Article
Biology
May E. Montasser, Stella Aslibekyan, Vinodh Srinivasasainagendra, Hemant K. Tiwari, Amit Patki, Minoo Bagheri, Tobias Kind, Dinesh Kumar Barupal, Sili Fan, James Perry, Kathleen A. Ryan, Alan R. Shuldiner, Donna K. Arnett, Amber L. Beitelshees, Marguerite Ryan Irvin, Jeffrey R. O'Connell
Summary: This study identified lipid species associated with rare population alleles through a genome-wide association scan of a founder population. The findings highlight the power of founder populations and detailed lipidomics in discovering novel trait-associated variants.
COMMUNICATIONS BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Elizabeth M. Humphries, Kwangmi Ahn, Rachel L. Kember, Fabiana L. Lopes, Evelina Mocci, Juan M. Peralta, John Blangero, David C. Glahn, Fernando S. Goes, Peter P. Zandi, Peter Kochunov, Cristopher Van Hout, Alan R. Shuldiner, Toni I. Pollin, Braxton D. Mitchell, Maja Bucan, L. Elliot Hong, Francis J. McMahon, Seth A. Ament
Summary: By conducting a genome-wide association study of mood disorders in a founder population, the Old Order Amish, four significant risk loci were identified, all of which were associated with more than a 2-fold relative risk. Further assessments revealed effects of these risk variants on sub-clinical depressive symptoms and information processing speed. Network analysis suggested that these risk loci may harbor novel risk-associated genes, which interact with known neuropsychiatry-associated genes through gene interaction networks. Annotation of the variants at these risk loci revealed enrichment of non-synonymous variants in two genes encoding neurodevelopmental transcription factors, CUX1 and CNOT1. These findings provide valuable insights into the genetic architecture of mood disorders and serve as a foundation for mechanistic and clinical studies.
MOLECULAR PSYCHIATRY
(2023)
Article
Oncology
Boyoung Park, Yeol Kim, Jaeho Lee, Nayoung Lee, Seung Hun Jang
Summary: This study analyzed the sex difference in the effect of smoking exposure on lung cancer in terms of absolute and relative risks, showing a higher incidence of lung cancer in men than women despite the similar smoking exposure, emphasizing the importance of considering sex in the selection of a lung cancer screening target population.
Article
Genetics & Heredity
Zineb Ammous, Lettie E. Rawlins, Hannah Jones, Joseph S. Leslie, Olivia Wenger, Ethan Scott, Jim Deline, Tom Herr, Rebecca Evans, Angela Scheid, Joanna Kennedy, Barry A. Chioza, Ryan M. Ames, Harold E. Cross, Erik G. Puffenberger, Lorna Harries, Emma L. Baple, Andrew H. Crosby
Summary: The study identifies a SNIP1 gene variant associated with neurodevelopmental disorders in a population with high prevalence, highlighting key clinical features including hypotonia and intellectual disability. Transcript studies reveal altered gene expression profiles potentially explaining clinical outcomes, providing important insights into the molecular roles of SNIP1 and potential therapeutic avenues for research.
Article
Oncology
Marianne F. Weber, Peter E. A. Sarich, Pavla Vaneckova, Stephen Wade, Sam Egger, Preston Ngo, Grace Joshy, David E. Goldsbury, Sarsha Yap, Eleonora Feletto, Amy Vassallo, Maarit A. Laaksonen, Paul Grogan, Dianne L. O'Connell, Emily Banks, Karen Canfell
Summary: The study found that smokers in Australia have significantly increased cancer risks, even for 'light' smokers. Lung cancer risk increases with smoking intensity, but even with quitting, the risk remains higher than never-smokers, especially for those who quit after the age of 25.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Public, Environmental & Occupational Health
Andrea C. Villanti, Elias M. Klemperer, Brian L. Sprague, Thomas P. Ahern
Summary: The study demonstrated a significant relationship between state-level rurality and smoking-related cancer outcomes, with higher smoking prevalence, cancer incidence, mortality, and proportion of smoking-attributable cancer deaths in highly rural areas. Tobacco control is crucial in reducing cancer disparities in rural populations.
PREVENTIVE MEDICINE
(2021)
Article
Medicine, General & Internal
Marushka L. Silveira, Colm D. Everard, Eva Sharma, Kristin Lauten, Apostolos A. Alexandridis, Kara Duffy, Ethel Taylor, Eric A. Tolliver, Carlos Blanco, Wilson M. Compton, Heather L. Kimmel, Timothy Iafolla, Andrew Hyland, Benjamin W. Chaffee
Summary: This study examined the associations between tobacco use and adverse oral health outcomes. The results showed that smoking was associated with gum disease, loose teeth, and tooth removal, while cigar smoking was associated with precancerous oral lesions. Additionally, hookah smoking was associated with gum disease, and ENDS use was associated with bleeding after brushing or flossing. These findings highlight the importance of longitudinal studies and tobacco cessation counseling in clinical practice.
