Review
Public, Environmental & Occupational Health
Zilin Luo, Xuesi Dong, Chenran Wang, Wei Cao, Yadi Zheng, Zheng Wu, Yongjie Xu, Liang Zhao, Fei Wang, Jibin Li, Jiansong Ren, Jufang Shi, Wanqing Chen, Ni Li
Summary: This study systematically reviewed observational studies on the association between socioeconomic status (SES) and adherence to colorectal cancer (CRC) screening. The findings showed that individuals with high SES had higher adherence to screening compared to those with low SES. Neighborhood SES or small-area SES was more effective in assessing the association between SES and adherence than individual SES.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2023)
Article
Biochemistry & Molecular Biology
Jacopo Troisi, Maria Tafuro, Martina Lombardi, Giovanni Scala, Sean M. Richards, Steven J. K. Symes, Paolo Antonio Ascierto, Paolo Delrio, Fabiana Tatangelo, Carlo Buonerba, Biancamaria Pierri, Pellegrino Cerino
Summary: The objective of this study was to develop a novel screening approach for colorectal cancer using serum metabolomic profiles, and to evaluate the metabolic alterations associated with the disease. The results showed that the metabolomic signature can be used as a non-invasive screening tool for colorectal cancer, and identified differences primarily associated with cell glucose metabolism.
Article
Oncology
Xuan Quy Luu, Kyeongmin Lee, Jae Kwan Jun, Mina Suh, Kyu-Won Jung, Kui Son Choi
Summary: This study investigated the long-term survival effects of colorectal cancer screening based on screening history and interval time since screening. The results showed that colorectal cancer screening was positively associated with favorable prognosis, especially among individuals screened within 1 year before diagnosis.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Oncology
Markus Dines Knudsen, Ane Sorlie Kvaerner, Edoardo Botteri, Oyvind Holme, Anette Hjartaker, Mingyang Song, Espen Thiis-Evensen, Kristin Ranheim Randel, Geir Hoff, Paula Berstad
Summary: This study investigated the relationship between lifestyle risk factors and inconsistent participation in FIT screening. The results showed that current smoking, BMI≥30 kg/m², and lower healthy lifestyle scores were associated with inconsistent participation.
Article
Chemistry, Analytical
Kai-Wen Lin, Yu-Chi Chang
Summary: This paper presents a rapid test system for fecal occult blood (FOB) detection with high sensitivity, linearity, and stability. The system detects the immune coloration response to accurately quantify the detection target, ranging from 0 ng/mL to 400 ng/mL of FOB with low coefficients of variation (CV) below 3.7%.
Review
Medicine, General & Internal
Ana Maria Wielandt, Claudia Hurtado, Mauricio Moreno, Alejandro Zarate, Francisco Lopez-Kostner
Summary: Screening programs for colorectal cancer commonly use fecal occult blood tests, with immunological tests showing higher sensitivity and participation rates compared to chemical tests. Quantitative methods allow for objective readings and stratification of patients in the screening programs.
REVISTA MEDICA DE CHILE
(2021)
Article
Medicine, General & Internal
Pei-Yu Yang, I-Ting Yang, Tzu-Hsuan Chiang, Chi-Hong Tsai, Yu-Ying Yang, I-Ching Lin
Summary: This study evaluated the effectiveness of colorectal cancer screening using the fecal immunochemical test (FIT) in a hospital in Taiwan. The results showed that FIT significantly increased the early detection of colorectal cancer. The non-invasiveness and low cost of FIT make it a promising screening method.
MEDICINA-LITHUANIA
(2023)
Article
Medicine, General & Internal
Ryo Sugaya, Takeshi Kanno, Hirohisa Yasaka, Misuzu Masu, Masataka Otomo, Tomoyuki Koike
Summary: This study aimed to clarify the effectiveness of interventions in outpatients who did not undergo colorectal cancer (CRC) screening. By actively promoting the immunological fecal occult blood test (FOBT), higher positive rates and detection rates of CRC were found compared to the nationwide administrative examination. The 7-year CRC-specific survival ratio was also high.
