Article
Oncology
Itai Margulis, Inna Naroditsky, Miriam Gross-Cohen, Neta Ilan, Israel Vlodavsky, Ilana Doweck
Summary: Activity of the endo-beta-glucuronidase heparanase, capable of cleaving heparan sulfate (HS), is often elevated in tumors, leading to increased metastasis and decreased survival rates of patients. Heparanase inhibitors are currently being tested in clinical trials for cancer treatment. Another enzyme called Hpa2 has been found to play a role in attenuating tumor growth in head and neck cancer by reducing tumor cell dissemination to lymph nodes. High levels of Hpa2 were associated with improved survival in these patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yumeng Cui, Xiaojie Wu, Jie Jin, Weiling Man, Jie Li, Xiang Li, Yanghua Li, He Yao, Rongbin Zhong, Shiyun Chen, Jiahui Wu, Tianhao Zhu, Yanli Lin, Junjie Xu, Youliang Wang
Summary: In this study, circHERC1 was found to be significantly upregulated in lung cancer tissues and cells, and its ectopic expression promoted proliferation, invasion, and metastasis while inhibiting apoptosis of lung cancer cells both in vitro and in vivo. Mechanistic studies revealed that circHERC1 acted as a competitive endogenous RNA of miR-142-3p to relieve the suppressive effect on its target HMGB1, thus activating the MAPK/ERK and NF-kappa B pathways and promoting migration and invasion. Additionally, circHERC1 was found to sequester FOXO1 in the cytoplasm, regulating AKT activity and BIM transcription, which led to increased cell proliferation and decreased apoptosis.
Review
Medicine, Research & Experimental
Jiajing Sun, Sikai Wu, Zixian Jin, Sijia Ren, William C. Cho, Chengchu Zhu, Jianfei Shen
Summary: Lung cancer has high morbidity and mortality rates, with tumor metastasis being a significant risk factor for death. Even after complete removal of a tumor at an early stage, there is still a risk of recurrence. Lymph node micrometastasis has been found to be associated with poor prognosis, but predicting prognosis and choosing the appropriate surgical and postoperative adjuvant chemotherapy options remain challenging for clinicians.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemical Research Methods
Yang Lin, Xiaoyong Pan, Hong-Bin Shen
Summary: This study presents an updated cell-line-specific predictor IncLocator 2.0, which uses deep models trained per cell line to predict IncRNA subcellular localization from sequences. By constructing benchmark datasets, learning word embeddings, and utilizing different neural networks, IncLocator 2.0 achieves varying effectiveness in different cell lines and demonstrates the necessity of training cell-line-specific models. Moreover, the use of Integrated Gradients helps explain the proposed model and identifies potential patterns related to specific nucleotides that determine the subcellular localizations of IncRNAs.
Article
Multidisciplinary Sciences
Casper de Boer, Zachary Armstrong, Vincent A. J. Lit, Uri Barash, Gijs Ruijgrok, Ilanit Boyango, Merle M. Weitzenberg, Sybrin P. Schroder, Alexi J. C. Sarris, Nico J. Meeuwenoord, Pedro Bule, Yasmine Kayal, Neta Ilan, Jeroen D. C. Codee, Israel Vlodavsky, Herman S. Overkleeft, Gideon J. Davies, Liang Wu
Summary: Research has shown that by developing effective HPSE inhibitors, extracellular HPSE activity can be reduced, thereby reducing the aggressiveness of cancer and potentially controlling pathological HPSE-driven malignancies.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Cell Biology
Yiyuan Yang, Fengyan Yuan, Huiqin Zhou, Jing Quan, Chongyang Liu, Yi Wang, Fen Xiao, Qiao Liu, Jie Liu, Yujing Zhang, Xing Yu
Summary: Heparanase (HPSE) is an enzyme that degrades heparan sulfate proteoglycans, and its activity is associated with tumor growth and angiogenesis. In this review, the roles and mechanisms of HPSE in cancer progression are systematically reviewed. Additionally, potential therapeutic strategies targeting HPSE, including HPSE inhibitors in clinical trials, are discussed.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Anna Cazzola, David Calzon Lozano, Dennis Hirsch Menne, Raquel Davila Pedrera, Jingcheng Liu, Daniel Pena-Jimenez, Silvia Fontenete, Cornelia Halin, Mirna Perez-Moreno
Summary: Lymph vessels and lymph node involvement are crucial in the staging of various cancers. In skin squamous cell carcinoma, lymph vessels have a significant role in cancer development and metastasis. However, their interaction with the cancer stem cell niche during early tumor stages has not been well understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Silvio Terra Stefanello, Isabelle Luchtefeld, Ivan Liashkovich, Zoltan Pethoe, Ihab Azzam, Etmar Bulk, Gonzalo Rosso, Lilly Doehlinger, Bettina Hesse, Andrea Oeckinghaus, Victor Shahin
Summary: NPCs play a crucial role in the malignant transformation and survival of lung cancer cells, with increased density during malignancy and potential for pharmacological interference to induce structural changes and halt migration. Decreased levels of Lamin A/C are associated with malignancy and reduced mechanical stability, suggesting modulation of the NPC barrier as a potential strategy for suppressing malignancy or enhancing chemotherapy effectiveness.
