Article
Multidisciplinary Sciences
Emily L. Clarke, Ryckie G. Wade, Derek Magee, Julia Newton-Bishop, Darren Treanor
Summary: The current subjective histopathological assessment of cutaneous melanoma is challenging, and the application of image analysis algorithms to histological images may improve workflow and prognostication. This review aimed to evaluate the accuracy of existing image analysis algorithms applied to digital histological images of cutaneous melanoma.
SCIENTIFIC REPORTS
(2023)
Review
Genetics & Heredity
Nannan Son, Yankun Cui, Wang Xi
Summary: TL shortening may promote skin aging development and reduce the risk of cutaneous melanoma and NMSCs.
FRONTIERS IN GENETICS
(2022)
Review
Oncology
Svenja Pauleck, Jennifer A. Sinnott, Yun-Ling Zheng, Shahinaz M. Gadalla, Richard Viskochil, Benjamin Haaland, Richard M. Cawthon, Albrecht Hoffmeister, Sheetal Hardikar
Summary: Colorectal cancer risk was not associated with telomere length in circulating leukocytes, but shorter leukocyte telomeres were associated with poorer survival in patients with colorectal cancer. Telomere length may serve as a potential biomarker for colorectal cancer prognosis. Larger prospective cohort studies are needed to confirm this potential association.
Review
Oncology
Ruolin Liu, Qianyi Wan, Rui Zhao, Haitao Xiao, Ying Cen, Xuewen Xu
Summary: In patients with rheumatoid arthritis and psoriasis, those treated with biologics have an increased risk of non-melanoma skin cancer (NMSC) compared to those not receiving biologics, but this increased risk was not seen in patients with inflammatory bowel disease. The underlying reasons for the increased risk of NMSC in IBD patients require further discussion.
CANCER CELL INTERNATIONAL
(2021)
Review
Biochemistry & Molecular Biology
Vincenzo De Falco, Stefania Napolitano, Daniela Esposito, Luigi Pio Guerrera, Davide Ciardiello, Luigi Formisano, Teresa Troiani
Summary: This study reviewed the potential roles of lncRNAs in melanoma, suggesting that they could serve as biomarkers or therapeutic targets in the treatment of this type of cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Lauren W. Y. McLester-Davis, Pedro Estrada, Waylon J. Hastings, Leila A. Kataria, Noelle A. Martin, Joshua T. Siebeneicher, Renee I. Tristano, Celia V. Mayne, Raquel P. Horlick, Samantha S. O'Connell, Stacy S. Drury
Summary: The source of tissue has a significant impact on the correlation between telomere length and health outcomes. This study aims to investigate the influence of study design and methodological features on the correlation between telomere lengths measured in different tissues from the same individual. It was found that the correlation is influenced by sample size, telomere length measurement methodology, and tissue source.
AGEING RESEARCH REVIEWS
(2023)
Review
Oncology
Seokyung An, Kyungsik Kim, Sungji Moon, Kwang-Pil Ko, Inah Kim, Jung Eun Lee, Sue K. Park
Summary: This study reviewed 54 studies and found that indoor tanning is associated with early-onset melanoma and NMSC, with higher risk in younger individuals. The findings emphasize the importance of avoiding indoor tanning in younger adults to reduce the risk of skin cancer.
Review
Environmental Sciences
Jaqueline Dal Curtivo Passos, Karoline Felisbino, Henrique Aparecido Laureano, Izonete Cristina Guiloski
Summary: The results of this systematic review and meta-analysis suggest an association between occupational exposure to pesticides and shorter telomere length. However, due to the limited number of included studies, more high-quality research is needed to strengthen these findings.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Oncology
Lin Li, Baoqiang Pei, Yanyan Feng
Summary: This study found that the use of exogenous hormones is associated with an increased risk of keratinocyte carcinoma (KC), specifically squamous cell carcinoma (SCC) and basal cell carcinoma (BCC), among women. Oral contraceptives (OC) were found to increase the risk of SCC, while no significant association was observed between hormonal replacement therapy (HRT) and SCC risk. Both OC and HRT use were linked to an increased risk of BCC.
Review
Public, Environmental & Occupational Health
Z. -q. Zong, S. -w. Chen, Y. Wu, S. -y. Gui, X. -j. Zhang, C. -y. Hu
Summary: This study aimed to investigate the associations between air pollution exposure during pre-and post-birth and adulthood with telomere length. A systematic review and meta-analysis was conducted using data from 18 studies. The results showed moderate evidence that prenatal PM2.5 and NO2 exposures were related to shortened telomere length. However, other exposures such as prenatal SO2 and CO, childhood PM2.5, PM10, and NO2, as well as short-term adulthood PM2.5 and PM10 exposures were not associated with telomere length. High-quality studies are needed for further investigation.
