Article
Food Science & Technology
Elena Mariani, Claudio Cipolat-Gotet, Bruno Stefanon, Alfonso Zecconi, Giorgia Stocco, Misa Sandri, Michela Ablondi, Maria Mountricha, Andrea Summer
Summary: This study investigated the effect of the interaction between total somatic cell count (SCC) and differential somatic cell count (DSCC) on milk yield, composition, and coagulation traits in individual dairy cows. The results showed that the combined use of SCC and DSCC can be utilized to assess dairy cow performance and monitor milk quality improvement.
INTERNATIONAL JOURNAL OF DAIRY TECHNOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Carsten Kirkeby, Daniel Schwarz, Matt Denwood, Michael Farre, Soren S. Nielsen, Maya Gussmann, Nils Toft, Tariq Halasa
Summary: The study found that the dynamics of SCC and DSCC after IMI varied between dairy herds, with differing effects depending on the causative pathogens.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Agriculture, Dairy & Animal Science
Yasemin Oner, Malena Serrano, Pilar Sarto, Laura Pilar Iguacel, Maria Piquer-Sabanza, Olaia Estrada, Teresa Juan, Jorge Hugo Calvo
Summary: This study conducted a genome-wide association study on Assaf sheep using Illumina Ovine Infinium HD SNP BeadChip (680K) to identify new single nucleotide polymorphisms and genes associated with mastitis resistance. By calculating the corrected phenotype estimates for somatic cell score (SCS), 192 extreme animals were selected for GWAS, identifying four significant SNPs at the chromosome level near genes related to the immune system response. The association results were validated in the total population through Kompetitive Allele-Specific PCR (KASP) genotyping, and one SNP was also found to be associated with lactose content.
Article
Agriculture, Dairy & Animal Science
H. Chen, A. Weersink, D. Kelton, M. von Massow
Summary: The study found a direct relationship between somatic cell count in individual cows and milk production and loss. Analyzing test-day records can estimate total herd milk loss to guide intervention strategies for improving milk quality.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Agriculture, Dairy & Animal Science
Rocio Jimenez-Granado, Antonio Molina, Chiraz Ziadi, Manuel Sanchez, Eva Munoz-Mejias, Sebastian Demyda-Peyras, Alberto Menendez-Buxadera
Summary: This study analyzed a total of 1,031,143 records of daily dairy control test of Spanish Florida goats, focusing on the evolution of somatic cell counts (SCS) in the last 14 years and the genetic analysis of SCS. The results showed a slight increase in SCS and highlighted the importance of mastitis risk. The heritabilities were higher in multi-character models, and genetic correlations between different parities were not unity. Principal component analysis suggested that the selection response varies across parities.
Article
Agriculture, Dairy & Animal Science
Tiantian Luo, Wilma Steeneveld, Mirjam Nielen, Lucio Zanini, Alfonso Zecconi
Summary: This study used milk test records of over 800,000 cows in Lombardy, Italy to investigate the association between somatic cell count (SCC) and milk production. The results confirmed a negative association between SCC and milk production, but the changes in milk production were different from previous studies, indicating the influence of local factors. These findings are important for estimating the economic impacts of mastitis and can guide interventions and inform similar regions.
Article
Infectious Diseases
Anne Bunge, Sonja Dreyer, Jan-Hendrik Paduch, Doris Klocke, Stefanie Leimbach, Nicole Wente, Julia Nitz, Volker Kromker
Summary: To optimise udder health at the herd level, it is necessary to identify incurable mastitis cases and provide adequate therapy and culling strategies. This study assessed the cell count and cell viability in DHI milk samples and found that the proportion of non-vital cells can enhance the prediction of whether antibiotic treatment of clinical mastitis is promising or not.
Article
Oncology
Andrey A. Yurchenko, Oltin T. Pop, Meriem Ighilahriz, Ismael Padioleau, Fatemeh Rajabi, Hayley J. Sharpe, Nicolas Poulalhon, Brigitte Dreno, Amir Khammari, Marc Delord, Antonio Alberti, Nadem Soufir, Maxime Battistella, Samia Mourah, Fanny Bouquet, Ariel Savina, Andrej Besse, Max Mendez-Lopez, Florent Grange, Sandrine Monestier, Laurent Mortier, Nicolas Meyer, Caroline Dutriaux, Caroline Robert, Philippe Saiag, Florian Herms, Jerome Lambert, Frederic J. de Sauvage, Nicolas Dumaz, Lukas Flatz, Nicole Basset-Seguin, Sergey Nikolaev
Summary: This study found that intrinsic resistance (IR) to vismodegib in locally advanced basal cell carcinoma (laBCC) is rare. IR-BCC patients often have resistance mutations in the Hh pathway, but also exhibit hyperactivation of the HIPPO-YAP and WNT pathways.
