Article
Chemistry, Analytical
Kai-Wen Lin, Yu-Chi Chang
Summary: This paper presents a rapid test system for fecal occult blood (FOB) detection with high sensitivity, linearity, and stability. The system detects the immune coloration response to accurately quantify the detection target, ranging from 0 ng/mL to 400 ng/mL of FOB with low coefficients of variation (CV) below 3.7%.
Article
Gastroenterology & Hepatology
Wladyslaw Januszewicz, Klaudiusz Witczak, Paulina Wieszczy, Magda Socha, Maryla H. Turkot, Urszula Wojciechowska, Joanna Didkowska, Michal F. Kaminski, Jaroslaw Regula
Summary: This study investigated the characteristics and risk factors of upper gastrointestinal cancers (UGICs) missed during endoscopy. The results showed that esophageal adenocarcinomas were most frequently missed, and missed cancers occurred more frequently within the primary care sector, in women, and in individuals with multiple comorbidities.
Article
Medical Laboratory Technology
Li Du, Xiaoling Cao, Jing Chen, Xiuqi Wei, Yi Zeng, Chen Cheng, Yuqi Lin, Wenbin Tan, Hui Wang
Summary: This study found that a fecal occult blood test combined with gastrointestinal symptoms could serve as a simple and effective screening approach for diagnosing GI in COVID-19 patients. Additionally, age and sex were identified as risk factors for UI in COVID-19 patients. Urinary cytology test may be a sensitive tool for assessing early UI when serum markers for renal injuries appear normal.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Gastroenterology & Hepatology
Ann G. Zauber, Sidney J. Winawer, Michael J. O'Brien, Glenn M. Mills, John I. Allen, Andrew D. Feld, Paul A. Jordan, Martin Fleisher, Irene Orlow, Reinier G. S. Meester, Iris Lansdorp-Vogelaar, Carolyn M. Rutter, Amy B. Knudsen, Margaret Mandelson, Aasma Shaukat, Robin B. Mendelsohn, Anne I. Hahn, Stephanie M. Lobaugh, Brittany Soto Palmer, Victoria Serrano, Julie R. Kumar, Sara E. Fischer, Jennifer C. Chen, Sharon Bayuga-Miller, Deborah Kuk, Kelli O'Connell, Timothy R. Church
Summary: This study compared the adherence and pathology findings of a single screening colonoscopy with sequential and nonsequential high sensitivity fecal occult blood testing (HSgFOBT). The results showed that adherence to a single screening colonoscopy was higher than sequential HSgFOBT, and the detection of advanced neoplasia or large serrated lesions (ADN-SERs) was inferior when nonsequential HSgFOBT adherence was compared with sequential adherence. Therefore, the effectiveness of an HSgFOBT screening program may be enhanced if crossover to screening colonoscopy is permitted.
Article
Gastroenterology & Hepatology
Ming Lu, Le Wang, Yuhan Zhang, Chengcheng Liu, Bin Lu, Lingbin Du, Xianzhen Liao, Dong Dong, Donghua Wei, Yi Gao, Jufang Shi, Jiansong Ren, Hongda Chen, Min Dai
Summary: The risk-adapted screening combining Asia-Pacific Colorectal Screening score, FIT, and colonoscopy showed higher sensitivity for advanced neoplasm but lower specificity compared to FIT alone. Adjusting the positivity threshold tailored to clinical practice could save colonoscopy resources and cost.
CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY
(2021)
Review
Gastroenterology & Hepatology
Ayesha Shah, Ali Eqbal, Naomi Moy, Natasha Koloski, Helmut Messmann, Bradley J. Kendall, Prateek Sharma, Uwe Dulleck, Michael P. Jones, Gerald J. Holtmann
Summary: A systematic review and meta-analysis found that there is a significant prevalence of upper gastrointestinal (UGI) lesions in FOBT+ subjects. Anemia is associated with UGI lesions, but symptoms and colonic pathology are not. Dual endoscopy may yield more malignancies in FOBT+ subjects, but further study is needed to determine its cost-effectiveness.