Review
Biochemistry & Molecular Biology
Marilina Mascaro, Eliana N. Alonso, Exequiel G. Alonso, Ezequiel Lacunza, Alejandro C. Curino, Maria Marta Facchinetti
Summary: Heme Oxygenase-1 (HO-1) is a detoxifying enzyme that catalyzes heme degradation, and its nuclear translocation may play a role in cancer progression. This enzyme leaves the smooth endoplasmic reticulum membrane and migrates to the nucleus, potentially contributing to therapy resistance and metastasis.
Review
Virology
Nadjet Lebsir, Fabien Zoulim, Boyan Grigorov
Summary: Heparanase-1 is an important enzyme involved in viral infections and cancer, and its inhibitors can be used as both anti-cancer drugs and antiviral agents, potentially solving drug resistance issues in current antiretroviral therapies.
Article
Biochemistry & Molecular Biology
Ying Ma, Jun Weng, Ning Wang, Yilei Zhang, Nagahiro Minato, Li Su
Summary: This study identified a novel nuclear localization region of SIPA1 which is crucial for translocating the proteins into the nucleus, and its impact on the sensitivity of breast cancer cells to epirubicin.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Cell Biology
Hind Al Khashali, Jadziah Wareham, Ravel Ray, Ben Haddad, Kai-Ling Coleman, Robert Ranzenberger, Patrick McCombs, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans
Summary: This study investigates the roles of heparanase and IGFBP-3 in regulating the survival of non-small-cell lung cancer cells. The results suggest that inhibiting heparanase activity or expression decreases the levels of soluble HS fragments and reduces interactions between IGFBP-3 and HS. Additionally, blocking HA-CD44 signaling increases p53 activity and the levels of IGFBP-3. Silencing p53 leads to increased heparanase levels, while silencing IGFBP-3 blocks p53 activity and increases heparanase levels.
Article
Cell Biology
Youhui Si, Yihan Wang, Qiaomu Tian, Qiang Wang, Jared M. Pollard, Pramod K. Srivastava, Aaron P. Esser-Kahn, Joel H. Collier, Anne I. Sperling, Anita S. Chong
Summary: The current study provides evidence that intranasal administration of peptide antigens primes naive CD8+ T cells in the lung independently before priming in the draining mediastinal lymph node. The transcriptional responses of lung cDC1 and cDC2 to intranasal nanofiber immunization were found to be distinct, but both subsets acquire shared transcriptional responses upon migration into the lymph node, revealing a stepwise activation process of cDC1 and cDC2 towards their ability to cross-prime effector and functional memory CD8+ T cell responses.
Article
Chemistry, Multidisciplinary
Hong Liu, Zhenfu Wen, Haolin Chen, Zeyu Yang, Zhicheng Le, Zhijia Liu, Yongming Chen, Lixin Liu
Summary: This study demonstrates the potential of modified nanoparticles to target lymph nodes and enhance immune responses for cancer therapy.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Biochemistry & Molecular Biology
Karolien Vanhove, Elien Derveaux, Liesbet Mesotten, Michiel Thomeer, Maarten Criel, Hanne Marien, Peter Adriaensens
Summary: In this paper, the authors discuss the metabolic changes in lung cancer patients and the metabolic cooperation between tumor cells and healthy tissue, as well as the potential application of metabolomics in the management of lung cancer patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Anna Shteingauz, Ilanit Boyango, Inna Naroditsky, Edward Hammond, Maayan Gruber, Ilana Doweck, Neta Ilan, Israel Vlodavsky
Article
Biochemistry & Molecular Biology
Yelena Kravtsova-Ivantsiv, Inna Shomer, Victoria Cohen-Kaplan, Berend Snijder, Giulio Superti-Furga, Hedva Gonen, Thomas Sommer, Tamar Ziv, Arie Admon, Inna Naroditsky, Muhammad Jbara, Ashraf Brik, Eli Pikarsky, Yong Tae Kwon, Ilana Doweck, Aaron Ciechanover
Article
Chemistry, Multidisciplinary
