Article
Multidisciplinary Sciences
Christopher R. Shaler, Alexandra A. Parco, Wael Elhenawy, Jasmeen Dourka, Jennifer Jury, Elena F. Verdu, Brian K. Coombes
Summary: Psychological stress impairs gut microbiome and immune system, allowing invasive bacteria to colonize; Immune modulation and administration of certain cytokines can counteract the negative impact of stress on gut health.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Kohei Sugihara, Sho Kitamoto, Prakaimuk Saraithong, Hiroko Nagao-Kitamoto, Matthew Hoostal, Caroline McCarthy, Alexandra Rosevelt, Chithra K. Muraleedharan, Merritt G. Gillilland, Jin Imai, Maiko Omi, Shrinivas Bishu, John Y. Kao, Christopher J. Alteri, Nicolas Barnich, Thomas M. Schmidt, Asma Nusrat, Naohiro Inohara, Jonathan L. Golob, Nobuhiko Kamada
Summary: Pathobiont AIEC can overcome dietary L-serine restriction and adapt to the gut by switching nutrient sources with the help of mucolytic bacteria, promoting the encroachment to the epithelial niche and acquiring L-serine from the colonic epithelium for proliferation.
Article
Microbiology
Gregoire Chevalier, Arnaud Laveissiere, Guillaume Desachy, Nicolas Barnich, Adeline Sivignon, Marc Maresca, Cendrine Nicoletti, Eric Di Pasquale, Margarita Martinez-Medina, Kenneth William Simpson, Vijay Yajnik, Harry Sokol, Temitayo Adegbamigbe, Tariq Ahmad, Ian Arnott, Yoram Bouhnik, Franck Carbonnel, Jean-Frederic Colombel, Glen Doherty, J. R. Fraser Cummings, Xavier Hebuterne, Hans Herfarth, David Kevans, Guillaume Pineton de Chambrun, Maria Nachury, Stephane Nancey, Xavier Roblin, Mark A. W. Tremelling, Jonathan Plassais, Francesco Strozzi, Alessandra Cervino, Rachel Morra, Christophe Bonny
Summary: The study identified a significant enrichment of FimH-expressing bacteria in the gut microbiome of CD patients, with FimH playing a crucial role in adhesion and inflammation induction. The specific FimH-blocker TAK-018 was shown to prevent bacterial adhesion and inflammation, potentially offering a promising treatment option for CD patients.
Review
Immunology
Lacey R. Lopez, Ju-Hyun Ahn, Tomaz Alves, Janelle C. Arthur
Summary: Inflammatory bowel disease (IBD) is a significant global health problem that involves chronic intestinal inflammation and severe comorbidities. Disease-associated alterations to the intestinal microbiota and microbial metabolites play a crucial role in IBD development. Understanding the microbial function in the context of IBD and characterizing disease-associated microbial metabolites are necessary for targeted treatment strategies.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Microbiology
Christopher J. Day, Alvin W. Lo, Lauren E. Hartley-Tassell, M. Pilar Argente, Jessica Poole, Nathan P. King, Joe Tiralongo, Michael P. Jennings, Mark A. Schembri
Summary: This study focused on dissecting the receptor specificity of different CU fimbriae in Escherichia coli using a glycan array analysis approach with whole-bacterial-cell surface plasmon resonance. The research revealed new information on fimbrial specificity and provided a rapid and scalable system to define novel adhesin-glycan interactions underlying bacterial colonization and disease. The findings contribute to a better understanding of bacterial adhesion mechanisms and offer a promising strategy to combat antibiotic resistance through blocking adhesion.
Article
Multidisciplinary Sciences
Yancong Zhang, Amrisha Bhosle, Sena Bae, Lauren J. McIver, Gleb Pishchany, Emma K. Accorsi, Kelsey N. Thompson, Cesar Arze, Ya Wang, Ayshwarya Subramanian, Sean M. Kearney, April Pawluk, Damian R. Plichta, Ali Rahnavard, Afrah Shafquat, Ramnik J. Xavier, Hera Vlamakis, Wendy S. Garrett, Andy Krueger, Curtis Huttenhower, Eric A. Franzosa
Summary: This article investigates the role of microbial communities and their associated bioactive compounds in inflammatory bowel diseases (IBD). It systematically identifies potentially bioactive protein families involved in gut inflammation during IBD and validates their bioactivity using a combination of metagenomics, metatranscriptomics, and metaproteomics. The results provide candidate microbial proteins that interact with the host immune system in IBD, expanding our understanding of potentially bioactive gene products in chronic diseases.
