Review
Biochemistry & Molecular Biology
Lara Alessandrini, Laura Astolfi, Antonio Daloiso, Marta Sbaraglia, Tiziana Mondello, Elisabetta Zanoletti, Leonardo Franz, Gino Marioni
Summary: This review aims to assess the current level of knowledge on neo-angiogenesis markers involved in the biology, behavior, and prognosis of head and neck squamous cell carcinoma (HNSCC). A search was conducted in PubMed, Scopus, and Web of Science databases, resulting in the inclusion of 84 articles. The understanding and discussion of angiogenesis in HNSCC presented in these articles are stratified into diagnostic markers, prognostic markers, predictive markers, and markers with a potential therapeutic role. Further research is needed to investigate the combination of antiangiogenic agents with conventional chemotherapy, immunotherapy, and targeted therapies in HNSCC, as well as to identify the patients who would benefit the most from these treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Usha Patel, Sadhana Kannan, Swapnil U. Rane, Neha Mittal, Poonam Gera, Asawari Patil, Subhakankha Manna, Vishwayani Shejwal, Vanita Noronha, Amit Joshi, Vijay M. Patil, Kumar Prabhash, Manoj B. Mahimkar
Summary: This study identifies CD44 and CD44v6 as potential predictive biomarkers for NCRT response in HPV-negative LA-HNSCC patients, and CD98hc as an independent negative prognostic biomarker. These findings can help identify which HNSCC patients are most suitable for specific treatments.
BRITISH JOURNAL OF CANCER
(2022)
Article
Multidisciplinary Sciences
Masakazu Hamada, Hiroaki Inaba, Kyoko Nishiyama, Sho Yoshida, Yoshiaki Yura, Michiyo Matsumoto-Nakano, Narikazu Uzawa
Summary: This study found that up-regulated autophagy-related genes and other genes in serum-starved cells are associated with the initiation and progression of head and neck squamous cell carcinoma. Further analysis revealed high expression of CALR, HSPA5, and TRIB3 in HNSCC patients to be correlated with poor prognosis.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Jacek Kabzinski, Monika Maczynska, Ireneusz Majsterek
Summary: This article discusses the potential use of microRNAs in the diagnosis of head and neck squamous cell carcinoma, highlighting their application in radiotherapy and immunotherapy, as well as addressing the challenges and future research directions in developing this promising technology.
Article
Oncology
Xiao-jie Luo, Min Zheng, Ming-xin Cao, Wei-long Zhang, Mei-chang Huang, Li Dai, Ya-ling Tang, Xin-hua Liang
Summary: The study developed miRNA signatures for both HPV+ and HPV- HNSCC to predict patients' prognosis, and explored their potential biological functions. Combined results suggested that HPV+ HNSCC patients with low signature scores had better immunity and treatment sensitivity, while HPV- HNSCC patients with high scores had poor prognosis due to treatment resistance and cell metabolism dysregulation. Identified signatures for HPV+ and HPV- HNSCC are significant for patient outcomes and may serve as new biomarkers and therapeutic targets.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Anna Maria Wirsing, Inger-Heidi Bjerkli, Sonja Eriksson Steigen, Oddveig Rikardsen, Synnove Norvoll Magnussen, Beate Hegge, Marit Seppola, Lars Uhlin-Hansen, Elin Hadler-Olsen
Summary: This study validated the prognostic value of selected markers for head and neck cancer in oral tongue squamous cell carcinoma, highlighting the importance of subsite-specific analyses for accurate prognosis.
Review
Medicine, General & Internal
Mayur D. Mody, James W. Rocco, Sue S. Yom, Robert Haddad, Nabil F. Saba
Summary: Head and neck cancer is the seventh most common type of cancer worldwide, with the predominant risk factors being tobacco use, alcohol abuse, and oncogenic viruses. Treatment typically involves a multidisciplinary approach with surgery, radiotherapy, and systemic therapy, and is challenging due to site-specific and histology-specific variations.
