Article
Chemistry, Medicinal
Li-An Chen, Yueh-Hsiang Yu, Wei-Ting Tian, Wei-Chen Lin, Cedric Grauffel, Chun-Yi Wu, Chuan-Lin Chen, Carmay Lim, Hsing-Mao Chu, Tse-Wen Chang, Chi-Jiun Peng
Summary: Antibodies conjugated with diagnostic/therapeutic radionuclides, such as TE-1132, show promise for treating inoperable cancers like pancreatic cancer. TE-1132, composed of α-CA19-9 scFv-Fc conjugated to 3 DOTA chelators, demonstrated high radioactivity and selective tumor accumulation in mouse models. The administration of [Lu-177]Lu-TE-1132 effectively inhibited tumor growth and improved survival without adverse effects.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Medicine, General & Internal
Xinmao Song, Shengzi Wang, Ji Li, Li Yan, Fu Chen, Jie Wang
Summary: The study found that the combination of nimotuzumab with chemoradiotherapy is effective for the treatment of nasopharyngeal carcinoma, especially when used in combination with induction chemotherapy and concurrent chemoradiotherapy. The addition of nimotuzumab did not result in a significant increase in toxicities.
ARCHIVES OF MEDICAL SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Jing Wang, Liangang Zhuo, Peng Zhao, Wei Liao, Hongyuan Wei, Yuchuan Yang, Shuming Peng, Xia Yang
Summary: This study reveals that the Lu-177 labeled CA19-9 mAb has a therapeutic effect on CRC with limited side effects. Additionally, the Zr-89 labeled mAb can be used for the diagnosis of CRC.
CHINESE CHEMICAL LETTERS
(2022)
Article
Public, Environmental & Occupational Health
Henrry Diaz, Jorge Jimenez, Aray Hernandez, Leivis Valdes, Ariadna Martinez, Leonor Porto, Raity Hernandez, Nadina Travieso, Julio Hector Jova, Loipa Medel, Mayelin Troche, Annia Gorte, Delmis Batista, Ana Rosa Valls, Leticia Cabrera, Milagros Domeq, Leslie Perez, Patricia Lorenzo-Luaces, Lizet Sanchez, Danay Saavedra, Mayra Ramos, Tania Crombet
Summary: Nimotuzumab is a safe antibody that can reduce the mortality of severe and critical COVID-19 patients.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Immunology
Anselmo A. Abdo Cuza, Jonathan Pi Avila, Rafael Machado Martinez, Jose Jordan Gonzalez, Guillermo Perez Aspuro, Juan A. Gutierrez Martinez, Mayra Ramos Suzarte, Danay Saavedra Hernandez, Ana L. Ane-Kouri, Tania Crombet Ramos
Summary: Nimotuzumab, a safe anti-EGFR antibody, when used to treat patients with COVID-19, significantly improved clinical symptoms, reduced lung lesions, and prevented fibrosis.
Article
Oncology
Bo Qiu, DaQuan Wang, QiWen Li, YingJia Wu, SuPing Guo, XiaoBo Jiang, JianLan Fang, JinYu Guo, FangJie Liu, Chu Chu, Bin Wang, Li Chen, Jun Zhang, YiMei Liu, YongHong Hu, Hui Liu
Summary: The study evaluated the efficacy and safety of nimotuzumab combined with CCRT in patients with unresectable squamous cell lung cancer. Results showed that the NIMO-CCRT group had a lower risk of brain metastasis and similar OS and PFS compared to the CCRT group. Further investigations are needed to confirm these findings.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Immunology
Henrry Diaz Londres, Jorge Jimenez Armada, Aray Hernandez Martinez, Anselmo A. Abdo Cuza, Yamilka Hernandez Sanchez, Aylin Granado Rodriguez, Sarahy Sepulveda Figueroa, Egda M. Llanez Gregorich, Mery L. Torres Lahera, Francisco Gomez Peire, Teresita Montero Gonzalez, Yaneth Zamora Gonzalez, Ana L. Ane Kouri, Addys Gonzalez Palomo, Mayelin Troche Concepcion, Loipa Medel Perez, Patricia Lorenzo Luaces-Alvarez, Daymys Estevez Iglesias, Danay Saavedra Hernandez, Mayra Ramos Suzarte, Tania Crombet Ramos
Summary: This study evaluated the safety and efficacy of nimotuzumab in COVID-19 patients. The results showed that nimotuzumab is a safe antibody that can reduce inflammation and prevent fibrosis.
