Review
Biochemistry & Molecular Biology
Ji He, Erika Fortunati, Dong-Xu Liu, Yan Li
Summary: Chemotherapeutics are a main therapy for metastatic breast cancers, but multidrug resistance due to ABC transporters remains a challenge. Targeting ABCB1 to reverse drug resistance in clinical trials has been disappointing, but ABC transporters may play roles in breast cancer development and metastasis beyond efflux function. Understanding the functions and regulations of ABC transporters in breast cancer biology may lead to more targeted and novel therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Malgorzata Szczygiel, Marcin Markiewicz, Milena Julia Szafraniec, Agnieszka Hojda, Leszek Fiedor, Krystyna Urbanska
Summary: The growth of a tumor affects the activity of xenobiotic transport in the host, leading to enhanced xenobiotic transport and changes in cytokine levels. This tumor-host interaction has implications for cancer therapies and personalized medicine.
Article
Materials Science, Multidisciplinary
Sinan Cheng, Zheng Lu, Yang Feng, Xuewei Zhao, Ruixia Zhao, Zuchun Qiu, Chenshuang Jia, Lirong Chen, Yue Yuan, Xinyao Li, Qian Gao, Jie Xu, Zhan Shu, Wei Duan, Yingchun Hou, Guochao Nie, Li Xiao
Summary: Breast cancer is the most common cancer and leading cause of death in women. Current chemotherapy has low efficacy and high side effects, necessitating the development of a novel targeted drug delivery formulation. The study discovered a new drug formulation that showed satisfactory therapeutic efficacy for breast cancer, particularly for drug resistant cases.
MATERIALS TODAY ADVANCES
(2022)
Article
Biochemistry & Molecular Biology
Wenqin Sun, Iris L. K. Wong, Helen Ka-Wai Law, Xiaochun Su, Terry C. F. Chan, Gege Sun, Xinqing Yang, Xingkai Wang, Tak Hang Chan, Shengbiao Wan, Larry M. C. Chow
Summary: Tea polyphenol derivative EC31 is a potent and nontoxic P-gp inhibitor that can reverse multidrug resistance and enhance the efficacy of anticancer drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yasmeen Cheema, Yusra Sajid Kiani, Kenneth J. J. Linton, Ishrat Jabeen
Summary: Researchers developed a pharmacophore model based on the cryo-EM structure of ABCB1 to screen for new inhibitors, resulting in the identification of six potential inhibitors with distinct chemistries and favorable properties. The compounds exhibited low nanomolar range inhibitory concentrations and two of them were able to resensitize ABCB1-expressing cells to taxol. This study demonstrates the utility of cryo-electron microscopy in drug identification and design.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Okan Tezcan, Asmaa Said Elshafei, Karina Benderski, Elena Rama, Maike Wagner, Diana Moeckel, Robert Pola, Michal Pechar, Tomas Etrych, Saskia von Stillfried, Fabian Kiessling, Ralf Weiskirchen, Steffen Meurer, Twan Lammers
Summary: Multidrug resistance (MDR) reduces the efficacy of chemotherapy by inducing drug efflux pumps and altering the tumor microenvironment (TME) composition, limiting drug delivery. Multidrug-resistant tumors displayed a more mesenchymal phenotype, increased collagen production, enriched TME, and enhanced vascular perfusion. Drug carriers accumulated more efficiently in resistant tumors but had a limited ability to penetrate the interstitium. Microenvironmental drug resistance affected liposomal doxorubicin performance more than free doxorubicin.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Pharmacology & Pharmacy
Sunil Kumar Dubey, Maithili Kali, Siddhanth Hejmady, Ranendra Narayan Saha, Amit Alexander, Prashant Kesharwani
Summary: Breast Cancer is a highly heterogeneous malignant carcinoma that affects women, and conventional therapies include chemotherapy, hormonal therapy, radiation, and nanotechnology. Dendrimers play a significant role in addressing the toxicity and resistance of chemotherapeutic agents in BC, with high loading capacity and targeted drug delivery capabilities.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Review
Nanoscience & Nanotechnology
Hong Tan, Mengyu Zhang, Yuqing Wang, Peter Timashev, Yuanyuan Zhang, Shouwen Zhang, Xing-Jie Liang, Fangzhou Li
Summary: Tumor multidrug resistance is a major cause of clinical chemotherapy failure, and nanotechnology offers various strategies to overcome this issue. Further research is needed to explore the mechanisms of drug endocytosis and fate.
