Article
Neurosciences
Alireza Soltani Khaboushan, Niloufar Yazdanpanah, Nima Rezaei
Summary: Neuroinflammation plays a fundamental role in the development of epilepsy, and proinflammatory cytokines (PICs) are crucial contributors. Understanding the role of PICs in epilepsy could provide promising targets for treatment.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Environmental Sciences
Tongtong Li, Dongcan Tian, Mengtian Lu, Bijiao Wang, Jun Li, Baohua Xu, Hao Chen, Shijin Wu
Summary: The study reveals a connection between brain inflammation induced by polychlorinated biphenyl 126 (PCB126) and gut microbiota disturbance, providing new insights into the toxicity mechanisms of PCB126 and potential therapeutic targets for CNS disease caused by environmental pollution.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Environmental Sciences
Sedigheh Amiresmaili, Nader Shahrokhi, Mohammad Khaksari, Gholamreza AsadiKaram, Mohammad Reza Aflatoonian, Sara Shirazpour, Ladan Amirkhosravi, Abbas Mortazaeizadeh
Summary: The study showed that estrogen E2 may improve liver injury after traumatic brain injury by modulating oxidative stress, and its protective effects are influenced by both classic and non-classic receptors.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
Kubra Kizil Ongay, Daniel Granato, George E. Barreto
Summary: Neuroinflammation plays a crucial role in both acute and chronic phases of traumatic brain injury (TBI). This study investigated the antioxidant capacity of apple pomace phenolics, phlorizin and phloretin, and their potential use in TBI treatment. The results showed that phloretin exhibited superior antioxidant properties compared to phlorizin, and both compounds regulated common proteins involved in TBI. It was found that estrogen receptor alpha (ESR1) might be a critical cellular hub regulated by both compounds and could be a potential therapeutic target for TBI.
Article
Biochemistry & Molecular Biology
Joseph J. Bivona, Hanna M. Crymble, Blas A. Guigni, Renee D. Stapleton, D. Clark Files, Michael J. Toth, Matthew E. Poynter, Benjamin T. Suratt
Summary: Skeletal muscle tissue may contribute to proinflammatory cytokines following acute endotoxin injury, and leukocytes can enhance this response via TNF alpha secretion.
Article
Biochemistry & Molecular Biology
Meenakshi Rani, Shannon R. Sayyadioskoie, Eva M. Galvan, Susannah E. Nicholson, Martin G. Schwacha
Summary: The study found that traumatic injury with hemorrhage leads to lung injury, activation of immune cells, and elevated cytokine production in the lungs. These cells play a key role in mediating inflammatory responses through TLRs.
Article
Pharmacology & Pharmacy
G. Kulturoglu, J. Ergil, M. O. Kulturoglu, A. Yalcindag, E. O. Onder
Summary: This study evaluated the effects of hydroxyurea treatment on leukocyte counts, inflammatory cytokines, and organ inflammation in rats with an experimental sepsis model. The results showed that early hydroxyurea treatment decreased proinflammatory cytokine levels and brain damage in rats with sepsis.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Anesthesiology
Weihua Ding, Zerong You, Qian Chen, Liuyue Yang, Jason Doheny, Xue Zhou, Na Li, Shiyu Wang, Kun Hu, Lucy Chen, Suyun Xia, Xinbo Wu, Changning Wang, Can Zhang, Liang Chen, Christine Ritchie, Peigen Huang, Jianren Mao, Shiqian Shen
Summary: This study found that oral antibiotics can alter gut microbiota and alleviate neuropathic pain induced by CCI, primarily through modulating proinflammatory and anti-inflammatory T cell responses. Depletion of regulatory T cells reversed the protective effect of gut microbiota changes on neuropathic pain.
ANESTHESIA AND ANALGESIA
(2021)
Review
Immunology
Bin Yuan, Xiao-jie Lu, Qi Wu
Summary: Research on the role of gut microbiota in acute central nervous system injuries has shown that altered gut microbiota composition can worsen secondary brain injury, cognitive impairments, and motor dysfunctions by triggering pro-inflammatory responses. Modulating gut microbiota with fecal microbiota transplantation, probiotics, and prebiotics may offer effective therapeutic interventions to alleviate secondary brain injury and improve functional outcomes after acute CNS injuries. This area of research represents an exciting frontier in both clinical and experimental medicine.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Elizabeth A. Kowalski, Eman Soliman, Colin Kelly, Erwin Kristobal Gudenschwager Basso, John Leonard, Kevin J. Pridham, Jing Ju, Alison Cash, Amanda Hazy, Caroline de Jager, Alexandra M. Kaloss, Hanzhang Ding, Raymundo D. Hernandez, Gabe Coleman, Xia Wang, Michelle L. Olsen, Alicia M. Pickrell, Michelle H. Theus
Summary: Circulating monocytes play a critical role in regulating the neuroinflammatory environment in various neuropathological disorders. EphA4, a prominent axon guidance molecule, has been shown to regulate neuroinflammation. In the absence of bone marrow-derived EphA4, mice exhibited neuroprotection, reduced monocyte/macrophage infiltration, and a shift in monocyte gene profile from pro- to anti-inflammatory. This study highlights the importance of monocyte polarization mediated by EphA4 in brain injury.