GASTROINTESTINAL ENDOSCOPY
(2023)
Review
Gastroenterology & Hepatology
Ayesha Shah, Ali Eqbal, Naomi Moy, Natasha Koloski, Helmut Messmann, Bradley J. Kendall, Prateek Sharma, Uwe Dulleck, Michael P. Jones, Gerald J. Holtmann
Summary: This study aimed to determine the prevalence of upper gastrointestinal (UGI) lesions in subjects with a positive fecal occult blood test (FOBT+). The results showed that the prevalence of UGI cancers in FOBT+ subjects was 0.8%, and the prevalence of UGI clinically significant lesions (CSLs) was 30.4%. Anemia was associated with UGI cancers and UGI CSLs, while gastrointestinal symptoms were not associated with UGI CSLs.
GASTROINTESTINAL ENDOSCOPY
(2023)
Article
Cardiac & Cardiovascular Systems
Yoshiyuki Takami, Atsuo Maekawa, Koji Yamana, Kiyotoshi Akita, Kentaro Amano, Yusuke Sakurai, Yasushi Takagi
Summary: We investigated the role of preoperative fecal immunochemical test (FIT) for detecting gastrointestinal bleeding and cancer in cardiac surgery. The study found that FIT has limited impact on identification of bleeding sites, but may be useful in detecting malignant lesions.
THORACIC AND CARDIOVASCULAR SURGEON
(2023)
Article
Engineering, Electrical & Electronic
Panpan Qiao, Luo Yu, Jingwen He, Ailin Zhang, Hongyig Liu, Xitian Pi
Summary: The study introduces a gastric occult blood detection capsule system for screening upper gastrointestinal bleeding and tumor diseases. Experimental results demonstrate that the system accurately detects occult blood and transmits the relevant information to external devices.
SENSORS AND ACTUATORS A-PHYSICAL
(2021)
Article
Public, Environmental & Occupational Health
Kenta Tanaka, Tomotaka Sobue, Ling Zha, Tetsuhisa Kitamura, Norie Sawada, Motoki Iwasaki, Manami Inoue, Taiki Yamaji, Shoichiro Tsugane
Summary: This study analyzed data from 30,381 middle-aged Japanese adults and found that fecal occult blood test (FOBT) and colonoscopy both reduced the risk of death and incidence of colorectal cancer (CRC).
JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Wen-Feng Hsu, Chi-Yang Chang, Chun-Chao Chang, Li-Chun Chang, Chien-Hua Chen, Chun-Che Lin, Yu-Min Lin, Chia-Long Lee, Hong-Yuan Wu, Hsin-Chung Lee, Yi-Chia Lee, Ming-Yao Su, Li-Ju Lin, Shu-Li Chia, Ming-Shiang Wu, Han-Mo Chiu
Summary: The study found that FIT-colonoscopy was associated with more than two-fold risk of significant bleeding, especially when polypectomy was performed.
Article
Gastroenterology & Hepatology
Stavroula Pelitari, Abhirami Gautham, Pritesh Mistry, Siddhartha Mohan, Matthew Brookes, Brian McKaig, Ashit Shah, Sarah Jewes, Gemma Fieldhouse, Andrew Veitch, Aravinth Murugananthan
Summary: The implementation of FIT in the Bowel Cancer Screening Program in England led to higher return and sample positivity rates compared to the previous FOBT. Patients in the FIT group required more endoscopic procedures, SSP time, radiology tests, and surgical procedures, resulting in considerable ongoing financial costs. The increase in services also had implications on histopathology services, with FIT leading to more histology samples and a higher number of polyps found per patient.
