Article
Biochemistry & Molecular Biology
Reda F. A. Abdelhameed, Amany K. Ibrahim, Mahmoud A. Elfaky, Eman S. Habib, Mayada Mahamed, Eman T. Mehanna, Khaled M. Darwish, Dina M. Khodeer, Safwat A. Ahmed, Sameh S. Elhady
Summary: Cynanchum acutum L. is a climbing vine in the Apocynaceae family, and seven compounds were isolated from its methanolic extract, including six flavonoids with anti-inflammatory and antioxidant properties. Among them, quercetin-3-O-galactoside and quercetin demonstrated superior anti-inflammatory activity compared to other bioactive metabolites.
Article
Medicine, Research & Experimental
Akiko Inujima, Keiichi Koizumi, Naotoshi Shibahara
Summary: Research on bioactive components of herbal medicines has traditionally focused on secondary metabolites of herbal plants, with limited information on primary metabolites. This study highlights the immunostimulatory effects of heat-resistant RNA in a decoction of Glycyrrhizae Radix, suggesting nucleic acids as a new research field in the bioactive components of herbal medicines. By activating specific pathways and inducing cytokine production, the RNA demonstrated potential for therapeutic applications.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Cell Biology
Qiang-Wei Wang, Wei-Wei Lin, Yong-Jian Zhu
Summary: This study integrated and analyzed the expression patterns and clinical significance of TNF family-related genes in gliomas. It was found that the expression of most TNF family members was positively correlated and most were related to the overall survival of patients. A TNF family-based signature was developed and shown to be an independent prognostic marker for glioma patients.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Genetics & Heredity
Rafael Renatino Canevarolo, Nathalia Moreno Cury, Jose Andres Yunes
Summary: Acute lymphoblastic leukemia (ALL) is a common childhood cancer with high relapse rate due to drug resistance. Methotrexate (MTX) is commonly used but its mechanism and resistance are complex. This study found that the TNF-alpha signaling pathway via the NF-kappa B pathway is the most enriched cancer hallmark in MTX-poor-responder patients.
Article
Nutrition & Dietetics
Won-Gun Kwack, Yoon-Je Lee, Eun-Young Eo, Jin-Haeng Chung, Jae-Ho Lee, Young-Jae Cho
Summary: The study found that simultaneous pretreatment with enteral administration of aspirin and omega-3 fatty acid could alleviate lung injury and reduce inflammatory response in a murine VILI model. This combined pretreatment method may become a preventive strategy for VILI in critically ill patients undergoing mechanical ventilation therapy.
Article
Biochemistry & Molecular Biology
Aline de Oliveira Rezende, Rafaella Santos Saboia, Adeliane Castro da Costa, Diana Messala Pinheiro da Silva Monteiro, Adrielle Zagmignan, Luis Angelo Macedo Santiago, Rafael Cardoso Carvalho, Paulo Vitor Soeiro Pereira, Ana Paula Junqueira-Kipnis, Eduardo Martins de Sousa
Summary: This study investigated the association of HIF-1 alpha expression and related mechanisms with latent or active tuberculosis infection. The results showed that IL-15 expression was higher in individuals with LTBI, while IL-18 and TNF-alpha expression were similar between LTBI and TB groups. Additionally, patients with active TB had higher serum 25(OH)D3 levels and expression of IL-6, HIF1A, and A20. The study also found that PBMCs from individuals with LTBI showed decreased NF-kappa B phosphorylation and increased TNF-alpha production after HIF-1 alpha blockade.
Article
Biochemistry & Molecular Biology
Changhao Jia, Ying Zhao, Hui Huang, Ke Fan, Tao Xie, Meilin Xie
Summary: The study found that apigenin can sensitize glioma to radiotherapy by inhibiting glycolytic enzymes and protein expressions, reducing cell stemness, and DNA damage repair.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Infectious Diseases
Yi-Jung Li, Jiun-Wen Wang, Hsin-Hsu Wu, Hsu-Han Wang, Yang-Jen Chiang, Huang-Yu Yang, Hsiang-Hao Hsu, Chih-Wei Yang, Ya-Chung Tian
Summary: Inhibition of TNF-alpha can attenuate the inflammatory response and viral replication induced by BKPyV infection, providing a potential therapeutic target for BKPyV-associated kidney damage.
