Article
Cell Biology
Marina Katsman, Aviva Azriel, Guy Horev, Yitzhak Reizel, Ben-Zion Levi
Summary: The study reveals the crucial role of N-VEGF as an autoregulatory arm of VEGF-A in angiogenesis and cell survival under hypoxic conditions.
Article
Biochemistry & Molecular Biology
Jakub Rech, Daniel Sypniewski, Dorota Zelaszczyk, Natalia Szkaradek, Wojciech Rogoz, Anna Waszkielewicz, Henryk Marona, Ilona Bednarek
Summary: The study revealed that four novel xanthone derivatives have the potential to inhibit proliferation, motility, and induce apoptosis in colon cancer cells, with comparable activity to cisplatin and 5-fluorouracil. Further research and development of these compounds as novel drugs for colorectal cancer treatment is recommended.
Review
Chemistry, Medicinal
Anurag Mathur, Abha Meena, Suaib Luqman
Summary: Monoterpenoids, a subclass of terpenoids, have been extensively studied for their antitumor properties, including antiproliferative, apoptotic, antiangiogenic, and antimetastatic effects. This review focuses on the effects of specific monoterpenoids on metastasis and relevant signaling pathways. Monoterpenoids exhibit complexity as natural products that regulate metastatic proteins through various signaling pathways. However, limited clinical trials hinder the drug usage of monoterpenoids in preventing cancer metastasis.
PHYTOTHERAPY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Anna Wrona, Veronika Aleksandrovych, Tomasz Bereza, Pawel Basta, Anna Gil, Magdalena Ulatowska-Bialas, Malgorzata Mazur-Laskowska, Kazimierz Pitynski, Krzysztof Gil
Summary: Oxygen balance is crucial for reproductive function, and there is a relationship between the oviduct and uterine myoma. Patients with uterine myoma have different expressions of sex steroid receptors and an increased number of telocytes. Blood biochemical analyses reveal a higher progesterone level and lower AMH in patients with uterine myoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Mariko Miyashita-Ishiwata, Malak El Sabeh, Lauren D. Reschke, Sadia Afrin, Mostafa A. Borahay
Summary: This study reveals an aberrant response of leiomyoma cells to hypoxia, characterized by increased cell proliferation and secretion of angiogenic factors. This abnormal response may contribute to the development and growth of leiomyoma.
Article
Oncology
Yunlong Yang, Yihai Cao
Summary: Metastasis, the leading cause of cancer-associated mortality, is still poorly understood. Both blood and lymphatic vasculatures play crucial roles in distal metastasis, with VEGF being a key angiogenic factor. Anti-VEGF drugs have been widely used in clinical treatment of various cancers, but their impact on cancer metastasis and systemic disease is largely unknown.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ajmal Ahmad, Mohd Imtiaz Nawaz
Summary: This review article summarizes the significant scientific contributions made in the past seven decades regarding the implications of vascular endothelial-derived growth factor (VEGF) in angiogenesis processes. It highlights the role of VEGF in pathological conditions and its potential as a therapeutic target for managing cancers and intraocular neovascular disorders. The article also emphasizes the need for further research and development of alternative strategies in the management of VEGF-mediated pathological angiogenesis. Additionally, it discusses the emerging field of therapeutic angiogenesis for the treatment of ischemic disorders.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Grazia Maugeri, Agata Grazia D'Amico, Salvatore Saccone, Concetta Federico, Daniela Maria Rasa, Rosario Caltabiano, Giuseppe Broggi, Salvatore Giunta, Giuseppe Musumeci, Velia D'Agata
Summary: The study shows that PACAP plays a role in regulating the hypoxic micro-environment, angiogenesis and EMT in GBM cells. By inhibiting specific pathways and molecules, PACAP can reduce invasiveness of GBM cells and interfere with VEGF release and vessel formation. This study provides new insights into the complex role of PACAP in GBM malignancy.
Article
Biochemistry & Molecular Biology
Tur-Fu Huang, Shih-Wei Wang, Yu-Wei Lai, Shih-Chia Liu, Yu-Jen Chen, Thomas Y. Hsueh, Chih-Chung Lin, Chun-Hsuan Lin, Ching-Hu Chung
Summary: The compound 4-acetylantroquinonol B (4AAQB) has shown inhibitory effects on cancer growth and angiogenesis, making it a potential candidate for prostate cancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Ophthalmology
Minsup Lee, Wendy Leskova, Randa S. Eshaq, Norman R. Harris
Summary: The study revealed that METH administration resulted in increased retinal hypoxia, HIF-1α, VEGFa, and angiogenesis.
