Review
Biochemistry & Molecular Biology
HyunTaek Jung, Jae Seok Kim, Keum Hwa Lee, Kalthoum Tizaoui, Salvatore Terrazzino, Sarah Cargnin, Lee Smith, Ai Koyanagi, Louis Jacob, Han Li, Sung Hwi Hong, Dong Keon Yon, Seung Won Lee, Min Seo Kim, Paul Wasuwanich, Wikrom Karnsakul, Jae Il Shin, Andreas Kronbichler
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract that mainly affects young people. Recent studies have shown that microRNAs (miRNAs) play an important role in the pathogenesis, diagnosis, and treatment of IBD.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Nutrition & Dietetics
Yan Jiang, Karolin Jarr, Cosima Layton, Christopher D. Gardner, Judith E. Ashouri, Maria T. Abreu, Sidhartha R. Sinha
Summary: Despite being an important issue for patients, the impact of diet on adult inflammatory bowel disease (IBD) is not well explored, with limited guidance. Current evidence on various diets used in the treatment of IBD is summarized, with potential applications of dietary data from related immune-mediated inflammatory diseases (IMIDs) to inform providers. Multiple diets, including Mediterranean, vegetarian/vegan, and reduced-calorie/fasting diets, have shown positive results in other inflammatory diseases, suggesting potential applicability to IBD, but further well-designed clinical trials are needed for guidance.
Review
Immunology
Susanna Esposito, Giulia Antoniol, Marialuisa Labate, Lucrezia Passadore, Patrizia Alvisi, Valeria Dacco, Chiara Ghizzi, Carla Colombo, Nicola Principi
Summary: The incidence of inflammatory bowel diseases (IBDs) is rising globally, leading to a higher risk of infections in children with dysfunctional immune systems. Vaccines are essential for preventing these infections, and should be administered according to specific immunization guidelines for IBD patients. Compliance with vaccination recommendations is generally low, highlighting the need for multidisciplinary educational programs to improve vaccination coverage and protect children with IBD from vaccine-preventable diseases.
Review
Biochemistry & Molecular Biology
Tyler Atagozli, David E. Elliott, Mirac Nedim Ince
Summary: Helminths are multicellular invertebrates that live in the gut of vertebrate animals, including humans. They can cause pathology and require treatment, but can also have commensal or symbiotic relationships with their hosts. Epidemiological data suggests that helminth exposure may provide protection against immune disorders, such as allergies and autoimmune illnesses.
Article
Immunology
Dengyong Xu, Yao Chen, Xing Gao, Weidong Xie, Ya Wang, Jiaying Shen, Guang Yang, Binbin Xie
Summary: This study conducted a two-sample Mendelian randomization analysis and found a causal relationship between inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), and low total body bone mineral density (BMD) and osteoporosis (OS).
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Maria Jose Sanchez-Quintero, Cristina Rodriguez-Diaz, Francisco J. Rodriguez-Gonzalez, Alejandra Fernandez-Castaner, Eduardo Garcia-Fuentes, Carlos Lopez-Gomez
Summary: Mitochondria play a crucial role in maintaining cellular functions and are involved in various cellular processes. Dysfunction of mitochondria has been linked to complex disorders, including inflammatory bowel diseases (IBD). The impact of mitochondrial dysfunction on IBD, including its role in intestinal mucosa, immune cell populations, mucosal repair, microbiota-brain-gut axes, and the development of colitis-associated colorectal cancer, is discussed in this review.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Clinical Neurology
Andrea Ballesio, Andrea Zagaria, Flavia Baccini, Federica Micheli, Giovanni Di Nardo, Caterina Lombardo
Summary: This study found that patients with inflammatory bowel disease have poorer subjective sleep quality compared to controls, with even worse sleep quality in those with active IBD. However, there were no differences within IBD subtypes. These results highlight the importance of considering sleep quality as a relevant comorbidity in IBD.
