadheq, Saad Alkahtani, Nada H. Aljarba, Mohammad Alanazi
Summary: This study found that rs1042522 SNPs within TP53 gene are correlated with the possibility of developing CRC in the Saudi population. This finding highlights that these polymorphisms could act as a diagnostic indicator for CRC.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Article
Genetics & Heredity
Shengbing Huang, Pei Qin, Qing Chen, Dongdong Zhang, Cheng Cheng, Chunmei Guo, Quanman Li, Qionggui Zhou, Gang Tian, Ranran Qie, Minghui Han, Xiaoyan Wu, Xingjin Yang, Yifei Feng, Yang Li, Yanyan Zhang, Yuying Wu, Dechen Liu, Jie Lu, Ming Zhang, Yang Zhao, Dongsheng Hu
Summary: The methylation level on a CpG locus of FTO was positively associated with T2DM, while SNPs were not. Additionally, FTO methylation was associated with some risk factors for T2DM. Further studies with a larger sample size and metabolomic data are needed to confirm the findings.
Article
Biochemistry & Molecular Biology
Yanan Zhu, Tao Shi, Xia Lu, Zhen Xu, Junxing Qu, Zhiyong Zhang, Guoping Shi, Sunan Shen, Yayi Hou, Yugen Chen, Tingting Wang
Summary: Mice lacking Dectin-3 showed increased tumorigenesis and Candida albicans burden, leading to enhanced IL-22 production in innate lymphoid cells, highlighting the significance of commensal fungi in regulating host immunity and promoting tumorigenesis.
Review
Immunology
Lauren A. Zenewicz
Summary: Cytokines, including IL-22, play crucial roles in inflammation, with their activity regulated by factors like IL-22BP. IL-22BP, a soluble receptor homolog, binds to IL-22 with greater affinity, impacting the biological functions of IL-22, yet further research is needed to fully understand its role and regulation mechanisms.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Nutrition & Dietetics
Nagisa Mori, Neil Murphy, Norie Sawada, David Achaintre, Taiki Yamaji, Augustin Scalbert, Motoki Iwasaki, Manami Inoue, Marc J. Gunter, Shoichiro Tsugane
Summary: This study measured the plasma concentrations of 35 polyphenols and assessed their associations with colon cancer risk. The results showed that certain polyphenols in coffee were inversely associated with colon cancer risk, although these associations were not significant after adjustment for multiple comparisons.
CLINICAL NUTRITION
(2022)
Article
Medical Laboratory Technology
Leila Jamali, Hossein Sadeghi, Mohammad-Reza Ghasemi, Roohollah Mohseni, Ehsan Nazemalhosseini-Mojarad, Vahid Reza Yassaee, Pegah Larki, Mohammad Reza Zali, Reza Mirfakhraie
Summary: This study evaluated the association between ATG16L1 rs2241880 and ATG5 rs1475270 variants with CRC risk in an Iranian population. The T allele of ATG16L1 rs2241880 was significantly associated with increased CRC risk, while no significant differences were found in ATG5 rs1475270 alleles and genotypes between cases and controls. Further investigations among different populations and ethnicities are needed to refine these conclusions.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Oncology
Yangtao Ji, Yue Yang, Zhihua Yin
Summary: This case-control study conducted on a Chinese northeast population suggests that rs1948915 may be associated with lung adenocarcinoma, while rs7013433 and rs6983267 may not be related to lung cancer. Additionally, there is no interaction between the three selected SNPs and smoking status.
Article
Biochemistry & Molecular Biology
Farhad Tabasi, Vahed Hasanpour, Shamim Sarhadi, Mahmoud Ali Kaykhaei, Pouria Pourzand, Mehrdad Heravi, Ahmad Alinaghi Langari, Gholamreza Bahari, Mohsen Taheri, Mohammad Hashemi, Saeid Ghavami
Summary: The miR-499 rs3746444 polymorphism is positively associated with Hashimoto thyroiditis (HT) risk, and may contribute to the regulation of immune system pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Respiratory System
Yan Wang, Qipeng Zhou, Lingzhu Chen, Lian Dong, Mingmei Xiong, Xiaohui Xie, Li Zhao, Jingyi Xu, Zeguang Zheng, Jian Wang, Wenju Lu
Summary: The incidence of chronic obstructive pulmonary disease (COPD) is influenced by both environmental exposure and genetic factors. IL-22 and its receptors are increased in patients with COPD and may contribute to disease development. This study identified certain variations in the IL-22 gene that are associated with a decreased risk of COPD and may modulate COPD susceptibility by regulating IL-22 expression and promoter activity.
CLINICAL RESPIRATORY JOURNAL
(2022)
Review
Immunology
Giovanni Monteleone, Claudia Maresca, Marco Colella, Teresa Pacifico, Daniele Congiu, Edoardo Troncone, Irene Marafini
Summary: This article reviews the current understanding of the involvement of interleukin-34 (IL-34) and its receptor, macrophage colony-stimulating factor-1 receptor (MCSF-1R), in colorectal cancer (CRC). It highlights the role of the IL-34/MCSF-1R axis in controlling tumor-associated macrophages (TAMs) and promoting cancer resistance to chemotherapy and immunotherapy. The findings suggest that targeting IL-34/MCSF-1R could be a potential therapeutic intervention in CRC.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Genetics & Heredity
Mengjie Sun, Suyun Li, Feng Ning, Li Zhang, Weijing Wang, Haiping Duan, Yili Wu
Summary: This study confirmed the associations of olfactory transduction pathway genes with obesity in Northern Han Chinese adults and identified an interaction between gene variants and smoking on obesity.
Article
Genetics & Heredity
Hanxiao Chen, Ze Du, Yaoyao Zhang, Mengling Li, Rui Gao, Lang Qin, Hongjing Wang
Summary: Current studies indicate that there is no causal association between vitamin C and the risk of cancer. Further research is needed to discover the potential protective and therapeutic effects of vitamin C on cancer and its underlying mechanisms.
FRONTIERS IN GENETICS
(2022)
Article
Clinical Neurology
Lotte Sahin Levison, Reimar Wernich Thomsen, Soren Hein Sindrup, Henning Andersen
Summary: This study found a significant association between incident cancer and an increased risk of subsequent Guillain-Barre syndrome (GBS) development. Different types of cancer have varying impacts on GBS risk.
Article
Environmental Sciences
Jianli Qu, Weili Mao, Kaizhen Liao, Yingying Zhang, Hangbiao Jin
Summary: This study demonstrates that elevated human exposure to BPA and BPS may be associated with the increased lung cancer risk.
ENVIRONMENTAL POLLUTION
(2022)