Article
Oncology
Gerhard Dyckhoff, Christel Herold-Mende, Sabine Scherer, Peter K. Plinkert, Rolf Warta
Summary: The specific combination of HLA alleles can affect the outcome and survival rate of cancer patients, with HLA-C*04 showing a negative impact on tumor outcomes and HLA-A*02 significantly improving survival rates.
Article
Biochemistry & Molecular Biology
Huazhen Liang, Chunning Zhang, Chaoming Li, Changguo Li, Yanli Wang, Huaming Lin
Summary: FOXD1 is highly expressed in head and neck squamous cell carcinoma (HNSC) and correlates with poorer survival rates, as well as promoting tumor-associated macrophage (TAM) infiltration. Additionally, FOXD1 expression is significantly associated with immune cell infiltration levels.
BIOSCIENCE REPORTS
(2021)
Article
Cell Biology
Jingjia Li, Weixiong Chen, Lixia Luo, Lieqiang Liao, Xuequan Deng, Yuejian Wang
Summary: This study identified miR-29c-5p as a potential therapeutic target for managing HNSCC by inhibiting cell migration and proliferation. The effects of miR-29c-5p on HNSCC tumors were confirmed using a mouse tumor xenograft model. TMEM98 was identified as a direct target of miR-29c-5p in HNSCC cells.
Article
Biochemistry & Molecular Biology
Nadine de Godoy Torso, Julia Coelho Franca Quintanilha, Maria Aparecida Cursino, Eder de Carvalho Pincinato, Carmen Silvia Passos Lima, Patricia Moriel
Summary: This study aimed to determine the most adequate endogenous normalizer for urinary miRNA relative quantification in head and neck cancer patients treated with cisplatin chemoradiotherapy. RNA-Seq was performed to identify differentially expressed miRNAs between groups with and without cisplatin nephrotoxicity. Four miRNAs were selected as candidate endogenous normalizers and validated by qRT-PCR in a cohort of 49 patients, with hsa-miR-875-5p shown to be an adequate normalizer due to its invariant expression between the two groups.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Qing-Qing Xu, Qing-Jie Li, Zhen Xu, Li-Long Lan, Zan Hou, Juan Liu, LiXia Lu, Yuan-Yuan Chen, Run-Zhe Chen, Xin Wen
Summary: By establishing an immunohistochemical (IHC) score model, we have developed a method for predicting the prognosis of head and neck squamous cell carcinoma (HNSCC). The results showed that the IHC score can independently predict the prognosis of HNSCC and is more accurate than the TNM system. Combining these two methods could enable individualized patient consultation and care.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Yanting Wang, Yuanyuan Li, Laibo Jiang, Xianyue Ren, Bin Cheng, Juan Xia
Summary: The higher expression levels of glycolysis markers, including GLUT1, MCT4, HK2, and PKM2, are associated with poorer overall survival and disease-free survival in head and neck squamous cell carcinoma patients. These markers could serve as potential prognostic predictors and therapeutic targets in the management of HNSCC.
Review
Oncology
Melysa Fitriana, Wei-Lun Hwang, Pak-Yue Chan, Tai-Yuan Hsueh, Tsai-Tsen Liao
Summary: Head and neck squamous cell carcinomas (HNSCCs) are heterogeneous malignancies with cancer stem cells (CSCs) playing vital roles in tumor progression, metastasis, and therapeutic resistance. MicroRNAs (miRNAs) regulate CSC features in HNSCC by modulating tumor microenvironment and signaling pathways, offering potential therapeutic applications.
