Article
Oncology
Jinggao Feng, Xiayu Tang, Liusong Song, Zhipeng Zhou, Yuan Jiang, Yao Huang
Summary: This study identifies telomerase regulation-related lncRNAs as prognostic indicators in gastric cancer and suggests their potential role in exploring more effective immunotherapeutic strategies.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Handong Xu, Can Hu, Yi Wang, Yunfu Shi, Li Yuan, Jingli Xu, Yanqiang Zhang, Jiahui Chen, Qin Wei, Jiangjiang Qin, Zhiyuan Xu, Xiangdong Cheng
Summary: Gastric cancer (GC) is a deadly malignancy that requires new therapeutic targets for effective treatment. Glutathione peroxidase-2 (GPx2) was found to be overexpressed in clinical GC samples and negatively correlated with prognosis. Knockdown of GPx2 inhibited GC progression and metastasis by suppressing the KYNU-kyn-AhR signaling pathway, which was activated by reactive oxygen species (ROS) accumulation.
Article
Medicine, Research & Experimental
Yan-Jie Chen, Shu-Neng Luo, Hao Wu, Ning-Ping Zhang, Ling Dong, Tao-Tao Liu, Li Liang, Xi-Zhong Shen
Summary: This study found that the expression of IRF-2 was downregulated in gastric cancer tissues and was negatively correlated with the prognoses of gastric cancer patients. IRF-2 inhibits tumor growth by regulating the transcription of AMER-1 and the Wnt/β-catenin signaling pathway.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Veterinary Sciences
Gennaro Altamura, Barbara degli Uberti, Giorgio Galiero, Giovanna De Luca, Karen Power, Luca Licenziato, Paola Maiolino, Giuseppe Borzacchiello
Summary: BIBR1532 shows multiple anti-cancer activities in feline oral squamous cell carcinoma by inhibiting telomerase pathway and interfering with signaling routes involved in cell proliferation, cell survival, and invasion, paving the way for future translational studies.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Jacek Kudelski, Anna Tokarzewicz, Monika Gudowska-Sawczuk, Barbara Mroczko, Piotr Chlosta, Marta Bruczko-Goralewska, Przemyslaw Mitura, Grzegorz Mlynarczyk
Summary: This study aimed to evaluate the expression and activity of matrix metalloproteinase 2 and 9 (MMP-2 and MMP-9) in urinary bladder cancer at different stages. The results showed that the content and activity of MMP-9 were higher than MMP-2, especially in high-grade cancer tissue. MMP-9 may have higher clinical utility as a potential therapeutic option and a diagnostic biomarker for urinary bladder cancer.
Article
Biochemistry & Molecular Biology
Joana Mota, Rosa Direito, Joao Rocha, Joao Fernandes, Bruno Sepodes, Maria Eduardo Figueira, Anabela Raymundo, Ana Lima, Ricardo Boavida Ferreira
Summary: The study isolated and characterized an MMP-2 and -9 inhibitor from Lupinus albus, showing its efficacy in inhibiting MMP-9 activity in colon cancer cells and significantly reducing colitis symptoms in a mouse model. This novel type of MMP inhibitor in lupine, edible and proteinaceous in nature, holds high potential for application as a nutraceutical or functional food targeting pathologies related to high MMP-9 activity in the digestive system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Tao Yang, Rui Xu, Junhao You, Fang Li, Bing Yan, Jia-nan Cheng
Summary: Gastric cancer is the fifth most common tumor worldwide. HER2-low expression in early-stage gastric cancer was associated with certain clinical characteristics, but did not have prognostic value for disease-free survival or overall survival.
