Article
Medicine, General & Internal
Maria Sztachelska, Donata Ponikwicka-Tyszko, Lydia Martinez-Rodrigo, Piotr Bernaczyk, Ewelina Palak, Weronika Polchlopek, Tomasz Bielawski, Slawomir Wolczynski
Summary: This study characterized the expression of nuclear and membrane estrogen and progesterone receptors in adenomyosis and investigated their functional effects. The results showed upregulation of membrane progesterone receptors and estrogen receptor beta in adenomyosis compared to normal tissue. Estradiol promoted cell proliferation in adenomyosis, while progesterone and cAMP stimulated prolactin secretion in a similar pattern as in normal tissue. These findings provide new insights into the role of sex steroid receptors in adenomyosis pathophysiology.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Food Science & Technology
Tingting Song, Xuemei Zhou, Xiangming Ma, Yanping Jiang, Weiren Yang, Faxiao Liu, Mei Liu, Libo Huang, Shuzhen Jiang
Summary: The study found that ZEA can linearly increase nutrient digestibility and availability, promote the expression of estrogen/progesterone receptors in the uterus and endometrial cells.
Article
Neurosciences
Alev Selek, Zehra Seda Unal Halbutogullari, Cigdem Inci Aydemir, Berrin Cetinarslan, Zeynep Canturk, Ilhan Tarkun, Gulay Erman, Cansu Subasi, Karaoz Erdal
Summary: This study investigates the potential of using an aromatase inhibitor as a substitute for testosterone in treating prolactinomas. The findings reveal that the aromatase inhibitor can inhibit cell proliferation and induce apoptosis in prolactinoma cells, as well as reduce prolactin and estrogen levels.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sylvia C. Hewitt, Artiom Gruzdev, Cynthia J. Willson, San-Pin Wu, John P. Lydon, Niels Galjart, Francesco J. DeMayo
Summary: Receptors for estrogen and progesterone interact through Cohesin/CTCF loop extrusion at enhancers distal from regulated genes. Loss-of-function CTCF mutation in endometrial tumors indicates its importance in uterine homeostasis. Our study reveals that uterine Ctcf plays a key role in progesterone-dependent expression of uterine genes underlying optimal post-pubertal uterine development.
Article
Biochemistry & Molecular Biology
Sylvia C. Hewitt, Artiom Gruzdev, Cynthia J. Willson, San-Pin Wu, John P. Lydon, Niels Galjart, Francesco J. DeMayo
Summary: Receptors for estrogen and progesterone interact via Cohesin/CTCF loop extrusion at enhancers distal from regulated genes. Loss-of- function CTCF mutation indicates its importance in uterine homeostasis. Deleting Ctcf gene in female reproductive tissues of mice resulted in reduced uterine glands and hypoplastic uteri with decreased endometrial stroma. Ctcf deletion also altered the expression of progesterone-responsive genes, including Ihh, Fst, and Errfi1. Our findings highlight the key role of uterine Ctcf in progesterone-dependent expression and optimal post-pubertal uterine development.
Article
Medicine, General & Internal
Li-Min Sun, Mei-Chun Chou, Cheng-Li Lin, Chia-Hung Kao
Summary: The study suggests that women with uterine myoma have a significantly higher risk of developing lung cancer, especially in younger age groups, those with medium income, higher urbanization level, office workers, and with longer follow-up periods for uterine myoma. Myomectomy does not seem to affect the risk pattern of lung cancer. Further comprehensive studies are needed to verify these findings and determine the underlying mechanisms.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Article
Obstetrics & Gynecology
Nathalie Soderhamn Bulow, Sven Olaf Skouby, Agnieszka Katarzyna Warzecha, Hanne Udengaard, Claus Yding Andersen, Marianne Dreyer Holt, Marie Louise Grondahl, Anders Nyboe Andersen, Negjyp Sopa, Anne Lis Englund Mikkelsen, Anja Pinborg, Nicholas Stephen Macklon
Summary: The use of letrozole during ovarian stimulation for IVF did not significantly decrease the proportion of women with premature progesterone levels above 1.5 ng/ml at the time of triggering final oocyte maturation. However, letrozole did significantly increase the proportion of women with mid-luteal progesterone levels above 30 ng/ml.
