Article
Biochemistry & Molecular Biology
Yuze Wei, Weiwei Ke, Zaiming Lu, Ying Ren
Summary: PI-3065 specifically inhibits survivin expression and exerts anti-HCC activity in vivo and in vitro, suggesting it may serve as an effective antitumor drug for HCC treatment.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Eva Aubets, Miguel Chillon, Carlos J. Ciudad, Veronique Noe
Summary: This study demonstrated that PPRHs, as RNA species, can reduce the expression of specific target genes through different pathways, leading to a decrease in cell viability. Viral vectors showed potential as a delivery system for PPRHs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
A. Ruhan, Naoto Kunimura, Shoko Tominaga, Erika Hirata, Shunya Nishioka, Misato Uesugi, Rion Yamazaki, Hideto Ueki, Koichi Kitagawa, Masato Fujisawa, Toshiro Shirakawa
Summary: This study developed a recombinant replication-deficient adenoviral vector for the treatment of triple-negative breast cancer. The study revealed the critical role of cancer stem cells in the recurrence and metastasis of triple-negative breast cancer. The intratumoral injections of the developed vector showed significant antitumor activity, indicating its potential for the treatment of patients with triple-negative breast cancer.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Wei Guo, Xingyuan Ma, Yunhui Fu, Chang Liu, Qiuli Liu, Fabiao Hu, Hui Miao, Tong Zhang, Yuping Liu, Myong Hun Han, Fang You, Yi Yang, Wenyun Zheng
Summary: By studying mutants of Survivin, it was found that TmSm34/84 has stronger pro-apoptotic activity against A549 cells, can reverse the resistance of A549 CSCs to adriamycin (ADM) by decreasing the expression levels of Survivin, P-gp, and Bcl-2, and increasing cleaved caspase-3 in CSCs.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jingjing Liu, Qi Zhang, Changli Wang, Jiaying Yang, Sheng Yang, Tianyi Wang, Bing Wang
Summary: The expression of BAP31 is increased in hepatocellular carcinoma (HCC) and its knockdown enhances the sensitivity of cancer cells to Doxorubicin. This is achieved by downregulating survivin expression and promoting cell apoptosis. BAP31 may serve as a potential therapeutic target for improving the treatment response of Doxorubicin-resistant HCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Jing Zhang, Xinyan Xu, Yongfeng Chen, Xiaoju Guan, Hong Zhu, Yuhong Qi
Summary: In this study, the regulatory effect of the CRM1-Survivin axis on the progression of ovarian cancer was explored. The results showed that CRM1 silencing inhibited the proliferation and colony formation of ovarian cancer cells and promoted cell apoptosis by promoting Caspase-3 activation. Survivin was positively regulated by CRM1 and promoted the development of ovarian cancer. This suggests that the CRM1-Survivin axis may serve as a potential therapeutic target for ovarian cancer.
Article
Oncology
Paulo Roberto Del Valle, Samir Andrade Mendonca, Fernanda Antunes, Aline Hunger, Rodrigo E. Tamura, Daniela Bertolini Zanatta, Bryan E. Strauss
Summary: A modified non-replicating adenoviral vector was developed for gene transfer in colorectal cancer cells, showing enhanced sensitivity to chemotherapy and increased cell death rates. The approach may be effective for the treatment of colorectal cancer, allowing for the use of limited drug doses.
CANCER BIOLOGY & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Bo-Kyeong Jung, Young Jun Kim, JinWoo Hong, Han-Gyu Chang, A-Rum Yoon, Chae-Ok Yun
Summary: Cancer is a complex and deadly disease with limited treatment options. Targeted therapy using small interfering RNA (siRNA) to silence cancer-enriched proteins is a powerful tool, but its application is limited. Oncolytic adenovirus-mediated therapy offers an alternative approach. This study reports the development of two oncolytic adenovirus systems that effectively and persistently target ErbB3.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Amanda Rosewell Shaw, Caroline Porter, Greyson Biegert, Lisa Jatta, Masataka Suzuki
Summary: Solid tumors are highly immunosuppressive and require simultaneous targeting of multiple inhibitory mechanisms for successful cancer immunotherapy. Adenoviral vectors have the ability to stimulate multiple immune pathways and are promising cancer gene therapy vectors. Helper-dependent adenoviral vectors can express multiple transgenes for immunomodulation in tumors.
