Article
Medicine, Research & Experimental
Mohamed El-Tanani, Hamdi Nsairat, Alaa A. Aljabali, Angel Serrano-Aroca, Vijay Mishra, Yachana Mishra, Gowhar A. Naikoo, Walhan Alshaer, Murtaza M. Tambuwala
Summary: The mammalian target of rapamycin (mTOR), a signalling system, is necessary for various cell proliferation activities. It recognizes PI3KAKT stress signals as a serine-threonine kinase. The abnormal regulation of mTOR pathway has been proven to be crucial in cancer growth and advancement. This review primarily discusses the normal functions of mTOR as well as its abnormal roles in cancer development.
Review
Cell Biology
MelissaR Pitman, Martin K. Oehler, Stuart M. Pitson
Summary: Ovarian cancer is a deadly gynaecological malignancy commonly diagnosed at an advanced stage, making treatment challenging. Novel strategies for early detection and therapeutics are urgently needed to improve patient survival, with the sphingolipid pathway showing promise as a potential therapeutic target against chemotherapy-resistant disease.
CELLULAR SIGNALLING
(2021)
Article
Biochemistry & Molecular Biology
Guoping Mao, Dedong Xin, Qian Wang, Dongmei Lai
Summary: Sodium molybdate induces both ferroptosis and apoptosis of ovarian cancer cells, making it a potential therapeutic candidate for ovarian cancer.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Review
Medicine, General & Internal
Petar Simic, Igor Pljesa, Lazar Nejkovic, Djurdja Jerotic, Vesna Coric, Jelena Stulic, Nenad Kokosar, Dunja Popov, Ana Savic-Radojevic, Vladimir Pazin, Marija Pljesa-Ercegovac
Summary: Chemotherapy resistance in ovarian cancer is a complex process involving multiple mechanisms, such as increased activity of efflux transporters, enhanced DNA repair, and altered apoptotic pathways. GSTP1 is recognized as a major enzyme responsible for converting chemotherapy drugs into less effective forms, while miRNAs can regulate drug resistance by targeting GST-mediated drug metabolism.
MEDICINA-LITHUANIA
(2022)
Review
Oncology
Si-yu Chen, Jin-long Cao, Kun-peng Li, Shun Wan, Li Yang
Summary: BIN1 protein has various physiological functions and is closely associated with the development of many diseases. Recent findings have revealed the potential mechanisms of BIN1 in cancer development and its feasibility as a prognostic marker and therapeutic target.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Fan Lin, Yunqi Liu, Lili Tang, Xiaohui Xu, Xueli Zhang, Yifan Song, Bicheng Chen, Yeping Ren, Xiangdong Yang
Summary: The study demonstrated that rapamycin protects against aristolochic acid-induced nephropathy by activating the mTOR-autophagy axis. This finding provides evidence for rapamycin as a promising pharmacological target for the treatment of aristolochic acid nephropathy.
MOLECULAR MEDICINE REPORTS
(2021)
Review
Neurosciences
Henry Querfurth, Han-Kyu Lee
Summary: mTOR is involved in regulating energy metabolism, neuronal growth, insulin signaling, and autophagy, playing both beneficial and pathogenic roles in neurodegenerative diseases. Balanced actions of mTOR complexes may have implications for Alzheimer's disease, Parkinson's disease, Huntington's disease, Frontotemporal dementia, and Amyotrophic Lateral Sclerosis. Beyond rapamycin, rapalogs with improved tolerability and delivery modes hold promise in treating age-related conditions.
MOLECULAR NEURODEGENERATION
(2021)
Article
Medicine, General & Internal
Aleksandra Mielczarek-Palacz, Sylwia Jasinska, Anna Strzelec
Summary: Ovarian cancer is a major issue in gynecological oncology, and research on diagnostic markers like caspase-3, -8, and -9 is ongoing. This study found significantly decreased levels of these caspases in ovarian cancer patients compared to healthy controls, suggesting a link to immune system disturbances and potential for future diagnostic use, pending further research.
