Article
Chemistry, Physical
Donald R. Griffin, Maani M. Archang, Chen-Hsiang Kuan, Westbrook M. Weaver, Jason S. Weinstein, An Chieh Feng, Amber Ruccia, Elias Sideris, Vasileios Ragkousis, Jaekyung Koh, Maksim Plikus, Dino Di Carlo, Tatiana Segura, Philip O. Scumpia
Summary: The study aimed to slow MAP scaffold degradation by changing the chirality of peptides, but unexpectedly, D-peptide crosslinked MAP scaffolds led to accelerated degradation in vivo, promoting tissue regeneration and enhancing wound healing. D-MAP triggered an immune response against D-chiral peptides and intact adaptive immune system was crucial for skin regeneration induced by the hydrogel.
Article
Chemistry, Multidisciplinary
Minting Liu, Ying Chen, Qiang Zhu, Junjun Tao, Changming Tang, Huajun Ruan, Yunlong Wu, Xian Jun Loh
Summary: This study discovered that supercritical CO2 extracted pearl peptide hydrogels have the potential to promote wound healing. These hydrogels can increase skin fibroblast viability, enhance antioxidant stress resistance, promote tissue remodeling and angiogenesis, and significantly accelerate wound healing.
CHEMISTRY-AN ASIAN JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
M. C. Linju, M. R. Rekha
Summary: The present study developed a L-proline conjugated chitosan scaffold for wound healing. The scaffold was characterized by various tests and showed no cytotoxicity. In vitro experiments demonstrated that the modified scaffold promoted wound closure and collagen deposition. These findings suggest that the L-proline conjugated scaffold has potential as a wound dressing to improve wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Cheng Yang, Yuhui Chen, Hai Huang, Shicai Fan, Chengliang Yang, Liping Wang, Wenqiang Li, Wenxin Niu, Jianwen Liao
Summary: The ROS-sensitive hydrogel prepared in this study showed strong free radical scavenging ability, accelerated wound healing, and promoted tissue regeneration in experiments.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Lianglong Chen, Chaoyang Huang, Yu Zhong, Yujia Chen, Huihui Zhang, Zijun Zheng, Ziwei Jiang, Xuerong Wei, Yujie Peng, Lei Huang, Libin Niu, Yanbin Gao, Jun Ma, Lei Yang
Summary: In this study, a compound network with physical-chemical double cross-linking was constructed using chemical cross-linking and the intertwining of ADM and chito-san chains under freezing conditions. The heparin-modified composite scaffold with good biocompatibility and cell/tissue affinity significantly promoted cell adhesion and proliferation to achieve adequate fixation and slow down the release of CGF. Polydopamine nanoparticles with excellent photothermal conversion ability promoted the survival of rat autologous skin grafts. In conclusion, this multifunctional composite scaffold shows great potential in delivering CGF to promote healing of full-thickness skin defects.
Article
Medicine, Research & Experimental
Dehong Tan, Wenxiang Zhu, Lujie Liu, Yuanwei Pan, Yangtao Xu, Qinqin Huang, Lingling Li, Lang Rao
Summary: Researchers have developed a versatile hydrogel wound dressing, consisting of royal jelly-derived extracellular vesicles (RJ-EVs) and methacrylic anhydride modified sericin (SerMA), to accelerate wound healing by inhibiting inflammation and promoting vascular reparation. In vitro experiments showed that RJ-EVs have satisfactory anti-inflammatory and antioxidant effects, and significantly promote cell proliferation and migration. The SerMA/RJ-EVs hydrogel dressing can gradually release RJ-EVs at the wound site, ensuring their restorative effect.
Article
Chemistry, Physical
Na Li, Wan Liu, Xiaoyan Zheng, Qing Wang, Lixin Shen, Junfeng Hui, Daidi Fan
Summary: Burns are a common medical problem worldwide, with wound infection as a major complication. To tackle this issue, a new strategy has been proposed to develop a pH-responsive antimicrobial P-ZIF by loading PHMB into ZIF-8 nanoparticles. These nanoparticles can release PHMB in the weak acid environment of an infected wound. Furthermore, P-ZIF nanoparticles were incorporated into a hydrogel dressing made of SA and H-A, which exhibited antibacterial and wound healing properties with dual pH responsiveness. The P-ZIF nanoparticles and corresponding hydrogel dressing are highly significant in antimicrobial, drug delivery, and wound repair applications.
