Article
Biochemistry & Molecular Biology
Assiya Kussainova, Olga Bulgakova, Akmaral Aripova, Zumama Khalid, Rakhmetkazhi Bersimbaev, Alberto Izzotti
Summary: This review discusses the role of mitochondrial miRNAs in the pathogenesis of lung cancer, with a particular focus on their association with radon exposure.
Review
Biochemistry & Molecular Biology
Israel Martinez-Espinosa, Jose Antonio Serrato, Blanca Ortiz-Quintero
Summary: The high mortality from lung cancer is mainly due to metastasis at the time of diagnosis. Recent research suggests that tumor cell exosomes play a significant role in tumor progression and metastasis. They release biologically active components to distant organs, directing tumor metastasis.
Review
Biochemistry & Molecular Biology
Jing Li, Xianmei Zhong, Yueshui Zhao, Jing Shen, Chalermchai Pilapong, Zhangang Xiao
Summary: Lung cancer is the second leading cause of cancer-related death globally. Abnormal expression of microRNAs has been found in lung cancer and they play important roles in its initiation and progression. Polyphenols, natural bioactive chemicals synthesized by plants, have shown promising anticancer effects against lung cancer and other types of cancer. Recent studies have revealed that polyphenols exert their anticancer effects by regulating the expression levels of microRNAs in lung cancer. Therefore, targeting microRNAs using polyphenols may provide a novel strategy for the prevention and treatment of lung cancer.
Article
Chemistry, Analytical
Chaoqun Wang, Hongjie Song, Xin Zhao, Rui Liu, Yi Lv
Summary: Biomimetic DNA walking machines have shown success in exploring the microscopic world and sensitive biosensing of disease biomarkers. This study presents multiplexing three-dimensional DNA walking machines for lung cancer-associated miRNA detection based on HR-ICPMS, demonstrating satisfactory analysis capabilities for complex biological samples.
ANALYTICAL CHEMISTRY
(2022)
Article
Oncology
Jody Vykoukal, Johannes F. Fahrmann, Nikul Patel, Masayoshi Shimizu, Edwin J. Ostrin, Jennifer B. Dennison, Cristina Ivan, Gary E. Goodman, Mark D. Thornquist, Matt J. Barnett, Ziding Feng, George A. Calin, Samir M. Hanash
Summary: Blood-based cancer biomarkers, including miRNA and four protein marker panel, have shown utility in improving the assessment and early detection of lung cancer.
Review
Medical Laboratory Technology
Shen Zhong, Heiko Golpon, Patrick Zardo, Juergen Borlak
Summary: Blood-borne miR-20a, miR-10b, miR-150, and miR-223 were identified as excellent diagnostic biomarkers for non-small cell lung cancer, while miR205 showed specificity for squamous cell carcinoma. Additionally, a systematic review revealed 38 commonly regulated miRNAs in tumor tissue and circulation, enabling the prediction of histological subtypes of LC.
TRANSLATIONAL RESEARCH
(2021)
Article
Oncology
Mackenzie L. Davenport, John B. Echols, Austin D. Silva, Joshua C. Anderson, Philip Owens, Clayton Yates, Qing Wei, Shuko Harada, Douglas R. Hurst, Mick D. Edmonds
Summary: miR-31 demonstrates oncogenic properties in specific subtypes of lung cancer, highlighting its potential as a therapeutic target in these subtypes.
Article
Chemistry, Analytical
Cheng Zheng, Xuemei Hu, Shujuan Sun, Lingye Zhu, Ning Wang, Jing Zhang, Guoqiao Huang, Yuzhe Wang, Xiaoying Huang, Liangxing Wang, Zhifa Shen
Summary: In this study, a biosensor is proposed for the specific detection of lung cancer-associated biomarker miRNA-21 through stimuli-induced strand displacement amplification and cascade signal amplification. The sensing system shows good specificity to discriminate coexisting miRNAs and achieves good detection performance in complex human serum samples.