Article
Cardiac & Cardiovascular Systems
Katie B. Williams, Michael Horst, Millie Young, Christine Pascua, Erik G. Puffenberger, Karlla W. Brigatti, Claudia Gonzaga-Jauregui, Alan R. Shuldiner, Samuel Gidding, Kevin A. Strauss, Devyani Chowdhury
Summary: This study characterized the biochemical and cardiac imaging features in children and young adults with familial hypercholesterolemia (FH) due to the founder variant Apolipoprotein B (ApoB(R3500Q)). Although ApoB(R3500Q) heterozygotes showed elevated LDL cholesterol and particles, there were no significant differences in atherosclerosis compared to sibling controls.
BMC CARDIOVASCULAR DISORDERS
(2022)
Article
Medicine, General & Internal
Yun Kyung Jung, Junghyun Yoon, Kyeong Geun Lee, Han Joon Kim, Boyoung Park, Dongho Choi
Summary: The incidence of cancer development after cholecystectomy remains debatable, with overall cancer rates similar between cholecystectomy patients and the general population, but younger patients who underwent cholecystectomy are at a higher risk. Particularly, incidences of colorectal cancer and liver cancer were higher in cholecystectomy patients across all age groups and genders.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Microbiology
Scott C. Weaver, Naomi L. Forrester, Jianying Liu, Nikos Vasilakis
Summary: Transmission of arthropod-borne viruses involves infection and replication in both arthropod vectors and vertebrate hosts, with population bottlenecks and founder effects playing important roles in arboviral evolution and spread, as well as the emergence of human disease.
NATURE REVIEWS MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Nick W. S. Payne, Katrina F. Brown, Christine Delon, Yannis Kotrotsios, Isabelle Soerjomataram, Jon Shelton
Summary: Deprived populations in England have higher cancer incidence rates and smoking prevalence. A study found that if nobody smoked, the majority of the deprivation gap in cancer incidence could have been prevented.
Article
Medicine, General & Internal
Muneeswar G. Nittala, Federico Corvi, Jyotsna Maram, Swetha B. Velaga, Jonathan Haines, Margaret A. Pericak-Vance, Dwight Stambolian, SriniVas R. Sadda
Summary: This population-based study in elderly Amish individuals found that high central drusen volume and intraretinal hyperreflective foci are risk factors for progression to late age-related macular degeneration (AMD).
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Oscar M. Camacho, Andrew Hill, Stacy Fiebelkorn, Aaron Williams, James Murphy
Summary: The study suggests that more complex models may be needed to assess interactions between multiple coexisting products in the marketplace. Data availability may hinder the effectiveness of three-product models, while two-product models could miss potential synergies between products. Scenario analyses for THPs and e-cigarettes in Italy show reductions in life-years lost, with larger reductions seen in the Japanese THP scenario compared to the USA e-cigarette projections.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Public, Environmental & Occupational Health
Majed Ramadan, Noara Alhusseini, Lara Samhan, Sara Samhan, Tasnim Abbad
Summary: This study aimed to evaluate the impact of tobacco control policies on smoking prevalence and lung cancer incidence in Saudi Arabia. The results showed that implementing the highest-level MPOWER tobacco control policies can effectively reduce smoking rates and potentially prevent a significant number of lung cancer cases. Therefore, further efforts are needed to strengthen the implementation of effective messaging to reduce tobacco-related cancers.
