Article
Biochemistry & Molecular Biology
Miriam Perez-Saldivar, Graciela Ordonez, Benjamin Pineda, Julio Sotelo, Adolfo Martinez-Palomo, Jose Flores-Rivera, Martha Espinosa-Cantellano
Summary: This study compared the response of T cells from multiple sclerosis (MS) patients, during relapse and remission, to in vitro stimulation with varicella zoster virus (VZV), adenovirus (AV) and Epstein-Barr virus (EBV). The results showed that relapsing MS patients had a stronger T cell response to VZV, and remitting patients' T cells predominantly secreted Th1 cytokines when stimulated with VZV. These findings support previous studies and suggest a possible role of VZV in the pathogenesis of MS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Brunella Zizolfi, Virginia Foreste, Simona Bonavita, Valentina Rubino, Giuseppina Ruggiero, Vincenzo Brescia Morra, Roberta Lanzillo, Antonio Carotenuto, Francesca Boscia, Maurizio Taglialatela, Maurizio Guida
Summary: This study reports the first Italian epidemiological analysis of the prevalence of multiple sclerosis (MS) in patients with endometriosis (EMS), by studying the endometriosis population of a referral center. It analyzes the clinical profile, immune profile, and the potential correlation to other autoimmune diseases in enrolled patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Pathology
Sofia Rodriguez Murua, Mauricio F. Farez, Francisco J. Quintana
Summary: Multiple sclerosis is a chronic disease affecting the central nervous system, characterized by immune dysregulation and resulting in demyelination, neuronal damage, and degeneration. Genetic and environmental factors are believed to play a role in the onset and progression of this disease.
ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE
(2022)
Article
Medicine, Research & Experimental
Paraskevi Kazakou, Dimitrios Tzanetakos, Aigli G. Vakrakou, John S. Tzartos, Maria-Eleptheria Evangelopoulos, Maria Anagnostouli, Panos Stathopoulos, Georgia N. Kassi, Leonidas Stefanis, Constantinos Kilidireas, Evangelia Zapanti
Summary: This prospective study analyzed the occurrence of autoimmune thyroid disease (AITD) in alemtuzumab-treated relapsing-remitting multiple sclerosis patients. Results showed that 54.8% of patients without prior thyroid dysfunction developed AITD, with Graves' disease being the most common. Interestingly, the majority of GD cases showed a fluctuating course.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Environmental Sciences
Chao Tang, Qing-Ru Li, Yan-Mei Mao, Yuan-Rui Xia, Heng-Sheng Guo, Jun-Ping Wang, Zong-Wen Shuai, Dong-Qing Ye
Summary: The study found through meta-analysis that only PM10 in the air is related to MS, while other pollutants are not. There was no publication bias, and the stability analysis results suggest that PM10 is associated with the disease MS.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Immunology
Nada Sherif Amin, Mostafa K. Abd El-Aziz, Mohamed Hamed, Ramez Reda Moustafa, Hend M. El Tayebi
Summary: This study found a correlation between genetic polymorphisms at rs205764 and rs547311 and the response to treatment and disability severity in multiple sclerosis patients. The results suggest that screening for specific genetic polymorphisms may help guide treatment choices.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cell Biology
Hayder M. Al-kuraishy, Majid S. Jabir, Ali I. Al-Gareeb, Hebatallah M. Saad, Gaber El-Saber Batiha, Daniel J. Klionsky
Summary: This study explores the protective and harmful effects of autophagy in the pathogenesis of multiple sclerosis (MS). Autophagy can prevent the progression of MS by reducing oxidative stress and inflammatory disorders, but over-activated autophagy can worsen the neuropathology of MS. Additionally, autophagy can modulate cell proliferation and affect demyelination and remyelination. Overall, autophagy plays a significant role in the pathogenesis of MS.