Morad K. Nakhleh, Haitham Amal, Raneen Jeries, Yoav Y. Broza, Manal Aboud, Alaa Gharra, Hodaya Ivgi, Salam Khatib, Shifaa Badarneh, Lior Har-Shai, Lea Glass-Marmor, Izabella Lejbkowicz, Ariel Miller, Samih Badarny, Raz Winer, John Finberg, Sylvia Cohen-Kaminsky, Frederic Perros, David Montani, Barbara Girerd, Giles Garcia, Gerald Simonneau, Farid Nakhoul, Shira Baram, Raed Salim, Marwan Hakim, Maayan Gruber, Ohad Ronen, Tal Marshak, Ilana Doweck, Ofer Nativ, Zaher Bahouth, Da-you Shi, Wei Zhang, Qing-ling Hua, Yue-yin Pan, Li Tao, Hu Liu, Amir Karban, Eduard Koifman, Tova Rainis, Roberts Skapars, Armands Sivins, Guntis Ancans, Inta Liepniece-Karele, Ilze Kikuste, Ieva Lasina, Ivars Tolmanis, Douglas Johnson, Stuart Z. Millstone, Jennifer Fulton, John W. Wells, Larry H. Wilf, Marc Humbert, Marcis Leja, Nir Peled, Hossam Haick
Article
Oncology
Miriam Gross-Cohen, Sari Feld, Ilana Doweck, Gera Neufeld, Peleg Hasson, Gil Arvatz, Uri Barash, Inna Naroditsky, Neta Ilan, Israel Vlodavsky
Article
Integrative & Complementary Medicine
Eran Ben-Arye, Ilana Doweck, Elad Schiff, Noah Samuels
EXPLORE-THE JOURNAL OF SCIENCE AND HEALING
(2018)
Article
Oncology
M. Gruber, U. Tisch, R. Jeries, H. Amal, M. Hakim, O. Ronen, T. Marshak, D. Zimmerman, O. Israel, E. Amiga, I. Doweck, H. Haick
BRITISH JOURNAL OF CANCER
(2014)
Article
Otorhinolaryngology
Benzion Joshua, Michael J. Kaplan, Ilana Doweck, Reetesh Pai, Irving L. Weissman, Mark E. Prince, Laurie E. Ailles
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2012)
Article
Biochemistry & Molecular Biology
Victoria Cohen-Kaplan, Jenny Jrbashyan, Yoav Yanir, Inna Naroditsky, Ofer Ben-Izhak, Neta Ilan, Ilana Doweck, Israel Vlodavsky
JOURNAL OF BIOLOGICAL CHEMISTRY
(2012)
Editorial Material
Clinical Neurology
Ronen Brand, Rabia Shihada, Yoram Segev, Ilana Doweck, Derald Brackmann, Michal Luntz
OTOLOGY & NEUROTOLOGY
(2012)
Article
Multidisciplinary Sciences
Uri Barash, Gil Arvatz, Roy Farfara, Inna Naroditsky, Ilana Doweck, Sari Feld, Ofer Ben-Izhak, Neta Ilan, Ofer Nativ, Israel Vlodavsky
Article
Oncology
Itai Margulis, Inna Naroditsky, Miriam Gross-Cohen, Neta Ilan, Israel Vlodavsky, Ilana Doweck
Summary: Activity of the endo-beta-glucuronidase heparanase, capable of cleaving heparan sulfate (HS), is often elevated in tumors, leading to increased metastasis and decreased survival rates of patients. Heparanase inhibitors are currently being tested in clinical trials for cancer treatment. Another enzyme called Hpa2 has been found to play a role in attenuating tumor growth in head and neck cancer by reducing tumor cell dissemination to lymph nodes. High levels of Hpa2 were associated with improved survival in these patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Health Care Sciences & Services
Rana Shibli, Ofra Barnett, Zomoroda Abu-Full, Naomi Gronich, Ronza Najjar-Debbiny, Ilana Doweck, Gad Rennert, Walid Saliba
Summary: The study suggests an association between the BNT162b2 mRNA COVID-19 vaccine and an increased risk of Bell's palsy, especially in older females. However, the attributable risks are relatively small, indicating a minor impact on public health. The benefits of vaccination outweigh the potential link to Bell's palsy, which has a high recovery rate if promptly treated with corticosteroids.
LANCET REGIONAL HEALTH-EUROPE
(2021)
Article
Medicine, General & Internal
Forsan Jahshan, Liana Doweck, Ohad Ronen
ISRAEL MEDICAL ASSOCIATION JOURNAL
(2016)
Article
Clinical Neurology
Maayan Gruber, Ariel Roitman, Ilana Doweck, Nechama Uri, Pninit Shaked-Mishan, Aharon Kolop-Feldman, Raanan Cohen-Kerem
OTOLOGY & NEUROTOLOGY
(2015)
Article
Medicine, General & Internal
Salem Billan, Orit Kaidar-Person, Fadi Atrash, Ilana Doweck, Nissim Haim, Abraham Kuten, Ohad Ronen
ISRAEL MEDICAL ASSOCIATION JOURNAL
(2013)