Article
Oncology
Qi Zhang, Jian Zhang, Haijun Zhong, Ying Yuan, Lei Yang, Qingyuan Zhang, Dongmei Ji, Jifang Gong, Jing Li, Zhenling Yao, Chuan Qi, Jianming Wang, Lingmin Lu, Michael Shi, Xueming Qian, Lin Shen, Jian Li, Xichun Hu
Summary: MSB2311 is a novel pH-dependent humanized anti-PD-L1 monoclonal antibody. This study aimed to determine the maximum tolerated dose and recommended phase 2 dose level of MSB2311 in patients with advanced solid tumors or lymphoma. The results showed manageable safety profile and promising antitumor activity of MSB2311.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Medicine, Research & Experimental
Jinpiao Lin, Jifeng Tang, Junyu Lin, Yujue He, Ziqing Yu, Renquan Jiang, Bin Yang, Qishui Ou
Summary: YY1 promotes the pathogenicity of Th17 cells in RA by interacting with T-bet and miR-124-3p negatively regulates YY1 expression. These findings suggest potential therapeutic targets in RA.
Article
Biology
Pan Hao, Chunli Zhang, Huan Ma, Rongfu Wang
Summary: Radioimmunotherapy (RIT) combined with gene therapy (GT) has a more effective role in inhibiting tumor development. The results of the study showed that the combination of RIT and GT significantly slowed tumor growth, while RIT or GT alone had no significant effect.
JOURNAL OF RADIATION RESEARCH
(2023)
Article
Chemistry, Analytical
Susanne Stander, Laura R. Grauslund, Maria Scarselli, Nathalie Norais, Kasper Rand
Summary: The study demonstrates the use of HDX-MS to map epitopes recognized by polyclonal antibody samples and identifies immunogenic regions on the target antigen. The results suggest that HDX-MS can provide unique insights into the binding impact of the entire set of polyclonal antibodies present in blood samples after vaccination, aiding in the design of improved vaccines against viruses or bacteria.
ANALYTICAL CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Natalia Riva, Manuel Molina, Berta L. Cornalo, Maria V. Salvador, Andrea Savransky, Silvia Tenembaum, Maria M. Katsicas, Marta Monteverde, Paulo Caceres Guido, Marcela Rousseau, Raquel Staciuk, Agustin Gonzalez Correas, Pedro Zubizarreta, Oscar Imventarza, Eduardo Lagomarsino, Eduardo Spitzer, Marcelo Tinelli, Paula Schaiquevich
Summary: Although rituximab is commonly used in pediatric patients with complex diseases, there is limited research on its safety. This study aims to provide evidence on the use of rituximab in clinical practice, document the incidence of adverse drug reactions (ADR) to rituximab biosimilar Novex(R) and innovator, and identify risk factors associated with ADR in a real-life cohort of pediatric patients.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Microbiology
Genna E. Davies, Christopher R. Thornton
Summary: A novel and non-invasive method for detecting mucormycosis caused by Rhizopus arrhizus has been developed using a rapid antibody test.
