Article
Surgery
Tomoki Abe, Taro Oshikiri, Hironobu Goto, Takashi Kato, Manabu Horikawa, Ryuichiro Sawada, Hitoshi Harada, Naoki Urakawa, Hiroshi Hasegawa, Shingo Kanaji, Kimihiro Yamashita, Takeru Matsuda, Yoshihiro Kakeji
Summary: Based on the research findings, the thoracic cavity-to-cage ratio could be a predictor of technical difficulties in both conventional minimally invasive esophagectomy and robot-assisted minimally invasive esophagectomy.
Article
Genetics & Heredity
Yuxia Jin, Ling Ai, Xiaojun Chai, Ping Tang, Weihua Zhang, Li Yang, Yue Hu, Ying Xu, Suping Li
Summary: This study identified maternal circulating exosomal miRNAs as potential non-invasive biomarkers for the early detection of fetal ventricular septal defects (VSDs), with hsa-miR-146a-5p showing high accuracy in distinguishing VSD cases from controls.
FRONTIERS IN GENETICS
(2021)
Review
Oncology
Justyna Raczkowska, Agnieszka Bielska, Adam Kretowski, Magdalena Niemira
Summary: Non-small cell lung cancer (NSCLC) is a malignant condition resistant to advanced-stage treatment and the leading cause of cancer death worldwide. Current diagnostic methods cannot detect the disease at an early stage or predict its development. Micro RNAs (miRNAs) show significant differences in NSCLC tissues and can be easily detected in biofluids without invasive collection techniques. Many studies support the importance of miRNAs as a promising biomarker for detecting and predicting NSCLC. This review discusses the role of biofluid miRNAs as a diagnostic tool in NSCLC and highlights future areas of interest.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Da Qin, Yu Zhao, Qingdong Guo, Shengtao Zhu, Shutian Zhang, Li Min
Summary: The study proposed a RNA ratio-based algorithm to quantify EVs-derived RNAs in PDAC and developed a promising prediction model that could effectively differentiate PDAC patients from noncancerous controls.
Review
Cell Biology
Amila Iriskic Atic, Maja Thiele, Alexander Munk, Louise Torp Dalgaard
Summary: MicroRNAs (miRNAs) secreted by the liver have the potential to be important biomarkers for nonalcoholic liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). Several miRNAs, including miR-122, miR-21, miR-34a, miR-192, miR-193, and the miR-17-92 miRNA-cluster, are consistently associated with NAFLD/NASH. These miRNAs show potential as diagnostic markers for NAFLD/NASH, although more research is needed to understand their specificity and regulation.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Oncology
Ruoqi Ning, Silu Meng, Lin Wang, Yao Jia, Fangxu Tang, Haiying Sun, Zhi Zhang, Chong Zhang, Xinran Fan, Bing Xiao, Chunhua Yan, Shuang Li
Summary: This study identified 6 circulating miRNAs associated with cervical lesions and established a classifier with high accuracy in both validation samples (0.7218) and an independent cohort (0.7021). In silico analyses predicted 958 target genes enriched in 23 pathways, with 55 genes identified as the most likely target genes through differential analysis.
Article
Biochemistry & Molecular Biology
Jen-Tai Lin, Kuo-Wang Tsai
Summary: The study showed that certain miRNAs in urine could potentially serve as noninvasive biomarkers for diagnosing bladder cancer, with implications for early detection and patient survival. Further validation in larger cohorts is necessary to confirm the clinical utility of urinary miRNAs in bladder cancer diagnosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Health Care Sciences & Services
Yingdong Feng, Lili Tian
Summary: This paper examines the potential misleading effects of commonly used pooling strategies in biomarker evaluation, proposing a new diagnostic framework and accuracy measures for such settings. Additionally, an ovarian cancer dataset is analyzed to demonstrate these concepts.
STATISTICAL METHODS IN MEDICAL RESEARCH
(2021)
Review
Oncology
L. Zhu, L. Zhao, Q. Wang, S. Zhong, X. Guo, Y. Zhu, J. Bao, K. Xu, S. Liu
Summary: miRNAs are small non-coding ribonucleic acids that play key roles in cancer development and can be encapsulated in exosomes released into the circulatory system. Circulating exosome-derived miRNAs have the potential to replace conventional biomarkers for early cancer diagnosis.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ting Guo, Xiao-Huan Tang, Xiang-Yu Gao, Yuan Zhou, Bo Jin, Zi-Qian Deng, Ying Hu, Xiao-Fang Xing, Zi-Yu Li, Jia-Fu Ji
Summary: This study aimed to develop a non-invasive blood test using an exosome-derived RNA model to predict the efficacy of neoadjuvant chemotherapy in gastric cancer patients. Through RNA sequencing, a variety of miRNAs, mRNAs, and lncRNAs associated with treatment response were identified and validated in an independent cohort. Furthermore, a panel of 6 exosome-derived RNAs was established to accurately distinguish responders from non-responders to fluorouracil-based neoadjuvant chemotherapy.