Article
Materials Science, Multidisciplinary
Rachita Lakra, Manikantan Syamala Kiran, Purna Sai Korrapati
Summary: Collagen plays a crucial role in wound healing, and furfural stabilized collagen has been found to have good blood compatibility and compatibility with tissue. Animal experiments have shown that the use of furfural stabilized collagen can promote cellular activities and facilitate wound recovery.
Article
Engineering, Biomedical
Xin Shi, Tong Zhou, Shenyu Huang, Yuejun Yao, Peifang Xu, Shaodan Hu, Chenxi Tu, Wei Yin, Changyou Gao, Juan Ye
Summary: Ocular alkali burn is a serious emergency characterized by persistent inflammation and irreversible vision loss. A double network biomaterial, composed of electrospun nanofibres of thioketal-containing polyurethane (PUTK) and a ROS-scavenging hydrogel (RH), was prepared and transplanted onto a rat corneal alkali burn model. The composite patch showed strong antioxidant activity and accelerated corneal wound healing by inhibiting inflammation, promoting epithelial regeneration, and decreasing scar formation.
ACTA BIOMATERIALIA
(2023)
Article
Biochemistry & Molecular Biology
Nahideh Asadi, Ahmad Mehdipour, Marjan Ghorbani, Mehran Mesgari-Abbasi, Abolfazl Akbarzadeh, Soodabeh Davaran
Summary: A bilayer wound dressing with multifunctional properties was designed in this study, showing enhanced wound healing performance, including antibacterial, free radical scavenging, and biocompatibility properties. Through a full thickness wound model study, it was found that this scaffold had a faster wound closure rate, effective collagen deposition, quick re-epithelialization, and regulation of transforming growth factor-β1 (TGF-β1) and tumor necrosis factor-alpha (TNF-α).
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Polymer Science
Elena Iulia Oprita, Andreea Iosageanu, Oana Craciunescu, Zhiyuan Jia, Holger Schoenherr, Nowsheen Goonoo
Summary: Diabetic chronic wounds are characterized by prolonged and disorganized stages compared to normal wound healing. Natural polymer hydrogels, with their high water content and biocompatibility, show great potential as wound dressings. Natural bioactive hydrogels loaded with compounds such as antibacterials and antioxidants can modulate inflammation and adhere to wounded tissue, providing promising applications for diabetic wound healing. Natural bioactive compounds like polyphenols, polysaccharides, and proteins have multiple advantages in promoting chronic wound healing in diabetes, including their antioxidant, anti-inflammatory, antimicrobial, anti-allergic, and wound healing properties.
Article
Engineering, Biomedical
Jianghong Huang, Xiaoling Lei, Zhiwang Huang, Zhibin Rong, Haihang Li, Yixin Xie, Li Duan, Jianyi Xiong, Daping Wang, Shihui Zhu, Yujie Liang, Jianhao Wang, Jiang Xia
Summary: This study reports the development of an all-protein hydrogel material that promotes skin regeneration and wound healing with biocompatibility and degradability.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2022)
Article
Biochemistry & Molecular Biology
Yifei Fang, Guangze Li, Chunlin Huang, Keqing Huang, Yi Zhao, Tianqi Nie, Jun Wu
Summary: Oxidative stress and infection are major factors delaying wound healing, with potential to cause inflammation and prolonged recovery. This study introduces a novel tissue engineering scaffold called SL/GelMA, developed using tomatoes and gelatin methacryloyl. By utilizing the natural antioxidative components found in tomatoes, such as carotenoids, flavonoids, phenolic acids, vitamin E, and vitamin C, SL/GelMA effectively regulates ROS levels, reduces oxidative stress, promotes cell migration and angiogenesis, and accelerates wound enclosure rate.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Biomedical
Aleksandr A. Levin, Pavel A. Karalkin, Elizaveta V. Koudan, Fedor S. Senatov, Vladislav A. Parfenov, Vladislav A. Lvov, Stanislav V. Petrov, Frederico D. A. S. Pereira, Alexey V. Kovalev, Egor O. Osidak, Sergey P. Domogatsky, Natalya E. Manturova, Vladimir A. Kasyanov, Natalia S. Sergeeva, Vadim L. Zorln, Yusef D. Khesuani, Vladimir A. Mironov
