Article
Health Care Sciences & Services
Ming-Feng Li, Huei-Lung Liang, Chia-Ling Chiang, Wei-Lun Tsai, Wen-Chi Chen, Cheng-Chung Tsai, I-Shu Chen
Summary: The new HAIC regimen is effective in treating Vp4 HCC patients, but additional sorafenib use does not provide any survival benefit.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Chemistry, Multidisciplinary
Takahiro Yamasaki, Issei Saeki, Yurika Kotoh-Yamauchi, Ryo Sasaki, Norikazu Tanabe, Takashi Oono, Takashi Matsuda, Takuro Hisanaga, Toshihiko Matsumoto, Isao Hidaka, Tsuyoshi Ishikawa, Taro Takami, Yutaka Suehiro, Isao Sakaida
Summary: The study discussed the clinical benefits of hepatic arterial infusion chemotherapy (HAIC) compared to sorafenib in treating patients with hepatocellular carcinoma (HCC), including the ability to treat a wider range of patients, minimal impact on Child-Pugh scores, and higher efficacy in patients with vascular invasion.
APPLIED SCIENCES-BASEL
(2021)
Article
Oncology
Takashi Niizeki, Hideki Iwamoto, Tomotake Shirono, Shigeo Shimose, Masahito Nakano, Shusuke Okamura, Yu Noda, Naoki Kamachi, Suzuki Hiroyuki, Miwa Sakai, Ryoko Kuromatsu, Hironori Koga, Takuji Torimura
Summary: Macrovascular invasion (MVI) is a poor prognostic factor in hepatocellular carcinoma (HCC). Hepatic arterial infusion chemotherapy (HAIC) is a promising treatment for MVI-HCC. New FP, a regimen involving fine-powder cisplatin and 5-fluorouracil suspended with lipiodol, showed superior therapeutic outcomes compared to low-dose cisplatin plus 5-fluorouracil (LFP) in treating MVI-HCC with preserved liver function. New FP is recommended as a preferred HAIC regimen for this patient population.
Article
Surgery
Ahmed Shehta, Ahmed Farouk, Ahmed Nabieh Elghawalby, Mohamed Elshobary, Ahmed Aboelenin, Amgad Fouad, Mahmoud Abdelwahab Ali
Summary: The study evaluated the experience of liver resection for hepatocellular carcinoma patients with macroscopic portal vein invasion and found that patients with macroscopic PVI had lower overall survival rates and higher incidence of post-operative morbidities. However, there were no significant differences in terms of recurrence rate and disease-free survival rates between the two groups.
JOURNAL OF SURGICAL RESEARCH
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kanglian Zheng, Xu Zhu, Shijie Fu, Guang Cao, Wen-Qing Li, Liang Xu, Hui Chen, Di Wu, Renjie Yang, Kun Wang, Wei Liu, Hongwei Wang, Quan Bao, Ming Liu, Chunyi Hao, Lin Shen, Baocai Xing, Xiaodong Wang
Summary: This study compared the efficacy and safety of sorafenib plus 3cir-OFF hepatic arterial infusion chemotherapy (HAIC) with sorafenib alone for advanced hepatocellular carcinoma (HCC) with major portal vein tumor thrombosis (PVTT). The results showed that sorafenib plus HAIC achieved better overall survival (OS) and longer progression-free survival (PFS) compared to sorafenib alone, but also had more adverse events.
Article
Pharmacology & Pharmacy
Zili Hu, Zhenyun Yang, Jiongliang Wang, Yizhen Fu, Zhiwen Hu, Zhongguo Zhou, Minshan Chen, Yaojun Zhang
Summary: This study suggests that neoadjuvant hepatic arterial infusion chemotherapy followed by hepatectomy is associated with longer survival outcome compared to hepatectomy alone for hepatocellular carcinoma patients with portal vein tumor thrombus. The survival benefit is limited to patients who respond to neoadjuvant FOLFOX-HAIC.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Oncology
Yu-Jie Xu, Zhi-Cheng Lai, Min-Ke He, Xiao-Yun Bu, Huan-Wei Chen, Yuan-Min Zhou, Li Xu, Wei Wei, Yao-Jun Zhang, Min-Shan Chen, Rong-Ping Guo, Ming Shi, Qi-Jiong Li
Summary: The study compared the efficacy and safety of toripalimab plus hepatic arterial infusion chemotherapy (HAIC) and lenvatinib in advanced HCC patients. Results showed that the TorHAIC group had better outcomes in terms of PFS, OS, disease control rate, and ORR compared to the lenvatinib group, with acceptable safety profiles for both treatments. Propensity score-matched analysis also supported the superiority of the TorHAIC group.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2021)
Article
Nutrition & Dietetics
Shengbo Sun, Xiangyun Zheng, Huanhu Zhang, Chuanji Han, Guowei Zhao
Summary: Hepatic portal venous gas (HPVG) is a rare and severe manifestation that may require emergency surgery. This case report describes a rare case of HPVG associated with the drip rate of postoperative enteral nutrition. Early detection and timely intervention led to a complete cure, avoiding unnecessary surgery.
