Article
Nutrition & Dietetics
Nena Karavasiloglou, David J. Hughes, Neil Murphy, Lutz Schomburg, Qian Sun, Vartiter Seher, Sabine Rohrmann, Elisabete Weiderpass, Anne Tjonneland, Anja Olsen, Kim Overvad, Marie-Christine Boutron-Ruault, Francesca Romana Mancini, Yahya Mahamat-Saleh, Rudolf Kaaks, Tilman Kuhn, Matthias B. Schulze, Rosario Tumino, Salvatore Panico, Giovanna Masala, Valeria Pala, Carlotta Sacerdote, Jeroen W. G. Derksen, Guri Skeie, Anette Hjartaker, Cristina Lasheras, Antonio Agudo, Maria-Jose Sanchez, Maria-Dolores Chirlaque, Eva Ardanaz, Pilar Amiano, Bethany Van Guelpen, Bjorn Gylling, Kathryn E. Bradbury, Keren Papier, Heinz Freisling, Elom K. Aglago, Amanda J. Cross, Elio Riboli, Dagfinn Aune, Marc J. Gunter, Mazda Jenab
Summary: Two large European cohort studies found that circulating calcium concentrations were associated with colorectal cancer risk. In the EPIC cohort, total serum calcium was not associated with colorectal cancer, while in the UK-BB cohort, serum ionized calcium was inversely associated with colorectal cancer risk.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Oncology
Fei Chen, Peggy Wan, Lynne R. Wilkens, Loic Le Marchand, Christopher A. Haiman
Summary: This study found an association between the use of statins and a lower risk of prostate cancer and mortality, particularly in aggressive forms of the disease. This association was consistent across different racial and ethnic groups.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Public, Environmental & Occupational Health
Helga H. Hektoen, Randi E. Gislefoss, Jo S. Stenehjem, Hilde Langseth, Karol Axcrona, Alison M. Mondul, Trude E. Robsahm, Bettina K. Andreassen
Summary: The deficiency of 25-hydroxyvitamin D (25(OH)D) may increase the risk of mortality among patients with urothelial bladder cancer (BC), especially for those with non-muscle invasive BC (NMIBC).
CLINICAL EPIDEMIOLOGY
(2021)
Article
Oncology
Jessica M. Madrigal, Rebecca Troisi, Helja-Marja Surcel, Hanna Ohman, Juha Kivela, Hannu Kiviranta, Panu Rantakokko, Jani Koponen, Danielle N. Medgyesi, Cari M. Kitahara, Katherine A. McGlynn, Joshua Sampson, Paul S. Albert, Mary H. Ward, Rena R. Jones
Summary: This study investigated the relationship between PFAS and thyroid cancer risk in Finnish maternity cohort. The results showed no clear association between most PFAS and thyroid cancer risk, except for PFHxS which was inversely associated. There were suggestive increased risks for PFOA, PFOS, and EtFOSAA among those diagnosed at ages <40 years.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Ziling Mao, Jacqueline Roshelli Baker, Masayoshi Takeuchi, Hideyuki Hyogo, Anne Tjonneland, Anne Kirstine Eriksen, Gianluca Severi, Joseph Rothwell, Nasser Laouali, Verena Katzke, Rudolf Kaaks, Matthias B. Schulze, Domenico Palli, Sabina Sieri, Maria Santucci de Magistris, Rosario Tumino, Carlotta Sacerdote, Jeroen W. G. Derksen, Inger T. Gram, Guri Skeie, Torkjel M. Sandanger, Jose Ramon Quiros, Marta Crous-Bou, Maria-Jose Sanchez, Pilar Amiano, Sandra M. Colorado-Yohar, Marcela Guevara, Sophia Harlid, Ingegerd Johansson, Aurora Perez-Cornago, Heinz Freisling, Marc Gunter, Elisabete Weiderpass, Alicia K. Heath, Elom Aglago, Mazda Jenab, Veronika Fedirko
Summary: Glyceraldehyde-derived advanced glycation end products (glycer-AGEs) are associated with the development and progression of colorectal cancer due to their oxidative and inflammatory properties. This study found that circulating glycer-AGEs concentrations are positively associated with both colorectal cancer-specific and all-cause mortality. The association between glycer-AGEs and colorectal cancer-specific mortality is stronger in patients with distal colon cancer.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Kyung Min Lee, Alex K. Bryant, Julie A. Lynch, Brian Robison, Patrick R. Alba, Fatai Y. Agiri, Kathryn M. Pridgen, Scott L. DuVall, Kosj Yamoah, Isla P. Garraway, Brent S. Rose
Summary: The study found that, at any given PSA level, Black men are more likely to develop prostate cancer than White men.