Summary: This study demonstrates the benefits of an originally developed commercial in situ bioprinter for the treatment of skin wounds in rat and porcine models. The in situ bioprinting technique, performed directly on the human body in the operating room, improves the quality of wound healing without interfering with the normal healing process. This suggests that in situ bioprinting could be a novel therapeutic modality in wound healing.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2023)
Article
Nanoscience & Nanotechnology
Matthew McGrath, Karolina Zimkowska, Katelyn J. Genoud, Jack Maughan, Javier Gutierrez Gonzalez, Shane Browne, Fergal J. O'Brien
Summary: A biomimetic, bilayered antimicrobial collagen-based scaffold was developed to deal with the etiology of diabetic foot ulcers (DFUs). The scaffold exhibited high structural stability, successfully inhibited the growth and infiltration of Staphylococcus aureus, and supported the proliferation of epidermal cells and vascularization. These results suggest that the bilayered scaffold is a promising candidate for enhancing diabetic wound healing.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Cell Biology
Sonia Sahvieh, Ahmad Oryan, Shadi Hassanajili, Amir Kamali
Summary: The study found that stem cell-loaded PLA/PCL/HA scaffolds showed better results in bone healing, assisting in bone tissue regeneration and healing. The experimental results demonstrated significant improvements in biomechanics, immunohistochemistry, and radiological evaluations in the BMSCs-loaded scaffold group, indicating higher levels of bone regeneration.
CELL AND TISSUE RESEARCH
(2021)
Article
Cell & Tissue Engineering
Ahmad Oryan, Shadi Hassanajili, Sonia Sahvieh
Summary: This study tested the effects of a scaffold made of different materials on the regeneration of critical bone defects in rats, finding that the cell-seeded scaffold group showed significantly better regeneration outcomes compared to the untreated group. Additionally, the cell-seeded scaffold group and autograft group demonstrated comparable results on day 80 post-treatment.
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2021)
Review
Medicine, Research & Experimental
Ahmad Oryan, Sonia Sahvieh
Summary: Osteoporosis mainly affects older individuals and postmenopausal women, with bisphosphonates (BPs) being the most effective medication for treatment. The use of zoledronate (Zol) within the BPs family shows promising results in improving bone density and preventing fractures, making it a potential treatment option for osteoporosis.
Correction
Parasitology
Fatemeh Khadir, Tahereh Taheri, Sima Habibzadeh, Farnaz Zahedifard, Elham Gholami, Maryam Heidari-Kharaji, Ahmad Oryan, Sima Rafati
VETERINARY PARASITOLOGY
(2021)
Review
Immunology
Maryam Akbari, Ahmad Oryan, Gholamreza Hatam
Summary: Leishmaniasis is a parasitic disease transmitted by sand fly vectors, causing a range of clinical features. Current treatments lack an effective vaccine, with chemotherapy being toxic and expensive. Immunotherapy has emerged as an alternative treatment option, aiming to reduce the toxicity of drugs and drug resistance.
IMMUNOLOGY LETTERS
(2021)
Article
Andrology
Asghar Mogheiseh, Saeed Nazifi, Mohsen Gharibnavaz, Reza Zamani, Behrooz Nikahval, Mohammad Hossein Khanbazi
Summary: The study found that melatonin treatment can reduce oxidative stress and cortisol levels in gonadectomized dogs, while increasing serotonin levels.
Article
Biochemistry & Molecular Biology
Anousheh Shasttiri, Misagh Moridi, Abbas Safari, Sayed Haidar Abbas Raza, Mostafa Ghaderi-Zefrehei, Massoud Houshmand, Ahmad Oryan, Mohammad Hossein Sanati, Jacqueline Smith, Motahareh Amjadi
Summary: The Iranian gene pool exhibits high haplogroup diversities and admixture of exotic groups, with the Arab subpopulation being independent from the others. Thalassemia patients showed some significant differences in their HVS2 sequence.
