Article
Health Care Sciences & Services
Lindsay White, Bailey Ingraham, Eric Larson, Paul Fishman, Sungchul Park, Norma B. Coe
Summary: Timely diagnosis of cognitive impairment is a key goal of the National Plan to Address Alzheimer's Disease, but studies on factors contributing to timely diagnosis are limited. This retrospective observational study found that only 26% of respondents with incident dementia and 11.4% with incident MCI received a timely diagnosis. Non-Hispanic Black and individuals with lower educational attainment were less likely to receive timely diagnosis of dementia or MCI compared to Non-Hispanic White respondents or those with a college degree.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2022)
Review
Public, Environmental & Occupational Health
Jui-Hung Hsu, Chien-Cheng Liu, I-Wen Chen, Jheng-Yan Wu, Po-Yu Huang, Ting-Hui Liu, Kuo-Chuan Hung
Summary: The visual cognitive assessment test (VCAT) is a language-neutral screening tool for detecting MCI/mild dementia. This meta-analysis showed that VCAT demonstrated acceptable diagnostic accuracy in distinguishing MCI/mild dementia in cognitively normal older adults.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Biochemistry & Molecular Biology
Kyoungjoo Cho
Summary: Cognitive impairment is a serious condition associated with aging and disruption of inflammation and innate immunity. Recent studies have shown that the innate immune system is prevalent in patients with Alzheimer's disease, and peripheral neutrophil markers can predict a decline in cognitive function in patients with mild cognitive impairment. Furthermore, altered levels of pro-inflammatory interleukins have been reported in patients with mild cognitive impairment, potentially playing a role in the progression from early cognitive impairment to dementia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Geriatrics & Gerontology
Sanne S. Mooldijk, Amber Yaqub, Frank J. Wolters, Silvan Licher, Peter J. Koudstaal, M. Kamran Ikram, M. Arfan Ikram
Summary: The study conducted on 648 community-dwelling individuals with mild cognitive impairment (MCI) and 6410 without MCI in the Rotterdam Study showed that total life expectancy for MCI decreases with age, with women and higher educated individuals living longer and spending more years with dementia. These findings suggest a more favorable prognosis for MCI in the general population compared to clinical observations, likely due to individuals with MCI in clinical settings not seeking medical attention in earlier stages.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2022)
Review
Virology
Amalia Cornea, Irina Lata, Mihaela Simu, Elena Cecilia Rosca
Summary: The use of modern combined antiretroviral treatment has decreased the incidence of HIV-associated dementia. Cognitive impairments, such as deficits in cognitive processing speed, attention, and memory, are common in people living with HIV. As HIV patients age and have more comorbidities and treatments, the prevalence and complexity of cognitive impairment are expected to increase. Currently, there is no specific intervention for managing cognitive impairment in HIV patients.
Article
Geriatrics & Gerontology
Randall L. Kuffel, Amy L. Byers, Brie Williams, Richard Fortinsky, Yixia Li, Michael A. Ruderman, Lisa C. Barry
Summary: This study examines the prevalence of dementia and mild cognitive impairment (MCI) among incarcerated individuals in the United States. The findings highlight the importance of understanding the link between cognitive impairment and incarceration in order to inform healthcare optimization and prevention strategies for this vulnerable population.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2022)
Article
Neurosciences
Angie A. Diaz Baquero, Manuel A. Franco-Martin, Esther Parra Vidales, Jose Miguel Toribio-Guzman, Yolanda Bueno-Aguado, Fernando Martinez Abad, Maria Perea Bartolome, Aysan Mahmoudi Asl, Henriette G. van der Roest
Summary: This study evaluated the effectiveness of the cognitive rehabilitation program GRADIOR in people with mild cognitive impairment and mild dementia. The results showed that the program improved and maintained cognitive functions in most participants, while the control group showed a worsening trend for most measures at 12 months.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Medicine, General & Internal