SLEEP MEDICINE REVIEWS
(2021)
Article
Pediatrics
Jeremy Vanhelst, Laurent Beghin, Dominique Turck, Julien Labreuche, Stephanie Coopman, Frederic Gottrand, Delphine Ley
Summary: This study aimed to assess physical activity patterns among children and adolescents with inflammatory bowel disease (IBD), comparing them with healthy controls. The results showed that pediatric patients with inactive or mildly active IBD have similar physical activity patterns compared with healthy controls, except for male patients who have reduced moderate-to-vigorous physical activity. Most patients with IBD did not meet the recommended levels of moderate-to-vigorous physical activity for health benefits.
PEDIATRIC RESEARCH
(2021)
Review
Medicine, General & Internal
Alicja Ewa Ratajczak, Aleksandra Szymczak-Tomczak, Anna Maria Rychter, Agnieszka Zawada, Agnieszka Dobrowolska, Iwona Krela-Kazmierczak
Summary: Smoking is a major modifiable risk factor for osteoporosis and can lead to various chronic diseases, including inflammatory bowel disease. Nicotine and compounds in cigarette smoke impact the RANK-RANKL-OPG pathway, intestinal microbiota composition, and calcium-phosphate balance.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Gastroenterology & Hepatology
Tilemachos Koutouratsas, Anastassios Philippou, George Kolios, Michael Koutsilieris, Maria Gazouli
Summary: The gut microbiome may be related to the pathogenesis of inflammatory bowel diseases, and the effects of physical exercise on the gut microbiome may be beneficial for certain patients with IBD.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Anna Krystyna Zielinska, Maciej Salaga, Pawel Siwinski, Marcin Wlodarczyk, Adam Dziki, Jakub Fichna
Summary: The study found that IBD patients had significantly decreased SOD activity, GSH and GSSG levels, and GPX activity was significantly diminished only in CD patients. CAT and COX-1 activity was increased, while COX-2 was significantly decreased in IBD patients. TBARS were significantly higher in CD patients compared to the control group. There was no correlation between pain scores, inflammatory status, disease activity, disease duration, or dietary habits and OS markers.
Review
Gastroenterology & Hepatology
Alexa N. Sasson, Ashwin N. Ananthakrishnan, Maitreyi Raman
Summary: The global incidence of inflammatory bowel diseases (IBDs) has increased significantly in the past few decades, with genetic and environmental factors playing a role in the pathogenesis. Diet is a potentially modifiable environmental risk factor for IBD, as it can promote intestinal inflammation through various mechanisms such as dysregulating the immune system and altering intestinal permeability. Dietary changes may be integrated into therapeutic strategies for IBD treatment.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Maia Kayal, David Kohler, Michael Plietz, Sergey Khaitov, Patricia Sylla, Alexander Greenstein, Marla C. Dubinsky
Summary: In this retrospective cohort analysis, early pouchitis was significantly associated with subsequent development of Crohn's disease-like pouch inflammation, indicating that early pouchitis may serve as an indicator of enhanced mucosal immune activation in the pouch.
INFLAMMATORY BOWEL DISEASES
(2022)
Review
Medicine, General & Internal
Eduard Brunet Mas, Xavier Calvet Calvo
Summary: Combination of two biological therapies (CoT) appears to be a safe and effective treatment option for refractory and severely ill patients with inflammatory bowel disease (IBD). Ustekinumab plus vedolizumab and vedolizumab plus anti-TNF are the most commonly used CoTs for Crohn's disease. For ulcerative colitis, vedolizumab plus anti-TNF and vedolizumab plus tofacitinib are the most commonly used CoTs.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Matthias Zilbauer, Robert Heuschkel
Summary: Inflammatory bowel diseases like Crohn's disease and ulcerative colitis are complex conditions that require personalized treatment approaches. Developing biomarkers to predict disease course and treatment response is challenging.
