Article
Oncology
Kyungseek Chang, Boram Song, In-Gu DO, Dong-Hoe Koo, Hyoun Wook Lee, Byung Ho Son, Chang Hak Yoo, Kyungeun Kim
Summary: The study showed that venous and perineural invasion are significant prognostic factors in relapse-free survival of N0 gastric cancer patients, while lymphatic invasion is not as important. Additionally, the number of invasive features plays a crucial role in predicting poor patient survival.
ANTICANCER RESEARCH
(2021)
Article
Oncology
Junhao Tu, Zongxi Yao, Wenqing Wu, Jianxiang Ju, Yinkai Xu, Yulin Liu
Summary: The study showed poor prognosis of PNI (+) in stage I and II colon cancer, but PNI was not a predictive factor for response to adjuvant chemotherapy in node-negative colon cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Surgery
Tao Wei, Xu-Feng Zhang, Jin He, Irinel Popescu, Hugo P. Marques, Luca Aldrighetti, Shishir K. Maithel, Carlo Pulitano, Todd W. Bauer, Feng Shen, George A. Poultsides, Oliver Soubrane, Guillaume Martel, Bas Groot Koerkamp, Endo Itaru, Yi Lv, Timothy M. Pawlik
Summary: This study investigated the impact of perineural invasion (PNI) on tumor recurrence and survival in patients with resected intrahepatic cholangiocarcinoma (ICC). The results showed that PNI was a strong independent predictor of tumor recurrence and long-term survival, even among patients with early-stage disease.
BRITISH JOURNAL OF SURGERY
(2022)
Article
Medicine, General & Internal
Hyun-Il Shin, Joo-In Bang, Geun-Jeon Kim, Dong-Il Sun, Sang-Yeon Kim
Summary: This retrospective study aimed to investigate the effect of perineural invasion (PNI) on the prognosis of laryngeal cancer. The results showed that PNI is an independent predictor for poor survival and local recurrence in patients with fresh or salvaged larynges.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Oncology
Yuequn Niu, Sarah Foerster, Michael Muders
Summary: Perineural invasion (PNI) is a common indicator of tumor metastasis in various malignancies, including prostate cancer. PNI involves the interaction between tumor cells and nerve components in the tumor microenvironment, creating a perineural niche that supports tumor cell survival and invasion, benefiting nerve cells. The molecular mechanisms of PNI are still limitedly understood. Clinically, PNI is associated with adverse clinicopathological parameters and poor outcomes for prostate cancer patients. However, there is controversy over whether PNI can act as an independent prognostic predictor due to inconsistent research aims, sample types, statistical methods, and the definition and inclusion criteria. This review summarizes and compares the prognostic significance of PNI in prostate cancer based on existing literature and suggests that a more standardized description of PNI would enhance the understanding of its clinical relevance.
Article
Oncology
Yu Ma, Jie Chen, Xi Yao, Zhenzhen Li, Wensheng Li, Hongtao Wang, Jianfei Zhu
Summary: This study found that perineural invasion is prevalent and highly heterogeneous in squamous cell carcinoma, and it is associated with tumor depth and lymph node status. Perineural invasion is an independent factor affecting disease-free survival and overall survival in ESCC.
Article
Health Care Sciences & Services
Yi-Fu Chen, Shan-Yu Wang, Puo-Hsien Le, Tsung-Hsing Chen, Chia-Jung Kuo, Chun-Jung Lin, Wen-Chi Chou, Ta-Sen Yeh, Jun-Te Hsu
Summary: The prognostic significance of perineural invasion in patients with stage II/III gastric cancer undergoing radical surgery is still under debate. This study aimed to determine the prognostic value of perineural invasion in these patients and found that perineural invasion is independently associated with aggressive tumor behaviors and higher recurrence rates, making it an unfavorable prognostic factor.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Sang Sik Cho, Ji Won Park, Gyeong Hoon Kang, Jung Ho Kim, Jeong Mo Bae, Sae-Won Han, Tae-You Kim, Min Jung Kim, Seung-Bum Ryoo, Seung-Yong Jeong, Kyu Joo Park
Summary: This study aimed to determine whether the location of lymphatic invasion, vascular invasion, and perineural invasion could affect the survival of patients with stage II colon cancer. The results showed that extramural invasion was associated with a worse prognosis, while intramural invasion was not. Therefore, pathologic reports about the location of invasion may be helpful for predicting prognosis and determining the need for adjuvant chemotherapy in stage II colon cancers.