Article
Multidisciplinary Sciences
Yosuke Kurashima, Takaaki Kigoshi, Sayuri Murasaki, Fujimi Arai, Kaoru Shimada, Natsumi Seki, Yun-Gi Kim, Koji Hase, Hiroshi Ohno, Kazuya Kawano, Hiroshi Ashida, Toshihiko Suzuki, Masako Morimoto, Yukari Saito, Ai Sasou, Yuki Goda, Yoshikazu Yuki, Yutaka Inagaki, Hideki Iijima, Wataru Suda, Masahira Hattori, Hiroshi Kiyono
Summary: The study demonstrates that pancreatic GP2 can protect the intestinal epithelial barrier from bacterial invasion and is linked to prevention of Crohn's disease. Pancreatic GP2 is the source of intestinal luminal GP2, binding bacteria to prevent their attachment to the epithelium, which also reduces pathology in a DSS colitis mouse model.
NATURE COMMUNICATIONS
(2021)
Article
Gastroenterology & Hepatology
Vadim Dubinsky, Leah Reshef, Keren Rabinowitz, Nir Wasserberg, Iris Dotan, Uri Gophna
Summary: This study reveals that Escherichia coli is a commensal species adapted to the overactive mucosal immune milieu in inflammatory bowel disease (IBD) rather than causing it. Mutations that may lead to attenuated antigenicity in some E. coli strains are also identified.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Biochemistry & Molecular Biology
Jun-Young Park, Cheorl-Ho Kim, Seung-Hak Cho
Summary: In this study, we developed a FimH inhibitor to prevent adhesion of enterohemorrhagic Escherichia coli on human intestinal epithelium during the early stage of infection. By investigating the ligand binding domain of FimH and analyzing its evolutionary characteristics, we identified a potential drug target and found that glycan-like peptides can serve as initial infection inhibitors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Imteyaz Ahmad Khan, Baibaswata Nayak, Manasvini Markandey, Aditya Bajaj, Mahak Verma, Sambudhha Kumar, Mukesh Kumar Singh, Saurabh Kedia, Vineet Ahuja
Summary: Crohn's disease and Intestinal tuberculosis are chronic intestinal diseases with similar phenotype but diverse etiologies. This study found a higher prevalence of host gene polymorphisms and pathobionts in colonic mucosa of patients with CD compared to ITB.
Review
Gastroenterology & Hepatology
Megan Lynn Otte, Raju Lama Tamang, Julia Papapanagiotou, Rizwan Ahmad, Punita Dhawan, Amar B. Singh
Summary: Mucosal healing (MH) is crucial for maintaining gut health and preventing inflammatory diseases. However, disturbances in intestinal homeostasis can lead to autoimmune diseases like inflammatory bowel disease (IBD), where the body's healing processes are impaired. Currently, there is a lack of effective therapies that can restore MH due to the complexity of the disease and healing processes. Developing therapeutics that enhance the body's healing response may offer potential strategies for treating IBD and promoting mucosal healing.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Wendy E. Thomas, Laura Carlucci, Olga Yakovenko, Gianluca Interlandi, Isolde Le Trong, Pavel Aprikian, Pearl Magala, Lydia Larson, Yulia Sledneva, Veronika Tchesnokova, Ronald E. Stenkamp, Evgeni Sokurenko
Summary: This study reveals that the FimH protein of Escherichia coli can undergo fast and sustained allosteric activation under static, non-shear conditions, expanding the understanding of the catch bond mechanism. The activation of the lectin domain conformation occurs intrinsically at a constant rate, independent of its interaction with the pilin domain or mannose. The findings suggest that the allosteric catch bond mechanism may play a broader role in cell-pathogen attachments under various hydrodynamic conditions.
