Article
Cardiac & Cardiovascular Systems
Tiuri E. Kroese, Willemieke P. M. Dijksterhuis, Peter S. N. van Rossum, Rob H. A. Verhoeven, Stella Mook, Nadia Haj Mohammad, Maarten C. C. M. Hulshof, Mark I. van Berge Henegouwen, Martijn G. H. van Oijen, Jelle P. Ruurda, Hanneke W. M. van Laarhoven, Richard van Hillegersberg
Summary: This study evaluated the management, overall survival, and prognostic factors of esophageal cancer patients with interval distant metastases. The findings suggest that the survival outcomes of these patients are influenced by treatment strategies and prognostic factors, and are comparable to those of synchronous metastatic patients.
ANNALS OF THORACIC SURGERY
(2022)
Review
Medicine, Research & Experimental
Ruoyu Shi, Mark Ting Le Tan, Gek Hsiang Lim, Jingzeng Du, Limin Zhang, Lixia Zeng, Puay Hoon Tan
Summary: Tumor budding (TB) is suggested as a strong prognostic marker in urinary tract urothelial carcinoma (UC). This systematic review conducted a meta-analysis of previously published studies to test the prognostic value of TB in UC. The analysis revealed that TB is a significant predictor of progression-free survival, overall survival, and cancer-specific survival in UC. These findings highlight the importance of considering TB as a factor in pathology reports and future oncologic staging systems.
LABORATORY INVESTIGATION
(2023)
Article
Oncology
Parbatraj Regmi, Aliza Paudyal, Pranita Paudyal, Hai-Jie Hu, Fei Liu, Wen-Jie Ma, Yan-Wen Jin, Fu-Yu Li
Summary: Tumor budding is identified as a significant predictor of poor survival for biliary tract cancer (BTC), associated with poor histologic differentiation, lymphovascular invasion, and other factors. It has the potential to serve as a prognostic marker for BTC, pending the development of a standardized international consensus.
Article
Oncology
Smita Sihag, Samuel C. Nussenzweig, Henry S. Walch, Meier Hsu, Kay See Tan, Sergio De La Torre, Yelena Y. Janjigian, Steven B. Maron, Geoffrey Y. Ku, Laura H. Tang, Pari M. Shah, Abraham Wu, David R. Jones, David B. Solit, Nikolaus Schultz, Karuna Ganesh, Michael F. Berger, Daniela Molena
Summary: MDM2 amplification and TP53 status are associated with response to therapy in patients with esophageal adenocarcinoma. Worsening TP53 dysfunction is directly correlated with worse treatment outcomes.
CLINICAL CANCER RESEARCH
(2022)
Article
Medicine, General & Internal
Sachiyo Onishi, Masahiro Tajika, Tsutomu Tanaka, Keisaku Yamada, Tomoyasu Kamiya, Tetsuya Abe, Eiji Higaki, Hironori Fujieda, Takuya Nagao, Yoshitaka Inaba, Kei Muro, Masahito Shimizu, Yasumasa Niwa
Summary: This study aimed to investigate the effects of changes in body composition during neoadjuvant chemotherapy (NAC) on perioperative complications and prognosis in patients with esophageal squamous cell carcinoma (ESCC). The results showed that patients who experienced weight loss and decreased psoas muscle index (PMI), as well as increased visceral fat mass (VFM) during NAC, had higher rates of postoperative complications and longer hospital stays. Furthermore, post-NAC sarcopenia, indicated by decreased PMI, was identified as a poor prognostic factor.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Surgery
Yoichi Hamai, Manabu Emi, Yuta Ibuki, Yuji Murakami, Ikuno Nishibuchi, Tomoaki Kurokawa, Toru Yoshikawa, Ryosuke Hirohata, Manato Ohsawa, Nao Kitasaki, Morihito Okada
Summary: Pretherapeutic CEA and NLR levels, pretherapeutic LNM, NACRT, poorly differentiated tumors, and LVI were significantly correlated with survivals in patients without pathological LNM after neoadjuvant therapy and surgery. Postoperative therapy should be considered in patients with ESCC with several indicators of recurrence, even in those without pathological LNM who underwent surgery following neoadjuvant therapy.
WORLD JOURNAL OF SURGERY
(2023)
Article
Surgery
Chi Zhang, Fei Xu, Yong Qiang, Zhuang-Zhuang Cong, Qin Wang, Zheng Zhang, Chao Luo, Bing-Mei Qiu, Li-Wen Hu, Yi Shen
Summary: This study evaluated the prognostic value of the modified Ryan scoring system for patients with esophageal squamous cell carcinoma treated with trimodal therapy. The results showed that the scoring system can predict survival and recurrence rates, but it is not an independent prognostic factor.
