Article
Pharmacology & Pharmacy
Alvaro Quincho-Lopez, Josmel Pacheco-Mendoza
Summary: The study reveals a significant increase in scientific research on polymyxin resistance over the past decade, with a focus on its relationship with public health, pharmacology, and genetics. China and the United States lead the scientific production in this field, while little contribution comes from central Asia, Sub-Saharan Africa, and Latin America.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Infectious Diseases
Xueping Yang, Changhong Guo, Guangjie Wu, Kai Zhao, Dong Xiang, Dong Xu, Dong Liu, Yan He
Summary: This report describes a case of central nervous system infection caused by carbapenem-resistant Acinetobacter baumannii, which was successfully treated with a combination of intraventricular and intravenous colistin sulfate. The treatment regimen was effective in controlling the infection without observed nephrotoxicity or neurotoxicity.
INFECTION AND DRUG RESISTANCE
(2023)
Review
Infectious Diseases
Jitka Rychlickova, Vendula Kubickova, Pavel Suk, Karel Urbanek
Summary: The emerging resistance of Gram-negative bacteria is a global problem that has led to the reintroduction of colistin as a therapeutic option. However, there are still many questions regarding the safety and efficacy of colistin. This review summarizes the available literature on the use of colistin in critically ill patients, focusing on stability, pharmacokinetics, plasma concentration determination methods, and therapeutic drug monitoring benefits and limitations. Based on these findings, the gaps in knowledge are identified, and future research directions are suggested.
Review
Environmental Studies
Lin Jiang, Yani Lai, Ke Chen, Xiao Tang
Summary: The recent economic advances in China have led to the need for urban village redevelopment. This study aims to fill the gap in understanding the drivers of urban village redevelopment in China. The findings suggest that population growth, income level improvement, market-oriented land reforms, and government intervention have been the main drivers of urban village redevelopment.
Article
Environmental Studies
Hui Cheng, Yani Lai, De Tong
Summary: This paper explores the new era of urban redevelopment in China, focusing on the changing roles of stakeholders in decision-making processes within the new inclusive governance model proposed in Guangdong province. Through a case study in Shenzhen, it highlights conflicts and compromises between land owners, developers, and government in industrial land redevelopment, offering valuable insights for similar projects in other cities.
Article
Microbiology
Caroline Pissetti, Eduardo de Freitas Costa, Karoline Silva Zenato, Marisa Ribeiro de Itapema Cardoso
Summary: This study analyzed data collected over 16 years in the Brazilian swine production chain to evaluate the antimicrobial resistance in Salmonella strains. The results showed that the minimum inhibitory concentration of some antimicrobials has increased over time, while the diameter of some halos has decreased, indicating the potential of this approach to enhance the sensitivity and timeliness of antimicrobial resistance surveillance.
Article
Environmental Studies
Jesper M. Paasch, Jenny Paulsson
Summary: The formation and alteration of real property and rights, restrictions and responsibilities are important parts of land administration. Research on the distribution of publications in the three-dimensional (3D) cadastral domain has been in focus as a specialised part of real property research during the last decades. The purpose of the research presented here is to contribute to these analyses of the number and thematic distribution of the 3D cadastral domain literature by analyzing three aspects.
Article
Multidisciplinary Sciences
Weike Zhao, Yuanpei Liao, Shengqiu Zhou, Bo Zhou
Summary: This study examines the impact of different land use types on soil heavy metal contamination in the Mianyang thermal power plant area, China. The results show that industrial land has a significant effect on soil heavy metal pollution. Additionally, the study provides an effective method for ecological remediation of soil heavy metals in brownfield renewal planning and helps develop different remediation strategies for different risk levels of human health.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Kehao Chen, Guiyu Wei
Summary: This study analyzes public comments on China's urban regeneration using massive data, and finds that overall, the public sentiment is positive with spatiotemporal divergences. In terms of time, sentiment was most negative in 2020, but became most positive in 2021 and consistently negative in 2022. Spatially, Guangdong province had the most comments, and Tibet, Shanghai, Guizhou, Chongqing, and Hong Kong had highly positive sentiment. The east and south coastal, southwestern, and western regions of China were more positive compared to the northeast, central, and northwest regions. Topics related to Shenzhen's renovations, development of China's urban regeneration, and complaints from residents were the focus of public attention. Governments should address spatiotemporal disparities and concerns of local residents for future urban regeneration development.