JOURNAL OF MOLECULAR BIOLOGY
(2022)
Article
Immunology
Omayra Martin-Rodriguez, Thierry Gauthier, Francis Bonnefoy, Melanie Couturier, Anna Daoui, Cecile Chague, Severine Valmary-Degano, Claire Gay, Philippe Saas, Sylvain Perruche
Summary: The study focuses on evaluating the efficacy of pro-resolving factors produced by macrophages after efferocytosis in treating IBD. Reintroduction of these factors was shown to reduce inflammation in colitis models and promote tissue repair, with TGF-beta, IGF-I and VEGF identified as key factors. The administration of these pro-resolving factors released by efferocytic macrophages represents an innovative treatment approach for IBD.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Pediatrics
Marleen Bouhuys, Willem S. Lexmond, Patrick F. van Rheenen
Summary: Inflammatory bowel diseases (IBDs) are chronic, immune-mediated disorders that include Crohn's disease and ulcerative colitis. Pediatric onset of the disease occurs in about 10% of cases. The management of pediatric IBD has evolved, with anti-tumor necrosis factor therapy being used upfront for patients at high risk for complications. Biochemical or endoscopic remission is the therapeutic goal, and pediatric IBD comes with unique challenges such as growth impairment and psychological issues. General pediatricians play a crucial role in integrating these challenges in the clinical care of patients with IBD and optimizing their outcomes.
Review
Microbiology
Li Zhang, Fang Liu, Jessica Xue, Seul A. Lee, Lu Liu, Stephen M. Riordan
Summary: This article reviews bacterial species associated with human IBD and their pathogenic mechanisms and proposes a three-stage pathogenesis model. Furthermore, microbe-targeted therapeutic strategies based on this model are recommended.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Marion Picard, Satoru Yonekura, Karolina Slowicka, Ioanna Petta, Conrad Rauber, Bertrand Routy, Corentin Richard, Valerio Iebba, Maryam Tidjani Alou, Sonia Becharef, Pierre Ly, Eugenie Pizzato, Christian H. K. Lehmann, Lukas Amon, Christophe Klein, Paule Opolon, Ivo Gomperts Boneca, Jean-Yves Scoazec, Antoine Hollebecque, David Malka, Francois Ghiringhelli, Diana Dudziak, Geert Berx, Lars Vereecke, Geert van Loo, Guido Kroemer, Laurence Zitvogel, Maria Paula Roberti
Summary: The study identified an ileal immune profile associated with the prognosis of colon cancer and responses to chemotherapy, showing upregulation of the ileal immune transcriptome in poor-prognosis patients with proximal colon cancer. Conversely, oxaliplatin-based chemotherapy could restore a favorable, attenuated ileal immune fingerprint in responders. These results suggest that chemotherapy inversely shapes the immune profile of the ileum-tumor axis, influencing clinical outcome.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Medicine, Research & Experimental
Gladys Ferrere, Maryam Tidjani Alou, Peng Liu, Anne-Gaelle Goubet, Marine Fidelle, Oliver Kepp, Sylvere Durand, Valerio Iebba, Aurelie Fluckiger, Romain Daillere, Cassandra Thelemaque, Claudia Grajeda-Iglesias, Carolina Alves Costa Silva, Fanny Aprahamian, Deborah Lefevre, Liwei Zhao, Bernhard Ryffel, Emeline Colomba, Monica Arnedos, Damien Drubay, Conrad Rauber, Didier Raoult, Francesco Asnicar, Tim Spector, Nicola Segata, Lisa Derosa, Guido Kroemer, Laurence Zitvogel
Summary: Limited experimental evidence suggests a link between nutrition and cancer immunosurveillance. This study demonstrates that ketogenic diet induces an anti-tumor effect through 3HB-mediated T cell-mediated cancer immunosurveillance. 3HB prevents immune checkpoint inhibition and promotes the expansion of specific T cells, while KD also leads to compositional changes in gut microbiota.