Article
Biochemistry & Molecular Biology
Ivana Simic, Ksenija Bozinovic, Nina Milutin Gasperov, Mario Kordic, Ena Pesut, Luka Manojlovic, Magdalena Grce, Emil Dediol, Ivan Sabol
Summary: Head and neck cancers (HNC) are a diverse group of tumours linked to tobacco, alcohol, and human papillomavirus (HPV). Most HNC cases are squamous cell carcinomas (HNSCC). A study on primary HNSCC patients revealed a predominance of male gender, HPV-negative tumors mainly located in the oral region, and a high proportion of stage IV cancer. Survival analysis showed that the presence of perineural and angioinvasion had a significant impact on patient survival. Additionally, upregulation of miR-21 was consistently associated with poor prognosis and could serve as a prognostic biomarker in HNSCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Otorhinolaryngology
M. Shrivastava, C. Harris, S. Holmes, S. Brady, S. Winter
Summary: This study reviewed the symptoms, imaging, and management strategies of patients with inclusion body myositis referred for dysphagia assessment. The results showed that common symptoms included swallowing difficulties and reflux symptoms. Video swallow identified tongue base retraction and residual pharyngeal pooling as common problems. Some patients showed features of aspiration on imaging. Some patients received treatment with balloon dilatation or cricopharyngeal myotomy.
JOURNAL OF LARYNGOLOGY AND OTOLOGY
(2023)
Editorial Material
Oncology
Adrian L. Harris
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Kathleen Greenway, Caterina Frisone, Andrea Placidi, Sanjay Kumar, Will Guest, Stuart C. Winter, Ketan Shah, Catherine Henshall
Summary: This study aimed to develop a digital recovery support package for head and neck cancer patients and assess its acceptability. The package included a WebXR platform that provided a virtual reality experience for patients to access targeted resources and learning materials. The results showed that participants found the platform realistic and useful, and it helped reduce anxiety.
EUROPEAN JOURNAL OF ONCOLOGY NURSING
(2023)
Review
Oncology
James M. Price, Asmithaa Prabhakaran, Catharine M. L. West
Summary: Advances in radiotherapy enable individualized treatment, but optimization is often based on the assumption that all tumors respond similarly to radiation. However, radiation affects multiple cellular pathways, so it is important to study genomic classifiers to guide personalized treatment decisions.
NATURE REVIEWS CLINICAL ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Felicia Lazure, Rick Farouni, Korin Sahinyan, Darren M. Blackburn, Aldo Hernandez-Corchado, Gabrielle Perron, Tianyuan Lu, Adrien Osakwe, Jiannis Ragoussis, Colin Crist, Theodore J. Perkins, Arezu Jahani-Asl, Hamed S. Najafabadi, Vahab D. Soleimani
Summary: Adult stem cells play a crucial role in tissue regeneration, but their function declines with age. In this study, we investigated the impact of the stem cell niche environment on their function using muscle stem cells as a model. We found that aging resulted in significant changes in the gene expression of muscle stem cells, and exposure to a young niche environment restored the expression of a large portion of age-altered genes. This emphasizes the potential of targeting the stem cell niche as a therapeutic strategy for enhancing tissue regeneration in aging.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Tong Yu, Archana Chandrabhan Jadhav, Jiabao B. Xu, Adrian L. L. Harris, Venugopal Nair, Wei E. E. Huang
Summary: Understanding the development of cancer resistance to therapies is crucial. Newcastle disease virus (NDV) is a promising oncolytic agent, but some colon cancer cells show resistance to NDV reinfection. By using Raman spectroscopic and stable isotopic techniques, we found that the resistant cells slow down their replication and divert energy to protein and lipid synthesis. Understanding metabolic reprogramming could aid in developing precision cancer treatments that target resistant cells at the single-cell level.
