Article
Biochemistry & Molecular Biology
Concetta Panebianco, Nadia Trivieri, Annacandida Villani, Fulvia Terracciano, Tiziana Pia Latiano, Adele Potenza, Francesco Perri, Elena Binda, Valerio Pazienza
Summary: miR-217 enhances the sensitivity of pancreatic cancer cells to gemcitabine by impairing cell cycle progression, as shown in this study.
Review
Cell Biology
Alica K. Beutel, Christopher J. Halbrook
Summary: Pancreatic ductal adenocarcinoma (PDA) is a leading cause of cancer-related deaths worldwide and its treatment is challenging due to a lack of durable responses to standard-of-care chemotherapies. Gemcitabine, a cornerstone in PDA treatment, faces resistance mechanisms that have not yet been overcome in patient care.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Medicine, Research & Experimental
Jing Cui, Yao Guo, Tao Yin, Shanmiao Gou, Jiongxin Xiong, Xueyi Liang, Chong Lu, Tao Peng
Summary: In this study, we found that the expression of ubiquitin-specific protease 8 (USP8) was increased in pancreatic cancer patients and was associated with Gem chemotherapy recurrence. USP8 was found to promote Gem resistance by regulating cell viability and apoptosis. Additionally, USP8 enhanced Nrf2 signaling activation, which was dependent on its deubiquitinase ability. Furthermore, we demonstrated that USP8 interacted directly with Nrf2 and deubiquitinated K48-linked polyubiquitin chains from Nrf2, stabilizing its expression.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Multidisciplinary Sciences
Chen Chen, Binfeng Wu, Mingge Wang, Jinghua Chen, Zhaohui Huang, Jin-Song Shi
Summary: Our findings suggest that GABRP may serve as a downstream target of CD44s to diminish gemcitabine resistance in pancreatic cancer, and both CD44s and GABRP molecules have the potential to become prognostic biomarkers for PDAC patients with gemcitabine resistance.
Article
Pharmacology & Pharmacy
Ying Tan, Xuanna Li, Zhenfeng Tian, Shangxiang Chen, Jinmao Zou, Guoda Lian, Shaojie Chen, Kaihong Huang, Yinting Chen
Summary: The study revealed that TIMP1 is highly expressed in PDAC and correlated with poorer overall survival. Down-regulation of TIMP1 can enhance sensitivity of PDAC cells to GEM and reverse chemoresistance.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yongmei Zhao, Yuanlin Zheng, Yan Zhu, Yi Zhang, Hongyan Zhu, Tianqing Liu
Summary: This study developed a specific drug delivery system based on M1 macrophage-derived exosomes for pancreatic cancer with chemoresistance. The nanoformulation combining GEM and DFX in M1Exo significantly enhanced therapeutic efficacy against GEM-resistant cancer cells.
Article
Oncology
Zongting Gu, Yongxing Du, Xueping Zhao, Chengfeng Wang
Summary: PDAC is a solid malignant tumor with a low operative rate and poor prognosis, with gemcitabine chemotherapy being one of the main treatment options. However, the efficacy of gemcitabine therapy is limited due to gemcitabine resistance, which may be influenced by the fibrotic tumor microenvironment and metabolic remodeling in PDAC. Targeting the tumor microenvironment may be a key strategy to overcome gemcitabine resistance and improve patient outcomes.
Article
Biochemistry & Molecular Biology
Chonghui Hu, Renpeng Xia, Xiang Zhang, Tingting Li, Yuancheng Ye, Guolin Li, Rihua He, Zhihua Li, Qing Lin, Shangyou Zheng, Rufu Chen
Summary: This study found that the CAF-specific circRNA circFARP1 plays a critical role in pancreatic ductal adenocarcinoma (PDAC), and is associated with gemcitabine resistance and poor patient survival. Mechanistically, circFARP1 regulates the interaction between CAV1, ZNRF1, and LIF, influencing the development of tumor cell stemness and drug resistance. Additionally, high levels of circFARP1 are associated with elevated serum LIF levels and poor patient survival in PDAC.