Review
Multidisciplinary Sciences
Abdulaziz Alqasim
Summary: Gram-negative bacteria (GNB) pose a significant health threat globally, with increasing antimicrobial resistance leading to the need for colistin treatment. Saudi Arabia's annual mass religious gatherings heighten the risk of infectious disease transmission. While colistin remains effective locally, high resistance has been observed among major GNB, and the role of mass gatherings in triggering colistin resistance is concerning.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2021)
Article
Infectious Diseases
Claudine Fournier, Patrice Nordmann, Olivier Pittet, Laurent Poirel
Summary: A high prevalence of fecal carriage of ESBL-producing E. coli was found among pigs from a Swiss farm attending an animal health and antibiotic stewardship program, mainly due to the spread of a clonal lineage within the farm. In contrast, a low prevalence of colistin-resistant Enterobacterales was identified in the study.
Review
Computer Science, Interdisciplinary Applications
L. B. P. da Silva, R. Soltovski, J. Pontes, F. T. Treinta, P. Leitao, E. Mosconi, L. M. M. de Resende, R. T. Yoshino
Summary: Digitalization is transforming the workplace and human resource management, presenting trends and challenges for HRM in the context of Industry 4.0. This study provides insights into the impact of digital trends on HRM by conducting a literature review and content analysis.
COMPUTERS & INDUSTRIAL ENGINEERING
(2022)
Article
Environmental Studies
Ryan Greenaway-McGrevy, Gail Pacheco, Kade Sorensen
Summary: The study shows that a large-scale upzoning in Auckland, New Zealand has significant effects on house prices and redevelopment premiums. The impact depends on the economic potential for site redevelopment, leading to appreciation of underdeveloped properties and depreciation of intensively developed properties.
Article
Chemistry, Applied
Spiro D. Alexandratos
Summary: Ion exchange is a simple and elegant concept with wide applications in various fields. Research interest in ion exchange has remained constant over the years, with chemistry being the dominant field and engineering seeing significant growth in later years. Resins have been the primary material, but the importance of membranes has been increasing over time.
REACTIVE & FUNCTIONAL POLYMERS
(2021)
Article
Veterinary Sciences
Wiebke Jansen, Jobke van Hout, Jeanine Wiegel, Despoina Iatridou, Ilias Chantziaras, Nancy De Briyne
Summary: This study investigated the use patterns of colistin in veterinary medicine in different European countries and sectors. The majority of veterinarians surveyed did not use or decreased their use of colistin, with gastrointestinal diseases and septicaemia being the main indications for use. Some veterinarians reported governmental/industry restrictions on colistin use, with the most common restriction being the requirement of susceptibility testing before use.
VETERINARY SCIENCES
(2022)
Article
Critical Care Medicine
Ernest A. Azzopardi, Robert T. Duncan, Mollie Kearns, Francesco Marangoni, Nader Ibrahim, Ernest A. F. Azzopardi, Dean Boyce, Matteo Tretti, Maxwell S. C. Mursion
Article
Surgery
Matteo Tretti Clementoni, Valerio Pedrelli, Giovanna Zaccaria, Paolo Pontini, Laura Romana Motta, Ernest A. Azzopardi
FACIAL PLASTIC SURGERY CLINICS OF NORTH AMERICA
(2020)
Article
Microbiology
Juliette L. Oakley, Rebecca Weiser, Lydia C. Powell, Julian Forton, Eshwar Mahenthiralingam, Philip D. Rye, Katja E. Hill, David W. Thomas, Manon F. Pritchard
Summary: The study showed that long-term exposure to OligoG CF-5/20 did not lead to extensive mutational changes in P. aeruginosa, but may decrease the pathogenicity of bacterial biofilm and improve its susceptibility to other classes of antibiotics.
