Article
Biochemistry & Molecular Biology
Luyan Sun, Yiran Jiang, Jing Xie, Hongyuan Zhu, Luming Wu, Xu Zhong, Weiwei Zhou, Tingwei Su, Weiqing Wang
Summary: The study found that CYP11B2 immunostaining could improve the differential diagnosis of unilateral hyperaldosteronism, and the adjusted CYP11B2 H-score reflects the severity of APA. Furthermore, abnormal beta-catenin staining was associated with various clinical indicators, suggesting that the Wnt pathway may be a potential therapeutic target in the treatment of hyperaldosteronism.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Oncology
Minhong Shen, Shanshan Xie, Michelle Rowicki, Sven Michel, Yong Wei, Xiang Hang, Liling Wan, Xin Lu, Min Yuan, John F. Jin, Frank Jaschinski, Tianhua Zhou, Richard Klar, Yibin Kang
Summary: The study found that MTDH promotes the progression of colorectal and lung cancers by facilitating Wnt activation and inducing T-cell exhaustion. Treatment with MTDH antisense oligonucleotides effectively suppresses MTDH expression and significantly attenuates the progression and metastasis of these cancers.
Article
Medicine, General & Internal
Valeria Masciullo, Tommaso Susini, Giacomo Corrado, Marina Stepanova, Alessandro Baroni, Irene Renda, Francesca Castiglione, Corrado Minimo, Alfonso Bellacosa, Benito Chiofalo, Enrico Vizza, Giovanni Scambia
Summary: This study evaluated the expression pattern and prognostic value of beta-catenin in endometrial carcinoma patients. The results showed that nuclear expression of beta-catenin was associated with a better prognosis, while membranous expression of beta-catenin was associated with a poorer prognosis. The five-year disease-related survival rate was higher for patients expressing nuclear beta-catenin compared to those expressing membranous beta-catenin.
Article
Oncology
Rahui Park, Seungmin Lee, Hyunjung Chin, Anh Thai-Quynh Nguyen, Daekee Lee
Summary: In this study, the researchers found that GNA14 promotes the progression of colorectal cancer (CRC) through the ERK and beta-catenin pathways. Knockdown of GNA14 inhibits the proliferation of CRC cells and suppresses malignant tumor progression in the intestine. These findings suggest that GNA14 may be a potential therapeutic target for CRC.
Article
Oncology
Markus A. Brown, Thomas Ried
Summary: The major signaling pathways in colon cancer are WNT, RAS, and TGF-beta. Mutations in these pathways reflect the behavior of intestinal stem cells and play a role in the progression of colon cancer. Understanding the intersection and interaction between these pathways can provide insights into the regulation of cell proliferation and the development of colon cancer.
Article
Oncology
Jiong Ning, Qi Sun, Zijie Su, Lifeng Tan, Yun Tang, Sapna Sayed, Huan Li, Vivian Weiwen Xue, Shanshan Liu, Xianxiong Chen, Desheng Lu
Summary: CK1 delta/epsilon enhance beta-catenin-mediated transcription by regulating beta-catenin acetylation. CK1 delta/epsilon interact with Tip60 and facilitate its recruitment to the beta-catenin complex, leading to increased beta-catenin acetylation at K49. Furthermore, this study discovers that a complex consisting of CK1 delta/CK1 epsilon/beta-catenin/Tip60 is present in colon cancer cells, and this complex plays an important role in beta-catenin acetylation.
FRONTIERS IN ONCOLOGY
(2022)
Article
Pathology
Edward H. Hurley, Junyan Tao, Silvia Liu, Yekaterina Krutsenko, Sucha Singh, Satdarshan P. Monga
Summary: Hepatoblastoma (HB) is the most common pediatric liver malignancy. The study found that HSF1 expression levels were higher in HB patients compared to normal liver, and correlated with mortality. Inhibition of HSF1 reduced tumor growth and promoted apoptosis, suggesting that HSF1 may be a potential therapeutic target for HB treatment.
AMERICAN JOURNAL OF PATHOLOGY
(2023)
Article
Oncology
Kaouther Ben Arfi, Christophe Schneider, Amar Bennasroune, Nicole Bouland, Aurore Wolak-Thierry, Guillaume Collin, Cuong Cao Le, Kevin Toussaint, Cathy Hachet, Veronique Lehrter, Stephane Dedieu, Olivier Bouche, Hamid Morjani, Camille Boulagnon-Rombi, Aline Appert-Collin
Summary: This study found that high expression of DDR1 is associated with worse event-free survival in CRC patients, and it may play a role in the invasive properties of colon adenocarcinoma.
