Review
Medicine, General & Internal
Mayur D. Mody, James W. Rocco, Sue S. Yom, Robert Haddad, Nabil F. Saba
Summary: Head and neck cancer is the seventh most common type of cancer worldwide, with the predominant risk factors being tobacco use, alcohol abuse, and oncogenic viruses. Treatment typically involves a multidisciplinary approach with surgery, radiotherapy, and systemic therapy, and is challenging due to site-specific and histology-specific variations.
Review
Oncology
Mehmet Gunduz, Esra Gunduz, Shunji Tamagawa, Keisuke Enomoto, Muneki Hotomi
Summary: Although progress has been made in understanding cancer stem cells, particularly in oropharyngeal cancer, much remains unknown. These stem cells play roles in tumor invasion, metastasis, drug resistance, and recurrence, but there are still many unanswered questions.
Review
Oncology
N. V. Vani, R. Madhanagopal, R. Swaminathan, T. S. Ganesan
Summary: The recent increase in HR-HPV-associated oral and oropharyngeal cancers is an important issue due to their distinct clinical and molecular characteristics. The natural history of oral HPV is still unclear, with a global prevalence ranging from 0.67% to 35% in healthy individuals and 31%-38.5% in head and neck cancer. The persistence rate of oral HR-HPV infection is globally 5.5%-12.8%. In India, HR-HPV-associated HNC accounts for 26% with an active infection in 8%-15% of these tumors. The expression of p16 as an HPV marker in HNC lacks concordance. Treatment de-escalation is not possible due to a lack of evidence despite improved outcomes in HPV-associated oropharyngeal cancers. A better understanding of the oncogenic role of HR-HPV in HNC is crucial for developing novel therapeutic approaches and implementing preventive strategies, which can have a significant public health impact.
Article
Oncology
Erin T. Wong, Shao Hui Huang, Brian O'Sullivan, Vincent Persaud, Jie Su, John Waldron, David P. Goldstein, John de Almeida, Jolie Ringash, John Kim, Andrew Hope, Scott Bratman, John Cho, Meredith Giuliani, Ali Hosni, Anna Spreafico, Aaron Hansen, Li Tong, Wei Xu, Eugene Yu
Summary: The study on surveillance imaging utilization pattern of head and neck revealed that imaging surveillance reduces the need for neck dissection, but routine surveillance without clinical symptoms/signs may not effectively identify locoregional failure or toxicity. For radiologic residual LNs, if two consecutive follow-up scans demonstrate stable/regressing features, clinical surveillance without further imaging appears to be safe.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Alex Whitmarsh, Miranda Pring, Steve J. Thomas, Andrea Waylen, Andy R. Ness, Tom Dudding, Michael Pawlita, Nicole Brenner, Tim Waterboer, Lea Schroeder
Summary: The study found that patients with HPV-positive oropharyngeal cancer have better survival rates, especially among younger patients. The HPV antibody pattern may affect survival, while the antibody level does not show a significant difference.
Article
Oncology
Alex Whitmarsh, Miranda Pring, Steve J. Thomas, Andrea Waylen, Andy R. Ness, Tom Dudding, Michael Pawlita, Nicole Brenner, Tim Waterboer, Lea Schroeder
Summary: Patients with HPV-driven oropharyngeal cancer generally experience better survival rates, with younger patients showing a more significant advantage in survival. The HPV antibody pattern may also influence survival, independent of antibody levels.
Article
Oncology
Qixian Zhang, Tingting Xu, Chunying Shen, Wei Qian, Hongmei Ying, Xiayun He, Yu Wang, Qinghai Ji, Chaosu Hu, Xin Zhou, Xueguan Lu
Summary: This study investigates the prognostic impact of induction chemotherapy (IC) response in patients with HPV-positive and -negative oropharyngeal squamous cell carcinoma (OPSCC), and finds that IC response plays a critical predictive role in prognosis.