Article
Chemistry, Analytical
Anqi Zhang, Zhanchen Guo, Ge Ge, Zhen Liu
Summary: This study investigates the effects of in vivo environmental factors on single-cell quantification of biomolecular interactions and immunorecognition. The study finds that molecular crowding greatly affects these processes, while spatial confinement has negligible effects. The use of a calibration curve with standard solutions can offset the effect of intracellular crowding and improve the accuracy of single-cell analysis.
ANALYTICAL CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Patricia Ramos-Ramirez, Omar Tliba
Summary: This passage discusses how glucocorticoids act through the GR receptor to produce different cellular responses throughout the body and the different effects of GRα and GRβ on the human body.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Zirui Liu, Yiquan Li, Yilong Zhu, Nan Li, Wenjie Li, Chao Shang, Gaojie Song, Shanzhi Li, Jianan Cong, Tingyu Li, Zhiru Xiu, Jing Lu, Chenchen Ge, Xia Yang, Yaru Li, Lili Sun, Xiao Li, Ningyi Jin
Summary: Apoptin inhibits the viability of HCT116 cells through inducing pyroptosis mediated by GSDME, as well as enhancing intracellular ROS production. The findings in nude mice xenografted with HCT116 cells demonstrate that Apoptin induces pyroptosis and significantly inhibits tumor growth. These discoveries provide a new strategy for colorectal cancer therapy.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Cell Biology
Chakravarthy Garlapati, Shriya Joshi, Shristi Bhattarai, Jayashree Krishnamurthy, Ravi Chakra Turaga, Thi Nguyen, Xiaoxian Li, Ritu Aneja
Summary: Protein diversity, as a result of alternative mRNA splicing or post-translational modifications, is crucial for various cellular functions. High expression levels of the kinases PLK1 and AURKB in African American TNBC cells suggest their potential role in racial disparities in TNBC cell proliferation. Inhibition of PLK1 and AURKB may be a promising therapeutic strategy for African American TNBC patients.
CELL DEATH & DISEASE
(2023)
Article
Cell Biology
Mengdong Wang, Yaxin Duan, Mao Yang, Yongfei Guo, Fengtan Li, Junping Wang, Tongguo Si
Summary: This study investigated whether ablation treatment induces immunogenic cell death (ICD) in hepatocellular carcinoma (HCC) cells, and found that different ablative treatments could induce different types of ICDs, providing a promising track for the development of individualized cancer therapies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ana Alfano, Eduardo G. A. Cafferata, Mariela Gangemi, Alejandro Nicola Candia, Cristian M. Malnero, Ismael Bermudez, Mauricio Vargas Lopez, Gregorio David Rios, Cecilia Rotondaro, Nicasio Cuneo, David T. Curiel, Osvaldo L. Podhajcer, Maria Veronica Lopez
Summary: More than one million women worldwide are diagnosed with gynecological cancer each year. Most cases are diagnosed at a late stage due to a lack of symptoms or limited access to prevention in low-resource countries. The oncolytic adenovirus AR2011 has shown promising results in inhibiting the growth of ovarian, uterine, and cervical cancers in vitro, as well as synergizing with chemotherapy. In animal models, AR2011 has demonstrated efficacy in treating ovarian cancer and inducing an abscopal effect. It is a potential novel medicine for intraperitoneal disseminated ovarian cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Ying Wu, Zhe Wang, Lu Han, Zhihao Guo, Bohua Yan, Lili Guo, Huadong Zhao, Mengying Wei, Niuniu Hou, Jing Ye, Zhe Wang, Changhong Shi, Suling Liu, Ceshi Chen, Suning Chen, Ting Wang, Jun Yi, JianPing Zhou, Libo Yao, Wenxia Zhou, Rui Ling, Jian Zhang
Summary: Cancer cells regulate their response to the chemotherapeutic drug doxorubicin through RNA m6A modification. They do this by inhibiting RNA m6A modification through PRMT5 and enhancing the nuclear translocation of the demethylase ALKBH5. This leads to increased DNA repair ability and decreased efficacy of doxorubicin. The approved drug tadalafil was identified as a PRMT5 inhibitor that could enhance doxorubicin sensitivity in breast cancer cells by decreasing RNA m6A methylation.
