期刊
CANADIAN JOURNAL OF MICROBIOLOGY
卷 56, 期 3, 页码 272-278出版社
CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
DOI: 10.1139/W10-007
关键词
surfactant biologique; eradication de biofilm; argent; Escherichia coli; synergie
资金
- Alberta Heritage Foundation for Medical Research (AHFMR) through Universities Technologie International
- Alberta Science and Research Authority, Innovation and Science Research Investments Program (ASRA ISRIP)
- Natural Sciences and Engineering Research Council (NSERC)
Biological contamination of surfaces, both in industry and in health care, plays an important role as a potential vector of disease transmission. Metals have been described to be effective antibiofilm agents, and the efficacy of silver ions as a disinfectant has been known for centuries. The activity of AgNO3 combined with the lipopeptide biosurfactant V9T14 has been studied against a preformed Escherichia coli biofilm on the Calgary Biofilm Device. Results indicated that the activity of silver can be synergistically enhanced by the presence of V9T14, both allowing for a reduction in the quantity of silver used and for greater antimicrobial activity. The concentration of silver needed to obtain this reduction in the silver biosurfactant solution was from 129- to 258-fold less than the concentration of silver alone. To our knowledge, this is the first time that a synergistic interaction between a lipopeptide biosurfactant and silver has been observed.
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