Article
Multidisciplinary Sciences
Rex H. Lee, Ritu Roy, Hua Li, Aaron Hechmer, Tian Ran Zhu, Adila Izgutdina, Adam B. Olshen, Daniel E. Johnson, Jennifer R. Grandis
Summary: Currently, there are no clinical strategies utilizing tumor gene expression to inform therapeutic selection for patients with head and neck squamous cell carcinoma (HNSCC). Patient-derived xenografts (PDXs) are translationally relevant preclinical models for human tumors; however, the overall transcriptomic concordance of HNSCC PDXs with primary human HNSCC, especially in HPV+ disease, is understudied. This study characterized 64 HNSCC PDXs at the transcriptomic level and found that PDXs can recapitulate HNSCC molecular subtypes and provide a resource for the discovery of predictive biomarkers for treatment selection in HNSCC.
Review
Immunology
Yuting Pu, Gangcai Zhu, Yimin Xu, Siyuan Zheng, Bin Tang, Huimei Huang, Irene X. Y. Wu, Donghai Huang, Yong Liu, Xin Zhang
Summary: The systematic review found that elevated activities of vitamin D by diet intake, genomic polymorphisms, or circulated 25-OHD may protect people from HNC and improve the prognosis of patients with HNC.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Shadi Basyuni, Gareth Nugent, Ashley Ferro, Eleanor Barker, Ian Reddin, Oliver Jones, Matt Lechner, Ben O'Leary, Terry Jones, Liam Masterson, Tim Fenton, Andrew Schache
Summary: This review examines the relationship between TP53 mutational status and survival in squamous cell carcinoma of the head and neck. The findings suggest that TP53 mutation is associated with worse overall survival, disease-specific survival, and disease-free survival in these patients.
SCIENTIFIC REPORTS
(2022)
Article
Otorhinolaryngology
Anna C. H. Willemsen, Walmari Pilz, Ann Hoeben, Frank J. P. Hoebers, Annemie M. W. J. Schols, Laura W. J. Baijens
Summary: This study investigates the relationship between cancer cachexia and oropharyngeal dysphagia in patients with head and neck cancer. The findings suggest that cachexia independently predicts the presence of patient-reported dysphagia.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Public, Environmental & Occupational Health
Giovanna Paduano, Sara Vaienna, Giuseppe Maisto, Gabriella Di Giuseppe, Maria Pavia
Summary: This study investigated women's knowledge, attitudes, and behaviors towards HPV infection and OPC in primary care services. The findings showed that about 34.7% of participants were aware of the association between OPC and HPV, with higher knowledge among women with personal experience of cancer and those who sought dental care. Only 22.5% had received HPV vaccination, but 62% intended to receive it in the future.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Oncology
Ricklie Julian, Malvi Savani, Julie E. Bauman
Summary: HPV-positive head and neck squamous cell carcinoma (HNSCC) differs from HPV-negative HNSCC in molecular, pathological, and clinical features, showing a better response to immunotherapy. Numerous clinical trials are underway to further refine the application of immunotherapy specifically for HPV-positive HNSCC.
Review
Biochemistry & Molecular Biology
Giuseppe Riva, Camilla Albano, Francesca Gugliesi, Selina Pasquero, Sergio Fernando Castillo Pacheco, Giancarlo Pecorari, Santo Landolfo, Matteo Biolatti, Valentina Dell'Oste
Summary: The APOBEC proteins play a significant role in HPV-positive HNSCC, with their expression depending on HPV infection status and their activity playing a major role in mutagenesis in HPV-positive HNSCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Lisanne van Dijk, Abdelrahman A. Abusaif, Jillian Rigert, Mohamed A. Naser, Katherine A. Hutcheson, Stephen Y. Lai, Clifton D. Fuller, Abdallah S. R. Mohamed
Summary: This study developed NTCP models based on mandible bone D30% and pre-RT dental extraction to predict the occurrence of ORNI-IV and ORNIV after HNC RT. These NTCP models can help identify patients at risk of ORN, improving prevention and management of ORN.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
