Article
Oncology
Luisa Matos do Canto, Jenilson Mota da Silva, Patricia Valeria Castelo-Branco, Ingrid Monteiro da Silva, Leudivan Nogueira, Carlos Eduardo Fonseca-Alves, Andre Khayat, Alexander Birbrair, Silma Regina Pereira
Summary: DNA sequencing plays a crucial role in understanding cancer mutational patterns. A study on HPV-associated PSCC from Latin Americans using whole-exome sequencing revealed novel pathogenic variants and potential therapeutic targets.
Article
Oncology
Natalia Domian, Grzegorz Mlynarczyk, Irena Kasacka
Summary: The study presented a case of penile squamous cell carcinoma and evaluated the expression of E-cadherin and beta-catenin through immunohistochemical analysis. It was found that E-cadherin expression decreased while beta-catenin expression slightly increased in tumor samples compared to healthy tissue, which may be related to tumor invasion and metastasis. The findings suggest potential roles of E-cadherin and beta-catenin in cell proliferation and adhesion during physiological and pathophysiological processes.
FRONTIERS IN ONCOLOGY
(2021)
Letter
Medicine, General & Internal
Nyall R. London, Melina J. Windon, Ameen Amanian, Fernando T. Zamuner, Justin Bishop, Carole Fakhry, Lisa M. Rooper
Summary: This case series examines the occurrence of HPV-associated SNSCC and the prevalence of HPV-positive SNSCC in US adults.
Review
Medical Laboratory Technology
Brian A. Keller, Elena Pastukhova, Bryan Lo, Harman S. Sekhon, Trevor A. Flood
Summary: Penile squamous cell carcinomas (PSCCs) can be classified into HPV-associated and non-HPV associated tumors, each with unique pathogenic mechanisms and clinical behaviors. Treatment options for localized PSCC tumors are associated with significant morbidity, while management of advanced disease is often challenging. Identification of actionable mutations is crucial for exploring personalized therapy options.
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2023)
Article
Oncology
George Daniel Grass, Dalia Ercan, Alyssa N. Obermayer, Timothy Shaw, Paul A. Stewart, Jad Chahoud, Jasreman Dhillon, Alex Lopez, Peter A. S. Johnstone, Silvia Regina Rogatto, Philippe E. Spiess, Steven A. Eschrich
Summary: This study provides the first description of the surfaceome in penile cancer and evaluates the impact of human papillomavirus (HPV) infection on surfaceome diversity. The analysis found a diverse surfaceome within patient tumors, with a high proportion of membrane proteins and transporters. The study also identified significant differences in protein classes based on HPV status and a prognostic immunoglobulin protein called BSG/CD147.
Article
Pathology
Diego F. Sanchez, Maria Jose Fernandez-Nestosa, Laia Alemany, Sofia Canete-Portillo, Belen Lloveras, Omar Clavero, Ingrid Rodriguez, Wim Quint, Nubia Munoz, Silvia de Sanjose, Francisco Xavier Bosch, Antonio L. Cubilla
Summary: This study evaluated different types of penile carcinoma and found variations in the genotypic composition of HPV based on their histological subtypes. HPV16 was the most common genotype, followed by HPV33 and HPV35. The current vaccination programs can cover 93% of the cases based on the identified genotypes. HPV16 was significantly more frequent in basaloid carcinomas and less frequent in warty carcinomas.
Rating: 8/10
Article
Microbiology
Abbas Karimi, Elham Mohebbi, Sandrine Mckay-Chopin, Hamideh Rashidian, Maryam Hadji, Vahideh Peyghambari, Maryam Marzban, Ahmad Naghibzadeh-Tahami, Mahin Gholipour, Farin Kamangar, Massimo Tommasino, Tarik Gheit, Kazem Zendehdel
Summary: This study analyzed the detection of alpha-, beta-, and gamma-HPVs in oral rinse samples of HNSCC cases and controls in Iran, finding that the contribution of alpha-HPVs to HNSCC in Iran is lower than global prevalence, and high-risk alpha-HPVs or cutaneous beta- and gamma-HPVs were not associated with HNSCC development.
