Article
Multidisciplinary Sciences
Zhiyang Li, Heng Zhang, Yujie Sun, Zhuangzhuang Feng, Bijia Cui, Jingxia Han, Yinan Li, Huijuan Liu, Tao Sun
Summary: Angiogenesis plays a crucial role in embryologic development, growth, and tissue repair, but dysregulation of this process is a hallmark of various pathologies, including cancer. Existing methods for evaluating cell vascular formation are often limited to static analysis, leading to bias. Researchers have developed code scripts to study the dynamic angiogenesis process, allowing for the screening of drugs that can affect various parameters of vascular formation. Animal experiments have confirmed the efficacy of these drugs in inhibiting blood vessel formation, providing a new perspective for angiogenesis research and drug development.
Article
Oncology
Maria Sol Recouvreux, Jiangyong Miao, Maricel C. Gozo, Jingni Wu, Ann E. Walts, Beth Y. Karlan, Sandra Orsulic
Summary: Tumors require a continuous supply of oxygen and nutrients for growth, and vasculogenic mimicry is a coping mechanism where cancer cells form vascular-like structures. FOXC2 gene expression is associated with vasculogenic mimicry and aggressive cancer behavior.
Article
Biochemistry & Molecular Biology
Sara Peri, Alessio Biagioni, Giampaolo Versienti, Elena Andreucci, Fabio Staderini, Giuseppe Barbato, Lisa Giovannelli, Francesco Coratti, Nicola Schiavone, Fabio Cianchi, Laura Papucci, Lucia Magnelli
Summary: Chemotherapy is widely used in gastric cancer treatment as an adjuvant when surgery is not feasible or in the presence of metastasis. Chemoresistance is a major challenge in cancer therapy, leading to tumor recurrence and treatment failure. Despite known mechanisms of chemoresistance, a universal marker for chemoresistant cancer cells has not yet been identified.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Yuxian Wu, Jinghai Gao, Xiaojun Liu
Summary: The study showed that upregulation of ANGPTL4 in ovarian cancer cells led to increased tumor angiogenesis, growth, and metastasis inhibition. Inactivation of VEGFR2 Y949 phosphorylation eliminated the tumor-suppressive effects of ANGPTL4 inhibition in spontaneous ovarian carcinoma.
CANCER CELL INTERNATIONAL
(2021)
Article
Biology
Anahita Fouladzadeh, Mohsen Dorraki, Kay Khine Myo Min, Michaelia P. Cockshell, Emma J. Thompson, Johan W. Verjans, Andrew Allison, Claudine S. Bonder, Derek Abbott
Summary: The development of vascular networks in solid tumours, formed through angiogenesis and vasculogenic mimicry (VM), demonstrate similar characteristics such as reducing path length over time. While endothelial cells in angiogenesis increase network clustering coefficients, maintaining small-world network properties, VM networks improve efficiency by reducing edges and vertices while increasing edge length.
COMMUNICATIONS BIOLOGY
(2021)
Article
Immunology
Haitao Hu, Ting Ma, Nanqi Liu, Hong Hong, Lujiao Yu, Dantong Lyu, Xin Meng, Biao Wang, Xuefeng Jiang
Summary: Vasculogenic mimicry (VM) is a vessel-like structure independent of endothelial cells, commonly found in solid tumors. It is closely associated with tumor proliferation, invasion, metastasis, and poor patient prognosis. Various factors, including immune cells, cytokines, and signaling molecules, have been reported to be involved in ovarian cancer progression and VM formation. This review discusses the mechanisms regulating VM formation in ovarian cancer, the impact of cells, cytokines, and signaling molecules in the tumor microenvironment on VM formation, and the current clinical application of drugs targeting VM formation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Xiaoxu Wei, Yunhua Chen, Xianjie Jiang, Miao Peng, Yiduo Liu, Yongzhen Mo, Daixi Ren, Yuze Hua, Boyao Yu, Yujuan Zhou, Qianjin Liao, Hui Wang, Bo Xiang, Ming Zhou, Xiaoling Li, Guiyuan Li, Yong Li, Wei Xiong, Zhaoyang Zeng
Summary: Overall, the use of VM inhibitors in combination with conventional anti-angiogenesis treatments is a promising strategy for improving the effectiveness of targeted angiogenesis treatments; further, considering the importance of hypoxia in tumor invasion and metastasis, drugs targeting the hypoxia signaling pathway seem to achieve good results.
Review
Biochemistry & Molecular Biology
Ana K. Herrera-Vargas, Eduardo Garcia-Rodriguez, Monserrat Olea-Flores, Miguel A. Mendoza-Catalan, Eugenia Flores-Alfaro, Napoleon Navarro-Tito
Summary: The ability of leptin to induce angiogenesis and vasculogenic mimicry in different types of cancer has been studied, with significant relationships observed in breast cancer. Leptin activates multiple pathways to promote the expression of angiogenic factors and vasculogenic mimicry, suggesting its potential role as a therapeutic target for tumor survival and metastasis.