DISEASES OF THE COLON & RECTUM
(2023)
Article
Oncology
Bin Zhang, Yanyun Lin, Chao Wang, Zexian Chen, Tianze Huang, Hao Chen, Guannan Wang, Ping Lan, Xiaowen He, Xiaosheng He
Summary: This study found that perineural invasion has significant prognostic value in colorectal cancer, not limited to stage II. Patients with stage II combined with perineural invasion have similar survival rates to those with stage III. Therefore, perineural invasion is an important prognostic factor in colorectal cancer.
Review
Oncology
Zirong Chen, Yan Fang, Weihong Jiang
Summary: Perineural invasion (PNI) is the fourth way for solid tumor metastasis and invasion, and it involves axon growth and possible nerve invasion to tumors. This article aims to summarize current theories on the molecular mediators and pathogenesis of PNI, provide updates on scientific research, and explore the use of single-cell spatial transcriptomics in understanding PNI.
Article
Oncology
Soo-Yoon Sung, Sung Hwan Kim, Hong Seok Jang, Jin Ho Song, Songmi Jeong, Ji-Han Jung, Jong Hoon Lee
Summary: This study evaluated the role of adjuvant chemotherapy in rectal cancer patients who received neoadjuvant chemoradiotherapy and surgery. It found that adjuvant chemotherapy significantly reduced the recurrence risk in patients with positive surgical margin or perineural invasion. The role of adjuvant chemotherapy may be limited in patients without positive margin and perineural invasion.
Article
Oncology
Christian D. Fankhauser, Hielke M. de Vries, Eduard Roussel, Jakob Kristian Jakobsen, Allaudin Issa, Esther W. C. Lee, Nicolo Schifano, Hussain Alnajjar, Fabio Castiglione, Luca Antonelli, Pedro Oliveira, Maurice Lau, Arie Parnham, Maarten Albersen, Nicholas A. Watkin, Asif Muneer, Ben E. Ayres, Oscar R. Brouwer, Vijay Sangar
Summary: The purpose of this study was to analyze the risk of inguinal lymph node (ILN) metastases in T1G2 penile cancer, stratified by lymphovascular invasion (LVI), perineural invasion (PNI), and tumor size. The results showed that despite being clinically node negative, approximately one out of ten men with T1G2 overall and one out of four men with either LVI + or PNI + still had ILN metastases. Therefore, invasive ILN staging should be strongly recommended in T1G2 patients with LVI + or PNI +, but must be discussed in patients with T1G2 with LVI- or PNI-.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Medicine, General & Internal
Steffen Spoerl, Silvia Spoerl, Stephanie Reil, Michael Gerken, Nils Ludwig, Juergen Taxis, Rene Fischer, Tobias Ettl, Torsten E. Reichert, Gerrit Spanier
Summary: This study analyzed the prognostic value of perineural invasion (PNI) on survival and recurrence in oral squamous cell carcinoma (OSCC) patients and found that PNI has an adverse impact on patient survival and recurrence.
Article
Medicine, Research & Experimental
Bianca Maria Festa, Andrea Costantino, Gian Marco Pace, Gerardo Petruzzi, Flaminia Campo, Raul Pellini, Giuseppe Spriano, Armando De Virgilio
Summary: The benefit of postoperative radiotherapy in oral squamous cell carcinoma patients with perineural invasion is still unclear, although it may have a positive impact on disease-free survival. Clinicians should consider individual patient's characteristics, tumor factors, and treatment goals when deciding whether to recommend postoperative radiotherapy. Further studies are needed to clarify which entity of perineural invasion really benefits from postoperative radiotherapy.
Review
Oncology
Angela Santoro, Giuseppe Angelico, Antonio Travaglino, Frediano Inzani, Damiano Arciuolo, Michele Valente, Nicoletta D'Alessandris, Giulia Scaglione, Alessia Piermattei, Federica Cianfrini, Patrizia Straccia, Roberta Benvenuto, Antonio Raffone, Giorgia Garganese, Valerio Gallotta, Gian Franco Zannoni
Summary: This study conducted a systematic review and metanalysis to determine the prognostic role of perineural invasion (PNI) in vulvar squamous cell carcinoma (VSCC). The results showed that PNI is associated with unfavorable prognosis in VSCC patients. PNI should be included in the pathological report and considered in prognostic assessment and adjuvant treatment planning.