Review
Oncology
Fausto Petrelli, Antonio Ghidini, Andrea Simioni, Luca Giovanni Campana
Summary: Electrochemotherapy with either intratumoral or intravenous bleomycin shows high therapeutic response in cutaneous metastatic melanoma, with no significant difference in efficacy based on different administration routes or tumor sizes. Some studies reported high local control rates and 1-year overall survival rates.
Review
Geriatrics & Gerontology
Cristina Valente, Renato Andrade, Luis Alvarez, Alexandre Rebelo-Marques, Emmanuel Stamatakis, Joao Espregueira-Mendes
Summary: Physically active individuals tend to have longer telomeres, especially in middle-aged individuals and athletes, but the effect may be overestimated. Exercise interventions do not show significant impact on telomere length.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Review
Oncology
Stefania Guida, Antonio Alma, Kaleci Shaniko, Johanna Chester, Silvana Ciardo, Ilaria Proietti, Roberta Giuffrida, Iris Zalaudek, Marco Manfredini, Caterina Longo, Francesca Farnetani, Giovanni Pellacani
Summary: Non-melanoma skin cancers (NMSC) can be monitored using noninvasive skin imaging in nonsurgical treatments. The accuracy of dermoscopy, reflectance confocal microscopy (RCM), and optical coherence tomography (OCT) in detecting clearance is uncertain. We aim to report the proportion of persisting tumors identified with noninvasive technologies available in the literature.
Review
Geriatrics & Gerontology
Huimin Xie, Yubo Ma, Ming Shao, Jiangping Kong, Tingting Zhou, Feier Wang, Guoqi Cai, Shenqian Xu, Faming Pan
Summary: The study systematically evaluated the relationship between telomere length (TL) and osteoarthritis (OA) by analyzing six original studies, showing that OA patients have shorter TL in peripheral blood leukocytes (PBLs) compared to healthy controls. Sex ratio and body mass index (BMI) were identified as possible sources of heterogeneity.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Mingtong Gao, Gege Zheng, Yun Li, Yingying Zhang, Po Hu, Yang Pan
Summary: This meta-analysis aimed to investigate the potential relationship between telomere length and cancer recurrence. The findings showed no significant correlation between telomere length and overall cancer recurrence, but specific types of cancers exhibited different associations with telomere length.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Alice Laffi, Lorenzo Gervaso, Oriana D'Ecclesiis, Sara Gandini, Agostino Riva, Rita Passerini, Francesca Spada, Stefania Pellicori, Manila Rubino, Chiara Alessandra Cella, Paola Simona Ravenda, Maria Giulia Zampino, Nicola Fazio
Summary: Research suggests that chemotherapy may result in a reduced immune response to COVID-19 vaccines in cancer patients, while the timing of vaccination and lymphocyte count have no significant effect on immune response.
Review
Otorhinolaryngology
Luca Giovanni Locatello, Serena Jiang, Lixiao Chen, Saverio Caini, Giandomenico Maggiore, Pin Dong, Oreste Gallo
Summary: The role of postoperative radiotherapy (PORT) after open partial laryngeal surgery (OPLS) in terms of oncology and function remains controversial. A systematic review and meta-analysis were conducted, and the outcomes of OPLS patients with and without PORT for laryngeal cancer were summarized. The meta-analysis of 10 studies showed no significant difference in overall survival between OPLS patients who did and did not receive PORT, except for a higher incidence of complications in the PORT cohort in one study.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Oncology
Carmine Valenza, Dario Trapani, Sara Gandini, Caterina Sposetti, Luca Boscolo Bielo, Antonio Marra, Tommaso Giarratano, Diletta Favero, Laura Cortesi, Luca Moscetti, Mirco Pistelli, Rossana Berardi, Alberto Zambelli, Matteo Lambertini, Lucia Del Mastro, Valentina Guarneri, Claudio Vernieri, Giuseppe Curigliano
Summary: Patients with germinal BRCA pathogenic variant and advanced breast cancer may have enhanced sensitivity to platinum-based chemotherapy and PARP inhibitors. However, the sensitivity and resistance to these treatments may partially overlap. The impact of prior exposure to PARP inhibitors/platinum-based chemotherapy on tumor response to subsequent treatment remains unclear.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Oncology