Article
Genetics & Heredity
Burcu F. Darst, Jiayi Shen, Ravi K. Madduri, Alexis A. Rodriguez, Yukai Xiao, Xin Sheng, Edward J. Saunders, Tokhir Dadaev, Mark N. Brook, Thomas J. Hoffmann, Kenneth Muir, Peggy Wan, Loic Le Marchand, Lynne Wilkens, Ying Wang, Johanna Schleutker, Robert J. MacInnis, Cezary Cybulski, David E. Neal, Borge G. Nordestgaard, Sune F. Nielsen, Jyotsna Batra, Judith A. Clements, Henrik Gronberg, Nora Pashayan, Ruth C. Travis, Jong Y. Park, Demetrius Albanes, Stephanie Weinstein, Lorelei A. Mucci, David J. Hunter, Kathryn L. Penney, Catherine M. Tangen, Robert J. Hamilton, Marie-Elise Parent, Janet L. Stanford, Stella Koutros, Alicja Wolk, Karina D. Sorensen, William J. Blot, Edward D. Yeboah, James E. Mensah, Yong-Jie Lu, Daniel J. Schaid, Stephen N. Thibodeau, Catharine M. West, Christiane Maier, Adam S. Kibel, Geraldine Cancel-Tassin, Florence Menegaux, Esther M. John, Eli Marie Grindedal, Kay-Tee Khaw, Sue A. Ingles, Ana Vega, Barry S. Rosenstein, Manuel R. Teixeira, Manoli Kogevinas, Lisa Cannon-Albright, Chad Huff, Luc Multigner, Radka Kaneva, Robin J. Leach, Hermann Brenner, Ann W. Hsing, Rick A. Kittles, Adam B. Murphy, Christopher J. Logothetis, Susan L. Neuhausen, William B. Isaacs, Barbara Nemesure, Anselm J. Hennis, John Carpten, Hardev Pandha, Kim De Ruyck, Jianfeng Xu, Azad Razack, Soo-Hwang Teo, Lisa F. Newcomb, Jay H. Fowke, Christine Neslund-Dudas, Benjamin A. Rybicki, Marija Gamulin, Nawaid Usmani, Frank Claessens, Manuela Gago-Dominguez, Jose Esteban Castelao, Paul A. Townsend, Dana C. Crawford, Gyorgy Petrovics, Graham Casey, Monique J. Roobol, Jennifer F. Hu, Sonja I. Berndt, Stephen K. van den Eeden, Douglas F. Easton, Stephen J. Chanock, Michael B. Cook, Fredrik Wiklund, John S. Witte, Rosalind A. Eeles, Zsofia Kote-Jarai, Stephen Watya, John M. Gaziano, Amy C. Justice, David V. Conti, Christopher A. Haiman
Summary: In this study, the predictive ability of several genome-wide polygenic risk score (GW-PRS) approaches was compared to a recently developed PRS of established prostate cancer-risk variants. The findings suggest that the PRS269 developed from multi-ancestry GWASs and fine-mapping has better predictive ability for prostate cancer risk compared to current GW-PRS approaches.
AMERICAN JOURNAL OF HUMAN GENETICS
(2023)
Article
Oncology
Simon R. Lord, Adrian L. Harris
Summary: Over the past 15 years, there has been extensive interest in repurposing the diabetes drug metformin as a cancer treatment. However, despite numerous large clinical trials in various tumor types, the results have been disappointing. This article summarizes the initial interest in metformin's potential in oncology, the current clinical program, and the lessons learned from this experience regarding further investigation of metformin in cancer.