Article
Multidisciplinary Sciences
Fredrika Hellgren, Alberto Cagigi, Rodrigo Arcoverde Cerveira, Sebastian Ols, Theresa Kern, Ang Lin, Bengt Eriksson, Michael G. Dodds, Edith Jasny, Kim Schwendt, Conrad Freuling, Thomas Mueller, Martin Corcoran, Gunilla B. Karlsson Hedestam, Benjamin Petsch, Karin Lore
Summary: Using unmodified mRNA vaccine encoding the rabies virus glycoprotein can induce a stronger immune response, generate higher levels of neutralizing antibodies, and has the potential to develop a broadly protective vaccine against related lyssavirus strains.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Cormac A. A. Kelderman, Patrick R. W. J. Davey, Michelle T. Ma, Michael de Veer, Ekaterina Salimova, Paul S. Donnelly, Brett M. Paterson
Summary: The synthesis, radiolabeling, and properties of a series of alkyl and ether substituted non-oxido/non-nitrido bis(thiosemicarbazonato)technetium(v) complexes were investigated. The results showed that modification of the complexes with various lipophilic groups altered their biodistribution in mice, despite limited stability under biologically relevant conditions.
DALTON TRANSACTIONS
(2022)
Article
Oncology
Lucely Cetina, Tania Crombet, Roberto Jimenez-Lima, Sergio Zapata, Mayra Ramos, Sandra Avila, Jaime Coronel, Eduardo Charco, Rafael Bojalil, Horacio Astudillo, Blanca Bazan, Alfonso Duenas-Gonzalez
CANCER BIOLOGY & THERAPY
(2015)
Article
Pharmacology & Pharmacy
Leyanis Rodriguez-Vera, Mayra Ramos-Suzarte, Eduardo Fernandez-Sanchez, Jorge Luis Soriano, Concepcion Peraire Guitart, Gilberto Castaneda Hernandez, Carlos O. Jacobo-Cabral, Niurys de Castro Suarez, Helena Colom Codina
JOURNAL OF CLINICAL PHARMACOLOGY
(2015)
Review
Oncology
Zaima Mazorra, Lisset Chao, Anabel Lavastida, Belinda Sanchez, Mayra Ramos, Normando Iznaga, Tania Crombet
SEMINARS IN ONCOLOGY
(2018)
Article
Oncology
Mayra Ramos-Suzarte, Patricia Lorenzo-Luaces, Nery Gonzalez Lazo, Mayte Lima Perez, Jorge Luis Soriano, Carmen Elena Viada Gonzalez, Ivis Mendoza Hernadez, Yisel Avila Albuerne, Beatriz Paredes Moreno, Eduardo Santiesteban Alvarez, Idael Pineda Callejo, Jose Alert, Juan Antonio Martell, Yanela Santiesteban Gonzalez, Yulainis Santiesteban Gonzalez, Horacio Astudillo de la Vega, Erika Betzabe Ruiz-Garcia, Tania Crombet-Ramos
CANCER BIOLOGY & THERAPY
(2012)
Article
Pharmacology & Pharmacy
Niurys de Castro-Suarez, Leyanis Rodriguez-Vera, Carlos Villegas, Jose M. Davalos-Iglesias, Raymed Bacallao-Mendez, Betsy Llerena-Ferrer, Christian Leyva-de la Torre, Patricia Lorenzo-Luaces, Mayelin Troche-Concepcion, Mayra Ramos-Suzarte
JOURNAL OF CLINICAL PHARMACOLOGY
(2019)
Article
Pharmacology & Pharmacy
Niurys de Castro-Suarez, Mirjam N. Trame, Mayra Ramos-Suzarte, Jose M. Davalos, Raymed A. Bacallao-Mendez, Anaelys R. Maceo-Sinabele, Victor Mangas-Sanjuan, Gledys Reynaldo-Fernandez, Leyanis Rodriguez-Vera
Article
Immunology
Lazaro Manuel Filgueira, Julio Betancourt Cervantes, Orlando Adolfo Lovelle, Carlos Herrera, Carlos Figueredo, Jorge Alain Caballero, Naivy Sanchez, Jorge Berrio, Geidy Lorenzo, Meylan Cepeda, Mayra Ramos, Danay Saavedra, Ana Laura Ane-Kouri, Zaima Mazorra, Kalet Leon, Tania Crombet, Armando Caballero
Summary: In COVID-19 patients, inflammation is associated with disease progression. Itolizumab, a monoclonal antibody, has shown to reduce inflammation and immune system activation, with promising results in three severe COVID-19 cases. This anti-inflammatory therapy may help reduce morbidity and mortality associated with COVID-19.