EXPERIMENTAL EYE RESEARCH
(2021)
Article
Chemistry, Medicinal
Donghwa Kim, Sang Won Choi, Jihee Cho, Jae-Hui Been, Kyoungsun Choi, Wenzhe Jiang, Jaeho Han, Jedo Oh, Changmin Park, Soongyu Choi, Songyi Seo, Koung Li Kim, Wonhee Suh, Sang Kook Lee, Sanghee Kim
Summary: Diabetic retinopathy is a leading cause of blindness associated with excessive angiogenesis. Researchers have developed a novel antiangiogenesis agent by modifying the structure of wondonin marine natural products, resulting in improved bioactivity and selectivity. This compound, 31, shows potential as a lead for developing small-molecule drugs to treat diabetic retinopathy and to uncover new mechanisms of angiogenesis.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Oncology
Giovanni Di Maira, Beatrice Foglia, Lucia Napione, Cristian Turato, Marina Maggiora, Salvatore Sutti, Erica Novo, Maria Alvaro, Riccardo Autelli, Sebastiano Colombatto, Federico Bussolino, Patrizia Carucci, Silvia Gaia, Chiara Rosso, Alessandra Biasiolo, Patrizia Pontisso, Elisabetta Bugianesi, Emanuele Albano, Fabio Marra, Maurizio Parola, Stefania Cannito
Summary: This study investigated the role of Oncostatin M (OSM), a pleiotropic cytokine of the IL-6 family, in the development and progression of hepatocellular carcinoma (HCC) in non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH). The results showed that OSM was selectively overexpressed in HCC cells of NAFLD/NASH patients and correlated with tumor grade and survival rate. Cell culture experiments and mouse models further demonstrated that OSM upregulation contributed to HCC progression by inducing epithelial-to-mesenchymal transition, increased invasiveness of cancer cells, and angiogenesis. Therefore, OSM may serve as a prognostic marker and a potential therapeutic target for HCC in NAFLD/NASH patients.
JOURNAL OF PATHOLOGY
(2022)
Article
Multidisciplinary Sciences
Christina Westhoff, Sabrina Mueller, Paul Jank, Matthias Kalder, Roland Moll
Summary: Several studies have shown the presence of lymphangiogenesis in metastases of breast cancer, and the number of lymph vessels in metastases is significantly correlated with metastasis size. However, no lymphangiogenesis was detected in tumor-free lymph nodes. D2-40 staining was frequently detected in the sinus endothelium of lymph nodes, and a higher proportion of stained sinus in sentinel lymph nodes was associated with worse overall survival and served as an independent prognostic factor. Further studies are needed to understand the biological and clinical significance of the observed immunophenotypic variations of nodal sinus endothelium.
Article
Chemistry, Medicinal
Miaomiao Tian, Kan Chen, Jianhua Huang, Dongqing Chu, Jialin Li, Keqiang Huang, Chunyu Ma
Summary: Asiatic acid (AA) has demonstrated inhibitory effects on angiogenesis in breast cancer models both in vitro and in vivo, potentially through downregulating the VEGF/VEGFR2 signal axis to inhibit cancer growth and metastasis.
PHYTOTHERAPY RESEARCH
(2021)
Article
Biochemical Research Methods
K. G. Akhmedzhanova, A. A. Kurnikov, D. A. Khochenkov, Yu A. Khochenkova, A. M. Glyavina, V. V. Kazakov, A. Yudintsev, A. Maslennikova, I. Turchin, P. Subochev, A. G. Orlova
Summary: This study compares the blood vessel structure and oxygen state of three xenografts. Colo320 tumor has the largest vessel size and fraction, and a higher number of hypoxic areas.