Article
Oncology
David Boyce-Fappiano, B. Ashleigh Guadagnolo, Ravin Ratan, Wei-Lien Wang, Michael J. Wagner, Shreyaskumar Patel, John A. Livingston, Patrick P. Lin, Kevin Diao, Devarati Mitra, Ahsan Farooqi, Alexander J. Lazar, Christina L. Roland, Andrew J. Bishop
Summary: This study reviewed the treatment experience of 60 patients with localized extraskeletal Ewing sarcoma and found that combined-modality local therapy did not provide a local control advantage compared to single-modality local therapy. Single-modality local therapy may be sufficient for local control in select patients with favorable disease features.
Article
Oncology
Stephen Grant, Kaiping Liao, Christopher Miller, Susan Peterson, Linda Elting, B. Ashleigh Guadagnolo
Summary: The study found higher levels of medical mistrust among white, younger, more-educated individuals with cancer or those with poorer health in a large cohort of cancer patients in Texas. This suggests recent societal trends toward mistrust in science may have implications for cancer care.
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
(2021)
Article
Health Care Sciences & Services
David Boyce-Fappiano, Kaiping Liao, Christopher Miller, Susan K. Peterson, Linda Elting, B. Ashleigh Guadagnolo
Summary: The study found that Black and Hispanic cancer patients are more likely to prefer more aggressive end-of-life pharmacologic care, while opposing potentially life-shortening palliative drugs. These preferences are influenced by factors such as age, living area, health literacy, and trust in the medical profession.
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2021)
Article
Oncology
Devarati Mitra, Gabriel Ologun, Emily Z. Keung, Ryan P. Goepfert, Rodabe N. Amaria, Merrick I. Ross, Jeffrey E. Gershenwald, Anthony Lucci, Sarah B. Fisher, Michael A. Davies, Jeffrey E. Lee, Andrew J. Bishop, Ahsan S. Farooqi, Jennifer Wargo, B. Ashleigh Guadagnolo
Summary: This study found that nodal recurrence is the primary driver of early disease relapse for patients with SLN-positive melanoma who do not undergo CLND. Patients with LVI, two or more involved nodes, or > 1 mm nodal disease are at particularly high risk of nodal relapse.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
David Boyce-Fappiano, Kaiping Liao, Christopher Miller, Susan K. Peterson, Linda S. Elting, B. Ashleigh Guadagnolo
Summary: Non-white cancer patients are more likely to prefer aggressive end-of-life care, such as dying at the hospital and using mechanical ventilation. These preferences remain consistent across different sociodemographic characteristics.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Medicine, General & Internal
Jace P. Landry, Kelsey L. Schertz, Yi-Ju Chiang, Angela D. Bhalla, Min Yi, Emily Z. Keung, Christopher P. Scally, Barry W. Feig, Kelly K. Hunt, Christina L. Roland, Ashleigh Guadagnolo, Andrew J. Bishop, Alexander J. Lazar, John M. Slopis, Ian E. McCutcheon, Keila E. Torres
Summary: This study investigated the prevalence of neoplasms and outcomes among patients with NF1, finding that these patients develop various tumors at a younger age and more frequently than the general population. Patients with certain neoplasms like undifferentiated pleomorphic sarcoma, high-grade glioma, and malignant peripheral nerve sheath tumor had significantly lower disease-specific survival rates.
Article
Oncology
Kilian E. Salerno, Kaled M. Alektiar, Elizabeth H. Baldini, Manpreet Bedi, Andrew J. Bishop, Lisa Bradfield, Peter Chung, Thomas F. DeLaney, Andrew Folpe, John M. Kane, X. Allen Li, Ivy Petersen, John Powell, Michael Stolten, Steven Thorpe, Jonathan C. Trent, Maria Voermans, B. Ashleigh Guadagnolo
Summary: This guideline provides evidence-based recommendations for the use of radiation therapy in primary, operable, localized soft tissue sarcoma in adults. Recommendations include the use of radiation therapy in cases of increased risk of local recurrence, with a preference for preoperative over postoperative radiation in most cases. The routine use of radiation therapy in addition to oncologic resection for retroperitoneal sarcoma is conditionally not recommended.