Article
Geography, Physical
Chuan Zhang, Gui Gao, Linlin Zhang, C. Chen, S. Gao, Libo Yao, Qilin Bai, Shiquan Gou
Summary: In this study, an adaptive ship detector using full-polarization SAR images was constructed and verified through experiments. The results showed that the proposed detector has a higher signal-clutter ratio and lower false alarm rate, indicating better detection accuracy compared to other methods.
ISPRS JOURNAL OF PHOTOGRAMMETRY AND REMOTE SENSING
(2022)
Article
Chemistry, Physical
Jialu Li, Libo Yao, Dezhen Wu, Jaelynne King, Steven S. C. Chuang, Bin Liu, Zhenmeng Peng
Summary: In this study, electrochemical methane oxidation reaction on iron-nickel hydroxide nanosheets was investigated. The Fe-Ni-OH catalysts showed good CH4OR activity in a specific potential range, with ethanol being the main product. The composition of the catalyst has a significant effect on the activity. Density functional theory simulations and in situ infrared characterizations confirmed the active site and reaction pathways. This study provides theoretical guidance for understanding methane oxidation reaction mechanisms and discovering effective catalyst materials.
APPLIED CATALYSIS B-ENVIRONMENTAL
(2022)
Article
Engineering, Environmental
Libo Yao, Yanbo Pan, Dezhen Wu, Abdulaziz Bentalib, Jialu Li, Bin Liu, Zhenmeng Peng
Summary: A new mechanism for direct CO reduction to formaldehyde (CORTF) is reported, which utilizes hydrogen underpotential deposition to balance the species coverage on the catalyst surface. By tuning the composition of Pt alloy catalyst and the potential of hydrogen underpotential deposition, the formaldehyde production rate is significantly increased.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Gastroenterology & Hepatology
Shaoying Zhang, Dan Wan, Mengchen Zhu, Guihu Wang, Xurui Zhang, Na Huang, Jian Zhang, Chongyu Zhang, Qi Shang, Chen Zhang, Xi Liu, Fanfan Liang, Chunyan Zhang, Guangyao Kong, Jing Geng, Libo Yao, Shemin Lu, Yongyan Chen, Zongfang Li
Summary: This study found that splenic monocyte-derived macrophages migrate to the liver and shift to macrophages, exacerbating liver fibrosis. These findings reveal the important role of the spleen-liver axis in hepatic pathogenesis.
Article
Chemistry, Physical
Jialu Li, Jinyao Tang, Dezhen Wu, Libo Yao, Zhenmeng Peng
Summary: This study presents a combined method of ethylamine dehydrogenation (EDH) and ethylamine electrolysis, which allows for fast and efficient release of hydrogen at ambient conditions. The results show that high hydrogen production rate and acetonitrile production can be achieved under low voltage, demonstrating the great potential of this new electrochemical approach for hydrogen storage applications.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2023)
Article
Geriatrics & Gerontology
Caini Song, Libo Yao, Huisu Chen, Ying Song, Lihua Liu
Summary: This study conducted a meta-analysis to investigate the prevalence of depression and the factors influencing depression among home-bound empty nesters in China. The results showed that the overall prevalence of depression among empty nesters was 43%, and several factors such as gender, income, marital status, chronic illness, relationship with children, and social support were found to be significantly associated with depression among urban empty nesters. Based on the factors influencing depression, early intervention by government departments can help improve the mental health of empty nesters.
Article
Education & Educational Research
Caini Song, Libo Yao, Huisu Chen, Lihua Liu
Summary: This study analyzed the research hotspots and trends of nursing scenario simulation teaching at home and abroad, aiming to provide reference for future nursing talent education. The research focus in China is on the application and application effect of nursing scenario simulation teaching, while the research hotspots abroad are the quality evaluation, reliability, and influence of nursing scenario simulation teaching. In conclusion, the research and development of nursing scenario simulation teaching are gradually becoming more systematic.
