期刊
JOURNAL OF DERMATOLOGICAL TREATMENT
卷 27, 期 4, 页码 351-354出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/09546634.2015.1117565
关键词
atopic dermatitis; beta-glucan; complementary medicine; pleuran; topical treatment
类别
资金
- Pleuran Ltd.
- Center of Experimental and Clinical Respirology [ITMS 26220120004]
Background: Atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases with serious impact on quality of life. beta-Glucans are natural substances with potent immunomodulatory and anti-inflammatory activity. Methods: In a multicentre open split-body study, we studied the effect of Imunoglukan P4H (R) cream in a group of 105 patients with AD (39 males, 37%). Evaluation of subjective (visual analogue scale, VAS) and objective (EASI score, eczema area and severity index) characteristics of AD was carried out. Results: In total, 80 patients (76.2%) completed the study. Topical beta-glucan application resulted in the significant improvement of both objective and subjective symptoms of AD. On the application side, significant decline in the number of days with AD exacerbation and its severity was observed. Moreover, the subjects experienced decline of pruritus on the beta-glucan half of the body (VAS score: 1.68 vs. 1.95, p<0.001). During the study, the continual and significant decline of EASI scores on the site of beta-glucan application was observed (V4: 1.57 vs. 1.85, p<0.001). The preparation was in general well tolerated. Conclusions: This is the first study evaluating and confirming the potential use of beta-glucan-based cream as a supportive complementary therapy of atopic dermatitis.
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