MICROBIOLOGY SPECTRUM
(2022)
Article
Oncology
Kang-Bo Huang, Sheng-Jie Guo, Yong-Hong Li, Xin-Ke Zhang, Dong Chen, Philippe E. Spiess, Zai-Shang Li, Chuang-Zhong Deng, Jie-Ping Chen, Qiang-Hua Zhou, Zheng Hu, Xin Ma, Jie-Tian Jin, Yun Cao, Jun-Hang Luo, Xiao-Bin Wang, Fang-Jian Zhou, Ran-Yi Liu, Hui Han
Summary: Penile squamous cell carcinoma (PSCC) is considered an HPV-related cancer, with unclear integration patterns and carcinogenic pathways. This study found that HPV integration in PSCC may not follow the traditional E6/E7 process, impacting host genes and activating oncogenic pathways. These insights enhance understanding of HPV-induced carcinogenesis in PSCC.
Article
Pathology
Justin R. Shinn, Seth J. Davis, Krystle A. Lang-Kuhs, Sarah Rohde, Xiaowei Wang, Ping Liu, William D. Dupont, Dale Plummer, Wade L. Thorstad, Rebecca D. Chernock, Mitra Mehrad, James S. Lewis
Summary: The study found a high positivity rate of p16 and HPV mRNA in oropharyngeal squamous cell carcinoma patients, with those who had concordant testing results showing higher survival rates. While patients with discordant testing results had survival rates falling between the two concordant groups, there was no significant difference found in outcomes in multivariate analysis.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Article
Ophthalmology
Ingvild Ramberg, Filipe Garrett Vieira, Peter Bjerre Toft, Christian von Buchwald, Mikkel Funding, Finn Cilius Nielsen, Steffen Heegaard
Summary: The study has identified two potentially distinct distributions of somatic mutations in conjunctival SCC based on HPV status, indicating the significant role of HPV in carcinogenesis in certain cases.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Multidisciplinary Sciences
Zhong Liang, Meijuan Wu, Peng Wang, Huatao Quan, Jianqiang Zhao
Summary: The study investigated the racial disparities in hypopharyngeal squamous cell carcinoma (HPSCC) in the US. It found that HPSCC incidence decreased among both males and females of different racial groups during the study period. Non-Hispanic black individuals had the highest incidence, while non-Hispanic Asian or Pacific Islanders had the lowest. NHB patients had worse prognosis and higher burden of HPSCC compared to NHW, while Hispanic patients had a better prognosis in certain stages. The study emphasizes the need for further research to reduce racial disparities and improve early detection of HPSCC.
Article
Oncology
Xinyi Liu, Ping Liu, Rebecca D. Chernock, Krystle A. Lang Kuhs, James S. Lewis, Hua Li, Hiram A. Gay, Wade L. Thorstad, Xiaowei Wang
Summary: This study identified differences in tumor microenvironment (TME) associated with HPV infection in OPSCC, with enrichment of specific cell types in HPV+ and HPV- OPSCCs. By constructing a coexpression network, it was found that HPV+ OPSCCs exhibit elevated immune activities and suppressed extracellular matrix-related activities compared to HPV- OPSCCs. Clinical analysis showed that TME-relevant genes were closely linked to prognosis and therapy response in OPSCC, with results validated in an independent OPSCC cohort.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Pathology
Burak Tekin, John C. Cheville, Loren Herrera Hernandez, Vivian Negron, Carin Y. Smith, Sarah M. Jenkins, Surendra Dasari, Elizabeth Ann L. Enninga, Andrew P. Norgan, Santosh Menon, Antonio L. Cubilla, Rumeal D. Whaley, Rafael E. Jimenez, R. Houston Thompson, Bradley C. Leibovich, R. Jeffrey Karnes, Stephen A. Boorjian, Lance C. Pagliaro, Lori A. Erickson, Ruifeng Guo, Sounak Gupta
Summary: This study investigated the expression of PD-L1, TROP2, and nectin-4 in advanced penile squamous cell carcinoma (pSCC). High expression of TROP2 and nectin-4 were associated with disease progression and mortality.
Article
Oncology
Jad Chahoud, Niki M. M. Zacharias, Rachel Pham, Wei Qiao, Ming Guo, Xin Lu, Angelita Alaniz, Luis Segarra, Magaly Martinez-Ferrer, Frederico Omar Gleber-Netto, Curtis R. R. Pickering, Priya Rao, Curtis A. A. Pettaway
Summary: In patients with penile squamous cell carcinoma, the expression of p16 is associated with better outcomes, while HPV status does not predict survival outcomes.