Article
Pharmacology & Pharmacy
Xianqiang Luo, Guohui Wang, Yuting Wang, Meichen Wang, Zhuomin Tan, Min Luo, Limei Zhang, Yan Song, Yinnong Jia, Hongyu Zhou, Chen Qing
Summary: Chemoresistance is a major challenge in breast cancer treatment. This study demonstrates that BMP6 downregulation is involved in multidrug resistance in MCF-7/Adr breast cancer cells, and the novel compound GA5 overcomes multidrug resistance by increasing BMP6 expression.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Physical
Hongmei Liu, Ding Ma, Jinpeng Chen, Li Ye, Yiping Li, Yuexia Xie, Xue Zhao, Hanbing Zou, Xiaojing Chen, Jun Pu, Peifeng Liu
Summary: This study aimed to develop a novel and facile strategy for preparing a highly efficient and safe gene and drug delivery system for multidrug-resistant (MDR) breast cancer. A targeted nanoplatform based on biodegradable boronic acid modified epsilon-polylysine was developed to co-deliver P-gp siRNA, Bcl-2 siRNA, and doxorubicin for overcoming MDR. The nanoplatform exhibited robust inhibitory effects against invasion, proliferation, and colony formation of MCF-7/ADR cells in vitro, and demonstrated ATP responsiveness. In vivo antitumor experiments showed significant inhibition of tumor growth and good biocompatibility with the targeted nanoplatform.
Review
Pharmacology & Pharmacy
Tuyelee Das, Uttpal Anand, Swaroop Kumar Pandey, Charles R. Ashby, Yehuda G. Assaraf, Zhe-Sheng Chen, Abhijit Dey
Summary: This article discusses the main cause of cancer chemotherapy resistance, which is multidrug resistance. The mechanisms of resistance to paclitaxel and docetaxel are explored, including alterations in microtubule-protein interactions and the expression of multidrug efflux transporters. Additionally, various pharmacological modulations and herbal formulations for reversing paclitaxel resistance are discussed, indicating a new era in modern medicine to combat multidrug resistance in cancer patients.
DRUG RESISTANCE UPDATES
(2021)
Review
Pharmacology & Pharmacy
Enrique Dominguez-Alvarez, Balint Racz, Malgorzata Anna Marc, Muhammad Jawad Nasim, Nikoletta Szemeredi, Jitka Viktorova, Claus Jacob, Gabriella Spengler
Summary: This article provides an overview of the biological activities of seleno- and tellurocompounds, including their antioxidant and pro-oxidant activities, anti-inflammatory activities, induction of apoptosis, inhibition of multidrug efflux pumps, and more. It also reviews the chemistry of relevant seleno- and tellurocompounds against drug-resistant cancers and the preparation of bioactive selenium or tellurium nanoparticles. The use of these compounds shows promise in the development of novel therapies or adjuvants against drug-resistant cancers.
DRUG RESISTANCE UPDATES
(2022)
Review
Biochemistry & Molecular Biology
Hye-Jin Park
Summary: This review discusses the anticancer potential and underlying molecular mechanisms of mushrooms as natural compounds. It provides information about the current clinical status and molecular actions of various mushrooms and their derived compounds, aiming to assist researchers and clinicians in designing evidence-based studies on the anticancer effects of mushrooms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Briana Kinnel, Santosh Kumar Singh, Gabriela Oprea-Ilies, Rajesh Singh
Summary: Breast cancer is the most common cancer type and leading cause of cancer-related death in women internationally. It is classified into in situ and invasive carcinoma, and further subclassified as ductal and lobular carcinomas. Treatments are based on the molecular subtype, which includes Luminal A, Luminal B, HER2 enriched, and basal-like/TNBC. Hormone-positive BC is easier to treat with endocrine therapy and chemotherapy, while TNBC is more challenging due to lack of hormone receptors and aggressiveness.
Article
Biotechnology & Applied Microbiology
Wenrui Wang, Mengyang Zhou, Yang Xu, Wei Peng, Shiwen Zhang, Rongjie Li, Han Zhang, Hui Zhang, Shumin Cheng, Youjing Wang, Xinyu Wei, Chengxu Yue, Qingling Yang, Changjie Chen
Summary: The study successfully formulated TPGS-Res-SLNs nanoparticles to improve therapeutic efficacy against breast cancer, showing significant anti-tumor activity and promotion of cell apoptosis. It also exhibited significant inhibition of cancer cell invasion and migration. In vivo experiments showed that TPGS-Res-SLNs had higher efficacy in promoting tumor cell apoptosis.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Medicine, General & Internal
Tycho R. Tromp, Merel L. Hartgers, G. Kees Hovingh, Antonio J. Vallejo-Vaz, Kausik K. Ray, Handrean Soran, Tomas Freiberger, Stefano Bertolini, Mariko Harada-Shiba, Dirk J. Blom, Frederick J. Raal, Marina Cuchel
Summary: Patients with homozygous familial hypercholesterolaemia (HoFH) globally face issues of late diagnosis, under-treatment, and high risk of premature ASCVD. The use of multiple lipid-lowering therapy regimens is associated with lower LDL cholesterol levels and better outcomes. Significant global disparities exist in treatment regimens, control of LDL cholesterol levels, and cardiovascular event-free survival.
