期刊
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE
卷 58, 期 2, 页码 76-83出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/070674371305800203
关键词
gene-environment interaction; major depressive disorder; DNA methylation; early adverse events
类别
资金
- National Institute of Mental Health
- Behrens-Weise Foundation
- European Research Council (GxE molmech) [281338]
- European Research Council (ERC) [281338] Funding Source: European Research Council (ERC)
Family, twin, and epidemiologic studies have suggested that both genes and environment are important risk factors for the development of major depressive disorder (MDD). In the absence of consistent and strong main genetic effects, numerous studies have supported gene-environment interactions in this disorder. While the impact of negative environmental factors, such as early life stress, traumatic experiences, and negative life events have been established as risk factors, they are not sufficient to predict MDD. This article will review evidence suggesting that genetic variants moderate the effects of adversities on the development of MDD, with a focus on the importance of careful characterization of the stressful life events as well as systemic and molecular mechanisms that potentially mediate these gene environment interactions.
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