Emerging roles of Jab1/CSN5 in DNA damage response, DNA repair, and cancer

Curcumin analogue T83 exhibits potent antitumor activity and induces radiosensitivity through inactivation of Jab1 in nasopharyngeal carcinoma

(2013) Yunbao Pan et al.   BMC CANCER

Inhibition of Csn3 expression induces growth arrest and apoptosis of hepatocellular carcinoma cells

(2012) Yong-sheng Yu et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Targeting Jab1/CSN5 in nasopharyngeal carcinoma

(2012) Yunbao Pan et al.   CANCER LETTERS

Jab1/CSN5 Negatively Regulates p27 and Plays a Role in the Pathogenesis of Nasopharyngeal Carcinoma

(2012) Y. Pan et al.   CANCER RESEARCH

Functional, Genetic, and Epigenetic Aspects of Base and Nucleotide Excision Repair in Colorectal Carcinomas

(2012) J. Slyskova et al.   CLINICAL CANCER RESEARCH

JAB1 Is Essential for B Cell Development and Germinal Center Formation and Inversely Regulates Fas Ligand and Bcl6 Expression

(2012) S. Sitte et al.   JOURNAL OF IMMUNOLOGY

Jun activation domain-binding protein 1 expression in oral squamous cell carcinomas inversely correlates with the cell cycle inhibitor p27

(2012) Ling Gao et al.   MEDICAL ONCOLOGY

Suppression of Jab1/CSN5 induces radio- and chemo-sensitivity in nasopharyngeal carcinoma through changes to the DNA damage and repair pathways

(2012) Y Pan et al.   ONCOGENE

Jab1 has negative effects on p53-mediated genotoxic stresses

(2011) Eun-Woo Lee et al.   BMB Reports

The Molecular Basis of CRL4DDB2/CSA Ubiquitin Ligase Architecture, Targeting, and Activation

(2011) Eric S. Fischer et al.   CELL

Deficiency of DNA repair nuclease ERCC1-XPF promotes prostate cancer progression in a tissue recombination model

(2011) Derek J. Matoka et al.   PROSTATE

Targeted Radiosensitization of Cells Expressing Truncated DNA Polymerase  

(2010) S. Neijenhuis et al.   CANCER RESEARCH

Origin of Chromosomal Translocations in Lymphoid Cancer

(2010) André Nussenzweig et al.   CELL

Dynamics of Cullin-RING Ubiquitin Ligase Network Revealed by Systematic Quantitative Proteomics

(2010) Eric J. Bennett et al.   CELL

Fank1 interacts with Jab1 and regulates cell apoptosis via the AP-1 pathway

(2010) Hailong Wang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial

(2010) Andrew Tutt et al.   LANCET

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial

(2010) M William Audeh et al.   LANCET

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

Fanconi anemia and breast cancer susceptibility meet again

(2010) Ephrat Levy-Lahad   NATURE GENETICS

Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis

(2010) Mary Ellen Moynahan et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Essential roles of Jab1 in cell survival, spontaneous DNA damage and DNA repair

(2010) L Tian et al.   ONCOGENE

JAB1/CSN5: a new player in cell cycle control and cancer

(2010) Terry J Shackleford et al.   Cell Division

How the Fanconi Anemia Pathway Guards the Genome

(2009) George-Lucian Moldovan et al.   Annual Review of Genetics

Loss of Rad51c Leads to Embryonic Lethality and Modulation of Trp53-Dependent Tumorigenesis in Mice

(2009) S. G. Kuznetsov et al.   CANCER RESEARCH

Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction

(2009) Ji Luo et al.   CELL

A Genome-wide RNAi Screen Identifies Multiple Synthetic Lethal Interactions with the Ras Oncogene

(2009) Ji Luo et al.   CELL

Recent Advances in Cancer Therapy Targeting Proteins Involved in DNA Double-Strand Break Repair

(2009) E. Bolderson et al.   CLINICAL CANCER RESEARCH

Cytoplasmic Localization of Jab1 and p27Kip1 Might Be Associated with Invasiveness of Papillary Thyroid Carcinoma

(2009) Jihyun AHN et al.   ENDOCRINE JOURNAL

The combined status of ATM and p53 link tumor development with therapeutic response

(2009) H. Jiang et al.   GENES & DEVELOPMENT

Significance of Jab1 Expression in Human Esophageal Squamous Cell Carcinoma

(2009) Feng Wang et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Polyethylene Glycosylated Curcumin Conjugate Inhibits Pancreatic Cancer Cell Growth through Inactivation of Jab1

(2009) J. Li et al.   MOLECULAR PHARMACOLOGY

DNA Damage, Aging, and Cancer

(2009) Jan H.J. Hoeijmakers   NEW ENGLAND JOURNAL OF MEDICINE

Symmetrical Modularity of the COP9 Signalosome Complex Suggests its Multifunctionality

(2009) Michal Sharon et al.   STRUCTURE

CSN5 Isopeptidase Activity Links COP9 Signalosome Activation to Breast Cancer Progression

(2008) A. S. Adler et al.   CANCER RESEARCH

Platinum Resistance: The Role of DNA Repair Pathways

(2008) L. P. Martin et al.   CLINICAL CANCER RESEARCH

Overexpression of Jab1 in Hepatocellular Carcinoma and Its Inhibition by Peroxisome Proliferator-Activated Receptor  Ligands In vitro and In vivo

(2008) M.-C. Hsu et al.   CLINICAL CANCER RESEARCH

Somatic mutations affect key pathways in lung adenocarcinoma

(2008) Li Ding et al.   NATURE

The COP9 signalosome: more than a protease

(2008) N WEI et al.   TRENDS IN BIOCHEMICAL SCIENCES