JOURNAL OF CROHNS & COLITIS
(2022)
Editorial Material
Medicine, General & Internal
Vivian Huang, Richard Fedorak
CANADIAN MEDICAL ASSOCIATION JOURNAL
(2016)
Article
Gastroenterology & Hepatology
Christopher Ma, Chad J. Evaschesen, Grenvil Gracias, Vivian W. Huang, Darryl K. Fedorak, Karen I. Kroeker, Levinus A. Dieleman, Brendan P. Halloran, Richard N. Fedorak
CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2015)
Article
Gastroenterology & Hepatology
Helen M. Becker, Daniel Grigat, Subrata Ghosh, Gilaad G. Kaplan, Levinus Dieleman, Eytan Wine, Richard N. Fedorak, Aida Fernandes, Remo Panaccione, Herman W. Barkema
CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2015)
Article
Gastroenterology & Hepatology
Vivian Wai-Mei Huang, Neil Dhami, Darryl Fedorak, Connie Prosser, Carol Shalapay, Karen Ivy Kroeker, Brendan Phillip Halloran, Levinus Albert Dieleman, Richard Neil Fedorak
CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2015)
Article
Gastroenterology & Hepatology
Brian Bressler, Remo Panaccione, Richard N. Fedorak, Ernest G. Seidman
CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2015)
Article
Gastroenterology & Hepatology
Maria E. Negron, Ali Rezaie, Herman W. Barkema, Kevin Rioux, Jeroen De Buck, Sylvia Checkley, Paul L. Beck, Matthew Carroll, Richard N. Fedorak, Levinus Dieleman, Remo Panaccione, Subrata Ghosh, Gilaad G. Kaplan
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2016)
Article
Gastroenterology & Hepatology
Richard N. Fedorak, Kathleen P. Ismond
DIGESTIVE DISEASES
(2016)
Article
Gastroenterology & Hepatology
Julia J. Liu, Theresa M. Kay, Elisabeth M. Davis, Yuefei Lou, Dina Kao, Brian Claggett, Richard N. Fedorak, Randall T. Irvin
DIGESTIVE DISEASES AND SCIENCES
(2016)
Editorial Material
Gastroenterology & Hepatology
Christopher Ma, Richard N. Fedorak, Brendan P. Halloran
Article
Gastroenterology & Hepatology
Miguel Regueiro, Brian G. Feagan, Bin Zou, Jewel Johanns, Marion A. Blank, Marc Chevrier, Scott Plevy, John Popp, Freddy J. Cornillie, Milan Lukas, Silvio Danese, Paolo Gionchetti, Stephen B. Hanauer, Walter Reinisch, William J. Sandborn, Dario Sorrentino, Paul Rutgeerts
Article
Gastroenterology & Hepatology
Thomas Lee, Thomas Clavel, Kirill Smirnov, Annemarie Schmidt, Ilias Lagkouvardos, Alesia Walker, Marianna Lucio, Bernhard Michalke, Philippe Schmitt-Kopplin, Richard Fedorak, Dirk Haller
Article
Gastroenterology & Hepatology
Krista M. Reich, Richard N. Fedorak, Karen Madsen, Karen I. Kroeker
INFLAMMATORY BOWEL DISEASES
(2016)
Article
Gastroenterology & Hepatology
Christopher Ma, Candace L. Beilman, Vivian W. Huang, Darryl K. Fedorak, Karen I. Kroeker, Levinus A. Dieleman, Brendan P. Halloran, Richard N. Fedorak
INFLAMMATORY BOWEL DISEASES
(2016)
Article
Endocrinology & Metabolism
Dina Kao, Kathleen P. Ismond, Victor Tso, Braden Millan, Naomi Hotte, Richard N. Fedorak
Article
Gastroenterology & Hepatology
Christopher Ma, Candace L. Beilman, Vivian W. Huang, Darryl K. Fedorak, Karen Wong, Karen I. Kroeker, Levinus A. Dieleman, Brendan P. Halloran, Richard N. Fedorak
CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2016)