Review
Endocrinology & Metabolism
Caroline S. S. Johnson, Paul E. Micevych, Paul G. G. Mermelstein
Summary: Recent studies have shown that traditional estrogen receptors, alpha and beta, can also act at the cell surface in addition to their nuclear functions. Signaling from these membrane-bound estrogen receptors can rapidly affect cellular excitability and ultimately impact gene expression. The interaction between these membrane receptors and metabotropic glutamate receptors (mGluRs) plays a key role in various female functions such as reproduction and motivation.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cell Biology
Tian Wang, Jinchun Xu, Yi Xu, Jie Xiao, Nanxi Bi, Xiaozhen Gu, Hui-Li Wang
Summary: This study found that socially dominant rats can be distinguished from subordinates based on their intestinal microbiota. Dysbiotic rats reclaim social dominance following microbiota transplantation. Core microbes and histone deacetylase HDAC2 play crucial roles in mediating dominance determination.
Article
Biochemistry & Molecular Biology
Gouri Chopra, Shivam Kaushik, Pinky Kain
Summary: Nutrient-sensing mechanisms in animals play a critical role in regulating food intake and maintaining metabolic homeostasis. The gut, especially in fruit flies, is a useful tissue for studying these mechanisms due to its genetic tools and ability to transmit signals to the brain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Sheng Liu, Xuejiao Men, Yang Guo, Wei Cai, Ruizhen Wu, Rongsui Gao, Weicong Zhong, Huating Guo, Hengfang Ruan, Shuli Chou, Junrui Mai, Suning Ping, Chao Jiang, Hongwei Zhou, Xiangyu Mou, Wenjing Zhao, Zhengqi Lu
Summary: This study reveals the potential linkage among the brain-gut-microbe axis in CADASIL, showing alterations in microbiota composition and functions, disrupted neurotransmitter balance, elevated inflammatory cytokines, and potential mechanisms involved in the disease.
Article
Biochemistry & Molecular Biology
Xiaoya Wang, Xinyu Zhang, Jianqing Su, Xiuling Chu
Summary: In this study, the therapeutic effects of Acanthopanax senticosus total flavonoids (ASTFs) were investigated using a mouse intestinal inflammation model induced by lipopolysaccharide (LPS). The results showed that ASTF intervention improved intestinal morphology, reduced inflammatory markers and related gene expression levels, and regulated the structure of gut microbiota in mice. This suggests that ASTFs have potential therapeutic benefits in intestinal inflammation.
BIOSCIENCE REPORTS
(2022)
Review
Cardiac & Cardiovascular Systems
Zahra Hajializadeh, Mohammad Khaksari
Summary: Cardiac hypertrophy (CH) is a major cause of morbidity and mortality worldwide, leading to heart failure. Sex differences in CH may be caused by sex hormones or their receptors, with the incidence increasing in postmenopausal women due to the decrease in female sex hormone 17-beta estradiol (E2). E2 and its receptors inhibit CH, while Silent information regulator 1 (SIRT1) plays a crucial role in biological processes and has a protective effect against CH.
HEART FAILURE REVIEWS
(2022)
Article
Neurosciences
Mohadeseh Chahkandi, Gholamreza Sepehri, Gholamreza Komeili, Mohammad Khaksari Hadad, Elham Haghparast, Majid Chahkandi
Summary: This study evaluated the role of GPR30 in the effects of marijuana and estrogen on spatial learning and memory in young and old female rats. The results showed that GPR30 did not have a significant effect in young rats, but there was a negative interaction in old rats. Additionally, hippocampal BDNF did not play a role in the interaction effects of marijuana and estrogen in both young and old rats.
BRAIN RESEARCH BULLETIN
(2022)
Article
Neurosciences
Fatemeh Farahani, Mohammad Khaksari, Sedigheh Amiresmaili, Maryam Iranpour, Nader Shahrokhi, Gholamreza AsadiKaram, Zahra Soltani
Summary: The aim of this study was to determine the anti-inflammatory effect of female sex hormones on the level of intracellular molecules of cytokine signaling pathway after diffuse traumatic brain injury (TBI) in ovariectomized rats. The results showed that female sex hormones can inhibit the increase of brain edema, decrease the levels of inflammatory factors, and increase the levels of molecules involved in the signaling pathway of inflammation. These effects primarily act on microglia and astrocytes.
BRAIN RESEARCH BULLETIN
(2022)
Article
Endocrinology & Metabolism
Zeinab Farhadi, Mohammad Khaksari, Hossein Azizian, Shahriar Dabiri
Summary: The study found that the effects of E2 on young animals included reducing weight and calorie intake, improving leptin sensitivity, increasing levels of neuropeptides, and enhancing p-STAT3 expression in the hypothalamic arcuate nucleus.