Article
Immunology
Anselmo A. Abdo Cuza, Jonathan Pi Avila, Rafael Machado Martinez, Jose Jordan Gonzalez, Guillermo Perez Aspuro, Juan A. Gutierrez Martinez, Mayra Ramos Suzarte, Danay Saavedra Hernandez, Ana L. Ane-Kouri, Tania Crombet Ramos
Summary: Nimotuzumab, a safe anti-EGFR antibody, when used to treat patients with COVID-19, significantly improved clinical symptoms, reduced lung lesions, and prevented fibrosis.
Article
Public, Environmental & Occupational Health
Henrry Diaz, Jorge Jimenez, Aray Hernandez, Leivis Valdes, Ariadna Martinez, Leonor Porto, Raity Hernandez, Nadina Travieso, Julio Hector Jova, Loipa Medel, Mayelin Troche, Annia Gorte, Delmis Batista, Ana Rosa Valls, Leticia Cabrera, Milagros Domeq, Leslie Perez, Patricia Lorenzo-Luaces, Lizet Sanchez, Danay Saavedra, Mayra Ramos, Tania Crombet
Summary: Nimotuzumab is a safe antibody that can reduce the mortality of severe and critical COVID-19 patients.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Immunology
Danay Saavedra, Ana L. Ane-Kouri, Egda M. Llanez Gregorich, Jilma Mena, Patricia Lorenzo-Luaces, Henrry Diaz Londres, Aray Hernandez Martinez, Jorge Jimenez Armada, Yamilka Hernandez Sanchez, Yaneth Zamora Gonzalez, Mayelin Troche, Loipa Medel, Mayra Ramos, Tania Crombet
Summary: SARS-CoV-2 infection induces changes in the immune system, and nimotuzumab may be an effective treatment option for COVID-19.
IMMUNOLOGY LETTERS
(2022)
Article
Immunology
Armando Caballero, Lazaro M. Filgueira, Julio Betancourt, Naivy Sanchez, Carlos Hidalgo, Alberto Ramirez, Alejandro Martinez, Rolando E. Despaigne, Alberto Escalona, Henrry Diaz, Elio Merino, Lilia M. Ortega, Ulises Castillo, Mayra Ramos, Danay Saavedra, Yanelda Garcia, Geydi Lorenzo, Meylan Cepeda, Maylen Arencibia, Leticia Cabrera, Milagros Domecq, Daymys Estevez, Carmen Valenzuela, Patricia Lorenzo, Lizet Sanchez, Zaima Mazorra, Kalet Leon, Tania Crombet
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2020)
Article
Geriatrics & Gerontology
Yayquier Diaz, Mayra Ramos-Suzarte, Yordanis Martin, Nestor Antonio Calderon, William Santiago, Orlando Vinet, La O. Yulieski, Jorge Perez Augusto Oyarzabal, Yoan Perez, Geidy Lorenzo, Meylan Cepeda, Danay Saavedra, Zaima Mazorra, Daymys Estevez, Patricia Lorenzo-Luaces, Carmen Valenzuela, Armando Caballero, Kalet Leon, Tania Crombet, Carlos Jorge Hidalgo
Article
Geriatrics & Gerontology
Danay Saavedra, Ana Laura Ane-Kouri, Naivy Sanchez, Lazaro Manuel Filgueira, Julio Betancourt, Carlos Herrera, Leniel Manso, Elibet Chavez, Armando Caballero, Carlos Hidalgo, Geydi Lorenzo, Meylan Cepeda, Carmen Valenzuela, Mayra Ramos, Kalet Leon, Zaima Mazorra, Tania Crombet
Article
Microscopy
M. Cedeno-Arias, C. E. Rengifo, M. Ramos-Suzarte, R. Blanco Santana, E. Rengifo, F. F. Nogales