Oliver John Kennedy, Michal Kicinski, Sara Valpione, Sara Gandini, Stefan Suciu, Christian U. Blank, Georgina Long, Victoria G. Atkinson, Stephane Dalle, Andrew M. Haydon, Andrey Meshcheryakov, Adnan Khattak, Matteo S. Carlino, Shahneen Sandhu, James Larkin, Susana Puig, Paolo A. Ascierto, Piotr Rutkowski, Dirk Schadendorf, Marye Boers-Sonderen, Anna Maria Di Giacomo, Alfonsus J. M. van den Eertwegh, Jean-Jacques Grob, Ralf Gutzmer, Rahima Jamal, Alexander C. J. van Akkooi, Caroline Robert, Alexander M. M. Eggermont, Paul Lorigan, Mario Mandala
Summary: This study investigated the prognostic and predictive value of metformin in melanoma, and found that metformin had no significant impact on the efficacy of pembrolizumab, especially in BRAF-mutated melanoma.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Infectious Diseases
Lisa Staadegaard, Marco Del Riccio, Sytske Wiegersma, Clotilde El Guerche-Seblain, Erica Dueger, Meral Akcay, Jean-Sebastien Casalegno, Michel Duckers, Saverio Caini, John Paget
Summary: The FluCov project, covering 22 countries, was initiated to monitor the impact of the SARS-CoV-2 pandemic on influenza activity. The survey results show the profound impact of SARS-CoV-2 on national influenza surveillance in the first 27 months of the pandemic. Most NICs were able to increase their laboratory testing capacity and the robustness of their surveillance systems, and anticipate the integration of SARS-CoV-2 surveillance into the existing respiratory surveillance system.
INFLUENZA AND OTHER RESPIRATORY VIRUSES
(2023)
Review
Biochemistry & Molecular Biology
Lisa Padroni, Laura De Marco, Lucia Dansero, Valentina Fiano, Lorenzo Milani, Paolo Vasapolli, Luca Manfredi, Saverio Caini, Claudia Agnoli, Fulvio Ricceri, Carlotta Sacerdote
Summary: Breast cancer is a multifactorial disease influenced by genetic predisposition and environmental exposures. MicroRNAs, a group of small non-coding RNA molecules, may act as tumor suppressor genes or oncogenes and play a role in cancer risk. A systematic review and meta-analysis were conducted to identify circulating microRNAs associated with breast cancer diagnosis, with emphasis on methodological issues. The analysis included 75 studies, and meta-analysis was performed for microRNAs analyzed in at least three independent studies. The study found that MIR21, MIR155, and MIR10b were differentially expressed in breast cancer patients compared to healthy controls, but there was little consistency among the included studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Jolien Robijns, Michele Aquilano, Suvam Banerjee, Saverio Caini, Julie Ryan Wolf, Corina van den Hurk, Mara Beveridge, Henry Lam, Pierluigi Bonomo, Edward Chow, Tara Behroozian
Summary: This systematic review and meta-analysis aimed to assess the efficacy of barrier films and dressings in preventing acute radiation dermatitis (RD). The results showed that Hydrofilm and Mepitel Film could effectively reduce the severity of RD and improve patient-reported outcomes. However, the overall evidence for studies on barrier films and dressings is weak due to limited study number, high risk of bias, small sample sizes, and minimal comparable outcome measures.
SUPPORTIVE CARE IN CANCER
(2023)
Review
Oncology
Jolien Robijns, Carlotta Becherini, Saverio Caini, Julie Ryan Wolf, Corina van den Hurk, Mara Beveridge, Henry Lam, Pierluigi Bonomo, Edward Chow, Tara Behroozian
Summary: This systematic review and meta-analysis aimed to evaluate the efficacy of natural and miscellaneous agents in preventing acute radiation dermatitis in cancer patients. The results showed that oral enzymes and olive oil significantly reduced the incidence of radiation dermatitis, while the other agents had no significant effect. However, the evidence supporting natural agents is inconsistent due to low study numbers, low-quality designs, and small sample sizes, therefore, concrete conclusions cannot be made.
SUPPORTIVE CARE IN CANCER
(2023)
Review
Nutrition & Dietetics
Oriana D'Ecclesiis, Elisa Pastore, Sara Gandini, Saverio Caini, Giulia Marvaso, Barbara A. Jereczek-Fossa, Giulia Corrao, Sara Raimondi, Federica Bellerba, Silvia Ciceri, Marialetizia Latella, Nora de Bonfioli Cavalcabo, Benedetta Bendinelli, Calogero Saieva, Miriam Fontana, Patrizia Gnagnarella
Summary: We conducted a systematic review and meta-analysis to investigate the association between alcohol consumption and prostate cancer prognosis. The analysis included 19 independent studies and found that high alcohol consumption may be associated with an increased risk of fatal prostate cancer in healthy individuals. However, further confirmation is needed due to inconsistencies in the results.