Article
Oncology
Meiyue Li, Shen Lin, Leslie Wilson, Pinfang Huang, Hang Wang, Shubin Lai, Liangliang Dong, Xiongwei Xu, Xiuhua Weng
Summary: The study evaluated the cost-effectiveness of HAIC plus sorafenib (SoraHAIC) versus standard care for HCC patients from the Chinese health system perspective. The results indicated that SoraHAIC was not cost-effective in medium- and low-income regions of China, but there was a 38.8% probability that it would be cost-effective in developed areas (such as Beijing).
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Yangxun Pan, Jie Mei, Jinbin Chen, Deyao Zhang, Juncheng Wang, Xiaohui Wang, Minjiang Yi, Zhongguo Zhou, Yaojun Zhang, Minshan Chen, Rongping Guo, Li Xu
Summary: This study aimed to investigate the survival associations of adjuvant portal vein perfusion chemotherapy (PVC) and neoadjuvant hepatic arterial infusion chemotherapy (HAIC) in patients with resectable BCLC stage B/C HCC. The results showed that compared with adjuvant PVC, patients treated with neoadjuvant HAIC had better survival outcomes and lower recurrence rates.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Health Care Sciences & Services
Yang Cheng, Lihong Gu, Xiaochun Yin, Xixuan Wang, Jiangqiang Xiao, Yi Wang, Wei Zhang, Lei Wang, Xiaoping Zou, Ming Zhang, Yuzheng Zhuge, Feng Zhang
Summary: The accuracy of wedge hepatic vein pressure (WHVP) in estimating portal pressure (PP) in patients with hepatic sinusoidal obstruction syndrome (HSOS) was not as good as in patients with virus- or alcohol-related cirrhosis. This was mainly due to an overestimation of PP.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Shiguang Chen, Wenchang Yu, Kongzhi Zhang, Weifu Liu, Xiaolong Wang, Chuanben Chen
Summary: This study compared tumor responses and survival benefits between patients with unresectable HCC with or without PVTT who underwent hepatic arterial infusion of oxaliplatin plus raltitrexed. The results showed that patients without PVTT had significantly longer median overall survival compared to those with PVTT.
GASTROENTEROLOGY REPORT
(2022)
Review
Oncology
Wei Zhang, Deliang Ouyang, Zhangkan Huang, Xu Che
Summary: This study compared the efficacy of hepatic artery infusion chemotherapy (HAIC) versus sorafenib in patients with hepatocellular carcinoma (HCC) accompanied by portal vein tumor thrombus (PVTT). The results showed that HAIC group had significantly higher rates of complete response, partial response, objective response rate, and disease control rate compared to the sorafenib group. Moreover, the overall survival and progression-free survival rates were significantly higher in the HAIC group.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Xiaolei Liu, Ruiquan Zhou, Shuang Si, Liguo Liu, Shiwei Yang, Dongdong Han, Haidong Tan
Summary: Hepatic epithelioid hemangioendothelioma (HEH) is a rare tumor with no standard treatment options. This study reports a case of a patient with a giant intrahepatic tumor who achieved partial response after combined therapy with sirolimus and IFN-a 2b, with no severe adverse events.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Dong-Dong Jia, Yanling Niu, Honglin Zhu, Sizhen Wang, Tonghui Ma, Tao Li
Summary: This study investigated the impact of prior IFN-alpha therapy on subsequent PD-1 blockade in melanoma patients. The findings showed that prior PEG-IFN-alpha therapy enhanced the efficacy of adjuvant pembrolizumab, reducing recurrence rates and prolonging recurrence-free survival. These results suggest that prior PEG-IFN-alpha treatment could be beneficial in designing combination or sequential immunotherapy for melanoma patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Keisuke Kakisaka, Yuichi Yoshida, Yuji Suzuki, Takuro Sato, Hidekatsu Kuroda, Akio Miyasaka, Yasuhiro Takikawa
HEPATOLOGY RESEARCH
(2018)
Article
Gastroenterology & Hepatology
Keisuke Kakisaka, Yuji Suzuki, Kojiro Kataoka, Yohei Okada, Yasuhiro Miyamoto, Hidekatsu Kuroda, Yasuhiro Takikawa