Article
Plant Sciences
Gabriela Bueno, Stefanni Liliane Chavez Rico, Larissa Lucena Perico, Rie Ohara, Vinicius Peixoto Rodrigues, Maycon Tavares Emilio-Silva, Renata Assuncao, Lucia Regina Machado da Rocha, Domingos Savio Nunes, Michele Aparecida Besten, Gustavo Heiden, Ana Carolina Lima Camargo, Luis Antonio Justulin, Clelia Akiko Hiruma-Lima
Summary: The study demonstrated that the essential oil from Baccharis trimera has protective and healing effects on gastric ulcers by decreasing myeloperoxidase activity, increasing vascular endothelial growth factor expression, and reducing matrix metalloproteinase-2 activity.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Oncology
Fu Chun-kai, Mong Mei-chin, Yu Chien-chih, Yang Mei-due, Wang Zhi-hong, Yang Ya-chen, Chen Jaw-chyun, Pei Jen-sheng, Hsia Ning-yi, Tsai Chia-wen, Chang Wen-shin, Bau Da-tian
Summary: This study found that the MMP-2 rs243865 genotype decreased the risk of GC in the Taiwanese population and was associated with smoking, alcohol drinking, and Helicobacter pylori infection status.
ANTICANCER RESEARCH
(2022)
Article
Microbiology
Brenda Furtado Costa, Tarcisio Navegante de Queiroz Filho, Adeniele Lopes da Cruz Carneiro, Aline Semblano Carreira Falcao, Maria Sueli da Silva Kataoka, Joao de Jesus Viana Pinheiro, Ana Paula Drummond Rodrigues
Summary: This study examines the presence and activity of MMP-2 and MMP-9 in Leishmania parasites, particularly in two different Leishmania species, L. amazonensis and L. braziliensis. The results show that MMP-9 has significantly higher gelatinolytic activity in L. amazonensis compared to L. braziliensis. The study suggests that MMP-2 and MMP-9 may play a role in the infection dynamics of these Leishmania species and could be potential markers for severe leishmaniasis and therapeutic targets.
Article
Multidisciplinary Sciences
Nighat Noureen, Shaofang Wu, Yingli Lv, Juechen Yang, W. K. Alfred Yung, Jonathan Gelfond, Xiaojing Wang, Dimpy Koul, Andrew Ludlow, Siyuan Zheng
Summary: The study suggests that telomerase activity can be robustly estimated from the expression of a 13-gene signature, and shows a strong correlation between telomerase activity and cancer stemness. This correlation is largely driven by a small population of proliferating cancer cells exhibiting both high telomerase activity and cancer stemness.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Taxiarchis Konstantinos Nikolouzakis, Elena Vakonaki, Polychronis D. Stivaktakis, Athanasios Alegakis, Aikaterini Berdiaki, Nikolaos Razos, John Souglakos, Aristidis Tsatsakis, John Tsiaoussis
Summary: The study suggests that micronuclei frequency may serve as a promising prognostic biomarker for monitoring CRC patients' treatment response, while telomerase activity should be evaluated in a larger group of patients to further validate its significance.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Deep Sankar Rudra, Uttam Pal, Nilkanta Chowdhury, Nakul Chandra Maiti, Angshuman Bagchi, Snehasikta Swarnakar
Summary: The repairing of damaged tissues in the gastric tract starts with extracellular matrix remodeling by matrix metalloproteinases (MMPs). The drug omeprazole, used to cure gastric ulcers, has been shown to restore MMP-2 activity and reduce apoptosis, preventing stress-induced gastric ulcers by modulating NF-kappa B and PPAR-gamma activity.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Oncology
Xinyue Qin, Yinhao Chen, Shuo Ma, Lei Shen, Shaoqing Ju
Summary: TM4SF18 is a promising biomarker for gastric cancer, promoting proliferation, migration, and invasion abilities of GC cells, and being associated with immune response.