Review
Oncology
Naotake Funamizu, Masahiko Honjo, Kei Tamura, Katsunori Sakamoto, Kohei Ogawa, Yasutsugu Takada
Summary: This review summarizes the current evidence for the role of microRNAs (miRNAs) in the mechanism of chemoresistance in pancreatic cancer. Pancreatic cancer has a poor prognosis due to its late discovery, aggressive nature, and chemoresistance. Aberrant miRNAs have been found to induce chemoresistance in pancreatic cancer, but the exact molecular mechanisms are still unclear. Novel biomarkers and therapeutic strategies for chemoresistance are urgently needed to improve patient outcomes.
Article
Biochemistry & Molecular Biology
Ella Rimmer, Sadaf Rashid, Igor Kraev, Francesc Miralles, Androulla Elia
Summary: Pancreatic cancer cells release extracellular vesicles that confer resistance to gemcitabine and TRAIL treatment. Removal of these vesicles during treatment may improve the response of pancreatic cancer cells to gemcitabine and TRAIL.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Jinsheng Ding, Hui Li, Yang Liu, Yongjie Xie, Jie Yu, Huizhi Sun, Di Xiao, Yizhang Zhou, Li Bao, Hongwei Wang, Chuntao Gao
Summary: This study identified OXCT1 as a key gene leading to GEM resistance in PDAC through the NF-kappa B signaling pathway, with high OXCT1 expression associated with shorter relapse-free survival under GEM treatment. OXCT1 overexpression in PDAC cell lines inhibited apoptosis after GEM treatment, and blocking the NF-kappa B signaling pathway reduced GEM resistance. These findings suggest that OXCT1 could be a potential therapeutic target for patients with PDAC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Jian Gan, Qin Gao, Li Li Wang, Ai Ping Tian, Long Dong Zhu, Li Ting Zhang, Wei Zhou, Xiao Rong Mao, Jun Feng Li
Summary: This study investigated the role of glucosylceramide synthase (GCS) in Con A-induced immune-mediated liver injury, revealing that GCS inhibition reduces the severity of liver damage, possibly due to its involvement in hepatocyte repair processes post-injury.
Article
Medicine, Research & Experimental
Yong-Qiang Hua, Ke Zhang, Jie Sheng, Zhou-Yu Ning, Ye Li, Wei-Dong Shi, Lu-Ming Liu
Summary: The study revealed that Fam83D is overexpressed in pancreatic adenocarcinoma and associated with clinical features and patient outcomes. Knockdown of Fam83D inhibited proliferation, suppressed metabolism, and increased sensitivity to gemcitabine in PDAC cells.
Article
Biotechnology & Applied Microbiology
Ryan N. Fuller, Janviere Kabagwira, Paul A. Vallejos, Andrew D. Folkerts, Nathan R. Wall
Summary: The study suggests a potential role of survivin splice variants, especially SSV 2 beta, in innate and acquired PDAC chemoresistance. Knockdown of SSVs using siRNA sensitized the GR cells to Gem, indicating their involvement in PDAC chemoresistance.
ONCOTARGETS AND THERAPY
(2022)
Article
Gastroenterology & Hepatology
Hongwei Zhu, Wenzhe Gao, Xia Li, Li Yu, Dong Luo, Yunfei Liu, Xiao Yu
Summary: S100A14 is highly expressed in PDAC and associated with tumor progression and chemoresistance. Targeting S100A14 could effectively inhibit the cancerous properties of PDAC cells, making it a valuable target for therapeutic strategies.
