Article
Endocrinology & Metabolism
Andrew M. South, Joseph Rigdon, Saroja Voruganti, Jeanette M. Stafford, Dana Dabelea, Santica Marcovina, Amy K. Mottl, Cate Pihoker, Elaine M. Urbina, Elizabeth T. Jensen
Summary: This study investigated the association between uric acid levels and blood pressure and arterial stiffness in adolescents and young adults with type 1 diabetes. The results showed no significant relationship between uric acid and blood pressure or arterial stiffness in these patients. These findings support the results of clinical trials in older adults with diabetes, which show that lowering uric acid levels does not improve cardiovascular health.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Medicine, General & Internal
Jose-Miguel Gonzalez-Clemente, Albert Cano, Lara Albert, Olga Gimenez-Palop, Ana Romero, Eugenio Berlanga, Joan Vendrell, Gemma Llaurado
Summary: Arterial stiffness integrates cardiovascular risk factors on the elastic wall of large arteries over a lifetime, impacting both macro- and microvasculature. It may affect microvascular development and is considered a target organ for intervention.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Cedric A. Korpijaakko, Mia D. Eriksson, Niko S. Wasenius, Miira M. Klemetti, Kari Teramo, Hannu Kautiainen, Johan G. Eriksson, Merja K. Laine
Summary: This study found that young adult offspring of mothers with type 1 diabetes show signs of increased arterial stiffness compared to offspring of mothers without diabetes. The findings suggest that exposure to an adverse intrauterine environment of type 1 diabetes mothers may affect the vascular health of offspring already in young adulthood.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Endocrinology & Metabolism
Gemma Llaurado, Nuria Amigo, Rocio Fuertes-Martin, Ana Romero, Albert Cano, Lara Albert, Olga Gimenez-Palop, Eugenio Berlanga, Sonia Fernandez-Veledo, Xavier Correig, Joan Vendrell, Jose-Miguel Gonzalez-Clemente
Summary: This study evaluated the utility of measuring serum GlycA and GlycB to assess vascular aging in adults with type 1 diabetes (T1D) of more than 10 years duration and no previous cardiovascular events. The results showed that GlycA and GlycB were positively correlated with the surrogate measure of arterial stiffness (aPWV) and independently associated with aPWV. Therefore, measuring serum GlycA and GlycB may be helpful in assessing vascular aging in adults with T1D.
Article
Cardiac & Cardiovascular Systems
Simon Helleputte, Luc Van Bortel, Francis Verbeke, Jos Op 't Roodt, Patrick Calders, Bruno Lapauw, Tine De Backer
Summary: This study evaluated arterial stiffness in patients with type 1 diabetes (T1D) and without known cardiovascular disease (CVD), and compared it to other cardiovascular risk evaluation tools used in T1D. The findings showed a substantial proportion of T1D patients without CVD displayed premature arterial stiffening, and arterial stiffness was strongly associated with the risk of future cardiovascular events as well as other cardiovascular factors. However, there were heterogeneity in cardiovascular risk and differences in risk categorization between different evaluation tools. Further research is needed to refine cardiovascular risk classification and determine the clinical usefulness of assessing arterial stiffness in T1D.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Endocrinology & Metabolism
Jing Mao, Shenglian Gan, Quan Zhou, Fang Yu, Haifeng Zhou, Huilin Lu, Jing Jin, Qin Liu, Zhiming Deng
Summary: In Chinese patients with T2DM, LAP was strongly and positively correlated with baPWV and elevated baPWV.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Luca D'Onofrio, Rocco Amendolara, Carmen Mignogna, Gaetano Leto, Lida Tartaglione, Sandro Mazzaferro, Ernesto Maddaloni, Raffaella Buzzetti
Summary: This study evaluated CHIT activity as an early biomarker of arterial stiffness in T2D patients without overt vascular complications. The results showed no association between CHIT activity and arterial stiffness, but the high-PWV group had other CVD risk factors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Einas H. Alkhatib, Jody B. Grundman, Anna M. Adamusiak, Melena D. Bellin, Joel P. Brooks, Kevin S. Buckley, Erin M. Janssen, Maleewan Kitcharoensakkul, Kyle P. Mcnerney, Thea L. Pfeifer, Brooke I. Polk, Brynn E. Marks
Summary: Insulin hypersensitivity reactions are rare but serious complications of T1D treatment, negatively affecting glycemic control and quality of life.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Anniina Tynjala, Valma Harjutsalo, Fanny Jansson Sigfrids, Per-Henrik Groop, Daniel Gordin
Summary: This study investigated the association between long-term glycemic variability and arterial stiffness in patients with type 1 diabetes. The results showed that the variability of HbA1c was significantly correlated with arterial stiffness. Importantly, this association was independent of the HbA1c mean.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Endocrinology & Metabolism
Mengying Wang, Jie Huang, Tao Wu, Lu Qi
Summary: The study found that pulse wave arterial stiffness index (ASI) is positively associated with the risk of type 2 diabetes (T2D), while the association between pulse pressure (PP) and T2D shows a nonlinear J-shaped relationship. Additionally, the association between ASI and T2D is more pronounced among individuals with higher genetic susceptibility to T2D.