CLINICAL CANCER RESEARCH
(2022)
Article
Agriculture, Dairy & Animal Science
Che-Hsuan Huang, Kenji Furukawa, Nobuyuki Kusaba
Summary: This observational study examined the effects of mastitis on milk production using somatic cell score (SCS) and differential somatic cell count (DSCC). The results showed that the interaction between SCS and DSCC had significant, nonlinear, and complex effects on milk yield and milk composition. High DSCC could mitigate the negative effects of high SCS on milk yield, while low DSCC exacerbated the drastic milk loss caused by high SCS, especially in high-parity cows. Additionally, high SCS and low DSCC led to pronounced changes in milk composition, including a decrease in lactose percentage and an increase in fat and protein percentages.
JOURNAL OF DAIRY SCIENCE
(2023)
Review
Veterinary Sciences
Sabine Farschtschi, Martin Mattes, Michael W. Pfaffl
Summary: A key challenge of the 21st century is to provide the growing world population with sustainable and secure food supply. Dairy farming's primary task is to reduce milk losses and inefficiencies associated with diseased cows. Differential cell counting has the potential to optimize mastitis diagnostics and monitor the overall health status of dairy cows.
VETERINARY SCIENCES
(2022)
Article
Agriculture, Dairy & Animal Science
Z. Deng, T. J. G. M. Lam, H. Hogeveen, G. Koop
Summary: The study analyzed SCC data from 1,000 cows milked by AMS from 55 dairy herds in 6 countries, identifying a remarkably regularly fluctuating SCC pattern (rfSCC) in 4.7% of the episodes. The rfSCC episodes had specific SCC values and cycle lengths. Bacteriological culture data from one Dutch AMS herd showed no clear association between pathogen species and the rfSCC pattern found in that herd. Further research is needed to understand the significance and mechanism behind this phenomenon.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Agriculture, Dairy & Animal Science
Sabine Farschtschi, Alex Hildebrandt, Martin Mattes, Benedikt Kirchner, Michael W. Pfaffl
Summary: This study monitored the immune status of eight healthy dairy cows throughout their whole lactation by measuring immune cell subtypes in their blood and milk samples. The differences in cell count progressions between blood and milk suggest that high-resolution differential cell counts can be a promising tool for milk diagnostics and support cattle health.
Article
Agriculture, Dairy & Animal Science
Zhuozhuo Zhu, Xinhua Zhu, Wenchuan Guo
Summary: This study explored the potential of dielectric spectroscopy in quantitatively determining the somatic cell count of raw milk. By using advanced data processing techniques and model establishment, the best prediction models were identified, providing a new approach for the detection of somatic cell count in raw milk.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Veterinary Sciences
Ashley Egyedy, Eduardo Barahona Rosales, Burim N. Ametaj
Summary: This study found a link between udder infection in dairy cows before drying off and the incidence of several postpartum diseases. Udder infection caused an increase in somatic cell count in milk, and high somatic cell count was associated with a higher risk of ketosis, retained placenta, uterine infection, and lameness after calving. Udder inflammation also led to lower milk yield and concentrations of milk sugar and protein.
VETERINARY SCIENCES
(2022)
Review
Agronomy
Jenna Williamson, Todd Callaway, Emmanuel Rollin, Valerie Ryman
Summary: Mastitis is a costly disease in dairy cattle, but effective antibiotic therapy can ensure the health and productivity of the cattle. Treatment is more effective when milk somatic cell counts (SCC) are lower prior to treatment. Evaluating milk SCC before administering treatment may increase the cure rates of mastitis. A reliable method for enumerating SCC is critical.
Article
Agriculture, Dairy & Animal Science
N. R. Roin, L. B. Larsen, I. Comi, T. G. Devold, T. I. Eliassen, R. A. Inglingstad, G. E. Vegarud, N. A. Poulsen
Summary: Genetic variation within and between cattle breeds influences the composition of milk and its technological properties. The study on 6 native Norwegian dairy breeds identified diverse genetic variants and rare isoforms of milk proteins, which have not been previously reported in these breeds.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Food Science & Technology
Miguel Aguilera-Toro, Martin Laage Kragh, Amalie Vestergard Thomasen, Vittoria Piccini, Valentin Rauh, Yinghua Xiao, Lars Wiking, Nina A. Poulsen, Lisbeth Truelstrup Hansen, Lotte B. Larsen
Summary: This study assessed the proteolytic activity of 56 Pseudomonas strains and found that the sequence similarity of the aprX-lipA operon significantly influenced the proteolytic activity. The average proteolytic activity of the strains was higher in the A1 group compared to the A2, B, and N groups. The proteolytic activity of the strains was not affected by the lab-scale UHT treatment, indicating high thermal stability. Conserved motifs in the AprX sequence could serve as potential genetic biomarkers for determining strain spoilage potential.