EDUCATION AND INFORMATION TECHNOLOGIES
(2023)
Article
Nanoscience & Nanotechnology
Libo Yao, Claire Yin, Kevin E. Rivera-Cruz, Charles C. L. McCrory, Nirala Singh
Summary: The electrochemical CO2 reduction reaction (CO2RR) in gas-fed flow electrolyzers using gas diffusion electrodes (GDEs) has the potential for carbon recycling. Developing effective catalyst systems on GDEs is crucial for high CO2RR activity. This study bridges the knowledge gap between liquid reaction platforms and GDE architectures by demonstrating the case of a cobalt phthalocyanine (CoPc)-poly-4-vinylpyridine (P4VP) catalyst-polymer composite (CPC). The study highlights the importance of considering the hydrophobicity of CPCs in gas-fed CO2RR and incorporating an engineering perspective in CPC design and evaluation.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Computer Science, Theory & Methods
Qiangqiang Jiang, Xu Xin, Libo Yao, Bo Chen
Summary: This paper proposes a multi-objective energy-efficient task scheduling technique (METSM) for edge heterogeneous multiprocessor systems. A mathematical model is established for the task scheduling problem, and a problem-specific algorithm (IMO) is designed for optimizing task scheduling and resource allocation. Experimental results show that the proposed algorithm can achieve optimal Pareto fronts and significantly save time and power consumption.
FUTURE GENERATION COMPUTER SYSTEMS-THE INTERNATIONAL JOURNAL OF ESCIENCE
(2024)
Review
Chemistry, Physical
Libo Yao, Kevin E. Rivera-Cruz, Nirala Singh, Charles C. L. McCrory
Summary: This article discusses the application of immobilized molecular catalysts (IMCs) in flow electrolyzers and the impact of the interactions between IMCs and different microenvironments on the performance of the electrochemical CO2 reduction reaction (CO2RR). Through electrochemical and spectroelectrochemical measurements as well as post-mortem catalyst characterization, a better understanding and optimization of the CO2RR performance of IMCs can be achieved.
CURRENT OPINION IN ELECTROCHEMISTRY
(2023)
Article
Computer Science, Information Systems
Fan Zhao, Wenda Zhao, Huimin Lu, Yong Liu, Libo Yao, Yu Liu
Summary: A new depth-distilled multi-focus image fusion framework (D2MFIF) is proposed in this paper, which gradually improves the performance of multi-focus image fusion by adaptively transferring depth knowledge and integrating multi-level decision maps.
IEEE TRANSACTIONS ON MULTIMEDIA
(2023)
Article
Computer Science, Artificial Intelligence
Jiawen Zhu, Wenda Zhao, Libo Yao, You He, Maodi Hu, Xiaoxing Zhang, Shuo Wang, Tao Li, Huchuan Lu
Summary: In this paper, we propose CDENet, an end-to-end trainable network that can handle both crowd and confusion regions with similar appearance. CDENet consists of two modules for mining and erasing confusion regions. Experimental results on four crowd counting benchmarks demonstrate that CDENet achieves superior performance compared to state-of-the-art methods.
IEEE TRANSACTIONS ON NEURAL NETWORKS AND LEARNING SYSTEMS
(2023)
Article
Geochemistry & Geophysics
Gui Gao, Ping Zhou, Libo Yao, Jia Liu, Chuan Zhang, Dingfeng Duan
Summary: Fine-grained ship classification in optical remote sensing images is a challenging task in the ocean observation field due to the expensive cost of acquiring ship images, complex background interference, and the similarity and diversity among different ships. In this study, a lightweight adaptive task attention-bi-prototype-Brownian distance covariance (LATA-BP-BDC) method is proposed to address these challenges and achieve superior performance in few-shot ship classification.
IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING
(2023)
Review
Chemistry, Physical
Libo Yao, Kevin E. Rivera-Cruz, Nirala Singh, Charles C. L. Mccrory
Summary: This perspective highlights recent studies on the interactions between immobilized molecular catalysts (IMCs) and microenvironment in gas diffusion electrode (GDE) configurations for the electrochemical CO2 reduction reaction (CO2RR). The transition from batch cells to flow electrolyzers poses challenges due to the drastic differences in microenvironment and a lack of understanding of its effects on CO2RR performance. Strategies such as electrochemical measurements, in situ spectroelectrochemical measurements, and post-mortem catalyst characterization are suggested for better understanding of microenvironment effects.
CURRENT OPINION IN ELECTROCHEMISTRY
(2023)