PRACTICAL RADIATION ONCOLOGY
(2021)
Article
Oncology
Elise F. Nassif, Brandon Cope, Raymond Traweek, Russell G. Witt, Derek J. Erstad, Christopher P. Scally, Prapassorn Thirasastr, Maria Alejandra Zarzour, Joseph Ludwig, Robert Benjamin, Andrew J. Bishop, B. Ashleigh Guadagnolo, Davis Ingram, Khalida Wani, Wei-Lien Wang, Alexander J. Lazar, Keila E. Torres, Kelly K. Hunt, Barry W. Feig, Christina L. Roland, Neeta Somaiah, Emily Z. Keung
Summary: This study reports on the real-world use and surgical outcomes associated with palbociclib treatment for patients with retroperitoneal WDLPS or DDLPS. The findings indicate that palbociclib monotherapy for advanced WDLPS and DDLPS is disappointing in terms of efficacy.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Oncology
Roshal R. Patel, Rose Parisi, Vivek Verma, Ramez Kouzy, Joseph Abi Jaoude, Timothy A. Lin, Clifton David Fuller, Noam A. VanderWalde, Reshma Jagsi, Benjamin D. Smith, Beverly Ashleigh Guadagnolo, Charles R. Thomas Jr, Ethan B. Ludmir
Summary: Recent studies have found an increasing incidence of age disparities in cancer clinical trials. One eligibility criterion that may inadvertently exclude the elderly is the exclusion of patients with prior malignancies. While strict enrollment criteria may improve internal validity, they can negatively impact generalizability. This study aimed to characterize the incidence of prior malignancy exclusion criteria in phase III trials and assess their association with age disparities. The findings suggest that these exclusion criteria contribute to age disparities and updating the criteria may help reduce such disparities in clinical trial enrollment.
Article
Oncology
David Boyce-Fappiano, Ethan P. Damron, Ahsan Farooqi, Devarati Mitra, Anthony P. Conley, Neeta Somaiah, Dejka M. Araujo, J. Andrew Livingston, Ravin Ratan, Emily Z. Keung, Christina L. Roland, B. Ashleigh Guadagnolo, Andrew J. Bishop
Summary: Hypofractionated radiotherapy (HFRT) is an effective treatment strategy for patients with unresectable or metastatic sarcoma, providing durable local disease control, symptom relief, and systemic therapy breaks with limited toxic effects.
ADVANCES IN RADIATION ONCOLOGY
(2022)
Article
Oncology
Andrew J. Bishop, Jing Zheng, Aparna Subramaniam, Amol J. Ghia, Chenyang Wang, Susan L. McGovern, Shreyaskumar Patel, B. Ashleigh Guadagnolo, Devarati Mitra, Ahsan Farooqi, Michael J. Reardon, Betty Kim, Nandita Guha-Thakurta, Jing Li, Vinod Ravi
Summary: This study evaluated patients with cardiac angiosarcomas and brain metastases, finding a high risk of intracranial hemorrhage that led to an alarming rate of terminal hemorrhage despite normal platelet counts. Early diagnosis and intervention, regular brain imaging, and prompt local therapy for brain metastases are recommended to mitigate the risk of terminal hemorrhage.
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
(2022)
Letter
Oncology
B. Ashleigh Guadagnolo
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Oncology
Sean Maroongroge, David G. Wallington, Paige A. Taylor, Diana Zhu, B. Ashleigh Guadagnolo, Benjamin D. Smith, James B. Yu, Leslie K. Ballas
Summary: The number of radiation therapy facilities in the United States has increased by 16.4% over the past 15 years, with 77.9% of the U.S. population living within 12.5 miles of an RT facility. Increased distance from RT is associated with nonmetro status, less insurance, older median age, and less populated regions.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Oncology
Devarati Mitra, Pallavi Krishna Rao, Priyadharsini Nagarajan, Andrew J. Bishop, Ahsan S. Farooqi, Jeffrey E. Gershenwald, Jennifer Wargo, Emily Z. Keung, Sarah B. Fisher, Rodabe N. Amaria, Michael A. Davies, Merrick I. Ross, B. Ashleigh Guadagnolo
Summary: This retrospective cohort study examined the treatment paradigm and outcomes of patients with anorectal melanoma undergoing sphincter-sparing excision and adjuvant radiation therapy. The results showed that this treatment approach resulted in excellent local control and ostomy-free survival, but overall oncologic outcomes remained poor. The study also revealed changes in treatment patterns over time, but their impact on prognosis was not significant.
PRACTICAL RADIATION ONCOLOGY
(2022)
Article
Oncology
Alexander D. Sherry, Tharakeswara K. Bathala, Suyu Liu, Bryan M. Fellman, Stephen G. Chun, Nikesh Jasani, B. Ashleigh Guadagnolo, Anuja Jhingran, Jay P. Reddy, Paul G. Corn, Amishi Y. Shah, Kelsey W. Kaiser, Amol J. Ghia, Daniel R. Gomez, Chad Tang
Summary: This study prospectively evaluated the effectiveness of local consolidative therapy (LCT) for oligometastatic solid tumors and found that it is a feasible and potentially beneficial treatment option. The results showed encouraging progression-free survival and low rates of severe toxic effects at mature follow-up.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)