Article
Agriculture, Dairy & Animal Science
M. Martin, M. D. Kleinhenz, K. S. Schwartzkopf-Genswein, D. Melendez, S. Marti, E. A. Pajor, E. D. Janzen, J. Coetzee
Summary: This study used ROC analysis to evaluate the predictive value of pain biomarkers in livestock. It found that plasma cortisol, hair cortisol, and IRT had higher AUC values, while salivary cortisol, MNT, substance P, kinematic gait analysis, and a visual analog scale for pain had lower AUC values.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Cell Biology
Alireza Bakhshi, Mohammad Khani, Saeed Alipour Parsa, Isa Khaheshi, Mohammad Hassan Namazi, Arash Mazouri, Peyman Bidram, Morteza Safi, Hossein Vakili, Vahid Eslami, Habib Saadat, Laleh Heidari, Nasim Sohrabifar
Summary: The expression levels of miR-17-3p, miR-101-3p, miR-335-3p, miR-296-3p, and NLRP3 were evaluated in STEMI, NSTEMI, and control groups. NLRP3 was upregulated in both STEMI and NSTEMI patients, while miR-17-3p, miR-101-3p, and miR-296-3p were downregulated. MiR-17-3p showed the highest diagnostic power in distinguishing STEMI patients from controls.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Oncology
Jianing Wu, Abdulrahman Al-Zahrani, Ozal Beylerli, Rinat Sufianov, Rustam Talybov, Svetlana Meshcheryakova, Galina Sufianova, Ilgiz Gareev, Albert Sufianov
Summary: This study found that circulating miR-181a/b, miR-410, and miR-155 could be useful diagnostic and prognostic biomarkers for high-grade gliomas.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Yang Zhang, Xiangyi Ma, Xuxia Shen, Shengping Wang, Yuan Li, Hong Hu, Haiquan Chen
Summary: Sublobar resection, especially wedge resection without lymph node dissection, may be the preferred surgical procedure for patients with AIS/MIA. Postoperative follow-up intervals may be extended if there are no risk factors. Further studies are needed to validate these implications.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Medicine, General & Internal
Halit Topal, Raymond Aerts, Annouschka Laenen, Andre Collignon, Joris Jaekers, Joachim Geers, Baki Topal
Summary: A comparative study of 396 patients with pancreatic adenocarcinoma found that minimally invasive pancreatic surgery (MIPS) was associated with better long-term overall survival (OS) and disease-free survival (DFS) compared to open pancreatic surgery (OPS).
Article
Immunology
Arutha Kulasinghe, Ning Liu, Chin Wee Tan, James Monkman, Jane E. Sinclair, Dharmesh D. Bhuva, David Godbolt, Liuliu Pan, Andy Nam, Habib Sadeghirad, Kei Sato, Gianluigi Li Bassi, Ken O'Byrne, Camila Hartmann, Anna Flavia Ribeiro Dos Santos Miggiolaro, Gustavo Lenci Marques, Lidia Zytynski Moura, Derek Richard, Mark Adams, Lucia de Noronha, Cristina Pellegrino Baena, Jacky Y. Suen, Rakesh Arora, Gabrielle T. Belz, Kirsty R. Short, Melissa J. Davis, Fernando Souza-Fonseca Guimaraes, John F. Fraser
Summary: The study reveals distinct transcriptomic profiles in cardiac tissues of SARS-CoV-2 and pH1N1 influenza infection, with upregulation of genes associated with DNA damage and repair, heat shock, and macrophage infiltration in COVID-19 patients' cardiac tissues. In comparison, pH1N1 infection showed upregulation of interferon and complement pathways. This highlights the need for further understanding of the effects on extra-pulmonary organs, including the cardiovascular system, in COVID-19 patients.