Article
Oncology
Jin Zhang, Quyang Yang, Jinyan Wu, Ruoyue Yuan, Xiansheng Zhao, Yue Li, Xiujun Cheng, Baojin Wu, Ningwen Zhu
Summary: This study analyzed the trend in incidence and incidence-based mortality for cutaneous squamous cell carcinoma (cSCC) on the lips in the USA using demographic characteristics from the SEER database. The overall incidence of cSCC on the lips decreased by 3.210% annually from 2000 to 2019, while incidence-based mortality increased by 4.975% per year during the same period.
FRONTIERS IN ONCOLOGY
(2023)
Article
Immunology
Feixue Wei, Ningshao Xia, Rebeca Ocampo, Marc T. Goodman, Nancy A. Hessol, Beatriz Grinsztejn, Ana P. Ortiz, Fanghui Zhao, Erna M. Kojic, Rupert Kaul, Isabelle Heard, Imran O. Morhason-Bello, Anna-Barbara Moscicki, Alexandra de Pokomandy, Joel M. Palefsky, Luana L. S. Rodrigues, Racheal S. Dube Mandishora, Reshmie A. Ramautarsing, Silvia Franceschi, Sheela Godbole, Fernanda K. Tso, Lynette J. Menezes, Chunqing Lin, Gary M. Clifford
Summary: Age-specific shifts in HPV16 prevalence from cervix to anus suggest that HPV infections may persist longer, or occur later in life, in the anus than cervix. This has important implications for using cervical screening results to direct anal cancer prevention.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Immunology
Feixue Wei, Marc T. Goodman, Ningshao Xia, Jun Zhang, Anna R. Giuliano, Gypsyamber D'Souza, Nancy A. Hessol, Maarten F. Schim van der Loeff, Jianghong Dai, Karin Neukam, Alexandra de Pokomandy, I. Mary Poynten, Ronald B. Geskus, Joaquin Burgos, Isabelle Etienney, Anna Barbara Moscicki, Maria Gabriella Dona, Maura L. Gillison, Alan G. Nyitray, Rebecca G. Nowak, Evy Yunihastuti, Huachun Zou, Carmen Hidalgo-Tenorio, Nittaya Phanuphak, Jean Michel Molina, Alice M. Schofield, Stephen Kerr, Song Fan, Yong Lu, Jason J. Ong, Admire T. Chikandiwa, Sirinya Teeraananchai, Nicola Squillace, Dorothy J. Wiley, Joel M. Palefsky, Damien Georges, Catharina J. Alberts, Gary M. Clifford
Summary: This study provides a comprehensive analysis of the natural history of anal high-risk HPV infection and identifies differences among different risk groups. These findings are crucial for designing effective anal cancer prevention programs.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Oncology
Kyle M. Walsh, Corey Neff, Melissa L. Bondy, Carol Kruchko, Jason T. Huse, Christopher Amos, Jill S. Barnholtz-Sloan, Quinn T. Ostrom
Summary: The incidence and outcomes of glioma differ in association with the geographic origins of Hispanic communities, with predominantly Mexican/Central American-origin counties at reduced risk and predominantly Caribbean-origin counties at greater risk. Higher incidence and improved survival are associated with European admixture in Hispanic patients.
Article
Oncology
Joshua D. Palmer, Rahul N. Prasad, Gino Cioffi, Carol Kruchtko, Nicholas G. Zaorsky, Daniel M. Trifiletti, Vinai Gondi, Paul D. Brown, Haley K. Perlow, Mark Mishra, Arnab Chakravarti, Jill S. Barnholtz-Sloan, Quinn T. Ostrom
Summary: This study suggests a potential association between exposure to high levels of particulate pollution and radon and increased incidence of non-malignant brain tumors. However, more research is needed to confirm these findings in other populations.
Article
Clinical Neurology
Kailey Takaoka, Gino Cioffi, Kristin A. Waiter, Jonathan L. Finlay, Daniel Landi, Kaitlyn Greppin, Carol Kruchko, Quinn T. Ostrom, Jill S. Barnholtz-Sloan
Summary: This study provides the latest epidemiological analysis of choroid plexus tumors in the US from 2004 to 2017, showing that choroid plexus papilloma is the most common subtype and the incidence is highest among young patients, while choroid plexus carcinoma has the lowest survival rate.