Article
Biochemistry & Molecular Biology
Samy A. F. Morad, Su-Fern Tan, David J. Feith, Mark Kester, David F. Claxton, Thomas P. Loughran, Brian M. Barth, Todd E. Fox, Myles C. Cabot
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2015)
Article
Biochemistry & Molecular Biology
Samy A. F. Morad, Terence E. Ryan, P. Darrell Neufer, Tonya N. Zeczycki, Traci S. Davis, Matthew R. MacDougall, Todd E. Fox, Su-Fern Tan, David J. Feith, Thomas P. Loughran, Mark Kester, David F. Claxton, Brian M. Barth, Tye G. Deering, Myles C. Cabot
JOURNAL OF LIPID RESEARCH
(2016)
Article
Oncology
Su-Fern Tan, Xin Liu, Todd E. Fox, Brian M. Barth, Arati Sharma, Stephen D. Turner, Andy Awwad, Alden Dewey, Kenichiro Doi, Barbara Spitzer, Mithun Vinod Shah, Samy A. F. Morad, Dhimant Desai, Shantu Amin, Junjia Zhu, Jason Liao, Jong Yun, Mark Kester, David F. Claxton, Hong-Gang Wang, Myles C. Cabot, Edward H. Schuchman, Ross L. Levine, David J. Feith, Thomas P. Loughran
Article
Chemistry, Multidisciplinary
Brian M. Barth, Sriram S. Shanmugavelandy, James M. Kaiser, Christopher McGovern, Erhan I. Altnoglu, Jeremy K. Haakenson, Jeremy A. Hengst, Evan L. Gilius, Sarah A. Knupp, Todd E. Fox, Jill P. Smith, Timothy M. Ritty, James H. Adair, Mark Kester
Article
Oncology
Kenichiro Doi, Qiang Liu, Krishne Gowda, Brian M. Barth, David Claxton, Shantu Amin, Thomas P. Loughran, Hong-Gang Wang
CANCER BIOLOGY & THERAPY
(2014)
Article
Cell Biology
Brian M. Barth, Sally J. Gustafson, Jody L. Hankins, James M. Kaiser, Jeremy K. Haakenson, Mark Kester, Thomas B. Kuhn
CELLULAR SIGNALLING
(2012)
Article
Gastroenterology & Hepatology
Gail L. Matters, Timothy K. Cooper, Christopher O. McGovern, Evan L. Gilius, Jiangang Liao, Brian M. Barth, Mark Kester, Jill P. Smith
DIGESTIVE DISEASES AND SCIENCES
(2014)
Article
Biochemistry & Molecular Biology
Jody L. Hankins, Todd E. Fox, Brian M. Barth, Kellee A. Unrath, Mark Kester
JOURNAL OF BIOLOGICAL CHEMISTRY
(2011)
Article
Biochemistry & Molecular Biology
Jody L. Hankins, Katherine E. Ward, Sam S. Linton, Brian M. Barth, Robert V. Stahelin, Todd E. Fox, Mark Kester
JOURNAL OF BIOLOGICAL CHEMISTRY
(2013)
Article
Neurosciences
Brian M. Barth, Sally J. Gustafson, Thomas B. Kuhn
JOURNAL OF NEUROSCIENCE RESEARCH
(2012)
Article
Biochemistry & Molecular Biology
William L. Holland, Russell A. Miller, Zhao V. Wang, Kai Sun, Brian M. Barth, Hai H. Bui, Kathryn E. Davis, Benjamin T. Bikman, Nils Halberg, Joseph M. Rutkowski, Mark R. Wade, Vincent M. Tenorio, Ming-Shang Kuo, Joseph T. Brozinick, Bei B. Zhang, Morris J. Birnbaum, Scott A. Summers, Philipp E. Scherer
Article
Chemistry, Medicinal
Colin M. McGill, Estefania J. Alba-Rodriguez, Shuo Li, Charles J. Benson, Regina M. Ondrasik, Lindsey N. Fisher, David F. Claxton, Brian M. Barth
PHYTOTHERAPY RESEARCH
(2014)
Article
Medicine, Research & Experimental
Diana M. Tacelosky, Amy E. Creecy, Sriram S. Shanmugavelandy, Jill P. Smith, David F. Claxton, James H. Adair, Mark Kester, Brian M. Barth
DISCOVERY MEDICINE
(2012)
Article
Oncology
Brian M. Barth, Myles C. Cabot, Mark Kester
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2011)