Article
Chemistry, Medicinal
Eric J. Devor, Brandon M. Schickling, Jace R. Lapierre, David P. Bender, Jesus Gonzalez-Bosquet, Kimberly K. Leslie
Summary: The study demonstrated that the use of the p53 reactivator HO-3867 could restore PLAC1 transcriptional suppression in tumors with TP53 mutations, leading to inhibited cell proliferation and increased apoptosis. This suggests the potential efficacy of HO-3867 as an adjuvant in treating ovarian cancers, but further validation through clinical trials is necessary.
Article
Environmental Sciences
Kuan-Chun Hsueh, Po-Chung Ju, Yi-Hsien Hsieh, Shih-Chi Su, Chao-Bin Yeh, Chiao-Wen Lin
Summary: HO-3867 triggers cell cycle arrest and apoptotic responses in liver cancer, possibly involving p38-mediated activation of caspase cascades.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Cell Biology
Chi-Wei Chen, Ming-Ju Hsieh, Po-Chung Ju, Yi-Hsien Hsieh, Chun-Wen Su, Yen-Lin Chen, Shun-Fa Yang, Chiao-Wen Lin
Summary: In this study, the therapeutic effect and mode of action of the curcumin analog, HO-3867, against human oral squamous cell carcinoma (OSCC) cells were explored. The results showed that HO-3867 effectively suppressed the growth of OSCC cells and induced apoptosis through the c-Jun N-terminal kinase (JNK)1/2 pathway.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Peace Wun-Ang Lu, Chia-Hsuan Chou, Jia-Sin Yang, Yi-Hsien Hsieh, Meng-Ying Tsai, Ko-Hsiu Lu, Shun-Fa Yang
Summary: HO-3867 induces apoptosis in human osteosarcoma cells through the JNK signaling pathway.
Article
Immunology
Amrita Das, Mohd. Kamran, Nahid Ali
Summary: The study demonstrates that the liposomal formulation of HO-3867 is effective in inducing apoptosis in Leishmania parasites while being safe for normal murine macrophages. The treatment effectively reduces intracellular L. donovani amastigote burden by inducing parasite killing through ROS and NO activity.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Medicine, General & Internal
Nan Zheng, Shan Liu, Huiting Zeng, Huajun Zhao, Lixu Jin
Summary: This study found that WZ10 can significantly inhibit the proliferation and invasion of ovarian cancer OVCAR3 cells by downregulating the activation of the Hippo-YAP pathway, and induce cell apoptosis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Huajing Peng, Ling Zhou, Huayang Li, Yitao Zhang, Shiyao Cheng, Zhichong Chen, Shuqi Yu, Sutian Hu, Wenzeng Chen, Mao Ouyang, Jiaojie Xue, Weijie Zeng
Summary: This study suggests that combined treatment with rapamycin and HO-3867 has a significant modulatory effect on monocrotaline-induced pulmonary arterial hypertension in rats. The combination therapy improves hemodynamic changes, lung vascular remodeling, and right ventricular remodeling and function. Furthermore, it normalizes protein levels in the signaling pathways.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Reproductive Biology
Yun Leng, Can Zhao, Guoliang Yan, Shuangyue Xu, Yinggui Yang, Ting Gong, Xin Li, Chenglin Li
Summary: This study revealed a specific inhibitory effect of ghrelin on platinum-resistance by suppressing p-P38 and subsequently promoting p-CDK1 mediated cell cycle arrest in HO-8910 PM.
JOURNAL OF OVARIAN RESEARCH
(2021)
Article
Medicine, Research & Experimental
Febina Ravindran, Anisha Mhatre, Jinsha Koroth, Suchitra Narayan, Bibha Choudhary
Summary: The study aims to understand the epigenetic role of curcumin in inducing cytotoxicity in two molecularly distinct ovarian cancer cell lines. The results show that curcumin activates different miRNA-mRNA regulatory networks to induce multiple modes of cellular cytotoxicity, showcasing its potential as a promising drug candidate for ovarian cancer treatment.
Article
Cell Biology
Mengna Shi, Min-Jie Zhang, Yang Yu, Rongying Ou, Yiyan Wang, Huitao Li, Ren-shan Ge
Summary: NL01 induces ferroptosis in ovarian cancer cells and inhibits their growth through the HCAR1/MCT1 pathway. NL01 exhibits better anti-tumor growth properties than curcumin.
CELLULAR SIGNALLING
(2023)
Article
Reproductive Biology
Sifan Sun, Hailiang Fang
Summary: This study demonstrated that curcumin inhibits ovarian cancer cell proliferation and promotes apoptosis by regulating the circ-PLEKHM3/miR-320a/SMG1 axis. This suggests a potential therapeutic role of curcumin in ovarian cancer through mediating the circRNA/miRNA/mRNA network.
JOURNAL OF OVARIAN RESEARCH
(2021)
Article
Cell Biology
Huanjie Chen, Zhoufan Li, Jingchao Xu, Ning Zhang, Junzhu Chen, Guangzhi Wang, Yongfu Zhao
Summary: In this study, it was found that HO-1 was abnormally overexpressed in follicular thyroid cancer (FTC) and this overexpression decreased cell viability and potentially activated the ferroptosis signaling pathway. Curcumin inhibited the growth of FTC by increasing HO-1 expression and further activating the ferroptosis pathway.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2023)
Article
Pharmacology & Pharmacy
Yuwan Liu, Zhangjin Shen, Tingjia Zhu, Weiguo Lu, Yunfeng Fu
Summary: Curcumin has been found to enhance the anti-cancer efficacy of paclitaxel in ovarian cancer by regulating the miR-9-5p/BRCA1 axis. These findings provide strong evidence for the clinical investigation of curcumin and paclitaxel combination as a novel strategy for ovarian cancer patients, and also identify miR-9-5p and BRCA1 as key targets for regulating sensitivity to this therapy.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Zhihui Liu, Bendong Shi, Yu Wang, Qingyang Xu, Hongxin Gao, Jun Ma, Xiaowen Jiang, Wenhui Yu
Summary: Curcumin has been shown to alleviate aristolochic acid I-induced renal injury in rats by activating the SIRT1/Nrf2/HO-1 signaling pathway.
Review
Reproductive Biology
Xiaoping Liu, Mingming Qi, Xidie Li, Jingjin Wang, Mingyuan Wang
Summary: Curcumin, extracted from the rhizomes of Curcuma longa, exhibits significant anti-tumor, antioxidant and anti-inflammatory activities. Its anti-tumor activity, in particular, has attracted extensive attention from scholars worldwide. Multiple studies have shown that curcumin can inhibit ovarian cancer growth, enhance its sensitivity to chemotherapy, and reduce chemotherapy-induced side effects. It exerts these effects by promoting cell apoptosis, suppressing cell cycle progression, inducing autophagy, inhibiting tumor metastasis, and regulating enzyme activity. Understanding the anti-ovarian cancer mechanism of curcumin will contribute to its broader clinical applications. This review summarizes recent studies on curcumin's anti-ovarian cancer activities and discusses the specific mechanisms, providing references for further research and applications.
JOURNAL OF OVARIAN RESEARCH
(2023)