Article
Oncology
Davide Serrano, Sara Gandini, Parjhitham Thomas, Katherine D. Crew, Nagi B. Kumar, Lana A. Vornik, J. Jack Lee, Paolo Veronesi, Giuseppe Viale, Aliana Guerrieri-Gonzaga, Matteo Lazzeroni, Harriet Johansson, Mauro D'Amico, Flavio Guasone, Stefano Spinaci, Bjorn-Erik Bertelsen, Gunnar Mellgren, Isabelle Bedrosian, Diane Weber, Tawana Castile, Eileen Dimond, Brandy M. Heckman-Stoddard, Eva Szabo, Powel H. Brown, Andrea DeCensi, Bernardo Bonanni
Summary: This study compared different dosing schedules of exemestane, an aromatase inhibitor, in patients with breast cancer. The results showed that a 25mg dose taken three times weekly was as effective as a daily dose in decreasing serum estradiol levels, suggesting that this alternative schedule warrants further investigation.
Article
Medicine, General & Internal
Simone Tavano, Saverio Caini, Idanna Sforzi, Caterina Silvestri, Fabio Voller, Tiziana Pisano
Summary: The COVID-19 pandemic has had significant effects on the lives of children and adolescents, particularly in terms of psychiatric disorders. A study was conducted comparing the trends in psychiatric disorders in the emergency room before (2018-2019) and during the pandemic (2020-2021). The results showed a decrease in admissions for non-psychiatric disorders and a significant increase in admissions for psychiatric emergencies, with greater impact on female patients, increased severity of disorders, and changes in diagnoses associated with symptoms presentation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Giovanna Masala, Melania Assedi, Benedetta Bendinelli, Elisa Pastore, Maria Antonietta Gilio, Vincenzo Mazzalupo, Andrea Querci, Miriam Fontana, Giacomo Duroni, Luigi Facchini, Calogero Saieva, Domenico Palli, Daniela Ambrogetti, Saverio Caini
Summary: This study investigated the association between volumetric mammographic breast density measures, their changes over time, and breast cancer risk. It was found that higher values of volumetric percent density and dense volume were positively associated with increased breast cancer risk, while an inverse association was evident for increasing non-dense volume. No clear effect of annual changes in mammographic breast density emerged.
Article
Biochemistry & Molecular Biology
Davide Serrano, Federica Bellerba, Harriet Johansson, Debora Macis, Valentina Aristarco, Chiara A. Accornero, Aliana Guerrieri-Gonzaga, Cristina M. Trovato, Maria Giulia Zampino, Emanuela Omodeo Sale, Bernardo Bonanni, Sara Gandini, Patrizia Gnagnarella
Summary: Vitamin D deficiency is associated with colorectal cancer (CRC), while adherence to World Cancer Research Fund (WCRF) recommendations significantly reduces the risk of developing CRC. In a randomized trial, CRC patients showed gender and microbiota-specific responses to Vitamin D supplementation. Following WCRF recommendations was associated with lower levels of leptin and IL-6, as well as a lower risk of events. Vitamin D supplementation did not have a significant impact on circulating biomarkers or follow-up events.
Review
Infectious Diseases
Elena C. Rosca, Carl Heneghan, Elizabeth A. Spencer, Annette Plueddemann, Susanna Maltoni, Sara Gandini, Igho J. Onakpoya, David Evans, John M. Conly, Tom Jefferson
Summary: This study systematically reviewed the clinical and laboratory features of SARS-CoV-2 and Strongyloides coinfection, assessed possible interventions and outcomes, and identified research gaps. The results indicate the need for further research on the frequency and risk of Strongyloides reactivation in COVID-19 patients, and suggest that screening and treatment for Strongyloides infection should be conducted in patients receiving immunosuppressive COVID-19 therapies.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2023)
Article
Nutrition & Dietetics
Debora Macis, Irene Maria Briata, Oriana D'Ecclesiis, Harriet Johansson, Valentina Aristarco, Tania Buttiron Webber, Massimo Oppezzi, Sara Gandini, Bernardo Bonanni, Andrea Decensi
Summary: This study found that the combination treatment of curcumin and anthocyanins did not directly affect circulating biomarkers of inflammation and metabolism, but revealed a complex modulation of inflammatory and metabolic biomarkers of colon carcinogenesis.