GASTROINTESTINAL ENDOSCOPY
(2021)
Review
Public, Environmental & Occupational Health
Zilin Luo, Xuesi Dong, Chenran Wang, Wei Cao, Yadi Zheng, Zheng Wu, Yongjie Xu, Liang Zhao, Fei Wang, Jibin Li, Jiansong Ren, Jufang Shi, Wanqing Chen, Ni Li
Summary: This study systematically reviewed observational studies on the association between socioeconomic status (SES) and adherence to colorectal cancer (CRC) screening. The findings showed that individuals with high SES had higher adherence to screening compared to those with low SES. Neighborhood SES or small-area SES was more effective in assessing the association between SES and adherence than individual SES.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2023)
Article
Oncology
Xuan Quy Luu, Kyeongmin Lee, Jae Kwan Jun, Mina Suh, Kyu-Won Jung, Kui Son Choi
Summary: This study investigated the long-term survival effects of colorectal cancer screening based on screening history and interval time since screening. The results showed that colorectal cancer screening was positively associated with favorable prognosis, especially among individuals screened within 1 year before diagnosis.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Public, Environmental & Occupational Health
Tingting Yao, Qin Sun, Kangwei Xiong, Yuan Su, Qian Zhao, Chenhong Zhang, Lijiu Zhang, Xuejun Li, Haiming Fang
Summary: This study compares different testing strategies for colorectal cancer screening, including multi-target fecal DNA testing, quantitative and qualitative fecal immunoassay tests (FITs). The efficacy of these strategies was examined in different populations, and it was found that single testing strategy is more suitable for general population screening, while combined testing strategy is more suitable for high-risk populations screening.
EUROPEAN JOURNAL OF PUBLIC HEALTH
(2023)
Article
Oncology
Christoph Wohlmuth, Zeina Ghorab, Michael Shier, Jill Tinmouth, Irving E. Salit, Allan Covens, Liying Zhang, Danielle Vicus
Summary: This study found a high prevalence of abnormal anal cytology and HPV positivity in women aged >= 40 years with a history of high-grade cervical SIL or cancer. Older age and smoking were significant risk factors for abnormal anal cytology. High-grade AIN had a higher prevalence in this population, suggesting the consideration of screening for anal cancer in these patients. Further research is needed to determine the optimal screening approach.
CANCER CYTOPATHOLOGY
(2021)
Review
Gastroenterology & Hepatology
Alexandra Shingina, Philip Vutien, Elizabeth Uleryk, Prakesh S. Shah, Eberhard Renner, Mamatha Bhat, Jill Tinmouth, Joseph Kim
Summary: Living donor liver transplantation (LDLT) offers superior patient and graft survival outcomes compared to deceased donor liver transplantation (DDLT) in pediatric patients with chronic liver failure and acute liver failure (ALF). Improved survival in the most recent cohort of patients suggests a learning curve for the LDLT technique. More resources may be needed to support living liver donation in pediatric patients.
LIVER TRANSPLANTATION
(2022)
Article
Public, Environmental & Occupational Health
Arlinda Ruco, Nancy N. Baxter, Jenna Jacobson, Jill Tinmouth, Diego Llovet
Summary: This study aimed to develop social media messages to promote colorectal cancer screening uptake. The findings suggest that Facebook users prefer messages with a positive or reassuring tone, educational content, and from credible sponsors. However, messages that use humor or a fearful tone may undermine campaign objectives.
Article
Public, Environmental & Occupational Health
Jill Tinmouth, Diego Llovet, Rinku Sutradhar, Kate Tsiplova, Jian Roushani, Alex Lee, Joanne Hader, Linda Rabeneck, Lawrence Paszat
Summary: Through two pragmatic randomized controlled trials, it was found that mailed invitations were effective in promoting colorectal cancer screening for both men and women. The use of behaviorally informed invitations appeared to further enhance the screening uptake, suggesting a greater benefit compared to no invitation.
PREVENTIVE MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Nancy N. Baxter, Marcia Facey, Arlinda Ruco, Natalie A. Baker, Anne Sorvari, Amina Benmessaoud, Catherine Dube, Linda Rabeneck, Jill Tinmouth
Summary: This study describes the challenges faced by organized colorectal cancer screening programs and the adaptive measures taken during the early stages of the COVID-19 pandemic. The study highlights the importance of quick decision-making, flexible management of screening capacity, and ethical considerations in effectively responding to crises.
