Review
Biochemistry & Molecular Biology
Emma Marie Wilber Hepworth, Shanta D. Hinton
Summary: MAPK signaling pathways are crucial regulators of eukaryotic cell function, with kinases and phosphatases controlling the activation and inhibition of MAPK. Pseudoenzymes also play a significant role in regulating these pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Shanelle Shillingford, Lei Zhang, Yulia Surovtseva, Sam Dorry, Elias Lolis, Anton M. Bennett
Summary: This study demonstrates the importance of a specific site (Y271) in the phosphatase domain of MKP7 for its catalytic activity and binding to p38 MAPK and JNK. Mutations in this site inhibited MKP7 function, leading to increased nuclear accumulation of p38 MAPK and JNK. These findings contribute to our understanding of the regulatory mechanisms of MKP7 and provide insights for potential therapeutic targeting of MKP7.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Neurosciences
Ambika Chandrasekhar, Prashanth Komirishetty, Aparna Areti, Anand Krishnan, Douglas W. Zochodne
Summary: This study reveals a crucial role of dual specificity phosphatases (DUSPs) in supporting axon plasticity and survival. Knockdown of DUSP 1 and 4 impairs neurite outgrowth in sensory neurons, rendering them more sensitive to axonopathy and accelerating neurofilament breakdown and axon degeneration.
MOLECULAR NEUROBIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ping-Ping Gao, Xiao-Wei Qi, Na Sun, Yuan-Yuan Sun, Ye Zhang, Xuan-Ni Tan, Jun Ding, Fei Han, Yi Zhang
Summary: Protein reversible phosphorylation controlled by kinases and phosphatases is involved in various cellular processes. Dual-specificity phosphatases (DUSPs) have been identified as key players in human cancers, with potential differential expression serving as a potential biomarker for tumor prognosis. Further exploration is needed for unstudied members of the DUSPs family to understand their precise roles and mechanisms in cancers.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Article
Neurosciences
Noopur Bhore, Bo-Jeng Wang, Po-Fan Wu, Yen-Lurk Lee, Yun-Wen Chen, Wen-Ming Hsu, Hsinyu Lee, Yi-Shuian Huang, Ding- Yang, Yung-Feng Liao
Summary: Research showed that DUSP15 can affect Notch processing by regulating ERK1/2 activity to influence Notch protein levels, revealing a novel signaling axis.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Chouhui Xuan, Haixia Cui, Zhengyong Jin, Yuyang Yue, Shuxia Cao, Songbiao Cui, Dongyuan Xu
Summary: Glutamine treatment can effectively alleviate hyp-induced brain injury and improve learning and memory impairment in neonatal rats. This neuroprotective effect may be related to the regulation of MKP-1 expression and inhibition of MAPK signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ping Chen, Min Pan, Qing-Song Lin, Xian-Zhong Lin, Zhangya Lin
Summary: The study revealed that CSF-CN contributes to cancer-induced bone pain through regulating the MKP-1-mediated p38-MAPK pathway. Targeted ablation of CSF-CN or overexpression of MKP-1 significantly affects pain sensitivity.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Lin Zhao, Jiali Su, Sijia Liu, Yang Li, Tao Xi, Jianping Ruan, Kristina Xiao Liang, Ruizhe Huang
Summary: Dental fluorosis is characterized by hypomineralization of tooth enamel caused by excessive fluoride ingestion during enamel formation. Research indicates that MKP-1 plays a critical role in regulating ERK-related kinases, and under high fluoride doses, MKP-1 acts as a negative regulator of fluoride-induced signaling pathways.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Cell Biology
Michael Mutlak, Izhak Kehat
Summary: Pressure overload and other stress stimuli lead to cardiac hypertrophy and heart failure through signaling cascades, with MAPK pathway and DUSPs playing important roles.
CELLULAR SIGNALLING
(2021)
Article
Biochemistry & Molecular Biology
Junfeng Ke, Wenzhao Han, Fanwei Meng, Feng Guo, Yuhong Wang, Liping Wang
Summary: Studies have shown that CTI-2 inhibits the activation of the MAPK signaling pathway, reduces the expression of E-cadherin, N-cadherin, and vimentin, thus preventing the metastasis of breast cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Yun Shang, Dami Yang, Yunmi Ha, Ju Yeon Lee, Jin Young Kim, Man-Ho Oh, Kyoung Hee Nam
Summary: The study highlights the critical role of OST1/SnRK2.6 in ABA signaling, revealing the autophosphorylation and transphosphorylation sites, as well as the phosphatase regulation mechanism of this key kinase in plants.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Review
Cell Biology
Valerie Lannoy, Anthony Cote-Biron, Claude Asselin, Nathalie Rivard
Summary: Phosphatases are important regulators of TLRs signaling and may represent novel therapeutic targets to control pathogenic TLRs signaling.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Biochemistry & Molecular Biology
Hongwei Wu, Shiyue Tang, Mengya Zhou, Jiji Xue, Zhenjun Yu, Jiansheng Zhu
Summary: Tim-3 plays a role in suppressing autoimmune hepatitis through regulating Th17 cells via the p38/MKP-1 pathway. Blocking Tim-3 signaling pathway increases liver damage and elevates Th17 cell frequency, while blocking p38 activity decreases Th17 cell frequency.
Review
Urology & Nephrology
Haiyang Li, Jiachuan Xiong, Yu Du, Yinghui Huang, Jinghong Zhao
Summary: Dual-specificity phosphatases (DUSPs) play essential roles in kidney diseases by dephosphorylating MAPKs activity, impacting disease progression and reversal. Research has shown decreased DUSPs in kidney disease models, while forced DUSPs expression can reverse the disease presentation, providing insights for clinical translation.
Article
Medicine, General & Internal
Sabire Guler, Abdullah Yalcin
Summary: The study aims to profile the expression of dual-specificity phosphatases (DUSPs) in ovarian adenocarcinoma cells undergoing epithelial-mesenchymal transition (EMT) induced by Transforming growth factor (TGF)β1. TGF(31) treatment decreased E-cadherin expression and increased expression of EMT markers Snail and Slug. The activation of MAPKs was enhanced and the expression of certain DUSPs was altered in response to TGF(31).
TURKISH JOURNAL OF MEDICAL SCIENCES
(2023)