Article
Biochemistry & Molecular Biology
Alexander Incledion, Megan Boseley, Rachael L. Moses, Ryan Moseley, Katja E. Hill, David W. Thomas, Rachel A. Adams, Tim P. Jones, Kelly A. BeruBe
Summary: Clays believed to have medicinal properties since prehistoric times are still used today as complementary medicines. Recent studies suggest that clays with antibacterial characteristics could serve as alternatives to antibiotics in combating antibiotic resistance. However, research indicates that the ion concentration in clay leachates is insufficient to have antibacterial effects, and all clay leachates displayed toxicity towards THP-1 monocytes.
Article
Surgery
E. A. Azzopardi, W. Abdelrahman, E. Azzopardi, B. O'Leary, J. Yarrow, N. Miles, C. Barbara, L. Camilleri, M. T. Clementoni, M. Murison
Summary: Basal cell carcinoma is the most common cancer, and excisional surgery is commonly used for treatment. However, this study shows that carbon dioxide laser extirpation assisted by immediate photodynamic therapy can achieve a high clearance rate with better functional and cosmetic outcomes at a lower cost compared to wide local excision. Further investigation through randomized controlled studies is needed.
ANNALS OF THE ROYAL COLLEGE OF SURGEONS OF ENGLAND
(2021)
Article
Biotechnology & Applied Microbiology
Lydia C. Powell, Muthanna Abdulkarim, Joana Stokniene, Qiu E. Yang, Timothy R. Walsh, Katja E. Hill, Mark Gumbleton, David W. Thomas
Summary: The study utilized multiple particle tracking (MPT) to quantify the effects of antibiotic treatments on the physical and mechanical properties of antimicrobial resistant (AMR) bacterial biofilms. Results showed size-dependent and strain-related differences in diffusion coefficient values of biofilms, and dose-dependent treatment effects induced by polymyxin B (PMB) in E. coli biofilms. The ability of MPT to assess diffusion and mechanical effects of antibiotic therapies within the AMR biofilm matrix was highlighted, providing a valuable tool for pre-clinical screening of anti-biofilm therapies.
NPJ BIOFILMS AND MICROBIOMES
(2021)
Article
Multidisciplinary Sciences
Emilie Chiron, Mathieu Varache, Joana Stokniene, David W. Thomas, Elaine L. Ferguson
Summary: The attachment of polysaccharide carriers increasingly improves the precision delivery and effectiveness of protein and peptide drugs. The stability of polysaccharide-based conjugates is crucial for their protective efficacy, and research on dextrin-colistin conjugates showed significant release of saccharides during prolonged storage at elevated temperatures, without affecting antimicrobial activity.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Zack Saud, Victoria J. Tyrrell, Andreas Zaragkoulias, Majd B. Protty, Evelina Statkute, Anzelika Rubina, Kirsten Bentley, Daniel A. White, Patricia Dos Santos Rodrigues, Robert C. Murphy, Harald Koefeler, William J. Griffiths, Jorge Alvarez-Jarreta, Richard William Brown, Robert G. Newcombe, James Heyman, Manon Pritchard, Robert WJ. Mcleod, Arvind Arya, Ceri-Ann Lynch, David Owens, P. Vince Jenkins, Niklaas J. Buurma, Valerie B. O'Donnell, David W. Thomas, Richard J. Stanton
Summary: The lipid envelope of SARS-CoV-2 is different from the host plasma membrane, which allows for selective antiviral approaches using oral rinses.