BMJ OPEN GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Dominika Bhatia, Rinku Sutradhar, Lawrence F. Paszat, Linda Rabeneck, Simron Singh, Jill Tinmouth, Lorraine L. Lipscombe
Summary: Individuals with comorbidities are less likely to receive colonoscopy after positive FOBT, indicating the need for better screening and follow-up strategies.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Immunology
Alexandra Shingina, Ioannis A. Ziogas, Philip Vutien, Elizabeth Uleryk, Prakesh S. Shah, Eberhard Renner, Mamatha Bhat, Jill Tinmouth, Joseph Kim
Summary: This study conducted a systematic review and meta-analysis to address concerns regarding subpar outcomes of living donor liver transplantation (LDLT) in patients with acute liver failure (ALF). The results showed no significant difference in 1, 3, and 5-year patient and graft survival between LDLT and deceased donor liver transplantation (DDLT). However, further studies are warranted due to the limited number of included studies.
TRANSPLANTATION REVIEWS
(2022)
Article
Medicine, General & Internal
Meghan J. Walker, Jonathan Wang, Joshua Mazuryk, Siew-Mei Skinner, Olivia Meggetto, Eta Ashu, Steven Habbous, Narges Nazeri Rad, Gabriela Espino-Hernandez, Ryan Wood, Munaza Chaudhry, Saba Vahid, Julia Gao, Daniela Gallo-Hershberg, Eric Gutierrez, Claudia Zanchetta, Deanna Langer, Victoria Zwicker, Michelle Rey, Martin C. Tammemagi, Jill Tinmouth, Rachel Kupets, Anna M. Chiarelli, Simron Singh, Padraig Warde, Leta Forbes, Julian Dobranowski, Jonathan Irish, Linda Rabeneck
Summary: This population-based cohort study in Ontario, Canada, observed significant reductions in cancer service volumes during the COVID-19 pandemic, particularly during the first wave. While most services recovered to prepandemic levels at the end of the first pandemic year, a substantial care deficit likely accrued.
Article
Gastroenterology & Hepatology
Jill Tinmouth, Deepak Swain, Katherine Chorneyko, Vicki Lee, Barbara Bowes, Yingzi Li, Julia Gao, David Morgan
Summary: This study developed and validated an NLP algorithm to identify colorectal adenomas and report ADR at the population level in Ontario, Canada. The algorithm showed high sensitivity and specificity in identifying adenomas, and it was accurately used to measure ADR at the system level.
GASTROINTESTINAL ENDOSCOPY
(2023)
Article
Medicine, General & Internal
Rui Fu, Rinku Sutradhar, Qing Li, Timothy P. Hanna, Kelvin K. W. Chan, Jonathan C. Irish, Natalie Coburn, Julie Hallet, Anna Dare, Simron Singh, Ambica Parmar, Craig C. Earle, Lauren Lapointe-Shaw, Monika K. Krzyzanowska, Antonio Finelli, Alexander Louie, Nicole J. Look Hong, Ian J. Witterick, Alyson Mahar, David R. Urbach, Daniel I. McIsaac, Danny Enepekides, Jill Tinmouth, Antoine Eskander
Summary: This study examines the impact of the COVID-19 pandemic on modalities and wait times for first cancer treatment. The findings suggest that patients diagnosed during the pandemic were more likely to receive nonsurgical therapy and experienced shorter waiting times.