Camilla Elefante, Giulio Emilio Brancati, Zahinoor Ismail, Sara Ricciardulli, Maria Francesca Beatino, Vittoria Lepri, Antonella Fama, Elisabetta Ferrari, Linda Giampietri, Filippo Baldacci, Roberto Ceravolo, Icro Maremmani, Lorenzo Lattanzi, Giulio Perugi
Summary: This study aimed to investigate the prevalence and differentiating features of Mild Behavioral Impairment (MBI) with respect to major neurocognitive disorders (MNDs) and primary psychiatric disorders (PPDs). The results showed that patients with MBI had higher scores of psychopathology, specifically in terms of negative symptoms, compared to patients with PPDs. Additionally, MBI patients frequently reported higher severity of apathy and motor retardation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Neurosciences
Anthony N. Correro, Kathryn Gauthreaux, Jaime Perales-Puchalt, Yen-Chi Chen, Kwun C. G. Chan, Walter A. Kukull, Jason D. Flatt
Summary: This study explored the cognitive decline and dementia outcomes among same-sex and mixed-sex couples. The results showed that both groups experienced cognitive decline regardless of baseline diagnosis. Generally, there were no statistically significant differences between the same-sex and mixed-sex groups in terms of functioning, dementia severity, or neuropsychological testing, except for two exceptions. Participants with mild cognitive impairment in same-sex relationships showed less functional impairment at baseline, while the same-sex group with dementia had a slower decline in attention/working memory. Therefore, there were no cognitive health disparities among same-sex couples consistent with a minority stress model. Further research on protective factors is needed.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Geriatrics & Gerontology
Woori Moon, Ji Won Han, Jong Bin Bae, Seung Wan Suh, Tae Hui Kim, Kyung Phil Kwak, Bong Jo Kim, Shin Gyeom Kim, Jeong Lan Kim, Seok Woo Moon, Joon Hyuk Park, Seung-Ho Ryu, Jong Chul Youn, Dong Young Lee, Dong Woo Lee, Seok Bum Lee, Jung Jae Lee, Jin Hyeong Jhoo, Ki Woong Kim
Summary: This study investigated the disease burden of various dementias and mild cognitive impairment in a representative South Korean population, predicting a significant increase in disability-adjusted life-years and years lived with disability due to these conditions by 2065.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2021)
Article
Clinical Neurology
Benjamin M. Hampstead, Anthony Y. Stringer, Alexandru D. Iordan, Robert Ploutz-Snyder, K. Sathian
Summary: Cognitive training is a potential technique for treating cognitive impairment caused by neurological injury and disease. Different training methods have different mechanisms of action and engage distinct brain regions. Mnemonic strategy training (MST) showed superior effects in the short term and increased activation and functional connectivity in multiple brain regions.
ALZHEIMERS & DEMENTIA
(2023)
Review
Clinical Neurology
Lei Zhuang, Yan Yang, Jianqun Gao
Summary: Mild cognitive impairment (MCI) is a clinical condition with a high risk of progressing to dementia. Early diagnosis and intervention at the MCI stage are considered critical strategies in disease management. Lack of consensus on guidelines for routine screening of MCI leads to a considerable number of undiagnosed patients in the community.
JOURNAL OF NEUROLOGY
(2021)
Editorial Material
Cell Biology
Zhuang-Yao D. Wei, Ashok K. Shetty
Summary: This article discusses a recent study that suggests using a miRNA triad, consisting of miR-181a-5p, miR-146a-5p, and miR-148a-3p, for diagnosing ACI, MCI, and AD. The study explores the impact of elevated levels of this miRNA triad on neural plasticity and cognitive function in the brain and the potential of inhibiting it to improve cognitive function in MCI and AD.
Review
Cell Biology
Xiuwen Li, Xiaojie Wang, Lan Guo, Keying Wu, Li Wang, Lu Rao, Xinjian Liu, Chenyao Kang, Bin Jiang, Qian Li, Huling Li, Fenfen He, Ciyong Lu
Summary: This systematic review and meta-analysis examined the association between lipocalin-2 (LCN2) and mild cognitive impairment (MCI) and dementia. The results showed no significant difference in peripheral blood LCN2 levels between Alzheimer's disease (AD), MCI, and control groups. However, cerebrospinal fluid (CSF) LCN2 levels were higher in vascular dementia (VaD) patients compared to controls and AD patients. LCN2 was increased in AD-related brain areas and cells, as well as in infarct-related brain areas and cells in mixed dementia (MD).