Article
Oncology
Susan R. Sturgeon, David A. Sela, Eva P. Browne, Jonah Einson, Asha Rani, Mohamed Halabi, Thomas Kania, Andrew Keezer, Raji Balasubramanian, Regina G. Ziegler, Catherine Schairer, Karl T. Kelsey, Kathleen F. Arcaro
Summary: Analysis of WBC DNA methylation in breast cancer cases and noncases revealed potential associations with breast cancer risk, although the specific patterns were not conclusively identified. Further research is needed to better understand the link between prediagnostic WBC DNA methylation marks and breast cancer.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2021)
Article
Nutrition & Dietetics
Yun Zhu, Jing Zhao, Jillian Vallis, Fuyan Shi, Jennifer R. Woodrow, Yujia Kong, Guangju Zhai, Patrick Parfrey, John R. Mclaughlin, Peizhong Peter Wang
Summary: High prediagnostic intake of cheese and dietary calcium may be associated with increased survival among colorectal cancer patients. This study suggests that manipulating diet could contribute to the development of novel therapies against CRC, although replication studies are needed before nutritional interventions can be implemented.
BRITISH JOURNAL OF NUTRITION
(2022)
Article
Multidisciplinary Sciences
Xu Lei, Tengfei Zhang, Zhixuan Deng, Tao Jiang, Yang Hu, Ning Yang
Summary: This study investigated the association between comprehensive coagulation markers and clinicopathological characteristics in prostate cancer (PCa) patients. The results showed that fibrinogen and d-dimer levels were independently associated with high-risk PCa and significantly correlated with multiple clinical parameters. These coagulation markers may serve as independent prognostic biomarkers for risk stratification and guide personalized treatment strategies in PCa.
SCIENTIFIC REPORTS
(2023)
Article
Emergency Medicine
Safa Hueseyin Kuecuek, Ali Batur, Nalan Metin Aksu, Meltem Akkas
Summary: This study aimed to investigate the relationship between serum calcium levels and the efficacy of diltiazem in the treatment of AFib with RVR. The results showed that the success rate of diltiazem treatment was highest in patients with normal ionized calcium levels.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2023)
Article
Clinical Neurology
Yuzhao Lu, Xin Ma, Kiarash Tazmini, Ming Yang, Xiaobing Zhou, Yang Wang
Summary: This study found a positive association between serum calcium levels and 30-day mortality in patients with ischemic stroke, and the relationship between them is linear.
FRONTIERS IN NEUROLOGY
(2022)
Article
Oncology
Sylvia H. J. Jochems, Josef Fritz, Christel Haggstrom, Paer Stattin, Tanja Stocks
Summary: This study found no significant association between insulin resistance markers and the risk of prostate cancer. However, higher levels of glucose and triglyceride-glucose index were associated with higher prostate cancer mortality. Other insulin resistance markers did not show significant associations with prostate cancer mortality.
Article
Medicine, General & Internal
Chunxia Li, Dafu Zhang, Xiaolin Pang, Hongjiang Pu, Ming Lei, Bingbing Fan, Jiali Lv, Dingyun You, Zhenhui Li, Tao Zhang
Summary: In addition to CEA, dynamic monitoring of CA19-9 and CA125 is recommended to monitor the prognosis of CRC patients. Different trajectory groups based on preoperative levels and longitudinal trajectories have significant impact on overall survival and recurrence-free survival of patients.
Article
Biochemistry & Molecular Biology
David J. Hughes, Lutz Schomburg, Mazda Jenab, Carine Biessy, Catherine Meplan, Aurelie Moskal, Qian Sun, Kamil Demircan, Veronika Fedirko, Elisabete Weiderpass, Maryam Mukhtar, Anja Olsen, Anne Tjonneland, Kim Overvad, Matthias Schulze, Therese Haugdahl Nost, Guri Skeie, Karina Standahl Olsen, Fulvio Ricceri, Sara Grioni, Domenico Palli, Giovanna Masala, Rosario Tumino, Fabrizio Pasanisi, Pilar Amiano, Sandra M. Colorado Yohar, Antonio Agudo, Maria-Jose Sanchez, Eva Ardanaz, Malin Sund, Anne Andersson, Aurora Perez-Cornago, Ruth Travis, Alicia K. Heath, Laure Dossus
Summary: The study found no significant association between selenium status and breast cancer risk. However, higher activity of the selenoenzyme GPX3 was associated with a lower risk of premenopausal breast cancer. Several genetic variants were also found to be associated with breast cancer risk.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Surgery
Yongsheng Pan, Cheng Shen, Xinfeng Chen, Dongliang Cao, Jie Jiang, Wei Xu, Chen Ji, Xiaodong Pan, Bing Zheng
Summary: This study compared the detection rates of prostate cancer (PCa) and clinically significant prostate cancer (csPCa) by biparametric (bp-) and multiparameter magnetic resonance imaging (mpMRI). The findings showed that bpMRI and mpMRI had similar diagnostic efficacies in detecting PCa and csPCa, but mpMRI detected more cases in the tPSA interval of 10-20 ng/ml.