Article
Oncology
Yang Liu, Libo He, Wang Wang
Summary: The importance of physical exercise in reducing cancer risk and improving treatment efficacy in tumor patients, especially those with lung cancer, has long been known. Though several molecular mechanisms have been identified, the role of microRNAs (miRNAs) in relation to these processes is still unclear. This study aimed to identify and analyze miRNAs associated with lung cancer and exercise intervention. The results identified 42 marker miRNAs, of which three core miRNAs (has-miR-195, has-miR-26b, and has-miR-126) were found to be co-regulated by exercise and cancer, with involvement in cell cycle and immunity. This study supports the potential of exercise intervention as adjuvant therapy for lung cancer patients, with the identified core miRNAs potentially serving as non-invasive biomarkers for cancer prevention.
FRONTIERS IN ONCOLOGY
(2022)
Article
Health Care Sciences & Services
Antonia Harangus, Raduly Lajos, Livia Budisan, Oana Zanoaga, Cristina Ciocan, Cecilia Bica, Radu Pirlog, Ioan Simon, Marioara Simon, Cornelia Braicu, Ioana Berindan-Neagoe
Summary: This study evaluates miRNA expression patterns and specific mechanisms in male patients with NSCLC. The results identify several overexpressed and underexpressed miRNAs, as well as a common miRNA signature. Additionally, mRNA-miRNA regulatory networks were created to identify critical molecules and reveal NSCLC signaling pathways. These findings contribute to understanding the mechanisms involved in NSCLC development and offer opportunities for potential therapeutic targets.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Qingyu Wang, Shuaibing Yu, Lianshun Zhang, Lei Wang, Jinming Kong, Lianzhi Li, Xueji Zhang
Summary: An electrochemiluminescence approach based on surface-initiated reversible addition-fragmentation chain transfer (SI-RAFT) was developed for the detection of miRNA-21. The method utilizes SI-RAFT polymerization to generate polymer chains with functional groups that recruit luminol, resulting in strong electrochemiluminescence signal output even at low concentrations of miRNA-21, thereby greatly improving the detection sensitivity.
CHEMICAL COMMUNICATIONS
(2022)
Article
Oncology
Lin Shi, Weiliang Zhu, Yuanyuan Huang, Lin Zhuo, Siyun Wang, Shaobing Chen, Bei Zhang, Bin Ke
Summary: This study found that exosomes released by cancer-associated fibroblasts (CAFs) can promote the progression and chemoresistance of non-small-cell lung cancer (NSCLC). Mechanistically, the exosomes transmit miR-20a to tumor cells, enhancing chemoresistance and proliferation by targeting PTEN.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Yuan Gu, Gianni Pais, Vivien Becker, Christina Korbel, Emmanuel Ampofo, Elke Ebert, Johannes Hohneck, Nicole Ludwig, Eckart Meese, Rainer M. Bohle, Yingjun Zhao, Michael D. Menger, Matthias W. Laschke
Summary: The research demonstrates that miR-22 is highly expressed in ECs and significantly downregulated in NSCLC tissues. Endothelial miR-22 acts as an angiogenesis inhibitor by targeting sirtuin 1 and FGFR1 to inhibit ECs' angiogenic activities, thus suppressing NSCLC growth.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Review
Biochemistry & Molecular Biology
Esperanza Salcedo Lobera, Macarena Arroyo Varela, Rafael Larrosa Jimenez, Rocio Bautista Moreno
Summary: Lung cancer, with its late diagnosis and limited treatment, is a disease with high prevalence and mortality. Finding biomarkers that allow a faster diagnosis and improve the survival of patients is essential. miRNAs, small RNA sequences, have shown considerable advancements as diagnostic, therapeutic, and prognostic biomarkers. Obtaining miRNA biomarkers from liquid biopsies provides better accessibility, safety, and repeatability for both diagnosis and monitoring of patients.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Oncology
David E. Cohn, Mateus C. Barros-Filho, Brenda C. Minatel, Michelle E. Pewarchuk, Erin A. Marshall, Emily A. Vucic, Adam P. Sage, Nikita Telkar, Greg L. Stewart, Igor Jurisica, Patricia P. Reis, Wendy P. Robinson, Wan L. Lam
Summary: Patterns of oncofetal microRNA expression were identified in fetal lung and lung adenocarcinoma samples, but absent in adult non-malignant lung samples. These microRNAs have potential as biomarkers for cancer detection and targets for novel therapies, representing important regulators of both normal development and tumourigenesis.