Review
Biochemistry & Molecular Biology
Junfang Yan, Yi Xie, Jing Si, Lu Gan, Hongyan Li, Chao Sun, Cuixia Di, Jinhua Zhang, Guomin Huang, Xuetian Zhang, Hong Zhang
Summary: In response to cellular stress triggered by the environment, cells integrate the caspase family and mammalian target of rapamycin (mTOR) signaling to regulate cell survival and fate. While mTOR pathway mediates cell growth and metabolism, the caspase family plays a crucial role in inflammation and apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Kakali Bhadra
Summary: This article reviews the alternative pathways of cancer cell death targeted by anticancer drug molecules, providing a molecular basis for new strategies in cancer treatment. Many drugs can effectively induce cell death through targeting the caspase-independent cell death pathway, which is significant for cancer therapy.
Article
Oncology
Guang-Ping Zou, Chun-Xia Yu, Sheng-Lan Shi, Qiu-Gen Li, Xiao-Hua Wang, Xin-Hui Qu, Zhang-Jian Yang, Wei-Rong Yao, Dan-Dan Yan, Li-Ping Jiang, Yu-Ying Wan, Xiao-Jian Han
Summary: The dynamics of mitochondria mediated by DRP1 and MFN2 play a crucial role in the development of cisplatin resistance in ovarian cancer cells. Modulating the expression of these proteins can impact cell migration capability and ATP levels.
Article
Environmental Sciences
Cheng-Hsun Lin, Kuang-Hsuan Lin, Hsiang-Ju Ku, Kun-Ching Lee, Song-Shei Lin, Fei-Ting Hsu
Summary: Amentoflavone has been found to inhibit the progression of colorectal cancer through mechanisms such as triggering G1 arrest, DNA damage, and apoptosis, making it a potential treatment option.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Oncology
Yi Ding, Vera Labitzky, Karen Legler, Minyue Qi, Udo Schumacher, Barbara Schmalfeldt, Christine Stuerken, Leticia Oliveira-Ferrer
Summary: The study found that ascites from ovarian cancer patients contained two cell populations: adherent cells with high proliferative rates and no tumor potential, and non-adherent cells mainly composed of tumor cell spheroids with low proliferative potential. Tumor cell spheroids obtained from ascites were highly tumorigenic and showed upregulation of genes related to chemoresistance, cell adhesion, and the OXPHOS pathway compared to tumor tissue. Response to OXPHOS inhibition correlated with mitochondrial membrane potential, suggesting a potential treatment option for advanced ovarian cancer.
MOLECULAR ONCOLOGY
(2021)
Review
Neurosciences
Aziz Unnisa, Nigel H. H. Greig, Mohammad Amjad Kamal
Summary: Traumatic brain injury (TBI) is a major cause of death and morbidity, and is the focus of translational research. Apoptosis is important in the pathophysiology of TBI, and inhibiting it may improve functional recovery. Caspases, such as Caspase-3 and Caspase-9, are key mediators of cell death due to apoptosis in TBI. Understanding these apoptotic pathways and finding ways to inhibit Caspases may have significant treatment implications for TBI.
CURRENT NEUROPHARMACOLOGY
(2023)
Review
Oncology
Katharina Joechle, Jessica Guenzle, Claus Hellerbrand, Pavel Strnad, Thorsten Cramer, Ulf Peter Neumann, Sven Arke Lang
Summary: mTORC2, a key effector of the PI3K/AKT/mTOR pathway, is associated with tumor growth, metastasis, and resistance to therapy. The central subunit Rictor of mTORC2 is upregulated in various cancers, linked to advanced tumor stages and poor prognosis, highlighting its significance in cancer development and treatment.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Carlos Cardenas, Michele K. Montagna, Mary Pitruzzello, Eydis Lima, Gil Mor, Ayesha B. Alvero
