期刊
CANCER CAUSES & CONTROL
卷 20, 期 7, 页码 1193-1203出版社
SPRINGER
DOI: 10.1007/s10552-009-9320-4
关键词
Prostate cancer; Inflammation; C-reactive protein (CRP); Interleukin-6 (IL-6); IL-6 rs1800795 (-174)
资金
- NCI NIH HHS [R25 CA094880, R25-CA94880, R25 CA094880-08] Funding Source: Medline
- NHLBI NIH HHS [N01-HC-85086, N01 HC085079, N01HC85079, N01-HC-85079, N01HC75150, N01 HC075150, U01 HL080295, N01 HC085086, N01 HC085084, N01 HC015103, N01HC85086, N01-HC-85080, N01-HC-75150, N01-HC-85083, N01 HC-55222, N01 HC085080, N01 HC055222, N01 HC045133, N01 HC035129, N01 HC085081, U01 HL080295-04, N01-HC-85085, N01-HC-85082, N01 HC085082, N01 HC085083, N01-HC-85081, N01HC55222] Funding Source: Medline
Inflammation is believed to play a role in prostate cancer (PCa) etiology, but it is unclear whether inflammatory markers C-reactive protein (CRP) and interleukin-6 (IL-6) associate with PCa risk in older men. Using Cox regression, we assessed the relationship between baseline concentrations of CRP and IL-6 and the subsequent PCa risk in the Cardiovascular Health Study, a population-based cohort study of mostly European American men of ages > 64 years (n = 2,234; mean follow-up = 8.7 years; 215 incident PCa cases). We also tested associations between CRP and IL-6 tagSNPs and PCa risk, focusing on SNPs that are known to associate with circulating CRP and/or IL-6. Neither CRP nor IL-6 blood concentrations was associated with PCa risk. The C allele of IL-6 SNP rs1800795 (-174), a known functional variant, was associated with increased risk in a dominant model (HR = 1.44; 95% CI = 1.03-2.01; p = 0.03), but was not statistically significant after accounting for multiple tests (permutation p = 0.21). Our results suggest that circulating CRP and IL-6 do not influence PCa risk. SNPs at the CRP locus are not associated with PCa risk in this cohort, while the association between rs1800795 and PCa risk warrants further investigation.
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