期刊
JOURNAL OF DIABETES AND ITS COMPLICATIONS
卷 29, 期 3, 页码 427-432出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jdiacomp.2015.01.013
关键词
T2DM; Mast cells; Ketotifen; Obesity; Inflammation
Aim: Mast cells are found to be an important contributor in obesity induced insulin resistance. We evaluate the effect of ketotifen in obese patient with type 2 diabetes (T2DM) treated with glimepiride. Method: In a randomized controlled study we recruited forty-eight obese patients with T2DM from Internal Medicine Department at Tanta University Hospital, Egypt. They were classified into three groups: group 1, those who received glimepiride (GL) 3 mg/d alone; group 2, those who received GL 3 mg/d + ketotifen 1 mg once daily; and group 3, those who received GL 3 mg/d + ketotifen 1 mg twice daily. Fasting blood samples were obtained before and 12 weeks after treatment for biochemical analysis of glycemic and inflammatory biomarkers. Data were statistically analyzed by paired Student's t-test and one way analysis of variance; p < 0.05 was considered statistically significant. Results: The obtained data suggested that the addition of ketotifen in twice daily dose has a beneficial effect on all measured parameters except adiponectin. However, glimepiride plus ketotifen once daily only affected the level of inflammatory biomarkers without any significant effect on other parameters. Conclusions: The co-administration of ketotifen twice daily plus glimepiride improves glycemic and inflammatory process in obese patients with T2DM. (C) 2015 Elsevier Inc. All rights reserved.
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