METABOLIC BRAIN DISEASE
(2022)
Article
Integrative & Complementary Medicine
Baran Ghezelbash, Nader Shahrokhi, Mohammad Khaksari, Gholamreza Asadikaram, Maryam Shahrokhi, Sara Shirazpour
Summary: This study aimed to evaluate the effect of Shilajit, an Ayurvedic medicine, on the serum changes in cytokines and adipokines caused by non-alcoholic fatty liver disease (NAFLD). The results showed that Shilajit can protect against NAFLD by modulating the levels of cytokines and adipokines, reducing insulin resistance, and improving blood glucose levels.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Neda Salmani, Masoumeh Nozari, Mahdieh Parvan, Sara Amini-Sardouei, Mohammad Shabani, Mohammad Khaksari, Massood Ezzatabadipour
Summary: This study examined the impact of environmental parameters on the severity of schizophrenia symptoms through an induced schizophrenia model in rats. The results suggest that environmental conditions play an important role in the development of schizophrenia and other neuropsychiatric disorders.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2022)
Article
Immunology
Nazanin Sabet, Zahra Soltani, Mohammad Khaksari, Alireza Raji-Amirhasani
Summary: This study investigated the effect of exercise and different diets on AKI. The results showed that exercise alone did not prevent kidney function impairment, oxidative stress, inflammation and SIRT1 alteration following AKI. However, implementing CR and TR diets during exercise had strong renoprotective effects, with TR diet showing greater protection.
JOURNAL OF INFLAMMATION-LONDON
(2022)
Article
Medicine, Research & Experimental
Zahra Hajializadeh, Mohammad Khaksari, Hamid Najafipour, Mojgan Sanjari, Fatemeh Darvishzadeh Mahani, Alireza Raji-Amirhasani
Summary: Calorie restriction can prevent and improve cardiometabolic risk factors in postmenopausal obesity, and it is also a good alternative to estrogen.
Review
Biochemistry & Molecular Biology
Nazanin Sabet, Zahra Soltani, Mohammad Khaksari
Summary: Exercise has a renoprotective effect on kidney injury patients by increasing the expression and activity of SIRT1. However, further research is needed to determine the role of SIRT1 in different types and severities of kidney injury following exercise.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Medicine, Research & Experimental
Amirhossein Moslemizadeh, Mohammad Hadi Nematollahi, Sedigheh Amiresmaili, Sanaz Faramarz, Elham Jafari, Mohammad Khaksari, Nima Rezaei, Hamideh Bashiri, Reza Kheirandish
Summary: This study evaluated the effects of combined administration of temozolomide (TMZ) and interferon-gamma (IFN-Y) on glioblastoma-induced anxiety-like behaviors, balance disorders, learning and memory in rats. The results showed that the combination treatment inhibited tumor growth and improved neurocognitive functioning. This was mediated through modulating oxidative stress, reducing cytokines, and downregulating the expression of TLR4 and p-CREB proteins.
Article
Neurosciences
Forouzan Rafie, Mohammad Khaksari, Sedigheh Amiresmaili, Zahra Soltani, Mohammad Pourranjbar, Sara Shirazpour, Elham Jafari
Summary: The study found that early exercise (24hA) and 1MBA groups provide neuroprotection and reduce the consequences of secondary injury, possibly by reducing neuronal apoptosis and oxidative stress.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Maryam Radavi-Asgar, Nazanin Sabet, Mohammad Khaksari, Elham Jafari, Zahra Soltani, Fatemeh Dehghanian
Summary: This study evaluated the therapeutic effect of oral mucosal mesenchymal stem cells (OMSCs) on inflammation and oxidative stress in the heart and kidneys after traumatic brain injury (TBI). The results showed that the application of OMSCs can reduce inflammation and oxidative stress in the heart and kidney tissues, leading to a reduction in damage.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Mahdis Rahimi Naiini, Beydolah Shahouzehi, Mohammad Khaksari, Shahrzad Azizi, Niloufar Naghibi, Mahdieh Nazari-Robati
Summary: The study demonstrated that ellagic acid has protective effects against hepatic lipid metabolism disorders induced by aging.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Fatemeh Darvishzadeh Mahani, Mohammad Khaksari, Maryam Iranpour, Zahra Soltani, Alireza Raji-Amirhasani, Zahra Hajializadeh
Summary: This study aimed to evaluate the effects of time restriction (TR) and calorie restriction (CR) diets on acute kidney injury in postmenopausal rats. The results showed that TR and CR diets reduced apoptosis and improved renal injury indices, with CR diet having a better effect.
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2022)
Meeting Abstract
Neurosciences
Nazanin Sabet, Behshad Mofid, Mohammad Khaksari, Zahra Soltani