FRONTIERS IN SURGERY
(2023)
Article
Oncology
Anna L. Johansson, Paul W. Dickman, Sandra Eloranta, Magnus Bjorkholm
Summary: Women have better cancer-specific survival than men following haematological malignancies. The effect of reproductive factors on prognosis in women remains unknown and population-based studies are needed. This study found that parity and high age at first birth were initially associated with better survival, but the associations were attenuated after adjusting for other factors. The associations with reproductive factors were non-significant across subtypes of haematological malignancy. Additionally, there was a tendency of higher excess mortality for an increasing number of boys compared to girls among women with three or more children.
Article
Oncology
Avalon Sundqvist, Louise Moberg, Paul W. Dickman, Thomas Hogberg, Christer Borgfeldt
Summary: This study investigates the time trends of cervical cancer incidence and net survival in Sweden from 1960 to 2014. The results show that the incidence of squamous cell carcinoma (SCC) decreased until 2000 and then remained stagnant, while adenocarcinoma continued to increase. The 5-year net survival improved overall, but decreased with increasing age and higher stage at diagnosis. There was no statistically significant difference in net survival between SCC and adenocarcinoma in recent years.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Statistics & Probability
Nurgul Batyrbekova, Hannah Bower, Paul W. Dickman, Robert Szulkin, Paul C. Lambert, Therese M. -L. Andersson
Summary: When analyzing cohort data, it is common to only consider one time-scale and include other time-scales as fixed covariates. This simulation study demonstrates that only modeling one time-scale can lead to biased estimates of survival proportions and hazard ratios, especially when there are non-proportional hazards on the second time-scale. Including non-proportional hazards and interactions with the time-scale is advisable when modeling only one time-scale.
COMMUNICATIONS IN STATISTICS-SIMULATION AND COMPUTATION
(2022)
Article
Oncology
Anna L. Johansson, Siri Laronningen, Charlotte Wessel Skovlund, Marnar Frioheim Kristiansen, Lina Steinrud Morch, Soren Friis, Tom Borge Johannesen, Tor Age Myklebust, Anna Skog, David Pettersson, Helgi Birgisson, Anni Virtanen, Nea Malila, Janne Pitkaniemi, Tomas Tanskanen, Laufey Tryggvadottir, Giske Ursin, Mats Lambe
Summary: The severity of the COVID-19 pandemic and subsequent mitigation strategies have led to a decline in new cancer cases in the Nordic countries, with Sweden experiencing the most significant reduction. Possible explanations include the severity of the pandemic, temporary halting of screening activities, and changes in healthcare seeking behavior.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Nutrition & Dietetics
Raul Zamora-Ros, Valerie Cayssials, Ramon Cleries, Maria Torrents, Graham Byrnes, Elisabete Weiderpass, Maria Sandstrom, Martin Almquist, Marie-Christine Boutron-Ruault, Anne Tjonneland, Cecilie Kyro, Verena A. Katzke, Charlotte Le Cornet, Giovanna Masala, Vittorio Krogh, Gabriella Iannuzzo, Rosario Tumino, Lorenzo Milani, Guri Skeie, Esther Ubago-Guisado, Pilar Amiano, Maria-Dolores Chirlaque, Eva Ardanaz, Suzanne Janzi, Linda Eriksson, Heinz Freisling, Alicia K. Heath, Sabina Rinaldi, Antonio Agudo
Summary: This study found that consumption of sweetened beverages was associated with an increased risk of differentiated thyroid cancer, while a dietary pattern characterized by alcohol consumption was associated with a decreased risk of thyroid cancer.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Rheumatology
Majd Bairkdar, Enoch Yi-Tung Chen, Paul W. Dickman, Roger Hesselstrand, Helga Westerlind, Marie Holmqvist
Summary: This study conducted a nationwide cohort study to investigate the survival patterns of patients with incident systemic sclerosis (SSc) in Sweden. The results showed that the survival rate of SSc patients diagnosed between 2004 and 2015 was significantly lower compared to the general population, despite advances in understanding and diagnosing the disease.
Article
Health Care Sciences & Services
Nurgul Batyrbekova, Hannah Bower, Paul W. Dickman, Anna Ravn Landtblom, Malin Hultcrantz, Robert Szulkin, Paul C. Lambert, Therese M-L. Andersson
Summary: This study introduces a method to model multiple time-scales in survival analysis, avoiding data splitting, saving time, and reducing the likelihood of errors.