AGEING RESEARCH REVIEWS
(2023)
Article
Clinical Neurology
Tommy Kwan Hin Fong, Teris Cheung, Sze Ting Joanna Ngan, Kelvin Tong, Wai Yan Vivian Lui, Wai Chi Chan, Corine Sau Man Wong, Calvin Pak Wing Cheng
Summary: This study aimed to assess the effectiveness and tolerability of transcranial pulse stimulation (TPS) with neuro-navigation in older adults with mild neurocognitive disorder (NCD). The results showed a significant improvement in cognition of elderly with mild NCD after receiving TPS intervention. This study provides valuable information for the long-term effect of TPS in cognition in older adults.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Audiology & Speech-Language Pathology
Perrine Ferre, Yassine Benhajali, Jason Steffener, Yaakov Stern, Yves Joanette, Pierre Bellec
LANGUAGE COGNITION AND NEUROSCIENCE
(2019)
Review
Clinical Neurology
Vladimir Hachinski, Karl Einhaeupl, Detlev Ganten, Suvarna Alladi, Carol Brayne, Blossom C. M. Stephan, Melanie D. Sweeney, Berislav Zlokovic, Yasser Iturria-Medina, Costantino Iadecola, Nozomi Nishimura, Chris B. Schaffer, Shawn N. Whitehead, Sandra E. Black, Leif Ostergaard, Joanna Wardlaw, Steven Greenberg, Leif Friberg, Bo Norrving, Brian Rowe, Yves Joanette, Werner Hacke, Lewis Kuller, Martin Dichgans, Matthias Endres, Zaven S. Khachaturian
ALZHEIMERS & DEMENTIA
(2019)
Article
Clinical Neurology
Vladimir Hachinski, Karl Einhaeupl, Detlev Ganten, Suvarna Alladi, Carol Brayne, Blossom C. M. Stephan, Melanie D. Sweeney, Berislav Zlokovic, Yasser Iturria-Medina, Costantino Iadecola, Nozomi Nishimura, Chris B. Schaffer, Shawn N. Whitehead, Sandra E. Black, Leif Ostergaard, Joanna Wardlaw, Steven Greenberg, Leif Friberg, Bo Norrving, Brian Rowe, Yves Joanette, Werner Hacke, Lewis Kuller, Martin Dichgans, Matthias Endres, Zaven S. Khachaturian
INTERNATIONAL JOURNAL OF STROKE
(2019)
Article
Clinical Neurology
Tanya Dash, Pierre Berroir, Yves Joanette, Ana Ines Ansaldo
FRONTIERS IN NEUROLOGY
(2019)
Letter
Clinical Neurology
Ahmad Reza Khatoonabadi, Yves Joanette, Michael Andreas Nitsche
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2020)
Article
Neurosciences
Hanieh Mohammadi, Thomas Vincent, Ke Peng, Anil Nigam, Mathieu Gayda, Sarah Fraser, Yves Joanette, Frederic Lesage, Louis Bherer
Summary: Recent studies have shown that optical indices of cerebral pulsatility can indicate cerebrovascular health in older adults and are influenced by cardiovascular status. Individuals with coronary artery disease (CAD) have higher global cerebral pulse amplitude, and walking can reduce this amplitude in all groups but extend its spatial distribution to the anterior prefrontal cortex in CAD patients compared to other groups.
HUMAN BRAIN MAPPING
(2021)
Article
Multidisciplinary Sciences
Niobe Haitas, Mahnoush Amiri, Maximiliano Wilson, Yves Joanette, Jason Steffener
Summary: This study aims to investigate the differences in semantic memory and compensatory neural activation in aging. By comparing young and older participants in a semantic judgment task, the study seeks to validate the predictions of the CRUNCH hypothesis under varying task demands.