Article
Biochemistry & Molecular Biology
Li Zhang, Isabel Mosquera, Eric Lucas, Mary Luz Rol, Andre L. Carvalho, Partha Basu, Daniel Sadowski, Bartlett Natasha, Alison Budd, Ashrafun Nessa, Isabel De Brabander, Annemie Haelens, Sarah Pringels, Jonas Tairo, Solveig Hofvind, J. B. Burrion, Zdravka Valerianova, Jill Tinmouth, Cindy Law, Simbi Ebenuwah, Bronwen McCurdy, Beata Janik, George Pupwe, Linn Fenna Groeneveld, Gry Baadstrand Skare, Penelope Layne, Tytti Sarkeala, Mwate Joseph Chaila, Michal Kaminski, Beata Kinel, Jolanta Lissowska, Inga Mumukunde, Vitor Rodrigues, Robinson Rodriguez, Elena Perez Sanz, Raquel Zubizarreta Alberdi, Guglielmo Ronco, Natasa Antoljak, Dinka Nakic, Davor Plazanin, Andrea Supe Parun, Mat Goossens, Andrzej Nowakowski, Harry de Koning, Els Dams, Asha Martin, Mara Epermane, Natalja Jankovska, Scott Antle, Jacques Fracheboud, Esther Toes-Zoutendijk, Heleen M. E. van Agt, Karen Budewig, Barbara Stomper, Ahti Anttila, Sorana McLeish, Alexandra Ramssl-Sauer, Georg Ziniel, Theopisti Kyprianou, Pavlos Pavlou, Fofo Kaliva, Maria Tsantidou, Shaokai Zhang, Huifang Xu, Wali Mushtaq, Biviana Paredes Barragan, Alexandra Montalvo, Ana Victoria de la Torre Santos, Marie-Helene Guertin, Sarah Fournier, Nicolas Duport, Ondrej Majek, Ondrej Ngo, Urska Ivanus, Katja Jarm, Maja Primic-Zakelj, Flavia de Miranda Correa, Arn Migowski, Marianna Cancela, Patricia Gallardo, Gisel Fattore, Adrian Puello, Victor Polanco, Nieves Ascunce Elizaga, Valerie Fabri, Paola Mantellini, Marco Zappa, Eliane Kellen, Elsebeth Lynge, Vanessa Kaab-Sanyal, Daniela Malek, Youssef Chami, Rugile Ivanauskiene, Nensy Bandhoe, Claire Dillenbourg, Karin Heckters, Astrid Scharpantgen, Oris Mariela Ruiz, Geneva Mireya Gonzalez, Elsa Arenas, Eduardo Alberto Palacios Cacacho, Alicia Pomata, Eliza Navarro, Milva Mencia, Gisela Abreu Ruiz, Ruth Campoverde, Claudia Camel, Rocio Donis, Yolanda Ines Sandoval, Heidy Garcia, Omaira Isabel Roldan, Teresa del Carmen Moreno, Mario Morales Velado, Gina Merino, Juvenal A. Rios, Sabrina Marte, Reina Oliva Hernandez, Marina Anea Chacon, Xiomara Isabel Ruiz, Xiomara del Carmen Hernandez Vivas, Roger Ivan Gonzalez, Damaris Isabel Medal Ruiz, Lourdes Ortega, Andrea Matos Orbegozo, Carlos Adolfo Chuquiyauri Haro, Miriam Dalmas, Fahriye Unlu, Loubna Abousselham, Rose-Marie De Waldt, Charlotte Buys, Yasine Hanna, Cathi-Ann Williams, Londi-Ann Ottey, Shana Philbert-Cyr, Crissah Emmanuel, Alexandra Jemmott, Nuno Augusto Alberto de Miranda, Stala Kioupi, Takelech Moges Asnake, Adel A. Attia, Gontse Tshisimogo, Lame Seema, Jonathan Chiwanda Banda, Feisul Idzwan Mustapha, Rosita Paulo Mugolo, Reginaldo de Alice Miguel Juliao, Mary Nyangasi, Valerian Mwenda, Sonia Tavares Ferreira, Carla Barbosa, Manala Makua, Yacubu Herve Julius Bakare, Myanna Charles, Leandra Charles, Vera Edwards-France, Cheshta Sewtahal, Bridget Kebirungi, Mugabe Frank Rwabinumi, Valarie Williams, Oritta Zachariah, Arlitha Scott, Camille Deleveaux, Martin Campbell, Cesaltina Ferreira, Suraj Perera, Padmaka Silva, Vindya Kumarapeli, Merisa Grant-Tate, Cherie Tulloch, Kumiko Saika, Kyeongmin Lee, Jae Kwan Jun, Sona Franklin Mukete, Plamen Dimitrov, Vaida Momkuviene, Viaceslavas Zaksas, Piret Veerus, Tatjana Kofol Bric, Dominika Novak Mlakar, Ana Lucija Skrjanec, Jozica Maucec Zakotnik, Tamar Skhirtladze, Stephanie Xuereb, Carol Colquhoun, Suleeporn Sangrajrang, Kumar Eshwar, Greig Stanners, Roger Black, Trude Andreassen, Andras Budai, Lajos Dobrossy, Attila Kovacs, Florian Nicula, Isabel Portillo, Jone Miren Altzibar, Edurne Arenaza, Ndabaningi Simango, Josep A. Espinas, Constance Glinton-Rolle, Jeanette Anews-Barr, Mariana