Article
Medicine, Research & Experimental
Yin-Yuan Su, Yu-Ling Liu, Hsuan-Cheng Huang, Chen-Ching Lin
Summary: This study used an ensemble learning model to identify genes associated with the NF kappa B/TNF signaling pathway in cancer using transcriptome data from the TCGA database. The identified genes were found to be involved in adaptive immunity, anti-apoptosis, and cellular response to cytokine stimuli, and had detrimental effects on patient survival. This research provides valuable insights for the discovery of precise and targeted cancer therapeutics.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Ting Zhao, Jianming Zeng, Yujie Xu, Zhongping Su, Yulong Chong, Tao Ling, Haozhe Xu, Hui Shi, Minggao Zhu, Qi Mo, Xiaoying Huang, Yingchang Li, Xiaoren Zhang, Hongbin Ni, Qiang You
Summary: This study reveals that CHI3L1 is overexpressed in glioma and plays a crucial role in tumor progression. It enhances the NF-kappa B signaling pathway and interacts with ACTN4 and NFKB1. Additionally, CHI3L1 reprograms the tumor microenvironment and contributes to M2 macrophage polarization. It is also positively correlated with the expression of immune checkpoints and remodels the TME to an immunosuppressive phenotype.
Review
Neurosciences
Mengtan Cai, Weihong Lin
Summary: NF-kappa B is a transcriptional regulator that plays important roles in inflammation, neuronal survival, and apoptosis. It is upregulated in epilepsy and causes functional changes in the central nervous system. Regulating NF-kappa B may be a safe and effective treatment strategy for epilepsy.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Pathology
Lisa J. Schlein, Douglas H. Thamm
Summary: Spontaneous tumors in dogs share similarities with human cancers, making them an attractive model. There is evidence of NF-kB signaling aberration in canine cancers, suggesting that dogs may serve as a good model for studying human cancers with overactivation of NF-kB.
VETERINARY PATHOLOGY
(2022)
Article
Biochemical Research Methods
Yi Liu, Michael J. Trnka, Liang He, A. L. Burlingame, Maria Almira Correia
Summary: We have found that the protein scaffold p62/SQSTM1 is closely associated with IκBα in liver cells, leading to the stabilization and nuclear entry of IκBα. This association is necessary for the termination of NF-κB activation cycle. Our study defines the structural hotspots of p62-IκBα association and reveals the influence of p62 on IκBα-protein interactions. We speculate that p62 may be involved in the piggy-back nuclear transport of IκBα following its NF-κB-elicited transcriptional activation.
MOLECULAR & CELLULAR PROTEOMICS
(2023)
Review
Immunology
Daniel Arthur Corpuz Fisher, Jared Scott Fowles, Amy Zhou, Stephen Tracy Oh
Summary: Myeloid neoplasms such as AML, MPNs, and MDS involve clonal dominance and remodeling of bone marrow niche leading to malignant hematopoiesis. Inflammatory signaling hyperactivation and cytokine overproduction play critical roles, with cytokines like TNF potentially contributing to malignant clonal dominance. Targeting cytokine-mediated signaling may be a promising therapeutic strategy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Qian Lu, Chao Jiang, Jialong Hou, Hao Qian, Feifan Chu, Weiqi Zhang, Mengke Ye, Ziyi Chen, Jian Liu, Hanbing Yao, Jianfeng Zhang, Jiake Xu, Te Wang, Shunwu Fan, Qingqing Wang
Summary: The incidence of osteoporosis is increasing, especially in postmenopausal women. Patchouli alcohol (PA), a natural compound with anti-inflammatory effects, has shown inhibitory effects on osteoclasts and may be a potential treatment for osteoporosis in the future.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Antonio Pontoriero, Paola Critelli, Alfredo Conti, Salvatore Cardali, Filippo Flavio Angileri, Antonino Germano, Sara Lillo, Alessandro Carretta, Anna Brogna, Anna Santacaterina, Silvana Parisi, Stefano Pergolizzi