Article
Hematology
Leylagul Kaynar, Emre Tekgunduz, Ilknur Kozanoglu, Hasan Atilla Ozkan, Salih Aksu, Fahir Ozkalemkas, Fatih Demirkan
Summary: Graft versus host disease (GVHD) is a significant cause of mortality and morbidity after allogeneic stem cell transplantation. Steroids are the first-line treatment, but there is no standard approach for second-line therapy. ECP, with its immunomodulatory effect, is favored for treating GVHD as it has a low risk of relapse or infection. However, it requires specific conditions and equipment.
TRANSFUSION AND APHERESIS SCIENCE
(2022)
Article
Hematology
Seval Akpinar, Emre Tekgunduz, Ramazan Esen, Mehmet Yilmaz, Volkan Karakus, Filiz Vural, Fusun Gediz, Ismet Aydogdu, Leylagul Kaynar, Hakan Goker, Engin Kelkitli, Orhan Ayyildiz, Fatih Demirkan
Summary: The study found that gender, age, and extraversion are reliable predictors of various types of social media use frequency, while other traits showed unreliable associations. The social media usage behavior of young adults can be categorized into different dimensions, which are significantly associated with individual differences.
TRANSFUSION AND APHERESIS SCIENCE
(2022)
Article
Oncology
Serhat Celik, Zeynep Tugba Guven, Funda Ipekten, Muzaffer Keklik, Ali Unal, Leylagul Kaynar
Summary: The objective of this study was to determine the fear level of COVID-19 in hemopoietic stem cell transplant patients and its relationship with quality of life. The Fear of COVID-19 Scale (FCV-19S) was used to evaluate the fear situation, while the European Organisation for Quality of Life Research and Treatment Core Questionnaire (EORTC QLQ-C30) was used to assess the quality of life. The results showed that the fear level was higher in urban residents compared to rural residents, and the strongest positive correlation between fear level and life quality was found in emotional function. Furthermore, the FCV-19S was proven to be a quick and valid tool for determining the fear level in vulnerable patient groups such as HSCT patients.
EUROPEAN JOURNAL OF CANCER CARE
(2022)
Article
Hematology
Zeynep Tugba Guven, Serhat Celik, Bulent Eser, Mustafa Cetin, Ali Unal, Leylagul Kaynar
Summary: This study retrospectively evaluated the efficacy and safety of ELT in the treatment of thrombocytopenia following HSCT. The results demonstrated that ELT is an effective and safe treatment option, and the adequacy of bone marrow megakaryocytes is an important factor affecting treatment response.
TURKISH JOURNAL OF HEMATOLOGY
(2022)
Article
Emergency Medicine
Emine Alp, Zeynep Burcin Gonen, Kursat Gundogan, Aliye Esmaoglu, Leylagul Kaynar, Aysun Cetin, Musa Karakukcu, Mustafa Cetin, Gamze Kalin, Mehmet Doganay
Summary: This study evaluated the clinical safety and efficacy of mesenchymal stem cells (MSCs) in sepsis and septic shock patients. The results suggest that MSCs treatment may have a positive impact on the survival rates of sepsis during the early phase, but further randomized controlled studies with a large group of patients are needed to confirm these findings.
EMERGENCY MEDICINE INTERNATIONAL
(2022)
Article
Nutrition & Dietetics
Serap Sahin Ergul, Gulsah Gunes Sahin, Nurhayat Tugra Ozer, Leylagul Kaynar, Serhat Celik, Kursat Gundogan
Summary: This study aimed to investigate the frequency of refeeding hypophosphatemia (RH) and its influencing factors in patients treated with hematopoietic stem cell transplantation (HSCT). The results showed that RH developed in 78% of patients receiving HSCT. Pre-transplant nutritional status, frequency of vomiting, and occurrence of infection were identified as factors affecting RH development.
CLINICAL NUTRITION ESPEN
(2022)
Article
Hematology
Yasa Gul Mutlu, Berrin Balik Aydin, Cem Erdogan, Deniz Kizilaslan, Huseyin Saffet Bekoz, Aliihsan Gemici, Leylagul Kaynar, Omur Gokmen Sevindik
Summary: This study retrospectively evaluated 40 patients who were admitted to the ICU during their post-transplant period. The analysis included baseline patient characteristics, reasons for ICU admissions, laboratory and clinical findings, supportive treatment in ICU, and short-term survival. The results showed a 8.8% ICU admission rate and a 75% mortality rate among the ICU patients. Factors such as mechanical ventilation, vasopressor use, heart rate, and elevated INR were significantly associated with survival in the ICU.
INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION
(2023)
Letter
Hematology
Istemi Serin, Tahir Alper Cinli, Sertac Tunc, Leylagul Kaynar, Omur Gokmen Sevindik, Osman Yokus
ANNALS OF HEMATOLOGY
(2023)
Article
Hematology
Mehmet Sinan Dal, Bahar Uncu Ulu, Ant Uzay, Olga Meltem Akay, Sevgi Besisik, Mustafa Nuri Yenerel, Serhat Celik, Leylagul Kaynar, Orhan Kemal Yucel, Burak Deveci, Mehmet Sonmez, Ozgur Mehtap, Huseyin Saffet Bekoz, Cenk Sunu, Ozan Salim, Turgay Ulas, Sami Karti, Fevzi Altuntas, Burhan Ferhanoglu, Tulin Firat Tuglular
Summary: Through analyzing the data of 71 patients with relapsed/refractory diffuse large B-cell lymphoma (DLBCL) treated with Polatuzumab vedotin (Pola) with bendamustine and rituximab (BR) from March 2018 to April 2021, it was found that Pola-BR is a promising option with an overall response rate of 47.9% and a complete response rate of 32.4% after a median of 3 cycles. The median overall survival was 5 months with manageable hematological toxicities of grade 3-4 neutropenia and thrombocytopenia.
ANNALS OF HEMATOLOGY
(2023)
Meeting Abstract
Hematology
Omur Sevindik, Hulya Bilgen, Istemi Serin, Elif Melek, Volkan Karaku, Kubra Cerci, Yasa Gul Mutlu, Berrin Balik Aydin, Sevil Sadri, Huseyin Bekoz, Leylagul Kaynar
Meeting Abstract
Hematology
Theodoros P. Vassilakopoulos, Fotios Panitsas, Zois Mellios, John Apostolidis, Alexia Piperidou, Michalis D. Michael, Ronit Gurion, Meltem Akay, Eleftheria Hatzimichael, Stamatis J. Karakatsanis, Maria Dimou, Christina Kalpadakis, Eirini Katodritou, Theoni Leonidopoulou, Ioannis Kotsianidis, Chara Giatra, Nikolaos Kanellias, Ayman Sayyed, Tamar Tadmor, Leylagul Kaynar, Miri Zektser, Argiris Symeonidis, Sc Atalar, Evgenia Verrou, Odit Gutwein, Chezi Ganzel, Giorgos Karianakis, Jonathan Isenberg, Gabriela Gainaru, Theodora Triantafyllou, Efimia Vrakidou, Maria Palassopoulou, Mehmet Ozgur, Semra Paydas, Panagiotis Tsirigotis, Maria Tsirogianni, Tulin Tuglular, Chrysovalantou Chatzidimitriou, Maria Kotsopoulou, Evangelos Terpos, Panagiotis Zikos, Argyro Koumarianou, Christos Poziopoulos, Dimitrios Boutsis, Anat Gafter-Gvili, Themistoklis Karmiris, Maria K. Angelopoulou, Maria Bakiri Papaioannou, Gerassimos Pangalis, Panayiotis Panayiotidis, Burhan Ferhanoglu, Netanel A. Horowitz, Sotirios Papageorgiou
Article
Health Care Sciences & Services
Aysenur Coskun, Selma Gokahmetoglu, Pelin Ozmen, Musa Karakuekcue, Mert Ahmet Kuskucu, Leylaguel Kaynar, Kenan Midilli
Summary: This study aimed to determine the genotypes of CMV strains obtained from patients with immune deficiency, and found that mixed genotypes were most commonly detected.
JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES
(2023)
Article
Hematology
Muzaffer Keklik, Burak Deveci, Serhat Celik, Kemal Deniz, Zeynep Burcin Gonen, Gokmen Zararsiz, Rabin Saba, Gulsah Akyol, Yusuf Ozkul, Leylagul Kaynar, Ertugrul Keklik, Ali Unal, Mustafa Cetin, Olcay Y. Jones
Summary: The safety and efficacy of mesenchymal stromal cell (MSC) therapy for steroid-refractory late acute graft versus host disease (late aGvHD) was evaluated and compared to acute GvHD (aGvHD) in a multicenter study. It was found that patients with late aGvHD had a higher response rate, lower non-relapse mortality (NRM), and improved survival probability at the 2-year follow-up, indicating the benefits of MSC treatment for late aGvHD.
ANNALS OF HEMATOLOGY
(2023)
Article
Environmental Sciences
Sibel Silici, Leylagul Kaynar, Asli Okan, Zueleyha Doganyigit
Summary: This study investigated the effect of olive oil extract of propolis (OEP) on rats receiving tamoxifen (TAM) treatment. The results showed that the combined application of OEP and TAM improved hematological and antioxidant parameters and reduced tissue damage.
ENVIRONMENTAL TOXICOLOGY
(2023)