Capote, Marisa Fazzino, Claire Armstrong, Andrew Gamble, Kenneth Mc Innes, Suzanne Wright, Helen Clayton, Radoslav Latinovic, Anne Mackie, Janet Rimmer, Clare Hall, Klara Miriam Elfstrom, Sven Tornberg, Manuel Zorzi, Marcis Leja, Dace Rezeberga, Marc Hagenimana, Francoise Hamers, Agnes Rogel, Frank Assogba, Patricia Fitzpatrick, Marc Arbyn, Jacqueline Figueroa, Alex Rovelo, Erosloa Salinas, Elias Yused Arguello, Adriana Milano Castillo, Velia Rosas, Stanislav Spanik, Merete Ronmos Houmann, Dorte Johansen, Joakim Dillner, Kunal Oswal, Yubei Huang, Ismail M. Siala, Michel Candeur, Sarah Hoeck, Josep M. Borras, Luc Bleyen, Bothwell Takaingofa Guzha, Adie Yao Mesmin Olivier, Elisabeth Fasching, Alexander Gollmer Gesundheit, Tonoy Taohid, Walkiria Bermejo Bencomo, Darbelis Tejada, Joseph Psaila Valletta, Judy Nisbett, Damaris Baptiste, Melanie Ann Layne
Summary: The CanScreen5 project is a global cancer screening data repository that aims to report the status and performance of breast, cervical and colorectal cancer screening programs across different countries. The data collected showed better overall organization of screening programs in Europe compared to other continents, but there were gaps in implementation across both high- and low-resource settings.
Article
Medicine, General & Internal
Arlinda Ruco, Alexandra Cernat, Sabine Calleja, Jill Tinmouth, Aisha K. Lofters
Summary: This scoping review aims to report on PCP interventions that maximize cancer screening participation among marginalized patients. The review will focus on cancers with strong evidence for screening, including lung, cervical, breast, and colorectal cancers. Peer-reviewed literature published in English from January 1, 2000, to March 31, 2022, describing PCP interventions for cancer screening will be included. The results will be disseminated to inform the development of interventions for marginalized patients.
Article
Oncology
Rui Fu, Rinku Sutradhar, Qing Li, Pabiththa Kamalraj, Anna Dare, Timothy P. Hanna, Kelvin K. W. Chan, Jonathan C. Irish, Natalie Coburn, Julie Hallet, Simron Singh, Ambica Parmar, Craig C. Earle, Lauren Lapointe-Shaw, Monika K. Krzyzanowska, Alexander V. Louie, Alyson Mahar, David R. Urbach, Daniel I. McIsaac, Danny Enepekides, David Gomez, Nicole J. Look Hong, Jill Tinmouth, Antoine Eskander
Summary: This study investigated the association between the COVID-19 pandemic and early survival among newly diagnosed cancer patients. It found that there was no difference in one-year overall survival between patients diagnosed during the pandemic and those diagnosed in the previous two years. This study highlights the complex impact of the COVID-19 pandemic on cancer care.
Review
Gastroenterology & Hepatology
Colin Sue-Chue-Lam, Matthew Castelo, Amina Benmessaoud, Teruko Kishibe, Diego Llovet, Christine Brezden-Masley, Amy Y. X. Yu, Jill Tinmouth, Nancy N. Baxter
Summary: A scoping review found limited research on non-pharmacological interventions to improve patient-reported outcomes of colonoscopy. There was significant variation in the characteristics and results of the included studies across different countries. Future research should focus on underinvestigated interventions and develop consensus-based guidelines for study design.
BMJ OPEN GASTROENTEROLOGY
(2023)
Article
Public, Environmental & Occupational Health
Naana Afua Jumah, Alethea Kewayosh, Bernice Downey, Laura Campbell Senese, Jill Tinmouth
Summary: The Indigenous Lens Tool was developed to facilitate the implementation of the HEIA Tool within Cancer Care Ontario and its principles can be applied to other health and social service policies.