Article
Multidisciplinary Sciences
Meejeong Kim, Hui Jeong Jeong, Hyun-min Ju, Ji-young Song, Se Jin Jang, Jene Choi
Summary: NEK9 plays a critical role in microtubule polymerization, chromosome alignment, and mitosis in colon cancer. Immunohistochemistry analysis of 138 patients with pT3 colon cancers revealed that NEK9 expression is associated with distant metastasis and is an independent predictive factor. Positive correlations were observed between NEK9 and EG5 or acetyl-alpha-tubulin, confirming the role of the NEK9-EG5 axis in colon cancer.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Young-Eun Cho, Jeong-Hee Kim, Young-Hyun Che, Yong-Jun Kim, Ji-Youn Sung, Yoon-Wha Kim, Bong-Geun Choe, Sun Lee, Jae-Hoon Park
Summary: ZKSCAN3 acts as an oncogenic transcription factor in human malignant tumors, and it has been identified as a downstream effector of the Wnt/β-catenin signaling pathway. It upregulates chromosomal instability in colon cancer cells by suppressing MAD2L2 expression. Moreover, the upregulation of ZKSCAN3 is an early event in the adenoma-carcinoma sequence during colon cancer development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Qihong Nie, Wei Wei Peng, Yuli Wang, Liting Zhong, Xuebing Zhang, Ling Zeng
Summary: This study revealed that berberine can inhibit the proliferation of colon cancer cells by regulating the β-catenin signaling pathway. The expression level of CTNNB1, the active component of berberine, was found to be higher in colon cancer patients compared to normal controls. This suggests that CTNNB1 may have potential clinical diagnostic and therapeutic value in colon cancer.
Article
Cell Biology
Jing Yuan, Tao Liu, Yuhong Zhang
Summary: Iron ion, as an essential microelement, plays a crucial role in cell proliferation, metabolism, and differentiation. This study identified the prognostic value of two iron metabolism-related genes (SLC39A8 and SLC48A1) in colon adenocarcinoma (COAD) and established a nomogram model to predict patient overall survival. Functional analysis showed differences in tumor microenvironment and immune cell infiltrate between low risk and high risk subgroups.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Qing Wu, Xingxing Du, Jianing Cheng, Xiuying Qi, Huan Liu, Xiaohong Lv, Xieyang Gong, Changxin Shao, Muhong Wang, Luxiao Yue, Xin Yang, Shiyu Li, Yafang Zhang, Xuemei Li, Huike Yang
Summary: Diabetes mellitus enhances the occurrence and progression of colon cancer through the internalization of platelet-endothelial cell adhesion molecule 1 (PECAM-1) and subsequent activation of beta-catenin-mediated endothelial-mesenchymal transition (EndMT).
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Biochemistry & Molecular Biology
Yung-Fu Wu, Chih-Yang Wang, Wan-Chun Tang, Yu-Cheng Lee, Hoang Dang Khoa Ta, Li-Chia Lin, Syu-Ruei Pan, Yi-Chun Ni, Gangga Anuraga, Kuen-Haur Lee
Summary: Colorectal cancer is a heterogeneous disease with genetic and epigenetic changes, and molecular assessment along with biomarker use for prognosis is gaining attention. This study identifies high mRNA levels of 10 upregulated genes in CRC cells and datasets, showing correlation with worse prognosis in CRC patients. CTNNB1 is found to be a key factor in the interaction with upregulated CRC-associated genes, particularly regulating NKD2, FOXQ1, and CEMIP, which when inhibited, can suppress CRC cell growth, providing efficient biomarkers for prognosis and a new molecular interaction network for CRC.
Article
Oncology
Lichao Guo, Wen Zhang, Yanqi Xie, Xi Chen, Emma E. Olmstead, Mengqiang Lian, Baochen Zhang, Yekaterina Y. Zaytseva, B. Mark Evers, H. Peter Spielmann, Xifu Liu, David S. Watt, Chunming Liu
Summary: Cancer cells undergo metabolic remodeling and a compound called DBI-1 that inhibits mitochondrial complex I, depriving rapidly growing cancer cells of energy needed for growth. The study suggests that DBI-1 and a glucose transport inhibitor, BAY-876, can synergistically inhibit colorectal cancer cell growth.
MOLECULAR CANCER THERAPEUTICS
(2022)