Article
Biotechnology & Applied Microbiology
Xia Li, Ruisheng Xu, Jun-Xing Ye, Feng-Lai Yuan
Summary: Oral bisphosphonates (BPs) are commonly used for the treatment of osteoporosis. This study found that long-term BP treatment can modulate the expression of specific microRNAs (miRNAs), specifically miR-30a-5p, which is negatively correlated with bone formation. In vitro and in vivo experiments demonstrated that miR-30a-5p inhibits osteoblastic differentiation and bone formation. This research provides important insights into the regulatory mechanisms of long-term BP treatment in postmenopausal osteoporosis.
Article
Biochemistry & Molecular Biology
Kengo Kato, Manami Ozaki, Kumiko Nakai, Maki Nagasaki, Junya Nakajima, Ryosuke Koshi, Hideki Tanaka, Takayuki Kawato, Morio Tonogi
Summary: This study found that high concentrations of azithromycin suppress osteogenic function in osteoblastic cells, while low concentrations have no effect.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Francesca Manuela Johnson de Sousa Brito, Andrew Butcher, Addolorata Pisconti, Blandine Poulet, Amanda Prior, Gemma Charlesworth, Catherine Sperinck, Michele Scotto di Mase, Ke Liu, George Bou-Gharios, Robert Jurgen van 't Hof, Anna Daroszewska
Summary: Syndecan-3 promotes new bone formation in osteoblasts by enhancing WNT signaling, and its deficiency in mice results in an early osteoporosis-like phenotype due to delayed osteoblast maturation and impaired function. Overexpressing Sdc3 in osteoblasts rescues the low bone volume phenotype and increases bone mass, making SDC3 a potential target for novel bone anabolic drug development.
Article
Biochemistry & Molecular Biology
Kabsun Kim, Jung Ha Kim, Inyoung Kim, Semun Seong, Jeong Eun Han, Keun-Bae Lee, Jeong-Tae Koh, Nacksung Kim
Summary: Lmx1b negatively regulates osteoblast differentiation and function through repression of Runx2, providing a molecular basis for therapeutic targets in bone diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
Michela Rossi, Giulia Battafarano, Viviana De Martino, Alfredo Scillitani, Salvatore Minisola, Andrea Del Fattore
Summary: This review discusses the impact of rare disorders on bone formation, such as sclerosteosis, van Buchem disease, hypophosphatasia, and Camurati-Engelmann disease. Research on these diseases can help us understand important pathways regulating bone formation, leading to new therapeutic approaches for managing common bone diseases.
JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Medicine, Research & Experimental
Yoon-Hee Cheon, Chang Hoon Lee, Soojin Kim, Gyeong Do Park, Sung Chul Kwak, Hae Joong Cho, Ju-Young Kim, Myeung Su Lee
Summary: Pitavastatin shows potential as a candidate for treating osteoporosis by enhancing osteoblast differentiation and bone growth, as well as inhibiting osteoclast differentiation and bone resorption. Its mechanisms include inhibiting signaling pathways and downregulating transcription factors to regulate osteoclast activity, and stimulating osteoblast differentiation and mineralization to promote bone formation.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Immunology
Yiming Zhong, Yiming Xu, Song Xue, Libo Zhu, Haiming Lu, Cong Wang, Hongjie Chen, Weilin Sang, Jinzhong Ma
Summary: This study suggests that nangibotide may have a protective effect on the bone-cartilage unit and could be an alternative treatment option for osteoarthritis.
INFLAMMOPHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Yan Li, Lingyu Li, Xiaoyun Li, Bingjie Luo, Qianyun Ye, Haoyu Wang, Li Yang, Xiaofeng Zhu, Li Han, Ronghua Zhang, Huaqin Tian, Panpan Wang
Summary: Bone reconstruction relies on the balance between bone formation and bone absorption. Polyphenols found in Chinese herbal medicines can affect this balance and have potential therapeutic effects on bone metabolic diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biology
Leyao Shen, Yilin Yu, Yunji Zhou, Shondra M. Pruett-Miller, Guo-Fang Zhang, Courtney M. Karner
Summary: Cellular differentiation is associated with unique biosynthetic demands. Osteoblast differentiation requires increased proline demand, provided by SLC38A2, for efficient synthesis of osteoblast proteins.
Article
Orthopedics
Masayoshi Ishida, Naoyuki Kawao, Yuya Mizukami, Yoshimasa Takafuji, Hiroshi Kaji
Summary: This study demonstrates that Angptl1 suppresses osteoclast formation and enhances osteoblastic differentiation in mouse cells, while inhibiting adipogenic differentiation of 3T3-L1 cells.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Endocrinology & Metabolism
Fan Wang, Petri Rummukainen, Terhi J. Heino, Riku Kiviranta
Summary: Wnt1 has been shown to play a crucial role in bone metabolism, influencing both early skeletal growth and adult bone formation. Deletion of Wnt1 in mesenchymal cells results in severe osteopenia and spontaneous fractures, indicating its importance in maintaining bone health throughout life.