BIOCHEMICAL GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Sogand Sasan Moghadam, Maryam Ghahramani, Kazem Khoshaman, Ahmad Oryan, Ali Akbar Moosavi-Movahedi, Boris Kurganov, Reza Yousefi
Summary: This study evaluated the impact of peroxynitrite (PON) and methylglyoxal (MGO) on alpha A-crystallin (alpha A-Cry) and found that the reaction of these compounds led to the formation of new chromophores, changes in protein structure, reduction in oligomer size, and increased chaperone activity of alpha A-Cry. Ascorbic acid and glutathione were able to reverse these effects. The results suggest that the lens antioxidant defense system, particularly glutathione, can provide strong protection against diabetic cataract.
BIOCHEMISTRY-MOSCOW
(2022)
Review
Cell Biology
Ahmad Oryan, Effat Alemzadeh, Esmat Alemzadeh, Maryam Barghi, Mohammad Zarei, Hamid Salehiniya
Summary: Adipose stem cell therapy can enhance the healing rate of burn wounds, especially when combined with hydrogels to significantly increase the viability of adipose stem cells. However, more clinical studies are needed to further explore the role of adipose stem cells in burn wound healing.
CELL AND TISSUE BANKING
(2022)
Article
Immunology
Ahmad Oryan, Hassan Sharifi Yazdi, Soodeh Alidadi, Sedigheh Doostmohammadi
Summary: GyrB PCR-RFLP can be used for diagnosing and detecting bovine and human tuberculosis. It is an accurate and reliable method for identifying the species of Mycobacterium tuberculosis complex (MBTC) and should be considered in tuberculosis control strategies, particularly the isolation of M. bovis from human specimens.
COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES
(2022)
Article
Genetics & Heredity
Azadeh Moradi Pirbaluty, Hossein Mehrban, Saeid Kadkhodaei, Rudabeh Ravash, Ahmad Oryan, Mostafa Ghaderi-Zefrehei, Jacqueline Smith
Summary: This bioinformatics study analyzed the transcriptome of chickens after influenza A virus challenge to explore the host expression response. The study identified different gene importance in lowly and highly pathogenic avian influenza infections, which can provide a basis for future development of treatments and preventions against avian influenza in chickens.
Article
Agriculture, Dairy & Animal Science
Zahra Hasanpour, Mousa Zarrin, Ahmad Oryan, Mostafa Mohaghegh-Dolatabad, Amir Ahmadpour
Summary: This study aims to validate the impact of feed restriction and the transition period on hepatic genes related to fat metabolism in fat-tailed sheep. The results show that feed restriction does not affect the mRNA abundance of the target genes during both pre- and post-partum periods. However, parturition suppresses the mRNA abundance of these genes. Fat-tailed sheep are well adapted to feed scarcity and have a higher capacity for fat mobilization during negative energy balance.
TROPICAL ANIMAL HEALTH AND PRODUCTION
(2022)
Article
Tropical Medicine
Ahmad Oryan, Effat Bemani, Somayeh Bahrami
Summary: Objective of this study was to evaluate the in vitro and in vivo efficacy of quercetin against Leishmania major, as well as its immunomodulatory and anti-oxidative activity. The results showed that quercetin exhibited anti-leishmanial activity, immunomodulatory, anti-oxidative, and anti-inflammatory effects. Therefore, it has the potential to be further explored as an effective drug for treating leishmaniasis.
ASIAN PACIFIC JOURNAL OF TROPICAL BIOMEDICINE
(2023)
Article
Veterinary Sciences
Sina Salavati, Asghar Mogheiseh, Saeed Nazifi, Atefeh Amiri, Behrooz Nikahval
Summary: This study aimed to assess the effects of melatonin on the concentrations of melatonin, cortisol, alpha-1-acid glycoprotein (AGP), serum amyloid A (SAA), c-reactive protein (CRP), interleukin-10 (IL-10), interleukin-8 (IL-8), interleukin-1 beta (IL-1 beta) and tumour necrosis factor-alpha (TNF-alpha) before and after ovariohysterectomy (OHE). The results showed that melatonin can decrease inflammatory response and stress, helping to control the inflammation and stress induced by OHE.
VETERINARY MEDICINE AND SCIENCE
(2023)
Correction
Engineering, Biomedical
A. Oryan, Baghaban M. Eslaminejad, A. Kamali, S. Hosseini, F. A. Sayahpour, H. Baharvand
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2022)