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
A. J. Buitenhuis, L. Hein, L. P. Sorensen, M. Kargo
Summary: The Danish dairy industry is interested in the milk fatty acid composition for new dairy product development and management. Correlations between milk fatty acid composition and breeding goals were studied in Danish Holstein and Danish Jersey cattle breeds. The results showed moderate correlations between fatty acid breeding values and the Nordic Total Merit index and production traits in both breeds. However, some correlations differed between the two breeds and some correlations were only significant in one breed. The correlations between fatty acid breeding values and nonproduction traits were low in both breeds.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
A. J. Buitenhuis, N. A. Poulsen
Summary: The aim of this study was to estimate the genetic parameters for milk urea content in three main Danish dairy breeds. The heritabilities for MU were low to moderate, and the genetic correlations between MU and fat and protein percentages were positive for all three dairy breeds. The study indicates that MU levels in milk can be reduced through farm management and genetic selection.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Nutrition & Dietetics
Brian Christensen, Albert J. Buitenhuis, Lotte N. Jacobsen, Marie S. Ostenfeld, Esben S. Sorensen
Summary: Osteopontin (OPN) is abundant in human milk and has a lower concentration in bovine milk. Both human and bovine milk OPN resist digestion and have beneficial effects on intestinal development. This study compared the effect of digested human and bovine milk OPN on gene expression in Caco-2 cells and found that both OPNs regulated the expression of genes related to biological processes such as the ubiquitin system, DNA binding, transcription, and transcription control pathways.
Article
Agriculture, Dairy & Animal Science
Gayani Madushani Sirinayake Lokuge, Marianne Johansen, Peter Lund, Lotte Bach Larsen, Nina Aagaard Poulsen
Summary: The objective of this study was to investigate the effects of proportion and organic matter digestibility (OMD) of grass-clover silage on milk composition. Feeding a high proportion of low-digestible grass-clover silage resulted in a higher content of milk urea nitrogen. Decreasing the grass-clover to maize silage ratio improved the nutritional value of milk fat by decreasing the share of saturated and increased the share of unsaturated fatty acids.
ACTA AGRICULTURAE SCANDINAVICA SECTION A-ANIMAL SCIENCE
(2023)
Article
Food Science & Technology
Natacha Roed Roin, Nina Aagaard Poulsen, Natalja Pustovalova Norskov, Stig Purup, Lotte Bach Larsen
Summary: Farm management systems and seasonal variation affect the concentrations of phytoestrogens in milk. This study analyzed the concentrations and composition of phytoestrogens in milk from different management systems over a one-year period. Biodynamic milk contained higher levels of most isoflavones compared to conventional milk, possibly due to differences in feeding strategies and botanical composition of feed. The concentration of the mammalian-derived isoflavone, equol, was highest during the indoor period in biodynamic milk. Lignan concentrations were less affected by farm management system.
INTERNATIONAL DAIRY JOURNAL
(2023)
Article
Nutrition & Dietetics
Martin Normark Thesbjerg, Soren Drud-Heydary Nielsen, Ulrik Kraemer Sundekilde, Nina Aagaard Poulsen, Lotte Bach Larsen
Summary: This study examined the activity of proteases and their resulting indigenous peptides in human milk. Plasmin was found to be more active in month 3 of lactation, while antimicrobial peptides were more abundant in month 1.
Article
Food Science & Technology
Ida Schwartz Roland, Miguel Aguilera-Toro, Soren Drud-Heydary Nielsen, Nina Aagaard Poulsen, Lotte Bach Larsen
Summary: The consumption of plant-based drinks is increasing, but they have lower protein content compared to bovine milk, and the proteins in these drinks have significant processing history. In this study, 17 commercially available plant-based drinks were analyzed for protein quality and processing-induced changes. Oat-based drinks had the highest levels of processing-induced markers, which may be due to their processing history, and drinks with added sugar had increased Maillard reaction-related markers.
Article
Food Science & Technology
Natacha Roed Roin, Gayani Madushani Sirinayake Lokuge, Mads Bugge Fredsted, Ulrik Kraemer Sundekilde, Mette Krogh Larsen, Lotte Bach Larsen, Nina Aagaard Poulsen
Summary: Highlighting factors driving natural variation in milk composition among different dairy milk lines is important for ensuring uniform products and exploring the potential benefits of inherent variation. This study investigated compositional variations related to management systems, feeding strategies, and seasonal periods. The results revealed significant differences in fatty acids, micronutrients, and metabolites associated with different management systems.
INTERNATIONAL DAIRY JOURNAL
(2023)