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2018)
Article
Medicine, General & Internal
Kei Endo, Hidekatsu Kuroda, Keisuke Kakisaka, Takayoshi Oikawa, Kei Sawara, Kazuyuki Ishida, Tamotsu Sugai, Yasuhiro Takikawa
Article
Acoustics
Tamami Abe, Hidekatsu Kuroda, Yudai Fujiwara, Yuichi Yoshida, Akio Miyasaka, Naohisa Kamiyama, Yasuhiro Takikawa
JOURNAL OF CLINICAL ULTRASOUND
(2018)
Article
Gastroenterology & Hepatology
Keisuke Kakisaka, Yuji Suzuki, Yudai Fujiwara, Tamami Abe, Miki Yonezawa, Hidekatsu Kuroda, Kazuyuki Ishida, Tamotsu Sugai, Yasuhiro Takikawa
JOURNAL OF GASTROENTEROLOGY
(2018)
Editorial Material
Medicine, General & Internal
Yuji Suzuki, Keisuke Kakisaka, Hidekatsu Kuroda, Tokio Sasaki, Yasuhiro Takikawa
KOREAN JOURNAL OF INTERNAL MEDICINE
(2018)
Article
Acoustics
Yudai Fujiwara, Hidekatsu Kuroda, Tamami Abe, Kazuyuki Ishida, Takuma Oguri, Sachiyo Noguchi, Tamotsu Sugai, Naohisa Kamiyama, Yasuhiro Takikawa
ULTRASOUND IN MEDICINE AND BIOLOGY
(2018)
Article
Gastroenterology & Hepatology
Kei Endo, Hidekatsu Kuroda, Takayoshi Oikawa, Yohei Okada, Yudai Fujiwara, Tamami Abe, Hiroki Sato, Kei Sawara, Yasuhiro Takikawa
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2018)
Letter
Gastroenterology & Hepatology
Keisuke Kakisaka, Yuji Suzuki, Yudai Fujiwara, Tamami Abe, Miki Yonezawa, Hidekatsu Kuroda, Kazuyuki Ishida, Tamotsu Sugai, Yasuhiro Takikawa
JOURNAL OF GASTROENTEROLOGY
(2019)
Article
Gastroenterology & Hepatology
Keisuke Kakisaka, Yuji Suzuki, Yukina Jinnouchi, Jo Kanazawa, Tokio Sasaki, Takehiro Yonezawa, Yuichi Yoshida, Hidekatsu Kuroda, Yasuhiro Takikawa
HEPATOLOGY RESEARCH
(2019)
Review
Radiology, Nuclear Medicine & Medical Imaging
Hiroko Naganuma, Hideaki Ishida, Hidekatsu Kuroda, Yasuaki Suzuki, Masahiro Ogawa
JOURNAL OF MEDICAL ULTRASONICS
(2020)
Article
Oncology
Hidekatsu Kuroda, Tomoaki Nagasawa, Yudai Fujiwara, Hiroki Sato, Tamami Abe, Yohei Kooka, Kei Endo, Takayoshi Oikawa, Kei Sawara, Yasuhiro Takikawa
Summary: Microwave ablation using Thermosphere(TM) technology showed similar overall survival and recurrence-free survival outcomes compared to radiofrequency ablation for hepatocellular carcinoma. Despite no significant differences in survival outcomes between the two methods, microwave ablation required fewer insertions, making it a recommended treatment option for tumors larger than 2 cm.
Article
Oncology
Kazunari Tanaka, Kunihiko Tsuji, Atsushi Hiraoka, Toshifumi Tada, Masashi Hirooka, Kazuya Kariyama, Joji Tani, Masanori Atsukawa, Koichi Takaguchi, Ei Itobayashi, Shinya Fukunishi, Toru Ishikawa, Kazuto Tajiri, Hironori Ochi, Hidenori Toyoda, Chikara Ogawa, Takashi Nishimura, Takeshi Hatanaka, Satoru Kakizaki, Noritomo Shimada, Kazuhito Kawata, Atsushi Naganuma, Hisashi Kosaka, Tomomitsu Matono, Hidekatsu Kuroda, Yutaka Yata, Hideko Ohama, Fujimasa Tada, Kazuhiro Nouso, Asahiro Morishita, Akemi Tsutsui, Takuya Nagano, Norio Itokawa, Tomomi Okubo, Taeang Arai, Keisuke Yokohama, Hiroki Nishikawa, Michitaka Imai, Yohei Koizumi, Shinichiro Nakamura, Hiroko Iijima, Masaki Kaibori, Yoichi Hiasa, Takashi Kumada
Summary: This study aimed to evaluate the ability of a TM score involving AFP, AFP-L3, and DCP to predict the prognosis and therapeutic efficacy in HCC patients treated with Atez/Bev. The results showed that the TM score was useful in predicting the overall survival (OS) and progression-free survival (PFS) in these patients. The mALBI grade was also a good predictor of OS and PFS.
Article
Gastroenterology & Hepatology
Yuichi Yoshida, Miki Yonezawa, Takuya Okamoto, Yudai Fujiwara, Akiko Suzuki, Yuji Suzuki, Kei Endo, Keisuke Kakisaka, Takayoshi Oikawa, Hidekatsu Kuroda, Akio Miyasaka, Yasuhiro Takikawa
CLINICAL JOURNAL OF GASTROENTEROLOGY
(2019)
Proceedings Paper
Engineering, Electrical & Electronic
Takuma Oguri, Naohisa Kamiyama, Sachiyo Noguchi, Yuko Kanayama, Yudai Fujiwara, Tamami Abe, Yuriko Mikami, Hidekatsu Kuroda
2018 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS)
(2018)