Article
Endocrinology & Metabolism
Mengying Wang, Jie Huang, Tao Wu, Lu Qi
Summary: Pulse wave arterial stiffness index (ASI) showed a dose-response association with type 2 diabetes (T2D), while pulse pressure (PP) displayed a nonlinear J-shaped association with T2D. Additionally, the association between ASI and T2D was partially strengthened by higher genetic susceptibility to T2D.
Article
Cardiac & Cardiovascular Systems
Shujie Wang, Juan Shi, Ying Peng, Qianhua Fang, Qian Mu, Weiqiong Gu, Jie Hong, Yifei Zhang, Weiqing Wang
Summary: The study found that compared to HOMA-IR, the TyG index is independently and more strongly associated with arterial stiffness in patients with T2D. Seemingly unrelated regression estimation analysis and multivariable logistic analyses showed that the TyG index was positively associated with the prevalence of increased arterial stiffness, especially in older patients with a longer duration of diabetes and poor glycaemic control. Subgroup analyses revealed a more significant association between the TyG index and arterial stiffness in specific patient populations.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tsung-Jui Wu, Du -An Wu, Bang-Gee Hsu
Summary: This study investigated the relationship between serum leptin levels and aortic stiffness in patients with type 2 diabetes mellitus (DM). The results showed that serum leptin levels are positively associated with aortic stiffness, suggesting that it can be used as an early marker for cardiovascular risk assessment.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2023)
Review
Endocrinology & Metabolism
Shivani K. Patel, Cindy S. Ma, Spiros Fourlanos, Jerry R. Greenfield
Summary: Studying autoantibody-negative T1D reveals the challenges and limitations in understanding this group, as they are excluded from immunomodulatory trials, hindering improvements in diagnostics and therapies for the disease.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Medicine, General & Internal
Ekaterina B. Luneva, Anastasia A. Vasileva, Elena Karelkina, Maria A. Boyarinova, Evgeny N. Mikhaylov, Anton Ryzhkov, Alina Y. Babenko, Alexandra O. Konradi, Olga M. Moiseeva
Summary: This study aimed to identify simple predictors of cardiac fibrosis in patients with diabetes mellitus. The study found that an increased serum galectin-3 level was associated with left ventricular concentric hypertrophy in patients with type 2 diabetes. Additionally, the study explored the relationship between fibrosis biomarkers and arterial stiffness with cardiac fibrosis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Meeting Abstract
Endocrinology & Metabolism
Kelsey B. Eitel, Alissa J. Roberts, Ralph Dagostino, Ronny A. Bell, Anna Bellatorre, Catherine E. Barrett, Angelica Cristello, Dana Dabelea, Lawrence M. Dolan, Elizabeth T. Jensen, Angela D. Liese, Santica M. Marcovina, Elizabeth J. Mayer-Davis, Kristi Reynolds, Catherine Pihoker
Meeting Abstract
Endocrinology & Metabolism
Ronny A. Bell, Joseph Rigdon, Anna Bellatorre, Dana Dabelea, Ralph Dagostino, Jasmin Divers, Lawrence M. Dolan, Giuseppina Imperatore, Elizabeth T. Jensen, Angela D. Liese, Eva Lustigova, Santica M. Marcovina, Lina Merjaneh, David J. Pettitt, Catherine Pihoker, Amy S. Shah, Andrew M. South, Lynne E. Wagenknecht
Review
Clinical Neurology
Beddome C. Allen, Sahil Kapoor, Anthony Anzalone, Kirby P. Mayer, Stacey Q. Wolfe, Pam Duncan, Andrew W. Asimos, Ralph D'Agostino Jr, James Tripp Winslow, Aarti Sarwal
Summary: This study reviewed the feasibility of transcranial ultrasonography (TCU) as a diagnostic tool for evaluating intracranial pathology in critical care or austere settings. The results showed that TCU has reasonable sensitivity and specificity in detecting intracranial pathology including intracranial hemorrhage and tumors. This suggests that TCU can be clinically valuable in remote areas or where standard imaging is unavailable.