CYTOKINE & GROWTH FACTOR REVIEWS
(2021)
Review
Oncology
Xinyu Lin, Sheng Long, Congcong Yan, Xiaofeng Zou, Guoxi Zhang, Junrong Zou, Gengqing Wu
Summary: Angiogenesis is a crucial process in cancer growth and metastasis, but its inhibition can lead to acquired resistance. Vasculogenic mimicry is an alternative mechanism of tumor angiogenesis and is associated with poor prognosis. Inhibiting vasculogenic mimicry may be an effective therapeutic strategy to overcome the limitations of anti-angiogenic treatment when used in combination with other anti-tumor therapies.
FRONTIERS IN ONCOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Prashant Jain, Chethan D. Shanthamurthy, Shani Leviatan Ben-Arye, Sharon Yehuda, Sharvani S. Nandikol, Hirekodathakallu Thulasiram, Vered Padler-Karavani, Raghavendra Kikkeri
Summary: A potential heparan sulfate (HS) ligand was discovered to target several growth factors using specific HS tetrasaccharide ligands. One tetrasaccharide ligand showed strong binding with the VEGF(165) growth factor, and in vitro experiments demonstrated the therapeutic potential of these synthetic HS ligands by inhibiting vascular endothelial cell proliferation, migration, and angiogenesis in the presence of VEGF(165) and the specific tetrasaccharides.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Yang Liu, Linyu Long, Fanjun Zhang, Xuefeng Hu, Jieyu Zhang, Cheng Hu, Yunbing Wang, Jianguo Xu
Summary: The study introduced a GelMA microneedle platform for sustained and controlled local delivery of AAV-VEGF, which achieved homogeneous distribution and high transfection efficiency in ischemic brains. Results showed that MNs loaded with AAV-VEGF increased VEGF expression in the brain cortex and enhanced functional angiogenesis and neurogenesis.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Clinical Neurology
Carlos Escudero, Jesenia Acurio, Eduardo Lopez, Andres Rodriguez, Antonia Benavente, Evelyn Lara, Steven J. Korzeniewski
Summary: Circulating VEGF levels were found to be elevated 24-48 hours after acute ischemic stroke and were associated with prognosis of moderate to severe disability at 6 months. Combining VEGF with interleukin 6 and C-reactive protein significantly improved predictive performance compared to using VEGF alone.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Cell Biology
Fan Li, Huizhi Sun, Yihui Yu, Na Che, Jiyuan Han, Runfen Cheng, Nan Zhao, Yuhong Guo, Chongbiao Huang, Danfang Zhang
Summary: In this study, it was found that RIPK1-dependent necroptosis promoted vasculogenic mimicry (VM) formation in triple-negative breast cancer (TNBC). The activation of RIPK1/p-AKT/eIF4E signaling pathway played a role in this process. Furthermore, eIF4E promoted epithelial-mesenchymal transition (EMT) and MMP2 expression and activity, contributing to VM formation. The findings suggest potential therapeutic targets for TNBC through necroptosis-mediated VM.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Menglu Zhang, Jiaqi Liu, Gang Liu, Zeyu Xing, Ziqi Jia, Jiaxin Li, Wenyan Wang, Jie Wang, Ling Qin, Xin Wang, Xiang Wang
Summary: Breast cancer, the highest incidence of female malignancy, is heavily reliant on neo-vascularization for growth and metastasis, with Vascular Endothelial Growth Factor (VEGF) playing a crucial role. This review focuses on the prognostic value of VEGF in breast cancer, clinical experiences with anti-VEGF therapeutics, and biomarkers for predicting the effectiveness of anti-angiogenic treatment.
Review
Chemistry, Medicinal
Yachana Mishra, Aditi Chattaraj, Vijay Mishra, Abhigyan Ranjan, Murtaza M. Tambuwala
Summary: Cancer is a deadly disease characterized by unregulated cell growth that can occur in any part of the body. Detecting ovarian cancer early can help lower the death rate, and aptamers have shown promise as probes for ovarian cancer detection. Compared to other probes, aptamers are more effective in targeting ovarian cancer. Several aptamers have been developed to detect the ovarian tumor marker VEGF, and this review discusses their potential for early-stage ovarian cancer detection and treatment efficacy.
