期刊
JOURNAL OF DIABETES AND ITS COMPLICATIONS
卷 29, 期 8, 页码 1071-1076出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jdiacomp.2015.06.010
关键词
Comorbidity; Dementia; Epidemiology; Retrospective cohort; Risk
资金
- Taiwan Ministry of Health and Welfare Clinical Trial and Research Center of Excellence [MOHW104-TDU-B-212-113002]
- China Medical University Hospital, Academia Sinica Taiwan Biobank Stroke Biosignature Project [BM104010092]
- NRPB Stroke Clinical Trial Consortium [MOST 103-2325-B-039-006]
- Tseng-Lien Lin Foundation, Taichung, Taiwan
- Taiwan Brain Disease Foundation, Taipei, Taiwan
- Katsuzo and Kiyo Aoshima Memorial Funds, Japan
Aims: Most diabetes mellitus (DM) patients have several comorbidities; the correlation of these comorbidities with dementia in DM requires clarification. Methods: Using claims data from Taiwan National Health Insurance, we identified 33,709 DM adults before the year 2000 and randomly selected 67,066 non-DM patients matched by sex and age. Subjects were followed until diagnosis with dementia, excluded due to death/withdrawal from the insurance program, or followed until 2011. We compared the incidence and hazard ratio (HR) for dementia in both cohorts. Results: Comorbidities were more prevalent in DM patients, including hypertension, hyperlipidemia, stroke, coronary artery and/or kidney disease. The HR was higher for the DM cohort with comorbidities than those without: 1.88 vs. 1.46 with hypertension; 1.56 vs. 1.39 with hyperlipidemia; 1.73 vs. 1.37 with coronary artery disease; 2.36 vs. 2.29 with stroke and 1.88 vs. 1.50 with kidney disease. The HR for dementia in diabetics rose from 1.41 in those without comorbidities to 2.49 in those with >= 4 comorbidities. In the DM cohort, HR was 1.22 for non-insulin-users and 1.41 for insulin-users, and 1.49 for type 1 DM and 1.23 for type 2 DM. Conclusion: Diabetic patients have an elevated risk of dementia, and comorbidity increases this risk. (C) 2015 Elsevier Inc. All rights reserved.
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