JOURNAL OF NEUROIMAGING
(2023)
Article
Health Care Sciences & Services
Annika Hoyer, Ralph Brinks, Thaddaeus Toennies, Sharon H. Saydah, Ralph B. D'Agostino Jr, Jasmin Divers, Scott Isom, Dana Dabelea, Jean M. Lawrence, Elizabeth J. Mayer-Davis, Catherine Pihoker, Lawrence Dolan, Giuseppina Imperatore
Summary: This study aimed to examine whether a partial differential equation (PDE) can be used to estimate the incidence of diabetes from prevalence. The results showed that the PDE method can accurately estimate the incidence rates of diabetes, and it has the advantage of cost savings compared to traditional methods.
BMC MEDICAL RESEARCH METHODOLOGY
(2023)
Review
Oncology
Ryan T. Hughes, Rediet R. Gebeyehu, John Mason Kalada, Thomas W. Lycan, Bart A. Frizzell, Rebecca D. Kinney, Ralph B. D'Agostino, Paul M. Bunch, Pierre Triozzi, Wei Zhang, Cristina M. Furdui, Mercedes Porosnicu
Summary: Effective treatment options for advanced/recurrent head and neck squamous-cell carcinoma are limited. The combination of the immune checkpoint inhibitor pembrolizumab and quad-shot, a hypofractionated palliative radiotherapy regimen, shows promise as a potential treatment strategy. This study aims to evaluate the response rates, survival outcomes, and treatment toxicity of this combined therapy, as well as identify molecular biomarkers and immune-related impacts using correlative multiomics analysis.
Article
Clinical Neurology
Christine Henry, Sahil Kapoor, Vivek Krishnan, John Levi, Kyle Fargen, Ralph D'Agostino, Sheryl Hendrix, Dana Foster, Patrick Brown, Charles A. Tegeler, Aarti Sarwal
Summary: This study used transcranial color-coded duplex (TCCD) to examine the transverse venous sinus (TVS), establish normative values, analyze physiological variability, and explore the validity of using TCCD to diagnose transverse venous sinus stenosis (TVSS).
JOURNAL OF NEUROIMAGING
(2023)
Article
Endocrinology & Metabolism
Allison L. B. Shapiro, Anna Bellatorre, Dana Dabelea, Jeanette M. Stafford, Ralph D'Agostino, Amy S. Shah, Elaine M. Urbina, Catherine E. Barrett, Catherine Pihoker, Santica Marcovina, Angela D. Liese, Amy K. Mottl, Elizabeth T. Jensen, Greta Wilkening
Summary: This study examined the relationship between diabetes complications and cognitive dysfunction in young adults with type 1 or type 2 diabetes. The results showed that hypoglycemia and peripheral neuropathy were associated with cognitive deficits in type 1 diabetes, while high blood pressure was associated with cognitive deficits in type 2 diabetes. These findings provide insights for targeting specific factors to mitigate cognitive issues in young people with diabetes.