Article
Biochemistry & Molecular Biology
Tabassum Khair Barbhuiya, Mark Fisher, Eric D. Boittier, Emma Bolderson, Kenneth J. O'Byrne, Derek J. Richard, Mark Nathaniel Adams, Neha S. Gandhi
Summary: The study investigates the mechanism of CDCA3 binding to APC/C-Cdh1 through the non-canonical ABBA-like motif. The research finds that H-bonds, hydrophobic and ionic interactions within the ABBA-like motif are crucial for the binding. Alanine mutations disrupt the structure of the linker region, leading to altered affinities and binding to alternate sites on Cdh1.
Article
Nutrition & Dietetics
Ian A. J. Darragh, Lorraine O'Driscoll, Brendan Egan
Summary: This study examined within-subject variability in the circulating metabolome under controlled conditions and investigated the association between divergent exercise training backgrounds and alterations in the circulating metabolome in resting samples. The results showed that the reliability of resting plasma metabolite concentrations varied at the level of individual metabolites, and a history of exercise training was associated with alterations in the abundance of certain metabolites.
INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM
(2023)
Article
Oncology
Lecia V. Sequist, James Chih-Hsin Yang, Nobuyuki Yamamoto, Kenneth O'Byrne, Vera Hirsh, Tony Mok, Sarayut Lucien Geater, Sergey Orlov, Chun-Ming Tsai, Michael Boyer, Wu-Chou Su, Jaafar Bennouna, Terufumi Kato, Vera Gorbunova, Ki Hyeong Lee, Riyaz Shah, Dan Massey, Victoria Zazulina, Mehdi Shahidi, Martin Schuler
Summary: The study compared the efficacy of chemotherapy with afatinib in the treatment of EGFR-mutated lung adenocarcinoma. Results showed that afatinib prolonged progression-free survival and improved the quality of life for patients, when compared with chemotherapy.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Endocrinology & Metabolism
Mark N. Adams, Laura V. Croft, Aaron Urquhart, Mohamed Ashick Mohamed Saleem, Anja Rockstroh, Pascal H. G. Duijf, Patrick B. Thomas, Genevieve P. Ferguson, Idris Mohd Najib, Esha T. T. Shah, Emma Bolderson, Shivashankar Nagaraj, Elizabeth D. Williams, Colleen C. Nelson, Kenneth J. O'Byrne, Derek J. Richard
Summary: This study evaluated the role of hSSB1/NABP2 in modulating the cellular response to androgens and ionizing radiation in prostate cancer. The expression of hSSB1 in prostate cancer is correlated with genomic instability and it regulates pathways involved in cell cycle progression and transcription. Additionally, hSSB1 is involved in modulating androgen response through transcriptional regulation. Exploiting hSSB1 in prostate cancer treatment might improve patient outcomes in ADT and/or radiotherapy.
Review
Oncology
Eabha O'Sullivan, Anna Keogh, Brian Henderson, Stephen P. Finn, Steven G. Gray, Kathy Gately
Summary: KRAS plays a crucial role in regulating cell growth and survival, and its activation is commonly observed in various types of tumors. Recent discoveries have identified a specific pocket in the structure of KRAS, leading to the development of inhibitors that target the G12C mutation. These inhibitors, such as sotorasib and adagrasib, have been approved for the treatment of non-small-cell lung cancer, but their efficacy may be limited by resistance mechanisms in cancer cells.
Article
Pharmacology & Pharmacy
Anindya Mukhopadhya, Dimitrios Tsiapalis, Niamh McNamee, Brian Talbot, Lorraine O'Driscoll
Summary: This study compared the suitability of MSC EVs and milk EVs as drug delivery vehicles. Milk EVs had significantly higher yields compared to MSC EVs. Electroporation was found to be the most effective method for loading the anti-cancer drug Dox into EVs. Additionally, sonication was observed to have detrimental effects on EVs.
Article
Oncology
Ming Tang, Joshua T. Burgess, Mark Fisher, Didier Boucher, Emma Bolderson, Neha S. Gandhi, Kenneth J. O'Byrne, Derek J. Richard, Amila Suraweera
Summary: This study aimed to explore the binding pose of COMMD4-H2B and develop a H2B peptide that disrupts the COMMD4-H2B interaction, which could serve as a potential therapeutic target for non-small cell lung cancer (NSCLC).