NEURO-ONCOLOGY PRACTICE
(2023)
Article
Oncology
Ashley Weir, Eun-Young Kang, Nicola S. Meagher, Gregg S. Nelson, Prafull Ghatage, Cheng-Han Lee, Marjorie J. Riggan, Aleksandra Gentry-Maharaj, Andy Ryan, Naveena Singh, Martin Widschwendter, Jennifer Alsop, Michael S. Anglesio, Matthias W. Beckmann, Jessica Berger, Christiani Bisinotto, Jessica Boros, Alison H. Brand, James D. Brenton, Angela Brooks-Wilson, Michael E. Carney, Julie M. Cunningham, Kara L. Cushing-Haugen, Cezary Cybulski, Esther Elishaev, Ramona Erber, Sian Fereday, Anna Fischer, Luis Paz-Ares, Javier Gayarre, Blake C. Gilks, Marcel Grube, Paul R. Harnett, Holly R. Harris, Arndt Hartmann, Alexander Hein, Joy Hendley, Brenda Y. Hernandez, Sabine Heublein, Yajue Huang, Tomasz Huzarski, Anna Jakubowska, Mercedes Jimenez-Linan, Catherine J. Kennedy, Felix K. F. Kommoss, Jennifer M. Koziak, Bernhard Kraemer, Nhu D. Le, Jaime Lesnock, Jenny Lester, Jan Lubinski, Janusz Menkiszak, Britta Ney, Alexander Olawaiye, Sandra Orsulic, Ana Osorio, Luis Robles-Diaz, Matthias Ruebner, Mitul Shah, Raghwa Sharma, Yurii B. Shvetsov, Helen Steed, Aline Talhouk, Sarah E. Taylor, Nadia Traficante, Robert A. Vierkant, Chen Wang, Lynne R. Wilkens, Stacey J. Winham, Javier Benitez, Andrew Berchuck, David D. Bowtell, Francisco J. Candido dos Reis, Linda S. Cook, Anna DeFazio, Jennifer A. Doherty, Peter A. Fasching, Maria J. Garcia, Ellen L. Goode, Marc T. Goodman, Jacek Gronwald, David G. Huntsman, Beth Y. Karlan, Stefan Kommoss, Francesmary Modugno, Joellen M. Schildkraut, Hans-Peter Sinn, Annette Staebler, Linda E. Kelemen, Caroline E. Ford, Usha Menon, Paul D. P. Pharoah, Martin Koebel, Susan J. Ramus, D. Bowtell, A. DeFazio, N. Traficante, S. Fereday, A. Brand, P. Harnett, R. Sharma
Summary: Recently, a study found a positive correlation between protein expression of FOXJ1 and the 5-year survival rate of patients with tubo-ovarian high-grade serous carcinoma (HGSC). However, protein expression of GMNN was not significantly associated with patient survival. This study provides preliminary evidence for the prognostic value of FOXJ1 in HGSC and validates the prior mRNA-based prognostic association through immunohistochemistry.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Theodore M. Brasky, Erinn M. Hade, David E. Cohn, Alison M. Newton, Stacey Petruzella, Kelli O'Connell, Kimberly A. Bertrand, Linda S. Cook, Immaculata De Vivo, Mengmeng Du, Jo L. Freudenheim, Christine M. Friedenreich, Marc T. Goodman, Jessica Gorzelitz, Torukiri I. Ibiebele, Vittorio Krogh, Linda M. Liao, Loren Lipworth, Lingeng Lu, Susan McCann, Tracy A. O'Mara, Julie R. Palmer, Jeanette Ponte, Anna Prizment, Harvey Risch, Sven Sandin, Leo J. Schouten, Veronica Wendy Setiawan, Xiao-ou Shu, Britton Trabert, Piet A. van den Brandt, Penelope M. Webb, Nicolas Wentzensen, Lynne R. Wilkens, Alicja Wolk, Herbert Yu, Marian L. Neuhouser
Summary: This study analyzed data from 12 prospective cohort studies and found that higher dietary intake of long-chain omega-3 polyunsaturated fatty acids (LCn3PUFA) may increase the risk of endometrial cancer, especially among specific subgroups characterized by body weight and tumor pathology.
GYNECOLOGIC ONCOLOGY
(2023)
Review
Oncology
Julie J. Miller, L. Nicolas Gonzalez Castro, Samuel McBrayer, Michael Weller, Timothy Cloughesy, Jana Portnow, Ovidiu Andronesi, Jill S. Barnholtz-Sloan, Brigitta G. Baumert, Mitchell S. Berger, Wenya Linda Bi, Ranjit Bindra, Daniel P. Cahill, Susan M. Chang, Joseph F. Costello, Craig Horbinski, Raymond Y. Huang, Robert B. Jenkins, Keith L. Ligon, Ingo K. Mellinghoff, L. Burt Nabors, Michael Platten, David A. Reardon, Diana D. Shi, David Schiff, Wolfgang Wick, Hai Yan, Andreas von Deimling, Martin van den Bent, William G. Kaelin, Patrick Y. Wen
Summary: This article discusses the diagnosis and management of IDH-mutant gliomas, as well as new treatment methods and future research directions.