Article
Microbiology
Giuseppina Campisciano, Valerio Iebba, Gabriella Zito, Stefania Luppi, Monica Martinelli, Leo Fischer, Francesco De Seta, Giuseppe Basile, Giuseppe Ricci, Manola Comar
Summary: Infertile couples undergoing assisted reproductive technology were studied to evaluate microbiological signatures affecting reproductive health. Lactobacilli were dominant in vaginal lavages, with L. iners linked to decreased fertility rates. Prevotella and HPV infection were associated with explained infertility, while L. gasseri was identified in unexplained infertility, affecting oocyte DNA fragmentation and sperm mobility. The study suggests that profiling the reproductive tract microbiome offers new perspectives on human reproduction.
Article
Biochemistry & Molecular Biology
Safae Terrisse, Lisa Derosa, Valerio Iebba, Francois Ghiringhelli, Ines Vaz-Luis, Guido Kroemer, Marine Fidelle, Stergios Christodoulidis, Nicola Segata, Andrew Maltez Thomas, Anne-Laure Martin, Aude Sirven, Sibille Everhard, Fanny Aprahamian, Nitharsshini Nirmalathasan, Romy Aarnoutse, Marjolein Smidt, Janine Ziemons, Carlos Caldas, Sibylle Loibl, Carsten Denkert, Sylvere Durand, Claudia Iglesias, Filippo Pietrantonio, Bertrand Routy, Fabrice Andre, Edoardo Pasolli, Suzette Delaloge, Laurence Zitvogel
Summary: This study found that specific gut commensals overabundant in breast cancer patients compared with healthy individuals have a negative impact on the prognosis of breast cancer, are modulated by chemotherapy, and may influence weight gain and neurological side effects of breast cancer therapies. Further prospective validation of these findings in adjuvant and neoadjuvant settings is warranted.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Biochemistry & Molecular Biology
Anne-Gaelle Goubet, Richard Wheeler, Aurelie Fluckiger, Bo Qu, Fabien Lemaitre, Kristina Iribarren, Laura Mondragon, Maryam Tidjani Alou, Eugenie Pizzato, Sylvere Durand, Lisa Derosa, Fanny Aprahamian, Noelie Bossut, Maryse Moya-Nilges, Diane Derrien, Guo Chen, Marion Leduc, Adrien Joseph, Nicolas Pons, Emmanuelle Le Chatelier, Nicola Segata, Satoru Yonekura, Valerio Iebba, Oliver Kepp, Didier Raoult, Fabrice Andre, Guido Kroemer, Ivo Gomperts Boneca, Laurence Zitvogel, Romain Daillere
Summary: The study demonstrates that the gut microbiome's deviation is associated with resistance to cancer immunotherapy, and Enterococcus hirae can compensate for tumor-associated dysbiosis in various cancer models by stimulating T cell responses, activating autophagy, and altering the host microbiome.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Biochemistry & Molecular Biology
Miles C. Andrews, Connie P. M. Duong, Vancheswaran Gopalakrishnan, Valerio Iebba, Wei-Shen Chen, Lisa Derosa, Md Abdul Wadud Khan, Alexandria P. Cogdill, Michael G. White, Matthew C. Wong, Gladys Ferrere, Aurelie Fluckiger, Maria P. Roberti, Paule Opolon, Maryam Tidjani Alou, Satoru Yonekura, Whijae Roh, Christine N. Spencer, Irina Fernandez Curbelo, Luis Vence, Alexandre Reuben, Sarah Johnson, Reetakshi Arora, Golnaz Morad, Matthew Lastrapes, Erez N. Baruch, Latasha Little, Curtis Gumbs, Zachary A. Cooper, Peter A. Prieto, Khalida Wani, Alexander J. Lazar, Michael T. Tetzlaff, Courtney W. Hudgens, Margaret K. Callahan, Matthew Adamow, Michael A. Postow, Charlotte E. Ariyan, Pierre-Olivier Gaudreau, Luigi Nezi, Didier Raoult, Catalin Mihalcioiu, Arielle Elkrief, Rossanna C. Pezo, Lauren E. Haydu, Julie M. Simon, Hussein A. Tawbi, Jennifer McQuade, Patrick Hwu, Wen-Jen Hwu, Rodabe N. Amaria, Elizabeth M. Burton, Scott E. Woodman, Stephanie Watowich, Adi Diab, Sapna P. Patel, Isabella C. Glitza, Michael K. Wong, Li Zhao, Jianhua Zhang, Nadim J. Ajami, Joseph Petrosino, Robert R. Jenq, Michael A. Davies, Jeffrey E. Gershenwald, P. Andrew Futreal, Padmanee Sharma, James P. Allison, Bertrand Routy, Laurence Zitvogel, Jennifer A. Wargo
Summary: The study showed that tumor-associated immune and genomic biomarkers of response to combined immune checkpoint blockade (CICB) in melanoma patients were similar to those of monotherapy, while toxicity from CICB was associated with a more diverse peripheral T-cell repertoire. Additionally, analysis of gut microbiota revealed a higher abundance of Bacteroides intestinalis in patients experiencing toxicity, along with an upregulation of the inflammatory factor IL-1 beta in colitis samples.