MOLECULAR ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kang Cao, Yanping Lyu, Jingwen Chen, Chenzhou He, Xuejie Lyu, Yuling Zhang, Liangping Chen, Yu Jiang, Jianjun Xiang, Baoying Liu, Chuancheng Wu
Summary: This study established a prognostic prediction model for gastric cancer patients based on a metabolism-associated signature and identified the unique role of metabolites in gastric cancer prognosis. The results indicated that purine metabolism and arachidonic acid metabolism play important roles in gastric cancer prognosis. The study highlights the important role of metabolites in the progression of gastric cancer and suggests that newly identified metabolites could be potential biomarkers or therapeutic targets for gastric cancer patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Long-Zi Liu, Zhao Zhang, Bo-Hao Zheng, Yang Shi, Men Duan, Li-Jie Ma, Zhi-Chao Wang, Liang-Qing Dong, Ping-Ping Dong, Jie-Yi Shi, Shu Zhang, Zhen-Bin Ding, Ai-Wu Ke, Ya Cao, Xiao-Ming Zhang, Ruibin Xi, Jian Zhou, Jia Fan, Xiao-Ying Wang, Qiang Gao
Article
Engineering, Environmental
Wenkun Zhu, Jia Lei, Yi Li, Lichun Dai, Tao Chen, Xueyuan Bai, Jian Zhou, Liang Wang, Tao Duan
CHEMICAL ENGINEERING JOURNAL
(2019)
Article
Engineering, Environmental
Xiaoliu Huangfu, Chengxue Ma, Ruixing Huang, Qiang He, Caihong Liu, Jian Zhou, Jin Jiang, Jun Ma, Yinying Zhu, Muhua Huang
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2019)
Article
Chemistry, Multidisciplinary
Jian Zhou, Jie Yu, Hui Liao, Yongde Zhang, Xuegang Luo
SEPARATION SCIENCE AND TECHNOLOGY
(2020)
Article
Engineering, Environmental
Yingmu Wang, Ziyuan Lin, Yue Wang, Wei Huang, Jiale Wang, Jian Zhou, Qiang He
Article
Microbiology
Yinhui Jiang, Jingxian Wang, Bi Yang, Qinrong Wang, Jianjiang Zhou, Wenfeng Yu
FRONTIERS IN MICROBIOLOGY
(2019)
Article
Agricultural Engineering
Ziyuan Lin, Yingmu Wang, Wei Huang, Jiale Wang, Li Chen, Jian Zhou, Qiang He
BIORESOURCE TECHNOLOGY
(2019)
Article
Oncology
Yi Yang, Qing Chen, Hai-Yan Piao, Biao Wang, Gui-Qi Zhu, Er-Bao Chen, Kun Xiao, Zheng-Jun Zhou, Guo-Ming Shi, Ying-Hong Shi, Wei-Zhong Wu, Jia Fan, Jian Zhou, Zhi Dai
INTERNATIONAL JOURNAL OF CANCER
(2020)
Article
Medicine, Research & Experimental
Gui-Qi Zhu, Yi Yang, Er-Bao Chen, Biao Wang, Kun Xiao, Shi-Ming Shi, Zheng-Jun Zhou, Shao-Lai Zhou, Zheng Wang, Ying-Hong Shi, Jia Fan, Jian Zhou, Tian-Shu Liu, Zhi Dai
JOURNAL OF TRANSLATIONAL MEDICINE
(2019)
Article
Chemistry, Physical
Miao Miao, Qingyang Liu, Jian Zhou, Jingjing Feng
Article
Agricultural Engineering
Jiahao Fu, Ziyuan Lin, Pengcheng Zhao, Yingmu Wang, Lei He, Jian Zhou
BIORESOURCE TECHNOLOGY
(2019)
Article
Engineering, Environmental
Yingmu Wang, Ziyuan Lin, Xiaosuan Su, Pengcheng Zhao, Jian Zhou, Qiang He, Hainan Ai
CHEMICAL ENGINEERING JOURNAL
(2019)
Article
Medical Laboratory Technology
Beili Wang, Jie Zhu, Xiaolu Ma, Hao Wang, Shuangjian Qiu, Baishen Pan, Jian Zhou, Jia Fan, Xinrong Yang, Wei Guo, Yunfeng Cheng
CLINICA CHIMICA ACTA
(2019)
Article
Energy & Fuels
Jie Yang, Jian Zhou, Wei Tong, Tianshi Zhang, Ming Kong, Shan Ren
JOURNAL OF THE ENERGY INSTITUTE
(2019)
Article
Chemistry, Multidisciplinary
Jie Meng, Xiaoyan Lin, Haonan Li, Yida Zhang, Jian Zhou, Yan Chen, Ran Shang, Xuegang Luo