Article
Oncology
Quinn T. Ostrom, Madison L. Shoaf, Gino Cioffi, Kristin Waite, Carol Kruchko, Patrick Y. Wen, Daniel J. Brat, Jill S. Barnholtz-Sloan, J. Bryan Iorgulescu
Summary: This study utilized data from the U.S. National Cancer Database to estimate the national-level overall survival patterns of molecularly-defined diffuse gliomas. The findings demonstrate differences in survival rates among different glioma types, and the impact of WHO grade and MGMT promoter methylation on survival.
Article
Clinical Neurology
Corey Neff, Gino Cioffi, Kristin Waite, Carol Kruchko, Jill S. Barnholtz-Sloan, Quinn T. Ostrom, J. Bryan Iorgulescu
Summary: This study investigated the testing and reporting completeness of a newly developed brain molecular marker (BMM) in the US. The overall completeness was 81.1%, with variations among different subgroups and hospital attributes.
NEURO-ONCOLOGY PRACTICE
(2023)
Article
Oncology
Nickolas Stabellini, Benjamin Tomlinson, Jennifer Cullen, John Shanahan, Kristin Waite, Alberto J. J. Montero, Jill S. S. Barnholtz-Sloan, Nelson Hamerschlak
Summary: This study conducted a comprehensive analysis of sex differences in acute myeloid leukemia (AML) and found that there are disparities in incidence and survival between males and females. Treatment and healthcare factors have important implications for survival rates.
Article
Oncology
Robin Taylor Wilson, Susan E. Safford, Quinn T. Ostrom, Ming Wang, Alicia C. McDonald, Anna C. Salzberg, Jill S. Barnholtz-Sloan, John P. Richie
Summary: In this cross-sectional study, little is known regarding factors associated with calcitriol and the calcitriol-24,25-dihydroxyvitamin D3-calcifediol proportion ratio (C24CPR). The study found that calcitriol and C24CPR were both significantly, positively, and monotonically associated with West African genetic ancestry proportion (WGA). These findings suggest that C24CPR may be more suitable for personalized medicine.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Oncology
Nickolas Stabellini, Jennifer Cullen, Marcio S. Bittencourt, Justin X. Moore, Lifen Cao, Neal L. Weintraub, Ryan A. Harris, Xiaoling Wang, Biplab Datta, Steven S. Coughlin, Jorge Garcia, John Shanahan, Nelson Hamerschlak, Kristin Waite, Nathanael R. Fillmore, Martha Terris, Alberto J. Montero, Jill S. Barnholtz-Sloan, Avirup Guha
Summary: Cardiovascular disease is the leading cause of death in men with prostate cancer, and accumulated stress plays a crucial role in its development. This study examined the impact of allostatic load (AL) on major cardiac events (MACE) in prostate cancer patients. The results showed that AL and its changes over time are associated with an increased risk of MACE.
JNCI CANCER SPECTRUM
(2023)
Article
Clinical Neurology
Mackenzie Price, Katherine Ryan, Madison L. Shoaf, Corey Neff, J. Bryan Iorgulescu, Daniel B. Landi, Gino Cioffi, Kristin A. Waite, Carol Kruchko, Jill S. Barnholtz-Sloan, Quinn T. Ostrom
Summary: This report summarizes the latest population-based incidence, mortality, and survival data for primary brain and other CNS tumors in the US, aiming to serve as a concise resource for neuro-oncology providers.
NEURO-ONCOLOGY PRACTICE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Charit Tippareddy, Louisa Onyewadume, Andrew E. Sloan, Gi-Ming Wang, Nirav T. Patil, Siyuan Hu, Jill S. Barnholtz-Sloan, Rasim Boyacioglu, Vikas Gulani, Jeffrey Sunshine, Mark Griswold, Dan Ma, Chaitra Badve
Summary: This study aimed to test the feasibility of using 3D MRF maps with radiomics analysis and machine learning in the characterization of adult brain intra-axial neoplasms. The results showed that MRF maps were able to differentiate tumors based on type, grade, and IDH1 status. Furthermore, the radiomics features of MRF maps can also characterize gliomas based on grade, IDH1 status, and survival.
EUROPEAN RADIOLOGY
(2023)