BRITISH JOURNAL OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Chen-Chun Pai, Samuel C. Durley, Wei-Chen Cheng, Nien-Yi Chiang, Jennifer Peters, Torben Kasparek, Elizabeth Blaikley, Boon-Yu Wee, Carol Walker, Stephen E. Kearsey, Francesca Buffa, Johanne M. Murray, Timothy C. Humphrey
Summary: Chromosomal instability (CIN) plays a crucial role in cell-to-cell heterogeneity and the development of genetic diseases, including cancer. Impaired homologous recombination (HR) has been identified as a major driver of CIN, but the exact mechanism behind it is still unclear. Using a fission yeast model, researchers have found that HR genes have a common role in suppressing DNA double-strand break (DSB)-induced CIN. Furthermore, they discovered that an unrepaired single-ended DSB, resulting from failed HR repair or telomere loss, is a potent driver of widespread CIN.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Oncology
Soumya Ghose, Sanghee Cho, Fiona Ginty, Elizabeth McDonough, Cynthia Davis, Zhanpan Zhang, Jhimli Mitra, Adrian L. Harris, Aye Aye Thike, Puay Hoon Tan, Yesim Gokmen-Polar, Sunil S. Badve
Summary: The authors developed a deep learning classification network to predict breast cancer events (BCEs) in patients with ductal carcinoma in situ (DCIS), providing early and accurate predictions for personalized therapy and avoiding over-treatment of low-risk patients.
Article
Oncology
Toby O. Smith, Angela Garrett, Tianshu Liu, Alana Morris, Victoria Gallyer, Bethany A. Fordham, Susan J. Dutton, Mae Chester-Jones, Sarah E. Lamb, Stuart Charles Winter
Summary: The aim of this study was to determine the feasibility of a randomised controlled trial to assess the effectiveness and cost-effectiveness of a rehabilitation intervention after neck dissection in patients with head and neck cancer. The study achieved five of its six feasibility targets, but failed to reach the recruitment target due to the COVID-19 pandemic. Based on the findings, a full trial can now be designed to further investigate the effectiveness of the proposed intervention.
FRONTIERS IN ONCOLOGY
(2023)
Article
Otorhinolaryngology
Cherie-Ann O. Nathan, Ameya A. Asarkar, Payam Entezami, June Corry, Primoz Strojan, Vincent Vander Poorten, Antti Makitie, Avraham Eisbruch, K. T. Robbins, Robert Smee, Maie St John, Carlos Chiesa-Estomba, Stuart C. Winter, Jonathan J. Beitler, Alfio Ferlito
Summary: Radiotherapy is crucial in the treatment of head and neck cancer, but it often causes xerostomia, which significantly impacts the patients' quality of life. Efforts have been made to decrease radiation to the salivary glands and surgical transfer of the submandibular gland is an effective preventive option. This review focuses on strategies to improve xerostomia following radiation therapy in head and neck cancers.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2023)
Editorial Material
Oncology
Nicole D. D. Machado, Lisa C. C. Heather, Adrian L. L. Harris, Geoff S. S. Higgins
Summary: The disappointing termination of clinical trials with potent complex I inhibitors, such as IACS-010759, has raised doubts about the justification for oxidative phosphorylation inhibitors and mitochondrial targeting strategies. Analyzing the potency, tissue selectivity, and toxicity of these agents can provide insights into the lessons learned from this failure and identify new opportunities.
BRITISH JOURNAL OF CANCER
(2023)
Article
Computer Science, Interdisciplinary Applications
Andrea Tangherloni, Simone G. Riva, Brynelle Myers, Francesca M. Buffa, Paolo Cazzaniga
Summary: Single-cell RNA sequencing experiments are valuable for identifying different cell types. This study introduces a fully-automatic framework called MAGNETO, which constructs optimal marker panels for distinguishing desired cell populations. The results demonstrate that MAGNETO outperforms other methods in identifying the cell populations of interest.
JOURNAL OF BIOMEDICAL INFORMATICS
(2023)
Article
Oncology
Rui Zhang, Jiarong Li, Dunarel Badescu, Andrew C. Karaplis, Jiannis Ragoussis, Richard Kremer
Summary: The 5-year survival rate for women with metastatic breast cancer is 29%. A genetically modified breast cancer mouse model was used to study the role of Parathyroid hormone-related peptide (PTHrP) in breast cancer growth and metastasis. A novel long non-coding RNA (lncRNA) was identified as a potential target for fatty acid metabolism regulated by PTHrP. These findings could contribute to the development of targeted strategies for breast cancer treatment.