Article
Biochemistry & Molecular Biology
Lisa Derosa, Bertrand Routy, Andrew Maltez Thomas, Valerio Iebba, Gerard Zalcman, Sylvie Friard, Julien Mazieres, Clarisse Audigier-Valette, Denis Moro-Sibilot, Francois Goldwasser, Carolina Alves Costa Silva, Safae Terrisse, Melodie Bonvalet, Arnaud Scherpereel, Herve Pegliasco, Corentin Richard, Francois Ghiringhelli, Arielle Elkrief, Antoine Desilets, Felix Blanc-Durand, Fabio Cumbo, Aitor Blanco, Romain Boidot, Sandy Chevrier, Romain Daillere, Guido Kroemer, Laurie Alla, Nicolas Pons, Emmanuelle Le Chatelier, Nathalie Galleron, Hugo Roume, Agathe Dubuisson, Nicole Bouchard, Meriem Messaoudene, Damien Drubay, Eric Deutsch, Fabrice Barlesi, David Planchard, Nicola Segata, Stephanie Martinez, Laurence Zitvogel, Jean-Charles Soria, Benjamin Besse
Summary: In addition to PD-L1 expression, biomarkers for predicting the response to immune checkpoint inhibitors (ICIs) in non-small-cell lung cancer (NSCLC) are needed. This study found that fecal Akkermansia muciniphila (Akk) was associated with clinical benefit of ICI treatment in NSCLC patients, independent of PD-L1 expression and other factors. The relative abundance of Akk in the gut microbiome may serve as a potential biomarker for patient stratification.
Review
Gastroenterology & Hepatology
Giovanni Di Nardo, Cesare Cremon, Annamaria Staiano, Vincenzo Stanghellini, Osvaldo Borrelli, Caterina Strisciuglio, Claudio Romano, Saverio Mallardo, Elena Scarpato, Giovanni Marasco, Silvia Salvatore, Letizia Zenzeri, Enrico Felici, Licia Pensabene, Simona Sestito, Ruggiero Francavilla, Paolo Quitadamo, Mariella Baldassarre, Valentina Giorgio, Renato Tambucci, Chiara Ziparo, Pasquale Parisi, Maria Raffaella Barbaro, Giovanni Barbara
Summary: Functional gastrointestinal disorders, such as IBS, affect many children worldwide due to disturbed neuroimmune function. Low-grade inflammation and mucosal immune activation play a significant role in symptom generation among pediatric patients with IBS, potentially influencing new therapeutic strategies.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Review
Medicine, General & Internal
Guglielmo Salvatori, Domenico Umberto De Rose, Anna Claudia Massolo, Neil Patel, Irma Capolupo, Paola Giliberti, Melania Evangelisti, Pasquale Parisi, Alessandra Toscano, Andrea Dotta, Giovanni Di Nardo
Summary: Newborn infants with congenital heart disease face various nutritional challenges, leading to inadequate energy intake, sub-optimal growth, increased morbidity, and mortality. To optimize their nutrition and growth, standardized protocols, regular assessment, and multidisciplinary teamwork are essential.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biology
Vincenzo Raieli, Mariarita Capizzi, Antonio Marino, Giovanni Di Nardo, Umberto Raucci, Pasquale Parisi
Summary: Migraine is a complex neurologic disorder that affects multiple systems of the central nervous system. Keeping an aura diary can help in diagnosing and preventing under-diagnosis of rare migraine manifestations. Complex migraine manifestations require a thorough diagnostic work-up to exclude dangerous neurologic pathologies.