Summary: The results of this study suggest that dose escalation for high-risk WHO grade 2 meningiomas using a Combo-RT approach is safe and particularly effective in patients with subtotal resection. Further studies are needed.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Davide Di Paola, Ramona D'Amico, Tiziana Genovese, Rosalba Siracusa, Marika Cordaro, Rosalia Crupi, Alessio Filippo Peritore, Enrico Gugliandolo, Livia Interdonato, Daniela Impellizzeri, Roberta Fusco, Salvatore Cuzzocrea, Rosanna Di Paola
Summary: This study suggests that vinclozolin induces nephrotoxicity by disrupting the transcription of mitochondrial function-related factors, the Nrf2 signaling pathway, and the extrinsic and intrinsic apoptotic pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ramona D'Amico, Davide Di Paola, Daniela Impellizzeri, Tiziana Genovese, Roberta Fusco, Alessio Filippo Peritore, Enrico Gugliandolo, Rosalia Crupi, Livia Interdonato, Salvatore Cuzzocrea, Rosanna Di Paola, Rosalba Siracusa, Marika Cordaro
Summary: Endocrine-disrupting substances (EDS) are common and pose a serious risk to human and animal health. Vinclozolin, a commonly used fungicide, not only affects the reproductive system but also induces lung damage and inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Vincenzo Di Nunno, Caterina Giannini, Sofia Asioli, Alfredo Conti, Julia Furtner, Damiano Balestrini, Alicia Tosoni
Summary: Only 1% of meningioma cases are classified as malignant (anaplastic) meningioma. Due to their rarity, there are gaps in the clinical management of these tumors. This review investigates the current knowledge of anaplastic meningioma in terms of pathological and radiological diagnosis, molecular assessment, and treatment approaches. Surgery and radiation therapy play a crucial role in managing grade 3 meningioma, while systemic therapy is not widely used. It is anticipated that the increasing understanding of molecular pathways will lead to the development of more effective systemic treatments.
Article
Neuroimaging
Arianna Rustici, Francesca Vari, Carmelo Sturiale, Alfredo Conti, Antonino Scibilia, Carlo Bortolotti, Raffaele Agati, Caterina Tonon, Raffaele Lodi, Diego Mazzatenta, Matteo Zoli, Ciro Princiotta, Massimo Dall'Olio, Luigi Cirillo
Summary: This study aimed to identify the angio-architectural characteristics associated with bleeding in brain arteriovenous malformations (bAVMs). The findings showed that a smaller diameter of the nidus, the absence of venous drainage alterations, and the presence of prenidal aneurysms were significantly related to the risk of bleeding in bAVMs.
NEURORADIOLOGY JOURNAL
(2023)
Article
Oncology
Gueliz Acker, Marcel Nachbar, Nina Soffried, Bohdan Bodnar, Anastasia Janas, Kiril Krantchev, Goda Kalinauskaite, Anne Kluge, David Shultz, Alfredo Conti, David Kaul, Daniel Zips, Peter Vajkoczy, Carolin Senger
Summary: Neoadjuvant stereotactic radiosurgery (NaSRS) is becoming increasingly important in the treatment of brain metastases. Our analysis showed that there was no significant difference in tumor volume pre- and postoperatively, and smaller tumors had a higher risk of volume increase. However, contouring resection cavities remains a challenge.
FRONTIERS IN ONCOLOGY
(2023)
Review
Neurosciences
Alfredo Conti, Nicola Maria Gambadauro, Paolo Mantovani, Canio Pietro Picciano, Vittoria Rosetti, Marcello Magnani, Sebastiano Lucerna, Constantin Tuleasca, Pietro Cortelli, Giulia Giannini
Summary: Modern brain atlases derived from neuroimaging and functional information are crucial for accurate neurosurgical procedures. They help avoid targeting errors caused by imaging artifacts or insufficient anatomical details.
Article
Biochemistry & Molecular Biology
Ylenia Marino, Alessia Arangia, Marika Cordaro, Rosalba Siracusa, Ramona D'Amico, Daniela Impellizzeri, Rosalia Cupi, Alessio Filippo Peritore, Enrico Gugliandolo, Roberta Fusco, Salvatore Cuzzocrea, Rosanna Di Paola
Summary: The study found that IL-6 plays a crucial role in fibromyalgia by activating the Jak/STAT3 pathway, increasing chemokine levels, and activating neuroinflammatory cells. Additionally, anti-IL-6 receptor antibody can provide analgesic effects and inhibit inflammatory responses. These findings may provide new insights for the treatment of fibromyalgia.