BMC MEDICAL RESEARCH METHODOLOGY
(2022)
Article
Obstetrics & Gynecology
Frida E. Lundberg, Leo Gkekos, Kenny A. Rodriguez-Wallberg, Irma Fredriksson, Anna L. V. Johansson
Summary: Breast cancer diagnosed during pregnancy increases the risks of preterm birth and low birthweight, but is not associated with other maternal pregnancy complications or adverse outcomes in children.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Oncology
Gerda Engholm, Frida E. Lundberg, Simon M. Konig, Elinborg Olafsdottir, Tom B. Johannesen, David Pettersson, Lina S. Morch, Anna L. V. Johansson, Soren Friis
Summary: This study aimed to evaluate the influence of assuming missing N and M as N0 and M0 on available TNM stage, stage distribution, and stage-specific relative survival in cancer patients. The results showed that assuming N0M0 for missing N and M had minor effects on stage-specific one-year relative survival, especially for high completeness of TNM registrations. Therefore, while complete TNM information is preferred, assuming N0M0 for missing N and M may be reasonable in future studies based on Nordic cancer registries. Rating: 8/10
Article
Oncology
Carl Sars, Helena Sackey, Jan Frisell, Paul W. Dickman, Fredrik Karlsson, Isabelle Kindts, Gustavo Nader Marta, Ruffo Freitas-Junior, Tove Filtenborg Tvedskov, Loay Kassem, Ahmed S. Ali, Hanna Ihalainen, Mathias Neron, Michalis Kontos, Orit Kaidar-Person, Icro Meattini, Anne Brecht Francken, Frederieke van Duijnhoven, Ingvild Ona Moberg, Tanja Marinko, Attila Kollar, Mahbubl Ahmed, Dennis Remoundos, Jenny Banks, Reshma Jagsi, Lesly A. Dossett, Ebba K. Lindqvist
Summary: Phyllodes tumors of the breast are rare fibroepithelial lesions classified as benign, borderline or malignant. Current clinical practice in managing these tumors shows considerable variation, indicating a need for education and further research to establish appropriate surgical margins, follow-up time, and a multidisciplinary approach.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Article
Obstetrics & Gynecology
Frida E. Lundberg, Hanne Stensheim, Gustav J. Ullenhag, Hanna Milerad Sahlgren, Kristina Lindemann, Irma Fredriksson, Anna L. V. Johansson
Summary: This study analyzed the national birth and cancer registers data in Sweden from 1973-2017, and calculated the incidence rates of pregnancy-associated cancer (PAC) during pregnancy and up to 1 year post-delivery. The results showed that advanced maternal age, smoking, nulliparity, and non-immigrant background were significant risk factors for PAC. The increasing incidence of PAC over time was partly attributed to the increase in maternal age.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Endocrinology & Metabolism
Rasmus Reinke, Stefano Christian Londero, Martin Almquist, Lars Rejnmark, Lars Rolighed
Summary: Restricting total thyroidectomy to surgeons who also perform parathyroid operations significantly reduces the incidence of postoperative hypoparathyroidism, especially in patients with Graves' disease. Therefore, it is recommended to centralize complex thyroid surgeries to centers and surgeons with extensive experience in parathyroid surgery.
ENDOCRINE CONNECTIONS
(2023)
Article
Health Care Sciences & Services
Anna L. Johansson, Anna Skog, Tom Borge Johannesen, Tor age Myklebust, Charlotte Wessel Skovlund, Lina Steinrud Morch, Soren Friis, Mads Gamborg, Marnar Frioheim Kristiansen, David Pettersson, Elinborg J. Olafsdottir, Helgi Birgisson, Runolfur Palsson, Elias Eythorsson, Sandra Irenaeus, Mats Lambe, Giske Ursin
Summary: Cancer patients had a higher risk of testing positive for SARS-CoV-2 during the first wave of the pandemic when testing availability was limited. Throughout 2020, recently treated cancer patients were more likely to test positive. The risks of severe COVID-19 outcomes such as hospitalisation, intensive care, and death were higher among cancer patients, with recent treatment and haematologic malignancy being the strongest risk factors.
LANCET REGIONAL HEALTH-EUROPE
(2023)
Review
Surgery
Klaas Van den Heede, Swathikan Chidambaram, Sam Van Slycke, Nele Brusselaers, Carl Fredrik Warfvinge, Hakan Ohlsson, Erik Nordenstrom, Martin Almquist
Summary: Primary tumour resection without curative intent is associated with increased survival in patients with advanced, metastatic siNETs.
BRITISH JOURNAL OF SURGERY
(2022)