PEDIATRIC DIABETES
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
W. Gregory Hundley, Ralph D'Agostino
JACC-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Katherine A. A. Sauder, Deborah H. H. Glueck, Kylie K. K. Harrall, Ralph D'Agostino, Lawrence M. M. Dolan, Abbi D. D. Lane, Angela D. D. Liese, Eva Lustigova, Faisal S. S. Malik, Santica Marcovina, Elizabeth Mayer-Davis, Amy Mottl, Catherine Pihoker, Kristi Reynolds, Amy S. S. Shah, Elaine M. M. Urbina, Lynne E. E. Wagenknecht, Stephen R. R. Daniels, Dana Dabelea
Summary: This study examined arterial stiffness in individuals with type 1 diabetes and explored the differences between Hispanic, non-Hispanic Black, and non-Hispanic White individuals. The results showed that cardiovascular and socioeconomic factors explain a quarter of the racial and ethnic differences in arterial stiffness, but non-Hispanic Black individuals still experienced higher arterial stiffness.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Oncology
Yin Liu, Margaret R. R. Smith, Yuezhu Wang, Ralph D'Agostino Jr, Jimmy Ruiz, Thomas Lycan, Gregory L. L. Kucera, Lance D. D. Miller, Wencheng Li, Michael D. D. Chan, Michael Farris, Jing Su, Qianqian Song, Dawen Zhao, Arvind Chandrasekaran, Fei Xing
Summary: This study reveals that tumor-infiltrating neutrophils secrete high levels of lipocalin 2 (LCN2), which enhances the stemness of tumor cells in brain metastasis. The interactions between neutrophils and brain metastatic cells provide new insights into treating brain metastasis.
Article
Oncology
Margaret R. Smith, Yuezhu Wang, Ralph D'Agostino, Yin Liu, Jimmy Ruiz, Thomas Lycan, George Oliver, Lance D. Miller, Umit Topaloglu, Jireh Pinkney, Mohammed N. Abdulhaleem, Michael D. Chan, Michael Farris, Jing Su, Kathryn F. Mileham, Fei Xing
Summary: Different therapy options are used for NSCLC based on tumor stage and genetic mutations. However, biomarkers to guide treatment selection are limited. A study collected clinical and sequencing data from 524 NSCLC patients to examine the association between mutation profiles and treatment response. Mutation composite scores (MCS) were generated for different treatments, and MCS showed superior predictive power compared to other biomarkers in immune therapy-treated patients.
NPJ PRECISION ONCOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Warren Szewczyk, Kerryn Reding, Richard Kar-Hang Cheng, Laura Johnson, Oxana Palesh, Alexi Vasbinder, Amy Ladd, Ralph Dagostino, Kathryn Weaver, Glenn J. Lesser, W. Gregory Hundley
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Meeting Abstract
Endocrinology & Metabolism
Kelsey B. Eitel, Alissa J. Roberts, Ralph D'Agostino, Catherine E. Barrett, Ronny A. Bell, Anna Bellatorre, Angelica Cristello, Dana Dabelea, Lawrence M. Dolan, Elizabeth T. Jensen, Angela D. Liese, Elizabeth J. Mayer-Davis, Kristi Reynolds, Santica M. Marcovina, Catherine Pihoker
HORMONE RESEARCH IN PAEDIATRICS
(2023)
Review
Cardiac & Cardiovascular Systems
Dimitrios Tsiachris, Christos-Konstantinos Antoniou, Ioannis Doundoulakis, Panagiota Manolakou, Demetrios Sougiannis, Athanasios Kordalis, Konstantinos A. Gatzoulis, Gian-Battista Chierchia, Carlo de Asmundis, Christodoulos Stefanadis, Konstantinos Tsioufis
Summary: Nowadays, cryoballoon (CB) has become an established alternative to radio frequency (RF) ablation for pulmonary vein isolation (PVI), with the ability to isolate PVs in a single application. In a study on over 1000 consecutive patients, our center optimized the CB PVI procedure. It is expected that future guidelines will recommend CB as the first-line PVI for patients with paroxysmal AF and a class I indication. In a long-term follow-up of the EARLY-AF trial, CB showed a lower incidence of persistent atrial fibrillation compared to anti-arrhythmic drugs.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Kerryn Reding, Nathaniel S. O'Connell, Warren Szewczyk, Richard K. Cheng, Johnny Nguyen, Amy C. Ladd, Jennifer H. Jordan, Alexander R. Lucas, Vanessa B. Sheppard, Yaorong Ge, Fadi N. Salloum, Youngdeok Kim, Edward J. Lesnefsky, Robert L. Franco, Giselle C. Melendez, Arnethea L. Sutton, Ralph Dagostino, Kathryn E. Weaver, Glenn J. Lesser, William G. Hundley