JOURNAL OF LIPID RESEARCH
(2022)
Article
Multidisciplinary Sciences
Joana Stokniene, Mathieu Varache, Philip D. Rye, Katja E. Hill, David W. Thomas, Elaine L. Ferguson
Summary: A model was developed to study the impaired diffusion of antibiotics across mucin barriers and showed that mucin binding leads to significant loss and reduced effectiveness of antibiotics. The use of mucolytics improves antibiotic diffusion and antimicrobial activity.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Lydia C. Powell, Jason K. Cullen, Glen M. Boyle, Tom De Ridder, Pei-Yi Yap, Wenya Xue, Carly J. Pierce, Manon F. Pritchard, Georgina E. Menzies, Muthanna Abdulkarim, Jennifer Y. M. Adams, Joana Stokniene, Lewis W. Francis, Mark Gumbleton, Jenny Johns, Katja E. Hill, Adam V. Jones, Peter G. Parsons, Paul Reddell, David W. Thomas
Summary: This study reports a non-antibiotic approach using naturally occurring and semisynthetic compounds to treat chronic skin wounds by modifying bacterial growth and inducing biofilm disruption. The compounds were found to stimulate immune responses and exhibit antimicrobial activity, leading to the resolution of infection and wound healing.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Nicholas Claydon, Dave W. Thomas, Robert J. Adams, Nicola West, Shaun Hodge
Summary: This study investigated the implementation of the new classification of periodontal diseases and conditions in general dental practice and found it to be feasible. The use of the new classification allows for close monitoring of periodontal status, enabling the effectiveness of care pathways to be closely monitored.
BRITISH DENTAL JOURNAL
(2022)
Article
Immunology
Lydia C. C. Powell, Jennifer Y. M. Adams, Sadik Quoraishi, Charlene Py, Anais Oger, Salvatore A. A. Gazze, Lewis W. W. Francis, Christopher von Ruhland, David Owens, Philip D. D. Rye, Katja E. E. Hill, Manon F. F. Pritchard, David W. W. Thomas
Summary: This study found that the combination of OligoG and nystatin can significantly reduce the minimum inhibitory concentration of various Candida infections, inhibit biofilm formation, and increase cell death. This suggests the potential utility of this combination therapy in the prevention and treatment of candidal biofilm infections.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Dentistry, Oral Surgery & Medicine
Mehreen Zakir, David Thomas, Robert Adams, Damian Farnell, Nicholas Claydon
Summary: This systematic review assessed the effectiveness of adjunctive therapies for treating peri-implantitis. Meta-analyses were performed on studies comparing conventional surgical or nonsurgical mechanical debridement with the addition of adjunctive therapies. The results showed that chemical therapy had significant effects in reducing probing pocket depth and increasing radiographic bone level, while no significant improvements were found in reducing bleeding on probing. The limited availability of standardized, controlled studies and heterogeneity between studies restrict the evidence for the benefits of adjunctive therapies.
JOURNAL OF ORAL IMPLANTOLOGY
(2023)
Article
Microbiology
Wenya Xue, Manon F. Pritchard, Saira Khan, Lydia C. Powell, Joana Stokniene, Jingxiang Wu, Nicholas Claydon, Paul Reddell, David W. Thomas, Katja E. Hill
Summary: EBC-1013, derived from the Queensland blushwood tree, demonstrates clear antimicrobial and antibiofilm formation potential, making it a promising candidate for the treatment of peri-implantitis.
JOURNAL OF ORAL MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Parkash Lohana, Albert Suryaprawira, Emma L. Woods, Jordanna Dally, Edward Gait-Carr, Nadia Y. A. Alaidaroos, Charles M. Heard, Kwok Y. Lee, Fiona Ruge, Jeremy N. Farrier, Stuart Enoch, Matthew P. Caley, Matthew A. Peake, Lindsay C. Davies, Peter J. Giles, David W. Thomas, Phil Stephens, Ryan Moseley
Summary: Unlike skin, oral mucosal wounds heal rapidly and with minimal scarring, possibly due to the enhanced healing properties of oral mucosal fibroblasts (OMFs). This study compared oxidative stress biomarker and antioxidant profiles between oral mucosal/skin tissues and OMFs/skin fibroblasts (SFs) to investigate the role of antioxidant capabilities and oxidative stress in the preferential healing of oral mucosa.
