期刊
CANCER BIOMARKERS
卷 11, 期 6, 页码 269-280出版社
IOS PRESS
DOI: 10.3233/CBM-120291
关键词
miRNA; breast cancer; metastasis; migration; invasion; EMT; MET; angiogenesis
类别
资金
- New Brunswick Innovation Foundation
- Beatrice Hunter Cancer Research Institute
- Craig Manufacturing Ltd
- Canadian Breast Cancer Foundation-Atlantic Chapter
- Canadian Institutes of Health Research (CIHR) New Investigator Award
- Universite de Moncton, Faculty of Sciences (Research Salary Award)
Cancer statistics show significant diagnosis numbers amongst men and women worldwide, where breast cancer is by far the most frequently diagnosed cancer in women. Multiple mechanisms and molecules have been shown to occupy major roles in cancer progression and aggressivity. Recently, small non-coding RNA molecules, called micro-RNAs, have become the subject of interest in many molecular pathways in relation to breast cancer, amongst many other pathologies. MiRNAs are capable of regulating gene expression in a sequence-specific manner and regulate diverse expression patterns which are dependent on the cell's state and identity. Studies have brought forward specific miRNAs that have the innate ability to govern unique gene expression profiles regulating cancer cell aggressivity. This review will outline recent findings of characterized miRNAs in relation to their molecular targets leading to cancer malignancy and progression. More specifically, we will focus on miRNAs associated with breast cancer metastatic processes including epithelial to mesenchymal and mesenchymal to epithelial transitioning (EMT/MET transition), migration, invasion and angiogenesis.
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