PREVENTIVE MEDICINE REPORTS
(2023)
Article
Public, Environmental & Occupational Health
Leiwen Fu, Tian Tian, Kai Yao, Xiang-Feng Chen, Ganfeng Luo, Yanxiao Gao, Yi-Fan Lin, Bingyi Wang, Yinghui Sun, Weiran Zheng, Peiyang Li, Yuewei Zhan, Christopher K. Fairley, Andrew Grulich, Huachun Zou
Summary: Penile cancer is on the rise in many countries, particularly in Europe. Measures to lower the risk of penile cancer, such as improving penile hygiene and promoting male human papillomavirus vaccination, may be necessary to reduce the burden of the disease on society.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2022)
Article
Biology
Agniva Som, Christopher M. Hans, Steven N. MacEachern
Article
Mathematics, Interdisciplinary Applications
Joseph W. Houpt, Steven N. MacEachern, Mario Peruggia, James T. Townsend, Trisha Van Zandt
JOURNAL OF MATHEMATICAL PSYCHOLOGY
(2016)
Article
Statistics & Probability
Andrew Bean, Xinyi Xu, Steven MacEachern
ELECTRONIC JOURNAL OF STATISTICS
(2016)
Article
Statistics & Probability
Zachary M. Thomas, Steven N. MacEachern, Mario Peruggia
JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION
(2018)
Article
Computer Science, Interdisciplinary Applications
X. Xu, P. Lu, S. N. MacEachern, R. Xu
JOURNAL OF STATISTICAL COMPUTATION AND SIMULATION
(2019)
Article
Veterinary Sciences
Eric C. Hans, Chris Pinard, S. A. van Nimwegen, Jolle Kirpensteijn, Ameet Singh, Steven MacEachern, Steven Naber, Robert M. Dudley
VETERINARY SURGERY
(2018)
Article
Statistics & Probability
Yoonsuh Jung, Steven N. MacEachern, Hang Kim
Summary: This study proposes a modified check loss function with quadratic adjustment to guard against overfitting, which has been empirically proven through various simulation settings of linear and nonlinear regressions.
JOURNAL OF APPLIED STATISTICS
(2021)
Article
Mathematical & Computational Biology
Jeffrey J. Gory, Peter F. Craigmile, Steven N. MacEachern
Summary: Two popular approaches for relating correlated measurements of a non-Gaussian response variable to predictors have their own advantages and limitations. The first approach is effective for parameter estimation but lacks a formal model for evaluating fit quality or making individual-level predictions. The second approach overcomes these deficiencies but requires interpreting parameter estimates conditional on latent variables.
STATISTICS IN MEDICINE
(2021)
Article
Statistics & Probability
Min Ho Cho, Sebastian Kurtek, Steven N. MacEachern
Summary: Shape classification is a key task in various fields, but the inherently infinite-dimensional and curved nature of shape data may require novel approaches. Therefore, methods such as using the square-root velocity function of curves for shape description, working with tangent spaces of shape manifolds to reduce dimensionality, and combining pairwise classifiers to improve misclassification rates may be necessary.
ANNALS OF APPLIED STATISTICS
(2021)
Article
Statistics & Probability
Koji Miyawaki, Steven N. MacEachern
Summary: This article discusses the problem of variable selection in regression and emphasizes the economic aspect. It formulates the variable selection problem in a decision theoretic manner based on the cost of predictors and adopts a Bayesian perspective to address uncertainty about the model and model parameters. The proposed restricted method is preferred from an objective or robust Bayes point of view. The method is applied to three popular datasets for illustration.
CANADIAN JOURNAL OF STATISTICS-REVUE CANADIENNE DE STATISTIQUE
(2023)
Article
Statistics & Probability
Chunjie Wu, Zhijun Wang, Steven MacEachern, Jingjing Schneider
Summary: This paper develops a latent CUSUM chart based on an exponential model to monitor customer attrition on varying time scales. Both maximum likelihood and least squares methods are studied, and a Markov chain algorithm is used to obtain the average run length (ARL) and calibrations for different parameter combinations. Three more complicated models are considered to test the robustness of deviations, and a real example from a Chinese insurance company is used to illustrate the scheme.
JOURNAL OF APPLIED STATISTICS
(2023)
Article
Statistics & Probability
Fernando A. Quintana, Peter Muller, Alejandro Jara, Steven N. MacEachern
Summary: Standard regression approaches assume finite characteristics of the response distribution vary with predictors, but in reality, responses often change in ways that cannot be represented by a finite dimensional form. This has led to the study of fully nonparametric regression models to tackle the general problem. Various Bayesian approaches, such as dependent Dirichlet processes, have been developed to define probability models where the response distribution can vary flexibly with predictors.
STATISTICAL SCIENCE
(2022)
Article
Statistics & Probability
Steven N. MacEachern, Koji Miyawaki
Summary: This paper addresses the issue of two-dataset problem, where data are collected from potentially different populations while sharing common aspects. It proposes statistical regression models to capture the measurement differences and introduces two prediction errors for evaluating the underlying data collection process. Two real datasets are used to illustrate the proposed method.
Article
Business
Jeffrey P. Dotson, John R. Howell, Jeff D. Brazell, Thomas Otter, Peter J. Lenk, Steve Maceachern, Greg M. Allenby
JOURNAL OF MARKETING RESEARCH
(2018)
Article
Statistics & Probability
Steven N. MacEachern
COMMUNICATIONS FOR STATISTICAL APPLICATIONS AND METHODS
(2016)