Review
Oncology
Enea Ferlizza, Rossella Solmi, Michela Sgarzi, Luigi Ricciardiello, Mattia Lauriola
Summary: Colorectal cancer (CRC) ranks as the third most common cancer worldwide, emphasizing the significance of early detection. Screening through fecal occult blood tests has shown to reduce CRC incidence and mortality, however, low participation rates and false positives are key challenges. Recent research has focused on new fecal tests, biomarkers, and liquid biopsy methods to enhance accuracy and participation in CRC screening.
Article
Oncology
P. H. A. Wisse, W. de Klaver, F. van Wifferen, L. Meiqari, M. Bierkens, M. J. E. Greuter, B. Carvalho, M. E. van Leerdam, M. C. W. Spaander, E. Dekker, V. M. H. Coupe, M. de Wit, G. A. Meijer
Summary: This study aims to validate the relative sensitivity of mtFIT compared to FIT in colorectal cancer (CRC) screening, and predict the lifetime health effects and costs using the Adenoma and Serrated Pathway to Colorectal CAncer model. The results of this study will provide important clinical utility information for the Dutch national CRC screening program.
Review
Oncology
V. Paul Doria-Rose, Iris Lansdorp-Vogelaar, Sharon McCarthy, Douglas M. Puricelli-Perin, Vicent Butera, Nereo Segnan, Stephen H. Taplin, Carlo Senore
Summary: The success of fecal occult blood-based colorectal cancer screening programs depends on repeated screening at short intervals. A literature review identified six broad classifications of longitudinal adherence, with stratified single round attendance being useful for describing screening yield and programmatic adherence measures best suited for evaluating screening efficacy. Collecting detailed longitudinal, individual-level data is recommended for maximum flexibility in reporting adherence patterns.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Gastroenterology & Hepatology
Ming Lu, Le Wang, Yuhan Zhang, Chengcheng Liu, Bin Lu, Lingbin Du, Xianzhen Liao, Dong Dong, Donghua Wei, Yi Gao, Jufang Shi, Jiansong Ren, Hongda Chen, Min Dai
Summary: The risk-adapted screening combining Asia-Pacific Colorectal Screening score, FIT, and colonoscopy showed higher sensitivity for advanced neoplasm but lower specificity compared to FIT alone. Adjusting the positivity threshold tailored to clinical practice could save colonoscopy resources and cost.
CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY
(2021)
Review
Oncology
Laura F. Gruner, Efrat L. Amitay, Thomas Heisser, Feng Guo, Tobias Niedermaier, Anton Gies, Michael Hoffmeister, Hermann Brenner
Summary: This systematic review examined the effectiveness of various invitation strategies in colorectal cancer screening programs, revealing that advance notification, mailing of fecal occult blood tests, and reminders have the potential to significantly increase participation rates. Multifaceted invitation strategies were found to be the most effective in increasing usage rates of fecal occult blood tests for colorectal cancer screening.
Article
Gastroenterology & Hepatology
Yu Jin Kim, Jeong-Im Shim, Eunjung Park, Minjoo Kang, Sinhee Kang, Jessie Lee, Ha Jin Tchoe, Kyeong Ae Kong, Duk Hwan Kim, Byung Chang Kim, Kui Son Choi, Chang Mo Moon
Summary: This retrospective cohort study evaluated the impact of adherence to follow-up examination after a fecal occult blood test (FOBT) on clinical outcomes in individuals with positive results. Those who underwent confirmative examination within a year had higher 5-year survival rates compared to those who did not. The study highlights the importance of timely follow-up examinations for early detection and improved survival outcomes in colorectal cancer patients.
DIGESTIVE AND LIVER DISEASE
(2021)
Article
Gastroenterology & Hepatology
Simon Ladefoged Rasmussen, Christian Torp-Pedersen, Kare Andersson Gotschalck, Ole Thorlacius-Ussing
Summary: This study aimed to assess the effects of antithrombotic treatment on the fecal immunochemical test (FIT)-based Danish national screening program for colorectal cancer (CRC). The results showed that individuals receiving antithrombotic treatment had a higher proportion of positive FIT results, and the detection rate of CRC was slightly lower among patients on antithrombotic treatment. Moreover, the positive predictive value (PPV) for CRC or high risk adenomas was decreased nearly twofold in patients treated with nonvitamin K oral anticoagulants (NOACs).