BIOMEDICAL OPTICS EXPRESS
(2022)
Article
Biochemistry & Molecular Biology
Dervla T. Isaac, Charlotte A. Berkes, Bevin C. English, Davina Hocking Murray, Young Nam Lee, Alison Coady, Anita Sil
MOLECULAR MICROBIOLOGY
(2015)
Article
Oncology
Caitlin E. Baum, Sandra B. Ockers, Bevin C. English, Douglas K. Price, Oliver Sartor, William D. Figg
CANCER BIOLOGY & THERAPY
(2010)
Article
Oncology
Cody J. Peer, Tristan M. Sissung, AeRang Kim, Lokesh Jain, Sukyung Woo, Erin R. Gardner, C. Tyler Kirkland, Sarah M. Troutman, Bevin C. English, Emily D. Richardson, Joel Federspiel, David Venzon, William Dahut, Elise Kohn, Shivaani Kummar, Robert Yarchoan, Giuseppe Giaccone, Brigitte Widemann, William D. Figg
CLINICAL CANCER RESEARCH
(2012)
Article
Oncology
William D. Figg, Erika K. Smith, Douglas K. Price, Bevin C. English, Paul W. Thurman, Seth M. Steinberg, Ezekiel Emanuel
JOURNAL OF CLINICAL ONCOLOGY
(2010)
Article
Oncology
Lokesh Jain, Tristan M. Sissung, Romano Danesi, Elise C. Kohn, William L. Dahut, Shivaani Kummar, David Venzon, David Liewehr, Bevin C. English, Caitlin E. Baum, Robert Yarchoan, Giuseppe Giaccone, Juergen Venitz, Douglas K. Price, William D. Figg
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2010)
Article
Urology & Nephrology
Douglas K. Price, Cindy H. Chau, Cathee Till, Phyllis J. Goodman, Caitlin E. Baum, Sandy B. Ockers, Bevin C. English, Lori Minasian, Howard L. Parnes, Ann W. Hsing, Juergen K. V. Reichardt, Ashraful Hoque, Catherine M. Tangen, Alan R. Kristal, Ian M. Thompson, William D. Figg
JOURNAL OF UROLOGY
(2010)
Review
Pharmacology & Pharmacy
Tristan M. Sissung, Bevin C. English, David Venzon, William D. Figg, John F. Deeken
Article
Health Care Sciences & Services
Bevin C. English, Caitlin E. Baum, David E. Adelberg, Tristan M. Sissung, Paul G. Kluetz, William L. Dahut, Douglas K. Price, William D. Figg
THERAPEUTICS AND CLINICAL RISK MANAGEMENT
(2010)
Article
Microbiology
Mariana X. Byndloss, April Y. Tsai, Gregory T. Walker, Cheryl N. Miller, Briana M. Young, Bevin C. English, Nubia Seyffert, Tobias Kerrinnes, Maarten F. de Jong, Vidya L. Atluri, Maria G. Winter, Jean Celli, Renee M. Tsolis
Article
Microbiology
April Y. Tsai, Bevin C. English, Renee M. Tsolis
MICROBIOLOGY SPECTRUM
(2019)
Article
Multidisciplinary Sciences
Gregory T. Walker, Guiyan Yang, Julia Y. Tsai, Jorge L. Rodriguez, Bevin C. English, Franziska Faber, Lattha Souvannaseng, Brian P. Butler, Renee M. Tsolis
Summary: Infection with Plasmodium parasite weakens the host's resistance against Salmonella, leading to an increased colonization of Salmonella in the upper gastrointestinal tract. This may be due to the parasite-induced hypochlorhydria, which allows for enhanced survival of Salmonella in the stomach.
Article
Microbiology
Hirotaka Hiyoshi, Bevin C. English, Vladimir E. Diaz-Ochoa, Tamding Wangdi, Lillian F. Zhang, Miako Sakaguchi, Takeshi Haneda, Renee M. Tsolis, Andreas J. Baumler
Summary: Intracellular pathogens use virulence factors to generate a complement-dependent find-me signal for efferocytosis, thereby avoiding exposure to the extracellular milieu.
CELL HOST & MICROBE
(2022)
Article
Microbiology
Dinara Azimova, Nadia Herrera, Lucian Duvenage, Mark Voorhies, Rosa A. Rodriguez, Bevin C. English, Jennifer C. Hoving, Oren Rosenberg, Anita Sil
Summary: Cbp1 is a fungal virulence factor that triggers host cell lysis and localizes to the cytosol of the host cell. It forms a complex with another cytosolic virulence factor, Yps-3. This is the first known instance of a phagosomal human fungal pathogen directing an effector into the host cell cytosol.
