期刊
CANCER
卷 112, 期 10, 页码 2241-2248出版社
WILEY
DOI: 10.1002/cncr.23398
关键词
lung cancer; flavonoids; epicatechin; catechin; quercetin; kaempferol
类别
资金
- NCI NIH HHS [CA96134, CA90833, CA77954, R03 CA077954, R01 CA090833, T32 CA009142, CA09142, P50 CA090388, U01 CA096134] Funding Source: Medline
- NIDA NIH HHS [DA11386, R01 DA011386] Funding Source: Medline
- NIEHS NIH HHS [R21 ES011667, ES 011667] Funding Source: Medline
BACKGROUND. Laboratory studies suggest that flavonoids are antimutagenic and anticarcinogenic. To investigate the associations between commonly consumed flavonoid compounds and lung cancer, the authors conducted a population-based case-control study of 558 lung cancer cases and a group of 837 controls. METHODS. Dietary intakes of flavonoids were estimated by combining the intake frequency (collected by a food frequency questionnaire), portion size, and food composition data. Unconditional logistic regression analysis was used to estimate odds ratios (ORs) and 95% confidence limits (95% CLs) with an adjustment for potential confounders, including age, sex, race-ethnicity, years of schooling, smoking status, pack-years of tobacco smoking, and daily energy intake. RESULTS. Lung cancer was associated inversely with the consumption of epicatechin (in 10 mg per day increment: OR, 0.64; 95% CL, 0.46-0.88), catechin (4 mg per day increment: OR, 0.49; 95% CL, 0.35-0.70), quercetin (9 mg per day increment: OR, 0.65; 95% CL, 0.44-0.95), and kaempferol (2 mg per day increment: OR, 0.68; 95% CL, 0.51-0.90) among tobacco smokers. There was little association between lung cancer and the flavonoid Compounds mentioned above among nonsmokers. Regardless of smoking status, there was little association with total flavonoids: thearubigins, hesperetin, naringenin, and myricetin. In addition, consumption of vegetables, tea, and wine, all of which are rich sources of flavonoids, was associated inversely with lung cancer among tobacco smokers. CONCLUSIONS. Certain flavonoid compounds, including epicatechin, catechin, quercetin, and kaempferol, were associated inversely With lung cancer among tobacco smokers, but not among nonsmokers. Further studies of these associations may be warranted.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据