Review
Oncology
Carlos Cardenas, Ayesha B. Alvero, Bo Seong Yun, Gil Mor
ENDOCRINE-RELATED CANCER
(2016)
Article
Oncology
Ayesha B. Alvero, Andrew Heaton, Eydis Lima, Mary Pitruzzello, Natalia Sumi, Yang Yang-Hartwich, Carlos Cardenas, Sahra Steinmacher, Dan-Arin Silasi, David Brown, Gil Mor
MOLECULAR CANCER THERAPEUTICS
(2016)
Article
Oncology
Xiaodan Fu, Yimin Li, Ayesha Alvero, Juanni Li, Qihui Wu, Qing Xiao, Yulong Peng, Yongbin Hu, Xiang Li, Wenguang Yan, Ke Guo, Wenjuan Zhou, Yong Wang, Junwen Liu, Yu Zhang, Gil Mor, Jifang Wen, Gang Yin
Article
Oncology
Yang Yang-Hartwich, Roslyn Tedja, Cai M. Roberts, Jamie Goodner-Bingham, Carlos Cardenas, Marta Gurea, Natalia J. Sumi, Ayesha B. Alvero, Carlotta A. Glackin, Gil Mor
MOLECULAR CANCER RESEARCH
(2019)
Article
Biochemistry & Molecular Biology
Y. Yang-Hartwich, M. G. Soteras, Z. P. Lin, J. Holmberg, N. Sumi, V. Craveiro, M. Liang, E. Romanoff, J. Bingham, F. Garofalo, A. Alvero, G. Mor
Article
Multidisciplinary Sciences
Ayesha B. Alvero, Dongin Kim, Eydis Lima, Natalia J. Sumi, Jung Seok Lee, Carlos Cardenas, Mary Pitruzzello, Dan-Arin Silasi, Natalia Buza, Tarek Fahmy, Gil Mor
SCIENTIFIC REPORTS
(2017)
Article
Multidisciplinary Sciences
Natalia J. Sumi, Eydis Lima, John Pizzonia, Sean P. Orton, Vinicius Craveiro, Wonduk Joo, Jennie C. Holmberg, Marta Gurrea, Yang Yang-Hartwich, Ayesha Alvero, Gil Mor
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2014)
Article
Biochemistry & Molecular Biology
Roslyn Tedja, Cai M. Roberts, Ayesha B. Alvero, Carlos Cardenas, Yang Yang-Hartwich, Sydney Spadinger, Mary Pitruzzello, Gang Yin, Carlotta A. Glackin, Gil Mor
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Juanni Li, Ayesha B. Alvero, Sudhakar Nuti, Roslyn Tedja, Cai M. Roberts, Mary Pitruzzello, Yimin Li, Qing Xiao, Sai Zhang, Yaqi Gan, Xiaoying Wu, Gil Mor, Gang Yin
Review
Cell Biology
Anthony J. Maxwell, Jiahui Ding, Yuan You, Zhong Dong, Hussein Chehade, Ayesha Alvero, Yechiel Mor, Sorin Draghici, Gil Mor
Summary: The immune response triggered by SARS-CoV-2 infection and the potential mechanisms behind various complications associated with COVID-19 need further investigation.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Article
Oncology
Christopher Walker, Tuan-Minh Nguyen, Shlomit Jessel, Ayesha B. Alvero, Dan-Arin Silasi, Thomas Rutherford, Sorin Draghici, Gil Mor
Summary: Ovarian cancer patients' survival is largely dependent on the disease extent at diagnosis, with early detection being crucial. A newly developed blood test measuring four proteins shows promise in distinguishing ovarian cancer samples, including early-stage disease, from healthy samples. Combining these proteins with the commonly used CA-125 biomarker improves accuracy and specificity in detecting ovarian cancer.
Article
Virology
A. N. van den Pol, X. Zhang, E. Lima, M. Pitruzzello, N. Albayrak, A. Alvero, J. N. Davis, G. Mor
Summary: The chimeric virus LASV-VSV showed selective infection and killing of ovarian cancer cells, leading to long-term survival and blocking cancer growth in the brain; treating mice with infected ovarian cancer cells effectively blocked the growth of non-infected cells. These results suggest LASV-VSV as a promising candidate for further study in the treatment of ovarian cancer.
Article
Oncology
Ayesha B. Alvero, Douglas Hanlon, Mary Pitruzzello, Renata Filler, Eve Robinson, Olga Sobolev, Roslyn Tedja, Alessandra Ventura, Marcus Bosenberg, Patrick Han, Richard L. Edelson, Gil Mor
Review
Immunology
Gil Mor, Paulomi Aldo, Ayesha B. Alvero
NATURE REVIEWS IMMUNOLOGY
(2017)