Review
Clinical Neurology
Melissa D. Stockbridge, Shannon-M Sheppard, Lynsey M. Keator, Laura L. Murray, Margaret Lehman Blake
Summary: The study confirmed consistent evidence for emotional prosody deficits in individuals with right hemisphere brain damage. Studies of higher quality and with a higher sample size/contrast ratio were more likely to report significant differences between participants with RHD and non-brain-damaged controls.
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
(2022)
Article
Geriatrics & Gerontology
Hanieh Mohammadi, Ke Peng, Ali Kassab, Anil Nigam, Louis Bherer, Frederic Lesage, Yves Joanette
Summary: The study revealed a significant association between cerebral pulsatility and cortical thickness in older adults, especially in the temporal and frontal regions perfused first by the internal carotid arteries. This suggests that higher brain pulsatility may be a potential risk factor contributing to cortical thinning in certain brain regions.
NEUROBIOLOGY OF AGING
(2021)
Article
Clinical Neurology
Neerja Chowdhary, Corrado Barbui, Kaarin J. Anstey, Miia Kivipelto, Mariagnese Barbera, Ruth Peters, Lidan Zheng, Jenni Kulmala, Ruth Stephen, Cleusa P. Ferri, Yves Joanette, Huali Wang, Adelina Comas-Herrera, Charles Alessi, Kusumadewi Suharya (Dy), Kibachio J. Mwangi, Ronald C. Petersen, Ayesha A. Motala, Shanthi Mendis, Dorairaj Prabhakaran, Ameenah Bibi Mia Sorefan, Amit Dias, Riadh Gouider, Suzana Shahar, Kimberly Ashby-Mitchell, Martin Prince, Tarun Dua
Summary: Dementia poses a major global challenge, especially in low- and middle-income countries. To address this challenge, the World Health Organisation has developed a Global Action Plan on the Public Health Response to Dementia. This paper presents evidence-based recommendations for reducing dementia risks through multisectoral interventions.
FRONTIERS IN NEUROLOGY
(2022)
Review
Psychology, Multidisciplinary
Tanya Dash, Yves Joanette, Ana Ines Ansaldo
Summary: Through fine-tuning methods and tools, there has been progress in understanding and classification of bilinguals; however, challenges remain in generalizing to a larger population and considering the multifactorial nature of bilingualism's impact on cognitive performance.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Audiology & Speech-Language Pathology
Julien Jarret, Perrine Ferre, Georges Chedid, Christophe Bedetti, Arnaud Bore, Yves Joanette, Isabelle Rouleau, Simona Maria Brambati
Summary: We mapped the cortical regions and fiber bundles involved in picture naming in adults by integrating task-based fMRI with dMRI tractography. We identified a ventral pathway that maps image and sound to meaning, and a dorsal pathway that maps sound to speech. We also identified the specific brain regions and fiber bundles involved in these pathways.
BRAIN AND LANGUAGE
(2022)
Article
Audiology & Speech-Language Pathology
Tanya Dash, Yves Joanette, Ana Ines Ansaldo
Summary: This study explores the effects of bilingualism on different subcomponents of attention using resting state functional connectivity analysis. The results show a positive correlation between behavioral performance and functional connectivity in the alerting and orienting networks, but not in the executive control network. Moreover, the levels of bilingualism modulate the functional connectivity of attention networks, with objective measures affecting all three networks and subjective measures only affecting specific networks. Therefore, language performance is a more effective measure in understanding the impact of bilingualism on attention processes.
BRAIN AND LANGUAGE
(2022)
Article
Geriatrics & Gerontology
Perrine Ferre, Julien Jarret, Simona Brambati, Pierre Bellec, Yves Joanette
FRONTIERS IN AGING NEUROSCIENCE
(2020)
Article
Psychology, Multidisciplinary
Ensie Abbassi, Isabelle Blanchette, Bess Sirmon-Taylor, Ana Ines Ansaldo, Bernadette Ska, Yves Joanette
FRONTIERS IN PSYCHOLOGY
(2019)