Article
Biotechnology & Applied Microbiology
Meng Dong, Lin Miao, Fengmei Zhang, Shengshui Li, Jingzhi Han, Ruohui Yu, Shuo Qie
ONCOTARGETS AND THERAPY
(2018)
Article
Multidisciplinary Sciences
Victoria J. Gennaro, Timothy J. Stanek, Amy R. Peck, Yunguang Sun, Feng Wang, Shuo Qie, Karen E. Knudsen, Hallgeir Rui, Tauseef Butt, J. Alan Diehl, Steven B. McMahon
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Multidisciplinary Sciences
Shuo Qie, Akihiro Yoshida, Stuart Parnham, Natalia Oleinik, Gyda C. Beeson, Craig C. Beeson, Besim Ogretmen, Adam J. Bass, Kwok-Kin Wong, Anil K. Rustgi, J. Alan Diehl
NATURE COMMUNICATIONS
(2019)
Article
Nutrition & Dietetics
Qi Xiang, Haicheng Yuan, Wang Cai, Shuo Qie
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2019)
Article
Multidisciplinary Sciences
Katelyn M. Williams, Shuo Qie, James H. Atkison, Sabrina Salazar-Arango, J. Alan Diehl, Shaun K. Olsen
NATURE COMMUNICATIONS
(2019)
Article
Oncology
Huocong He, Shuo Qie, Qiaojuan Guo, Shuyang Chen, Changyan Zou, Tianzhu Lu, Ying Su, Jingfeng Zong, Hanchuan Xu, Dan He, Yun Xu, Bijuan Chen, Jianji Pan, Nianli Sang, Shaojun Lin
CANCER MANAGEMENT AND RESEARCH
(2019)
Article
Multidisciplinary Sciences
Akihiro Yoshida, Yiwen Bu, Shuo Qie, John Wrangle, E. Ramsay Camp, E. Starr Hazard, Gary Hardiman, Renee de Leeuw, Karen E. Knudsen, J. Alan Diehl
Review
Oncology
Shuo Qie, J. Alan Diehl
SEMINARS IN CANCER BIOLOGY
(2020)
Correction
Oncology
H. He, S. Qie, Q. Guo
CANCER MANAGEMENT AND RESEARCH
(2019)
Review
Oncology
Shuo Qie, Nianli Sang
Summary: Stanniocalcin 2 (STC2) is a glycoprotein that is widely expressed in various tumor cells and tissues. It plays a role in promoting cell tolerance to stress and preventing apoptosis. Overexpression of STC2 is positively correlated with tumor growth, invasion, metastasis, and patients' prognosis, making it a potential biomarker and therapeutic target.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Review
Oncology
Shuo Qie
Summary: Fbxo4 is an E3 ubiquitin ligase that forms a complex with S-phase kinase-associated protein 1 and Cullin1 to catalyze the ubiquitylation of its substrates. It is defined as a tumor suppressor and regulates various biological functions such as cell cycle progression, DNA damage response, tumor metabolism, cellular senescence, and metastasis. The expression of Fbxo4 is associated with patients' prognosis in different tumor types. Further studies are needed to understand the detailed molecular mechanisms and develop targeted therapies.
Article
Multidisciplinary Sciences
Bartosz Mucha, Shuo Qie, Sagar Bajpai, Vincenzo Tarallo, J. Nathaniel Diehl, Frank Tedeschi, Gao Zhou, Zhaofeng Gao, Samuel Flashner, Andres J. Klein-Szanto, Hanina Hibshoosh, Shimonosono Masataka, Olga S. Chajewski, Ireneusz Majsterek, Dariusz Pytel, Maria Hatzoglou, Channing J. Der, Hiroshi Nakagawa, Adam J. Bass, Kwok-Kin Wong, Serge Y. Fuchs, Anil K. Rustgi, Eckhard Jankowsky, J. Alan Diehl
Summary: This study demonstrates the important role of SCFFbxo4-mediated polyubiquitylation of hnRNPK in restricting c-Myc translation and limiting cancer progression.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Zewei Zhao, Huijuan Wang, Ning Kang, Zhongyu Wang, Xiukun Hou, Linfei Hu, Shuo Qie, Jianping Guo, Songfeng Wei, Xianhui Ruan, Xiangqian Zheng
Summary: This study reveals that AURKA plays a critical role in regulating the progression of papillary thyroid carcinoma (PTC) by activating the mTORC2-AKT pathway, indicating the potential of targeting AURKA for the treatment of PTC.
CELL AND BIOSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Akihiro Yoshida, Jaewoo Choi, Hong Ri Jin, Yan Li, Sagar Bajpai, Shuo Qie, J. Alan Diehl
Summary: This study identified SCF-Fbxl8 as the E3 ligase for Thr-283 phosphorylated cyclin D3, which poly-ubiquitylates p-Thr-283 cyclin D3 and targets it to the proteasome. Functional investigation showed that Fbxl8 antagonizes cell cycle progression, hematopoietic cell proliferation, and oncogene-induced transformation through degradation of cyclin D3. Clinical data suggested that the expression of cyclin D3 is inversely correlated with the expression of Fbxl8 in lymphomas, implicating Fbxl8 as a potential tumor suppressor.
Article
Oncology
Shuo Qie, J. Alan Diehl
MOLECULAR & CELLULAR ONCOLOGY
(2019)