FRONTIERS IN SURGERY
(2023)
Article
Oncology
Jinah Chu, Hyun-soo Kim, Sung -Im Do
Summary: This study evaluated the role of tumor budding in predicting the response to neoadjuvant chemotherapy in patients with breast carcinoma. High tumor budding was associated with more frequent lymph node metastasis and lower pathological complete response rate. Multivariate logistic regression analysis showed that high tumor budding independently predicted non-pathological complete response.
ANTICANCER RESEARCH
(2023)
Article
Oncology
Moyuru Yamada, Koji Tanaka, Makoto Yamasaki, Kotaro Yamashita, Tomoki Makino, Takuro Saito, Tsuyoshi Takahashi, Yukinori Kurokawa, Masaaki Motoori, Yutaka Kimura, Kiyokazu Nakajima, Hidetoshi Eguchi, Yuichiro Doki
Summary: Studies have shown that neoadjuvant chemotherapy followed by surgical resection improves the survival of patients with esophageal squamous cell carcinoma, and the neutrophil-to-lymphocyte ratio (NLR) may serve as a prognostic biomarker. This retrospective study analyzed the changes in NLR before and after neoadjuvant chemotherapy in 338 patients with esophageal squamous cell carcinoma. The results indicate that post-NLR was a better prognostic factor than pre-NLR for patients receiving neoadjuvant chemotherapy followed by surgical resection.
Article
Pathology
Adil Aziz Khan, Shaivy Malik, Sherrin Jacob, Durre Aden, Sana Ahuja, Sufian Zaheer, Sunil Ranga
Summary: Colorectal carcinoma is a common, highly fatal cancer. Although the staging system provides guidance for treatment, clinical outcomes can vary greatly among patients with the same stage. Additional prognostic markers are needed for better accuracy.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Cardiac & Cardiovascular Systems
Han Tang, Dongxian Jiang, Shumin Zhang, Zhaochong Zeng, Lijie Tan, Yingyong Hou, Qun Wang, Hao Wang, Jiangyi Zhu, Yaxing Shen, Jun Yin, Di Ge
Summary: The study found that residual tumors in esophageal squamous cell carcinoma are primarily located in the mucosa and submucosa, making them difficult to detect with current techniques. Additionally, there is a low rate of pathological complete response in lymph nodes, and diverse regression patterns further complicate the identification of residual tumors.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Oncology
Keting Li, Wentao Hao, Xianben Liu, Yin Li, Haibo Sun, Shilei Liu, Wenqun Xing, Yan Zheng
Summary: This study compared the efficacy of adjuvant chemotherapy and postoperative observation in patients with esophageal squamous cell carcinoma (ESCC) after neoadjuvant chemotherapy. The results showed that adjuvant chemotherapy did not improve overall survival (OS) in these patients, but it may benefit certain groups of patients.
Review
Oncology
M. Usman Ahmad, Christopher Javadi, George A. Poultsides
Summary: Neoadjuvant and/or perioperative therapy has emerged as a treatment tool to improve patient selection and locoregional control for resectable proximal gastric, gastroesophageal junction, and distal esophageal cancer. Treatment recommendations differ based on histologic type and tumor location. Neoadjuvant chemoradiation with concurrent taxane- or fluoropyrimidine-based chemotherapy has shown efficacy for both adenocarcinoma and squamous cell carcinoma of the distal esophagus and gastroesophageal junction.
Article
Dentistry, Oral Surgery & Medicine
Marco Mascitti, Lucrezia Togni, Vito Carlo Alberto Caponio, Khrystyna Zhurakivska, Lorenzo Lo Muzio, Corrado Rubini, Andrea Santarelli, Giuseppe Troiano
Summary: Tumor budding is found to be a reliable prognostic factor in oral tongue squamous cell carcinoma (OTSCC), but a standardized scoring system is lacking. This study aims to evaluate the prognostic role of tumor budding in 211 OTSCC patients. The results confirm the predictive value of tumor budding in disease-specific survival.
Editorial Material
Medicine, General & Internal
Jing Wen, Shuogui Fang, Yi Hu, Mian Xi, Zelin Weng, Chuqing Pan, Kongjia Luo, Yihong Ling, Renchun Lai, Xiuying Xie, Xiaodan Lin, Ting Lin, Jiyang Chen, Qianwen Liu, Jianhua Fu, Hong Yang
Summary: This study used single-cell RNA sequencing to examine the cellular and molecular dynamics in esophageal squamous cell carcinoma (ESCC) patients before and after neoadjuvant chemoradiotherapy (neoCRT). The findings revealed that neoCRT increased the infiltration of CD8(+) T cells in the tumor microenvironment but also promoted their exhaustion. Additionally, neoCRT influenced the differentiation and abundance of other immune cell types, including Th cells, Treg cells, cDC1s, and macrophages.