Meeting Abstract
Oncology
Xiaojie Yu, Zhenze Zhao, Xiuye Ma, Liqin Du, Alexander Pertsemlidis
Meeting Abstract
Oncology
Adriana Guerrero, Jane Zhao, Xiaojie Yu, Alexander Pertsemlidis, Andreas G. Bader
Meeting Abstract
Oncology
Xiuye Ma, Xiaojie Yu, Harsh Patolia, Zhenze Zhao, Liqin Du, Alexander Pertsemlidis
Article
Oncology
Xiaojie Yu, Yiqiang Zhang, Xiuye Ma, Alexander Pertsemlidis
Article
Cell Biology
Xiaojie Yu, Yiqiang Zhang, David Cavazos, Xiuye Ma, Zhenze Zhao, Liqin Du, Alexander Pertsemlidis
CELL DEATH & DISEASE
(2018)
Article
Multidisciplinary Sciences
Jing Lin, Roza Zandi, Ruping Shao, Jian Gu, Yuanqin Ye, Jing Wang, Yang Zhao, Alexander Pertsemlidis, Ignacio I. Wistuba, Xifeng Wu, Jack A. Roth, Lin Ji
SCIENTIFIC REPORTS
(2017)
Article
Multidisciplinary Sciences
Zhenze Zhao, Veronica Partridge, Michaels Sousares, Spencer D. Shelton, Cory L. Holland, Alexander Pertsemlidis, Liqin Du
Article
Oncology
Xiaojie Yu, Yiqiang Zhang, Binggen Wu, Jonathan M. Kurie, Alexander Pertsemlidis
MOLECULAR THERAPY-ONCOLYTICS
(2019)
Article
Oncology
Adam Kosti, Liqin Du, Haridha Shivram, Mei Qiao, Suzanne Burns, Juan Gabriel Garcia, Alexander Pertsemlidis, Vishwanath R. Iyer, Erzsebet Kokovay, Luiz O. F. Penalva
MOLECULAR CANCER RESEARCH
(2020)
Article
Oncology
Adam Kosti, Rodrigo Barreiro, Gabriela D. A. Guardia, Shiva Ostadrahimi, Erzsebet Kokovay, Alexander Pertsemlidis, Pedro A. F. Galante, Luiz O. F. Penalva
Summary: miRNAs act as key regulators of gene expression, contributing to cancer phenotypes as oncogenes or tumor suppressors. Cooperative action of miRNAs regulates biological processes and pathways, suggesting that miRNA combinations could be more effective in targeting cancer stem cells. Using combinations of tumor suppressor miRNAs may offer new routes to disrupt cancer phenotypes and growth of cancer-initiating cell populations.
Article
Multidisciplinary Sciences
Justin B. Moroney, Anusha Vasudev, Alexander Pertsemlidis, Hong Zan, Paolo Casali
NATURE COMMUNICATIONS
(2020)
Article
Genetics & Heredity
Yi Li, Chance M. Nowak, Daniel Withers, Alexander Pertsemlidis, Leonidas Bleris
Meeting Abstract
Cell Biology
X. Yu, Y. Zhang, L. Du, X. Ma, A. Pertsemlidis
MOLECULAR BIOLOGY OF THE CELL
(2017)
Meeting Abstract
Oncology
Yiqiang Zhang, Xiuye Ma, Xiaojie Yu, Harsh Patolia, Zhenze Zhao, Liqin Du, Alexander Pertsemlidis
Meeting Abstract
Oncology
Xiaojie Yu, Xiuye Ma, Yiqiang Zhang, Zhenze Zhao, Liqin Du, Alexander Pertsemlidis