Article
Environmental Sciences
Alessio Filippo Peritore, Gianluca Antonio Franco, Francesco Molinari, Alessia Arangia, Livia Interdonato, Ylenia Marino, Salvatore Cuzzocrea, Enrico Gugliandolo, Domenico Britti, Rosalia Crupi
Summary: This study revealed that chronic exposure to Vinclozolin can cause myocardial damage, cardiovascular dysfunction, and detrimental effects on cardiac enzymes and gene expression.
Review
Biochemistry & Molecular Biology
Alessio Filippo Peritore, Enrico Gugliandolo, Salvatore Cuzzocrea, Rosalia Crupi, Domenico Britti
Summary: Perfluorinated and polyfluorinated alkyl substances (PFAS), numbering more than 4700, are persistent chemicals that accumulate in living organisms and the environment. Due to their extensive use, PFAS are globally present, presenting concerns for animals, humans, and the environment. They can have various adverse health effects, and dietary intake is the most significant source of exposure. The review analyzes the characteristics, uses, and environmental presence of PFAS, highlighting the toxic potential, exposure, and related mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Lucia Longhitano, Alfio Distefano, Angela Maria Amorini, Laura Orlando, Sebastiano Giallongo, Daniele Tibullo, Giuseppe Lazzarino, Anna Nicolosi, Amer M. Alanazi, Concetta Saoca, Vincenzo Macaione, M'hammed Aguennouz, Federico Salomone, Emanuela Tropea, Ignazio Alberto Barbagallo, Giovanni Li Volti, Giacomo Lazzarino
Summary: This study aimed to investigate the effects of lipoic acid on lipotoxicity and mitochondrial dynamics in an in vitro model of liver steatosis. The results showed that lipoic acid treatment reduced lipotoxicity and improved mitochondrial functions, suggesting its potential as a pharmacological tool for NAFLD treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Edoardo Agosti, Marco Zeppieri, Lucio De Maria, Marcello Mangili, Alessandro Rapisarda, Tamara Ius, Leopoldo Spadea, Carlo Salati, Alessandro Tel, Antonio Pontoriero, Stefano Pergolizzi, Filippo Flavio Angileri, Marco Maria Fontanella, Pier Paolo Panciani
Summary: This study compares and analyzes the clinical and surgical outcomes of different surgical approaches used for the treatment of SOMs. The results show that different surgical approaches have varying rates of gross total resection, complications, and functional outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Oncology
Gerardo Caruso, Rosamaria Ferrarotto, Antonello Curcio, Luisa Metro, Francesco Pasqualetti, Paola Gaviani, Valeria Barresi, Filippo Flavio Angileri, Maria Caffo
Summary: Meningiomas are common tumors of the central nervous system and often associated with decreased quality of life. Total resection is the preferred treatment method. Molecular alterations have been identified that may be responsible for grading, site, and prognosis. Recurrence rates are relatively high and current treatment options are insufficient. Further research is needed to understand the mechanisms of tumor formation and progression. Combination therapies targeting multiple molecular targets show promise as adjuvant treatments. Recent literature reviews provide insight into recent therapeutic treatments for meningiomas.
Article
Endocrinology & Metabolism
Salvatore Giovinazzo, Giovanni Oliverio, Oana R. Cotta, Ylenia Alessi, Filippo F. Angileri, Felicia Ferreri, Rosaria Certo, Antonio De Maria, Angela Alibrandi, Pasquale Aragona, Salvatore Cannavo, Francesco Ferrau
Summary: In this study, the relationship between visual field status and clinical, neuroradiological, histopathological features and treatment strategy in patients with craniopharyngiomas (CP) was retrospectively evaluated. It was found that panhypopituitarism, CP recurrence, and pituitary dysfunction were independent predictors of worse visual field outcome. Factors such as older age, CP histological subtype, invasiveness, CP recurrence, pituitary dysfunction, and weight were also associated with worse visual field outcome.