期刊
CANCER BIOLOGY & THERAPY
卷 11, 期 6, 页码 592-598出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cbt.11.6.14668
关键词
formosanin C; migration; antitumor effect; MMPs; lung cancer
类别
资金
- National Natural Science Foundation of China [30873378]
- Science and Technology in China [2009ZX09103-362]
Formosanin C (FC) isolated from Rhizoma paridis, showed pro-apoptosis and immunoregulation with antitumor activity in cultured cells and animal systems. However, there is no report about its anti-metastatic effect on cancer cells. This research used the wound healing and the migration assay to detect the anti-invasive effect of FC on LA795 cells. Through the gelatin zymography assay and immunofluorescence analysis, FC showed suppression of enzyme activity of MMP-2 and MMP-9, and protein expression of MMP-1, -2, -3, -9 and -14 excreted from LA795 cells. Finally, FC exhibited much more effective inhibition of tumor growth and pulmonary metastasis in T739 mice than cisplatin did. Overall, the strong inhibition of MMP expression by FC might provide a potential therapeutic modality for lung tumors.
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