Review
Immunology
Negar Sadeghi Hassanabadi, Bieke Broux, Sonja Marinovic, Dagmar Gotthardt
Summary: Multiple sclerosis (MS) is a debilitating autoimmune disease with millions of patients worldwide. Recent studies have shown that innate lymphoid cells (ILCs), in addition to T cells, play a role in the disease pathology. However, the exact role of ILCs in MS is still controversial.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biology
Niels J. M. Verstegen, Ruth R. Hagen, Jet van den Dijssel, Lisan H. Kuijper, Christine Kreher, Thomas Ashhurst, Laura Y. L. Kummer, Maurice Steenhuis, Mariel Duurland, Rivka de Jongh, Nina de Jong, C. Ellen van der Schoot, Amelie Bos, Erik Mul, Katherine Kedzierska, Koos P. J. van Dam, Eileen W. Stalman, Laura Boekel, Gertjan Wolbink, Sander W. Tas, Joep Killestein, Zoe L. E. van Kempen, Luuk Wieske, Taco W. Kuijpers, Filip Eftimov, Theo Rispens, S. Marieke van Ham, Anja ten Brinke, Carolien E. van de Sandt
Summary: This study analyzed the immune responses to SARS-CoV-2 vaccination in MS and RA patients treated with immunosuppressants. The results showed that MS patients treated with OCR still exhibited a CD8(+) T cell response after vaccination, but humoral and B cell responses were strongly impaired. In contrast, RA patients experienced delayed antibody levels and B cell reactivation following the first vaccination. These findings have important implications for guiding vaccination strategies in patients with autoimmune diseases.
Review
Clinical Neurology
Sarah-Jane Martin, Raphael Schneider
Summary: Research suggests that physical exercise may have a positive impact on neuroinflammatory diseases. Animal studies on exercise intervention in multiple sclerosis have shown promising results. However, there are fundamental differences between animals and humans, and clinical studies in early disease cohorts are needed to determine the disease-modifying potential of exercise for people with multiple sclerosis.
FRONTIERS IN NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Nozomi Sachi, Naganori Kamiyama, Benjawan Saechue, Sotaro Ozaka, Astri Dewayani, Shimpei Ariki, Thanyakorn Chalalai, Yasuhiro Soga, Chiaki Fukuda, Yomei Kagoshima, Supanuch Ekronarongchai, Takashi Kobayashi
Summary: Multiple sclerosis is an autoimmune disease characterized by immune attack on the nerve myelin sheath. The balance between pathogenic Th17 cells and regulatory Treg cells, expressing chemokine receptor CCR6, is crucial in determining disease activity. The role of CCL20, the ligand of CCR6, in attracting immune cells to the central nervous system (CNS) in multiple sclerosis has not been fully understood. This study generated CCL20-knockout and CCR6-knockout mice using CRISPR/Cas9 system and found that the migratory function mediated by CCL20/CCR6 may not be necessary for the onset of experimental autoimmune encephalomyelitis (EAE).
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Immunology
Yinxiang Wang, Jue Wang, Juan Feng
Summary: This article provides an update on pregnancy-related issues in women with multiple sclerosis, including general recommendations for management at each stage of pregnancy.
AUTOIMMUNITY REVIEWS
(2023)
Review
Medicine, General & Internal
Zuber Khan, Ghanshyam Das Gupta, Sidharth Mehan
Summary: This study examines the difficulties in detecting and treating multiple sclerosis in India. A lack of MS knowledge among healthcare professionals and the general public delays diagnosis and treatment. Inadequate numbers of neurologists and professionals with knowledge of MS management exacerbate the situation. MS medications are expensive and not covered by insurance, making them inaccessible to most patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Immunology
Woori Kim, Nikolaos A. Patsopoulos
Summary: Multiple sclerosis is an inflammatory neurodegenerative disease with a strong genetic component. Genome-wide association studies have identified over 200 genetic loci associated with MS susceptibility, but there are still many unknowns and challenges. Definitive studies of disease progression and endophenotypes have yet to be conducted, and the functional characterization of the identified MS variants is still lacking. Despite these shortcomings, the unraveling of MS genetics has provided insights into the causal mechanisms of the disease.
SEMINARS IN IMMUNOPATHOLOGY
(2022)
Review
Health Care Sciences & Services
Viviana Nociti, Marina Romozzi
Summary: Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease of the central nervous system with broad heterogeneity and different prognoses. Autoimmune comorbidities play a crucial role in MS, affecting its pathogenesis, diagnostic delay, disease activity, disability progression, brain atrophy, and treatment choices. However, the impact of autoimmune comorbidities on MS is not fully understood.
JOURNAL OF PERSONALIZED MEDICINE
(2022)