Article
Biochemistry & Molecular Biology
Anke Baranowsky, Jessika Appelt, Kristina Tseneva, Shan Jiang, Denise Jahn, Serafeim Tsitsilonis, Karl-Heinz Frosch, Johannes Keller
Summary: The study demonstrates the differential action of tranexamic acid on bone cells, including osteoanabolic, anti-resorptive, and anti-inflammatory effects in vitro, suggesting novel treatment applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Allahdad Zarei, Anna Ballard, Linda Cox, Peter Bayguinov, Taylor Harris, Jennifer L. Davis, Philip Roper, James Fitzpatrick, Roberta Faccio, Deborah J. Veis
Summary: Mitochondria are essential organelles forming highly complex networks inside cells, with GTPase mitofusin 2 (MFN2) regulating mitochondrial morphology and affecting metabolic and signaling functions. The role of mitochondria in bone formation is unclear, but MFN2 levels increase during osteoblast differentiation. Deficiency of MFN2 leads to increased oxygen consumption, mineralization, and expression of osteoblast markers in bone marrow-derived mesenchymal stromal cells.
Article
Pharmacology & Pharmacy
Sungyub Lee, Minsun Kim, Sooyeon Hong, Eom Ji Kim, Jae-Hyun Kim, Youngjoo Sohn, Hyuk-Sang Jung
Summary: Postmenopausal osteoporosis is caused by an imbalance between osteoclasts and osteoblasts, leading to severe bone loss. This study found that Sparganii Rhizoma (SR) inhibits osteoclast differentiation and promotes osteoblast differentiation, while also protecting against bone loss in an osteoporosis model. These findings suggest that SR may have potential as a herbal medicine for the treatment of postmenopausal osteoporosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Gaoran Ge, Sen Yang, Zhenyang Hou, Minfeng Gan, Huaqiang Tao, Wei Zhang, Wenming Li, Zheng Wang, Yuefeng Hao, Ye Gu, Dechun Geng
Summary: Our study confirmed that TFDG could promote osteoblast differentiation in an inflammatory environment, enhance their mineralization ability, and ultimately increase bone mass in ovariectomized mice.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Engineering, Biomedical
J. Renwick Beattie, Antonia Sophocleous, M. Clare Caraher, Olive O'Driscoll, Niamh M. Cummins, Steven E. J. Bell, Mark Towler, Alireza Rahimnejad Yazdi, Stuart H. Ralston, Aymen I. Idris
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2019)
Article
Endocrinology & Metabolism
Silvia Marino, Ryan T. Bishop, Giovana Carrasco, John G. Logan, Boya Li, Aymen I. Idris
CALCIFIED TISSUE INTERNATIONAL
(2019)
Article
Oncology
Ryan T. Bishop, Silvia Marino, Danielle de Ridder, Richard J. Allen, Diane V. Lefley, Andrew H. Sims, Ning Wang, Penelope D. Ottewell, Aymen I. Idris
Article
Cell Biology
Thabat Khatib, Pietro Marini, Sudheer Nunna, David R. Chisholm, Andrew Whiting, Christopher Redfern, Iain R. Greig, Peter McCaffery
CELL COMMUNICATION AND SIGNALING
(2019)
Article
Chemistry, Medicinal
Chih-Chung Tseng, Gemma Baillie, Giulia Donvito, Mohammed A. Mustafa, Sophie E. Juola, Chiara Zanato, Chiara Massarenti, Sergio Dall'Angelo, William T. A. Harrison, Aron H. Lichtman, Ruth A. Ross, Matteo Zanda, Iain R. Greig
JOURNAL OF MEDICINAL CHEMISTRY
(2019)
Article
Endocrinology & Metabolism
Silvia Marino, Giovana Carrasco, Boya Li, Karan M. Shah, Darren L. Lath, Antonia Sophocleous, Michelle A. Lawson, Aymen I. Idris
CALCIFIED TISSUE INTERNATIONAL
(2020)
Article
Oncology
Ryan T. Bishop, Silvia Marino, Giovana Carrasco, Boya Li, Richard J. Allen, Anna Sparatore, Penelope D. Ottewell, Patrick Mollat, Andrew H. Sims, Mattia Capulli, Ning Wang, Aymen I. Idris
Article
Neurosciences
Catharine A. Mielnik, Kim S. Sugamori, David B. Finlay, Hayley H. A. Thorpe, Matthieu Schapira, Nirunthan Sivananthan, Chun Kit Li, Vincent M. Lam, Sean Harrington, Mostafa H. Abdelrahman, Laurent A. Trembleau, W. McIntyre Burnham, Jibran Y. Khokhar, Ali Salahpour, Amy J. Ramsey, Michelle Glass, Iain R. Greig, Ruth A. Ross
Summary: The endocannabinoid system plays a significant role in various psychiatric disorders, including schizophrenia. A CB1 receptor allosteric modulator, ABM300, has shown the ability to reduce behavioral deficits in transgenic models, particularly those with hyperdopaminergia.
NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Genetics & Heredity
David Mellis, Katherine A. Staines, Silvia Peluso, Ioanna Ch Georgiou, Natalie Dora, Malgorzata Kubiak, Rob Van't Hof, Michela Grillo, Colin Farquharson, Elaine Kinsella, Anna Thornburn, Stuart H. Ralston, Donald M. Salter, Natalia A. Riobo-Del Galdo, Robert E. Hill, Mark Ditzel
Summary: The mammalian Hedgehog (HH) signalling pathway is crucial for tissue homeostasis, with UBR5 being identified as a regulator in maintaining cartilage homeostasis and suppressing metaplasia. Loss of Ubr5 function results in severe articular cartilage degradation, abnormal bone formation, and extensive tissue metaplasia. Additionally, Ubr5 interacts with smoothened to regulate the HH pathway and increase PKA activity, highlighting its important role in musculoskeletal system regulation.
Article
Neurosciences
Mina G. Nashed, Shannon Waye, S. M. Nageeb Hasan, Diana Nguyen, Micaela Wiseman, Jing Zhang, Harry Lau, O. Chandani Dinesh, Roger Raymond, Iain R. Greig, Francis Rodriguez Bambico, Jose N. Nobrega
Summary: This study found that the SK channel is impaired in the chronic unpredictable stress model, which is associated with the pathophysiology of depressive disorders. Inhibition of SK3 channels can alleviate depressive-like behavior without affecting general locomotor activity.
PSYCHOPHARMACOLOGY
(2022)
Article
Neurosciences
Victoria Gorberg, Veronika Borisov, Iain R. Greig, Roger G. Pertwee, Peter McCaffery, Sharon Anavi-Goffer
Summary: Delta(9)-THC and HU-308, a selective CB2 receptor agonist, have different effects on tics in individuals with Tourette syndrome. CB2 receptors play an important role in reducing tics, and their effects vary with gender and age.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Cell Biology
Katie J. Lee, Lisa Rambault, George Bou-Gharios, Peter D. Clegg, Riaz Akhtar, Gabriela Czanner, Rob van't Hof, Elizabeth G. Canty-Laird
Summary: The study found that mice lacking the alpha 2(I) chain do not exhibit impaired bone biomechanical or structural properties like oim homozygous mice. However, male mice from both lines were affected in terms of Mendelian inheritance, and male mice null for the alpha 2(I) chain showed age-related loss of condition. Compound heterozygotes had impaired bone structural properties compared to oim heterozygotes, but to a lesser extent than oim homozygotes, suggesting a genetic interaction between homotrimeric type I collagen and the oim mutant allele leads to bone fragility.
DISEASE MODELS & MECHANISMS
(2022)
Article
Chemistry, Medicinal
Hayley M. Green, David B. Finlay, Ruth A. Ross, Iain R. Greig, Stephen B. Duffull, Michelle Glass
Summary: This study systematically characterized the in vitro activity of the positive allosteric modulator ZCZ011 and found that it had similar signaling profiles to orthosteric agonists. However, its positive allosteric modulation was limited compared to THC-induced effects. Further investigation into the differences between allosteric and orthosteric agonism is required.
ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE
(2022)
Article
Physiology
Karen J. Thompson, Sonia Watson, Chiara Zanato, Sergio Dall'Angelo, Joriene C. De Nooij, Bethany Pace-Bonello, Fiona C. Shenton, Helen E. Sanger, Beverly A. Heinz, Lisa M. Broad, Noelle Grosjean, Jessica R. Mcquillian, Marina Dubini, Susan Pyner, Iain Greig, Matteo Zanda, David Bleakman, Robert W. Banks, Guy S. Bewick
Summary: The metabotropic glutamate receptor coupled to phospholipase D (PLD-mGluR) has been identified as a homomeric GluK2 receptor signaling metabotropically. This finding is significant because it helps us better understand the role and importance of PLD-mGluR in muscle spindle mechanosensory primary endings.
EXPERIMENTAL PHYSIOLOGY
(2023)
Article
Ophthalmology
Sally Miller, Laura Daily, Maya Ploss, Iain Greig, Ruth Ross, Naga Pradeep Rayana, Jiannong Dai, Chenna Kesavulu Sugali, Weiming Mao, Alex Straiker
EXPERIMENTAL EYE RESEARCH
(2020)