HUMAN REPRODUCTION
(2022)
Article
Obstetrics & Gynecology
Saswati Banerjee, Wei Xu, Indrajit Chowdhury, Adel Driss, Mohamed Ali, Qiwei Yang, Ayman Al-Hendy, Winston E. Thompson
Summary: Researchers have established an organoid model using both normal and patient myometrial stem cells, which can recapitulate the tissue characteristics of uterine fibroids and respond to reproductive hormones. This model provides a new approach for understanding the pathogenesis of uterine fibroids and developing novel therapies.
REPRODUCTIVE SCIENCES
(2022)
Article
Oncology
R. J. Edmondson, R. L. O'Connell, S. Banerjee, L. Mileshkin, P. Sykes, P. Beale, A. Fisher, A. Bonaventura, D. Millan, S. Nottley, C. Benson, A. Hamilton, K. Sjoquist, L. Alexander, C. Kelly, K. Carty, L. Divers, N. Bradshaw, M. Friedlander
Summary: Anastrozole shows clinical benefit in treating patients with uterine leiomyosarcomas and carcinosarcomas, especially in a subset of patients with good tolerance. However, the objective response rates are relatively low.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Endocrinology & Metabolism
C. Allison Stewart, M. David Stewart, Ying Wang, Rachel D. Mullen, Bonnie K. Kircher, Rui Liang, Yu Liu, Richard R. Behringer
Summary: Female mice with an engineered Gnrhr E90K mutation have infertility due to disrupted gonadotropin-releasing hormone signaling. These mice have impaired uterine gland development during adolescence and show pathology in their uterine glands in adulthood. This study suggests that chronically elevated levels of estradiol and low progesterone disrupt postpubertal uterine gland development and homeostasis.
Review
Oncology
Giuseppe Carruba
Summary: This review explores the role of estrogen in the human liver and investigates the mechanisms behind its transition from protective to harmful. Estrogens play key roles in liver development, homeostasis, and function, but excess estrogen may lead to chronic diseases, and even cancer. Multiple pieces of experimental evidence suggest that estrogen is involved in the development and progression of hepatocellular carcinoma.
Article
Cell Biology
Koushik Bhattacharya, Pallav Sengupta, Sulagna Dutta, Alak Kumar Syamal
Summary: This study aims to determine the minimum dose of estradiol required to induce uterine receptivity for successful implantation in mice. The results showed that a single dose of 50.0 ng of estradiol can effectively induce uterine receptivity for implantation.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Medicine, Research & Experimental
N. K. Yarygina, A. V. Asaturova, K. N. Yarygin
Summary: The study found that remnants of uterine tissues exhibit signs of disorganized histogenesis but maintain activity, containing cells expressing estrogen and progesterone receptors and VEGF, as well as poorly differentiated precursor cells or stem cells. These findings contribute to further research on the mechanisms of uterine rudiment formation and the development of correction methods.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2021)
Article
Endocrinology & Metabolism
Wisanee Wisanwattana, Kanjana Wongkrajang, Dong-yi Cao, Xiao-ke Shi, Zhong-hui Zhang, Zong-yuan Zhou, Fu Li, Qing-gang Mei, Chun Wang, Apichart Suksamrarn, Guo-lin Zhang, Fei Wang
Summary: The study showed that compounds synthesized using icariin analogs can promote estrogen biosynthesis in osteoblastic cells, enhancing bone growth and remodeling. Compound 14 activates PKG to stimulate SHP2, Src, and ERK signaling pathways, leading to increased estrogen biosynthesis, suggesting its potential for treating osteoporosis.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Oncology
Emanuele Perrone, Riccardo Tudisco, Pia Clara Pafundi, Davide Guido, Alessandra Ciucci, Enrica Martinelli, Gian Franco Zannoni, Alessia Piermattei, Saveria Spadola, Giulia Ferrante, Claudia Marchetti, Giovanni Scambia, Anna Fagotti, Daniela Gallo
Summary: This study explored the relationship between hormone receptor status and BRCA1/2 mutation in high-grade serous ovarian carcinoma (HGSOC) patients. The results showed interesting differences in receptor expression patterns and their association with outcomes between BRCA-mutated and BRCA wild-type women. The findings suggest a potential role of estrogen-mediated pathways in BRCA1/2-associated HGSOC tumorigenesis, revealing a possible therapeutic potential for targeting this interaction.