BRITISH JOURNAL OF CANCER
(2023)
Article
Neurosciences
Ian A. J. Darragh, Niamh McNamee, Roisin Daly, Sarai Martinez Pacheco, Lorraine O'Driscoll, Brendan Egan
Summary: This study investigated whether individuals with different exercise training histories had varied abundances of small extracellular vesicles (EVs) in resting samples. The results suggest that the abundance and metabolomic profile of small EVs derived from men with divergent exercise training histories are similar to those in resting blood samples.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Oncology
Sugandha Bhatia, Jennifer H. Gunter, Joshua Burgess, Mark N. Adams, Kenneth O'Byrne, Erik W. Thompson, Pascal H. G. Duijf
Summary: Epithelial-mesenchymal plasticity (EMP) is a characteristic of cancer that promotes invasion, metastasis, and therapy resistance. This study shows that non-cancerous human epithelial lung cells can spontaneously shift towards a mesenchymal-like state without genetic changes. This suggests that acquisition of metastasis-associated features may occur prior to genetic alterations and cancerous transformation.
TRANSLATIONAL ONCOLOGY
(2023)
Article
Biology
Zachariah P. Schuurs, Alexander P. Martyn, Carl P. Soltau, Sam Beard, Esha T. Shah, Mark N. Adams, Laura V. Croft, Kenneth J. O'Byrne, Derek J. Richard, Neha S. Gandhi
Summary: This study explores small molecules that bind to hSSB1, an important protein related to the survival of cancer cells. Through computational and experimental approaches, three small molecules were discovered that prevent hSSB1 from binding to DNA, potentially interfering with the cell's ability to repair DNA. Further research is needed to understand the interaction between these compounds and cells, and to develop them as selective hSSB1 inhibitors.
Article
Chemistry, Physical
Ming Tang, Amila Suraweera, Xuqiang Nie, Zilin Li, Pinglin Lai, James W. Wells, Kenneth J. O'Byrne, Robert J. Woods, Emma Bolderson, Derek J. Richard
Summary: In this study, the atomic-level mechanisms of Banf1-DNA binding and the effects of mono- and di-phosphorylation on Banf1's DNA-binding capability were explored using molecular modelling and dynamics simulations. It was found that mono-phosphorylation induces changes in Banf1's secondary structure, leading to the elimination of its DNA-binding capability. The study also demonstrated that phosphorylated Banf1 binds to DNA with lower affinity and less stable binding poses. These findings have implications for predicting the effects of Banf1 mutations on its DNA-binding capability and potential development of therapeutic drugs targeting cell proliferation.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Cell & Tissue Engineering
Dimitrios Tsiapalis, Achilleas Floudas, Tobias Tertel, Verena Boerger, Bernd Giebel, Douglas J. Veale, Ursula Fearon, Lorraine O'Driscoll
Summary: This study investigated the effect of human mesenchymal/stromal stem cells and their extracellular vesicles (EVs) on CD4+ T cells from rheumatoid arthritis (RA) patients. The researchers found that EVs from IFN-beta-primed MSCs had a stronger immune-regulatory effect on RA CD4+ T cells compared to MSCs or EVs from naive MSCs. In addition, EVs from IFN-beta-primed MSCs effectively inhibited RA FLS migration and downregulated RA FLS surface markers. These findings suggest that EVs from IFN-beta-primed MSCs could be a potential therapy for RA.
STEM CELLS TRANSLATIONAL MEDICINE
(2023)
Article
Physiology
Ian A. J. Darragh, Sarai Martinez-Pacheco, Lorraine O'Driscoll, Brendan Egan
Summary: This study investigated the effects of plasma from different training groups on BT-549 breast cancer cells. The results showed that supplementing media with plasma from trained athletes did not impact the proliferation, migration, invasion, and anoikis resistance of the cells.
EXPERIMENTAL PHYSIOLOGY
(2023)
Article
Multidisciplinary Sciences
Thais Sobanski, Amila Suraweera, Joshua T. Burgess, Iain Richard, Chee Man Cheong, Keyur Dave, Maddison Rose, Mark N. Adams, Kenneth J. O'Byrne, Derek J. Richard, Emma Bolderson
Summary: This study reveals that the glycolytic protein ALDOA plays a direct role in DNA double-strand break (DSB) repair. Upon DNA damage, ALDOA translocates into the nucleus and associates with the DNA DSB marker γ-H2AX. Depletion of ALDOA leads to increased DNA damage before and slower repair after ionising radiation. It is suggested that targeting ALDOA may be a potential strategy for simultaneous disruption of cancer metabolism and DNA repair.
SCIENTIFIC REPORTS
(2023)