期刊
CANCER AND METASTASIS REVIEWS
卷 33, 期 2-3, 页码 747-756出版社
SPRINGER
DOI: 10.1007/s10555-014-9502-8
关键词
Circulating tumour cells; Disseminated tumour cells; Metastasis; Dormancy
类别
资金
- University of Western Sydney
- University of New South Wales
- Cancer Institute New South Wales for the South West Sydney Translational Cancer Research Unit
- University of New South Wales Equipment Grant
- Prostate Cancer Foundation of Australia
Circulating tumour cells (CTCs) are emerging as important prognostic markers and have potential clinical utility as tumour biomarkers for targeted cancer therapy. Although CTCs were proposed more than 100 years ago as potential precursors that may form metastatic lesions, formal evidence that CTCs are indeed capable of initiating metastases is limited. Moreover, the process of CTCs shedding into the circulation, relocating to distant organ sites and initiating metastatic foci is complex and intrinsically inefficient. To partially explain the metastatic process, the concepts of CTCs as metastatic precursors or pre-metastatic conditioners have been proposed; however, it is questionable as to whether these are both variable pathways to metastasis or just markers of metastatic burden. This review explores the evidence for CTCs in the initiation and progression of metastatic cancer and the data supporting these different concepts in an attempt to better understand the role of CTCs in metastasis. A greater understanding of the metastatic potential of CTCs will open new avenues for therapeutic interventions in the future.
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