Article
Pediatrics
Paolo Quitadamo, Giusy Ranucci, Stefania Ragozzino, Sonia Tamasi, Marcella Giugliano, Giovanni Gaglione, Daniele De Brasi, Augusto Mastrominico, Giovanni Di Nardo
Summary: A young girl with autism spectrum disorder was admitted for acute abdominal pain and a giant bezoar filling the stomach was found. It was surgically removed.
JOURNAL OF PEDIATRIC SURGERY CASE REPORTS
(2022)
Article
Gastroenterology & Hepatology
Giovanni Di Nardo, Enrico Felici, Letizia Zenzeri, Maurizio Mennini, Melania Evangelisti, Pasquale Parisi, Anna Claudia Massolo, Cesare Hassan, Marisa Piccirillo, Livia Lucchini, Silvia Furio, Giovanna Quatrale, Caterina Strisciuglio
Summary: This study aimed to assess the superiority of split-dose regimen of SPMC compared with SPMC day-before regimen for bowel cleansing before colonoscopy in children. The results showed that the rate of successful cleansing level was significantly higher in the split-dose group. The BBPS scores were significantly higher in the split-dose group for the whole colon, right colon, and transverse colon. Patient acceptability was better in the split-dose group and the percentage of children needing nasogastric tube placement was lower.
DIGESTIVE ENDOSCOPY
(2023)
Review
Nutrition & Dietetics
Sabrina Cenni, Veronica Sesenna, Giulia Boiardi, Marianna Casertano, Giovanni Di Nardo, Susanna Esposito, Caterina Strisciuglio
Summary: The Mediterranean diet, rich in antioxidants and anti-inflammatory nutrients, has been recognized as one of the healthiest dietary patterns worldwide. Numerous studies have shown a strong correlation between the Mediterranean diet and chronic gastrointestinal diseases. This narrative review aims to analyze the effectiveness of the Mediterranean diet in preventing and managing these disorders, providing a useful overview.
Review
Pediatrics
Angela Mauro, Teresa Giani, Clelia Di Mari, Martina Sandini, Antonella Talenti, Valentina Ansuini, Luigi Biondi, Giovanni Di Nardo, Luca Bernardo
Summary: Systemic lupus erythematosus (SLE) is a systemic autoimmune disorder. When it presents before the age of 18 years (childhood-onset systemic lupus erythematosus, cSLE), the disease course tends to be more severe with a higher rate of organ involvement and requires an early diagnosis. Gastrointestinal involvement in cSLE is rare and scarcely reported in the literature. This manuscript provides a narrative review of gastrointestinal manifestations in cSLE, focusing on hepatic, pancreatic, and intestinal involvement, based on a comprehensive literature search using the PubMed database.
Review
Medicine, General & Internal
Alessandro Ferretti, Mattia Gatto, Margherita Velardi, Giovanni Di Nardo, Thomas Foiadelli, Gianluca Terrin, Manuela Cecili, Umberto Raucci, Massimiliano Valeriani, Pasquale Parisi
Summary: The relationship between migraines and allergies is still not well understood, although there is an epidemiological link between them. Genetic and biological factors contribute to both migraines and allergic disorders. The histaminergic system, particularly the H3 and H4 receptors, may play a role in the pathophysiology of both conditions. Antihistamine drugs could potentially be helpful in treating migraines and allergic disorders. Further research is needed to fully understand the mechanistic link between these two common and debilitating conditions.
JOURNAL OF CLINICAL MEDICINE
(2023)